Protein: P00533

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P00533 (Uniprot) EGFR_HUMAN EGFR Epidermal growth factor receptor human No
Uniprot: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Plays a role in enhancing learning and memory performance (By similarity).Isoform 2 may act as an antagonist of EGF action.(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0044260 cellular macromolecule metabolic process 24, 323, 821 GO:0033036 macromolecule localization 517 4.56e-06 3.25e-28
GO:0044260 cellular macromolecule metabolic process 24, 323, 821 GO:0022610 biological adhesion 869 6.74e-23 3.02e-10
GO:0034641 cellular nitrogen compound metabolic process 35, 245, 327, 477, 492 GO:0007165 signal transduction 355, 486, 512, 803, 282, 308 4.22e-144 6.90e-18
GO:0034641 cellular nitrogen compound metabolic process 35, 245, 327, 477, 492 GO:0006928 movement of cell or subcellular component 496 7.55e-40 5.63e-168
GO:0034641 cellular nitrogen compound metabolic process 35, 245, 327, 477, 492 GO:0033036 macromolecule localization 517 4.14e-25 1.17e-53
GO:0034641 cellular nitrogen compound metabolic process 35, 245, 327, 477, 492 GO:0022610 biological adhesion 869 6.87e-63 4.34e-65
GO:0007166 cell surface receptor signaling pathway 108 GO:0034641 cellular nitrogen compound metabolic process 35, 245, 327, 477, 492 5.53e-55 9.57e-64
GO:0007166 cell surface receptor signaling pathway 108 GO:0006725 cellular aromatic compound metabolic process 484, 614 3.09e-47 2.24e-87
GO:0007166 cell surface receptor signaling pathway 108 GO:0009059 macromolecule biosynthetic process 551, 682, 779 2.49e-18 9.18e-29
GO:0007166 cell surface receptor signaling pathway 108 GO:0006139 nucleobase-containing compound metabolic process 698 6.88e-41 1.21e-84
GO:0007165 signal transduction 187, 282, 308, 355, 486, 512 GO:0006725 cellular aromatic compound metabolic process 484, 614 5.44e-126 5.27e-27
GO:0007165 signal transduction 187, 282, 308, 355, 486, 512 GO:0006139 nucleobase-containing compound metabolic process 698 1.10e-111 5.07e-25
GO:0034641 cellular nitrogen compound metabolic process 35, 245, 327, 477, 492 GO:0010646 regulation of cell communication 284 1.59e-39 2.52e-03
GO:0010646 regulation of cell communication 284 GO:0006725 cellular aromatic compound metabolic process 484, 614 4.64e-30 1.07e-07
GO:0010646 regulation of cell communication 284 GO:0006139 nucleobase-containing compound metabolic process 698 6.71e-28 7.52e-07
GO:0043170 macromolecule metabolic process 367, 410 GO:0033036 macromolecule localization 517 2.48e-08 1.95e-27
GO:0043170 macromolecule metabolic process 367, 410 GO:0022610 biological adhesion 869 2.68e-16 4.92e-03
GO:0006725 cellular aromatic compound metabolic process 484, 614 GO:0006928 movement of cell or subcellular component 496 1.24e-32 2.63e-196
GO:0006725 cellular aromatic compound metabolic process 484, 614 GO:0033036 macromolecule localization 517 1.29e-20 6.46e-74
GO:0006725 cellular aromatic compound metabolic process 484, 614 GO:0022610 biological adhesion 869 6.51e-58 2.68e-107
GO:0006928 movement of cell or subcellular component 496 GO:0006139 nucleobase-containing compound metabolic process 698 1.95e-31 6.36e-195
GO:0033036 macromolecule localization 517 GO:0009059 macromolecule biosynthetic process 551, 682, 779 2.32e-08 6.09e-30
GO:0033036 macromolecule localization 517 GO:0006139 nucleobase-containing compound metabolic process 698 4.58e-19 9.70e-72
GO:0009059 macromolecule biosynthetic process 551, 682, 779 GO:0022610 biological adhesion 869 2.22e-23 6.08e-57
GO:0006139 nucleobase-containing compound metabolic process 698 GO:0022610 biological adhesion 869 2.30e-55 4.36e-110
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
24 GO:0016070 RNA metabolic process
24 GO:0006464 cellular protein modification process
24 GO:0034654 nucleobase-containing compound biosynthetic process
24 GO:0006796 phosphate-containing compound metabolic process
24 GO:0031325 positive regulation of cellular metabolic process
24 GO:0010604 positive regulation of macromolecule metabolic process
24 GO:0051173 positive regulation of nitrogen compound metabolic process
24 GO:2000112 regulation of cellular macromolecule biosynthetic process
24 GO:0010468 regulation of gene expression
24 GO:0019219 regulation of nucleobase-containing compound metabolic process
24 GO:0051246 regulation of protein metabolic process
24 GO:0007165 signal transduction
28 GO:0006464 cellular protein modification process
28 GO:0031324 negative regulation of cellular metabolic process
28 GO:0010605 negative regulation of macromolecule metabolic process
28 GO:0051172 negative regulation of nitrogen compound metabolic process
28 GO:0031325 positive regulation of cellular metabolic process
28 GO:0010604 positive regulation of macromolecule metabolic process
28 GO:0051173 positive regulation of nitrogen compound metabolic process
28 GO:0048584 positive regulation of response to stimulus
28 GO:0009966 regulation of signal transduction
28 GO:0006355 regulation of transcription, DNA-templated
29 GO:0060255 regulation of macromolecule metabolic process
29 GO:0007165 signal transduction
35 GO:0044271 cellular nitrogen compound biosynthetic process
35 GO:0044267 cellular protein metabolic process
35 GO:0090304 nucleic acid metabolic process
35 GO:0010468 regulation of gene expression
35 GO:0009966 regulation of signal transduction
108 GO:0007167 enzyme linked receptor protein signaling pathway
108 GO:0006139 nucleobase-containing compound metabolic process
108 GO:0031325 positive regulation of cellular metabolic process
108 GO:1902533 positive regulation of intracellular signal transduction
108 GO:0010604 positive regulation of macromolecule metabolic process
108 GO:0006468 protein phosphorylation
111 GO:0006955 immune response
111 GO:0035556 intracellular signal transduction
111 GO:0009967 positive regulation of signal transduction
111 GO:0006468 protein phosphorylation
111 GO:0060255 regulation of macromolecule metabolic process
111 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
128 GO:0007165 signal transduction
138 GO:0006464 cellular protein modification process
138 GO:0007165 signal transduction
155 GO:0006464 cellular protein modification process
155 GO:0060255 regulation of macromolecule metabolic process
166 GO:0044267 cellular protein metabolic process
166 GO:0006139 nucleobase-containing compound metabolic process
166 GO:0060255 regulation of macromolecule metabolic process
166 GO:0007165 signal transduction
171 GO:0006464 cellular protein modification process
171 GO:0035556 intracellular signal transduction
171 GO:0009966 regulation of signal transduction
175 GO:0044267 cellular protein metabolic process
175 GO:0006139 nucleobase-containing compound metabolic process
175 GO:0010468 regulation of gene expression
186 GO:0048468 cell development
186 GO:0007166 cell surface receptor signaling pathway
186 GO:0044267 cellular protein metabolic process
186 GO:0035556 intracellular signal transduction
186 GO:0030182 neuron differentiation
186 GO:0006796 phosphate-containing compound metabolic process
186 GO:0120036 plasma membrane bounded cell projection organization
186 GO:0060255 regulation of macromolecule metabolic process
186 GO:0009966 regulation of signal transduction
187 GO:0007166 cell surface receptor signaling pathway
187 GO:0006464 cellular protein modification process
187 GO:0070887 cellular response to chemical stimulus
187 GO:0035556 intracellular signal transduction
187 GO:0006928 movement of cell or subcellular component
187 GO:0006796 phosphate-containing compound metabolic process
187 GO:0010647 positive regulation of cell communication
187 GO:0048584 positive regulation of response to stimulus
187 GO:0023056 positive regulation of signaling
187 GO:0060255 regulation of macromolecule metabolic process
187 GO:0009966 regulation of signal transduction
197 GO:0044267 cellular protein metabolic process
197 GO:0060255 regulation of macromolecule metabolic process
202 GO:0044267 cellular protein metabolic process
202 GO:0070887 cellular response to chemical stimulus
202 GO:0060255 regulation of macromolecule metabolic process
202 GO:0007165 signal transduction
205 GO:0071310 cellular response to organic substance
205 GO:0007167 enzyme linked receptor protein signaling pathway
205 GO:0090304 nucleic acid metabolic process
205 GO:0034654 nucleobase-containing compound biosynthetic process
205 GO:0043085 positive regulation of catalytic activity
205 GO:0031325 positive regulation of cellular metabolic process
205 GO:0010604 positive regulation of macromolecule metabolic process
205 GO:0051173 positive regulation of nitrogen compound metabolic process
205 GO:0009967 positive regulation of signal transduction
205 GO:0006468 protein phosphorylation
205 GO:2000112 regulation of cellular macromolecule biosynthetic process
205 GO:0032268 regulation of cellular protein metabolic process
205 GO:0010468 regulation of gene expression
205 GO:1902531 regulation of intracellular signal transduction
205 GO:0019219 regulation of nucleobase-containing compound metabolic process
205 GO:0042325 regulation of phosphorylation
205 GO:0051049 regulation of transport
212 GO:0007165 signal transduction
214 GO:0044267 cellular protein metabolic process
214 GO:0006355 regulation of transcription, DNA-templated
215 GO:0044267 cellular protein metabolic process
215 GO:0007167 enzyme linked receptor protein signaling pathway
215 GO:0010467 gene expression
215 GO:0016310 phosphorylation
215 GO:1902531 regulation of intracellular signal transduction
215 GO:0060255 regulation of macromolecule metabolic process
237 GO:0022607 cellular component assembly
237 GO:0034645 cellular macromolecule biosynthetic process
237 GO:0044271 cellular nitrogen compound biosynthetic process
237 GO:0006464 cellular protein modification process
237 GO:0051649 establishment of localization in cell
237 GO:0010467 gene expression
237 GO:0031324 negative regulation of cellular metabolic process
237 GO:0010605 negative regulation of macromolecule metabolic process
237 GO:0051172 negative regulation of nitrogen compound metabolic process
237 GO:0090304 nucleic acid metabolic process
237 GO:0033365 protein localization to organelle
237 GO:0015031 protein transport
237 GO:0050790 regulation of catalytic activity
237 GO:0051128 regulation of cellular component organization
238 GO:0060255 regulation of macromolecule metabolic process
245 GO:0044271 cellular nitrogen compound biosynthetic process
245 GO:0090304 nucleic acid metabolic process
245 GO:1901362 organic cyclic compound biosynthetic process
245 GO:2000112 regulation of cellular macromolecule biosynthetic process
245 GO:0019219 regulation of nucleobase-containing compound metabolic process
258 GO:0006464 cellular protein modification process
258 GO:0031325 positive regulation of cellular metabolic process
258 GO:0060255 regulation of macromolecule metabolic process
259 GO:0007165 signal transduction
282 GO:0035556 intracellular signal transduction
282 GO:0043085 positive regulation of catalytic activity
282 GO:0031325 positive regulation of cellular metabolic process
282 GO:0051173 positive regulation of nitrogen compound metabolic process
282 GO:0060255 regulation of macromolecule metabolic process
282 GO:0019220 regulation of phosphate metabolic process
283 GO:0006464 cellular protein modification process
283 GO:0060255 regulation of macromolecule metabolic process
284 GO:0009966 regulation of signal transduction
297 GO:0007165 signal transduction
301 GO:0006464 cellular protein modification process
301 GO:0060255 regulation of macromolecule metabolic process
308 GO:0007166 cell surface receptor signaling pathway
308 GO:0071310 cellular response to organic substance
308 GO:0035556 intracellular signal transduction
308 GO:0043085 positive regulation of catalytic activity
308 GO:0031328 positive regulation of cellular biosynthetic process
308 GO:0010604 positive regulation of macromolecule metabolic process
308 GO:0045935 positive regulation of nucleobase-containing compound metabolic process
308 GO:0009967 positive regulation of signal transduction
308 GO:0006468 protein phosphorylation
308 GO:0031399 regulation of protein modification process
308 GO:0006355 regulation of transcription, DNA-templated
316 GO:0044267 cellular protein metabolic process
316 GO:0060255 regulation of macromolecule metabolic process
323 GO:0016070 RNA metabolic process
323 GO:0034654 nucleobase-containing compound biosynthetic process
323 GO:0009893 positive regulation of metabolic process
323 GO:0006468 protein phosphorylation
323 GO:2000112 regulation of cellular macromolecule biosynthetic process
323 GO:0010468 regulation of gene expression
323 GO:0019219 regulation of nucleobase-containing compound metabolic process
323 GO:0007165 signal transduction
327 GO:0044271 cellular nitrogen compound biosynthetic process
327 GO:0044267 cellular protein metabolic process
327 GO:0006139 nucleobase-containing compound metabolic process
327 GO:0031325 positive regulation of cellular metabolic process
327 GO:0031326 regulation of cellular biosynthetic process
327 GO:0010468 regulation of gene expression
327 GO:0007165 signal transduction
333 GO:0060255 regulation of macromolecule metabolic process
333 GO:0009966 regulation of signal transduction
355 GO:0007166 cell surface receptor signaling pathway
355 GO:0006464 cellular protein modification process
355 GO:0035556 intracellular signal transduction
355 GO:0016310 phosphorylation
355 GO:0010647 positive regulation of cell communication
355 GO:0048584 positive regulation of response to stimulus
355 GO:0023056 positive regulation of signaling
355 GO:0060255 regulation of macromolecule metabolic process
355 GO:0009966 regulation of signal transduction
367 GO:0010467 gene expression
367 GO:0007399 nervous system development
367 GO:0006139 nucleobase-containing compound metabolic process
367 GO:0019538 protein metabolic process
367 GO:0051128 regulation of cellular component organization
367 GO:0060255 regulation of macromolecule metabolic process
367 GO:0007165 signal transduction
381 GO:0006464 cellular protein modification process
381 GO:0010467 gene expression
381 GO:0016310 phosphorylation
381 GO:0010604 positive regulation of macromolecule metabolic process
381 GO:0050790 regulation of catalytic activity
381 GO:0032268 regulation of cellular protein metabolic process
381 GO:0007165 signal transduction
404 GO:0044267 cellular protein metabolic process
404 GO:0007165 signal transduction
410 GO:0010467 gene expression
410 GO:0007165 signal transduction
440 GO:0006464 cellular protein modification process
440 GO:0007167 enzyme linked receptor protein signaling pathway
440 GO:0035556 intracellular signal transduction
440 GO:0006928 movement of cell or subcellular component
440 GO:0016310 phosphorylation
440 GO:0031325 positive regulation of cellular metabolic process
440 GO:0010604 positive regulation of macromolecule metabolic process
440 GO:0051173 positive regulation of nitrogen compound metabolic process
440 GO:0009967 positive regulation of signal transduction
440 GO:0051128 regulation of cellular component organization
440 GO:0010468 regulation of gene expression
475 GO:0031325 positive regulation of cellular metabolic process
475 GO:0060255 regulation of macromolecule metabolic process
477 GO:0044271 cellular nitrogen compound biosynthetic process
477 GO:0090304 nucleic acid metabolic process
477 GO:1901362 organic cyclic compound biosynthetic process
477 GO:2000112 regulation of cellular macromolecule biosynthetic process
477 GO:0007165 signal transduction
484 GO:0006139 nucleobase-containing compound metabolic process
484 GO:1901362 organic cyclic compound biosynthetic process
484 GO:0019538 protein metabolic process
484 GO:0060255 regulation of macromolecule metabolic process
484 GO:0007165 signal transduction
486 GO:0007166 cell surface receptor signaling pathway
486 GO:0006464 cellular protein modification process
486 GO:0060255 regulation of macromolecule metabolic process
492 GO:0044271 cellular nitrogen compound biosynthetic process
492 GO:0051252 regulation of RNA metabolic process
492 GO:2000112 regulation of cellular macromolecule biosynthetic process
492 GO:0010468 regulation of gene expression
496 GO:0048870 cell motility
496 GO:0071310 cellular response to organic substance
496 GO:0090304 nucleic acid metabolic process
496 GO:0034654 nucleobase-containing compound biosynthetic process
496 GO:0043085 positive regulation of catalytic activity
496 GO:0031325 positive regulation of cellular metabolic process
496 GO:1902533 positive regulation of intracellular signal transduction
496 GO:0010604 positive regulation of macromolecule metabolic process
496 GO:0051173 positive regulation of nitrogen compound metabolic process
496 GO:0051128 regulation of cellular component organization
496 GO:2000112 regulation of cellular macromolecule biosynthetic process
496 GO:0010468 regulation of gene expression
496 GO:0043549 regulation of kinase activity
496 GO:0019219 regulation of nucleobase-containing compound metabolic process
496 GO:0001932 regulation of protein phosphorylation
496 GO:0009719 response to endogenous stimulus
496 GO:1901700 response to oxygen-containing compound
496 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
512 GO:0035556 intracellular signal transduction
512 GO:0006468 protein phosphorylation
512 GO:0060255 regulation of macromolecule metabolic process
517 GO:0008104 protein localization
517 GO:0019538 protein metabolic process
551 GO:0034645 cellular macromolecule biosynthetic process
551 GO:0090304 nucleic acid metabolic process
551 GO:0034654 nucleobase-containing compound biosynthetic process
551 GO:0010604 positive regulation of macromolecule metabolic process
551 GO:0051173 positive regulation of nitrogen compound metabolic process
555 GO:0006464 cellular protein modification process
555 GO:0060255 regulation of macromolecule metabolic process
555 GO:0007165 signal transduction
569 GO:0007165 signal transduction
577 GO:0006464 cellular protein modification process
577 GO:0033554 cellular response to stress
577 GO:0006796 phosphate-containing compound metabolic process
577 GO:0031326 regulation of cellular biosynthetic process
577 GO:0010556 regulation of macromolecule biosynthetic process
577 GO:0009966 regulation of signal transduction
590 GO:0048468 cell development
590 GO:0007166 cell surface receptor signaling pathway
590 GO:0022607 cellular component assembly
590 GO:0032989 cellular component morphogenesis
590 GO:0006464 cellular protein modification process
590 GO:0006928 movement of cell or subcellular component
590 GO:0030182 neuron differentiation
590 GO:0120036 plasma membrane bounded cell projection organization
590 GO:0010628 positive regulation of gene expression
590 GO:0045935 positive regulation of nucleobase-containing compound metabolic process
590 GO:0051128 regulation of cellular component organization
590 GO:0042325 regulation of phosphorylation
590 GO:0051246 regulation of protein metabolic process
590 GO:0006357 regulation of transcription from RNA polymerase II promoter
614 GO:0006139 nucleobase-containing compound metabolic process
655 GO:0006464 cellular protein modification process
655 GO:0071310 cellular response to organic substance
655 GO:0035556 intracellular signal transduction
655 GO:0031325 positive regulation of cellular metabolic process
655 GO:0010604 positive regulation of macromolecule metabolic process
655 GO:0051173 positive regulation of nitrogen compound metabolic process
655 GO:0032268 regulation of cellular protein metabolic process
655 GO:0009966 regulation of signal transduction
655 GO:0006355 regulation of transcription, DNA-templated
655 GO:0009719 response to endogenous stimulus
682 GO:0034645 cellular macromolecule biosynthetic process
682 GO:0006464 cellular protein modification process
682 GO:0035556 intracellular signal transduction
682 GO:0090304 nucleic acid metabolic process
682 GO:0010468 regulation of gene expression
682 GO:0019219 regulation of nucleobase-containing compound metabolic process
698 GO:0090304 nucleic acid metabolic process
698 GO:0010646 regulation of cell communication
698 GO:0060255 regulation of macromolecule metabolic process
698 GO:0023051 regulation of signaling
698 GO:0007165 signal transduction
705 GO:0060255 regulation of macromolecule metabolic process
706 GO:0044267 cellular protein metabolic process
706 GO:0090304 nucleic acid metabolic process
706 GO:0034654 nucleobase-containing compound biosynthetic process
706 GO:2000112 regulation of cellular macromolecule biosynthetic process
706 GO:0010468 regulation of gene expression
706 GO:0019219 regulation of nucleobase-containing compound metabolic process
706 GO:0007165 signal transduction
731 GO:0044267 cellular protein metabolic process
731 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
731 GO:0010629 negative regulation of gene expression
731 GO:0045934 negative regulation of nucleobase-containing compound metabolic process
731 GO:0010604 positive regulation of macromolecule metabolic process
731 GO:0006357 regulation of transcription from RNA polymerase II promoter
731 GO:0007165 signal transduction
761 GO:0031324 negative regulation of cellular metabolic process
761 GO:0010605 negative regulation of macromolecule metabolic process
761 GO:0051172 negative regulation of nitrogen compound metabolic process
761 GO:0090304 nucleic acid metabolic process
761 GO:0034654 nucleobase-containing compound biosynthetic process
761 GO:2000112 regulation of cellular macromolecule biosynthetic process
761 GO:0019219 regulation of nucleobase-containing compound metabolic process
779 GO:0034645 cellular macromolecule biosynthetic process
779 GO:0090304 nucleic acid metabolic process
779 GO:0034654 nucleobase-containing compound biosynthetic process
779 GO:0060255 regulation of macromolecule metabolic process
803 GO:0007166 cell surface receptor signaling pathway
803 GO:0044267 cellular protein metabolic process
803 GO:0071310 cellular response to organic substance
803 GO:0035556 intracellular signal transduction
803 GO:0009966 regulation of signal transduction
821 GO:0006259 DNA metabolic process
821 GO:0007166 cell surface receptor signaling pathway
821 GO:0034613 cellular protein localization
821 GO:0071495 cellular response to endogenous stimulus
821 GO:0071310 cellular response to organic substance
821 GO:0031324 negative regulation of cellular metabolic process
821 GO:0010605 negative regulation of macromolecule metabolic process
821 GO:0051172 negative regulation of nitrogen compound metabolic process
821 GO:0031328 positive regulation of cellular biosynthetic process
821 GO:0010557 positive regulation of macromolecule biosynthetic process
821 GO:0045935 positive regulation of nucleobase-containing compound metabolic process
821 GO:0048584 positive regulation of response to stimulus
821 GO:0006468 protein phosphorylation
821 GO:0031399 regulation of protein modification process
821 GO:0006355 regulation of transcription, DNA-templated
821 GO:1901700 response to oxygen-containing compound
869 GO:0007155 cell adhesion
869 GO:0048468 cell development
869 GO:0016477 cell migration
869 GO:0000902 cell morphogenesis
869 GO:0044255 cellular lipid metabolic process
869 GO:0071363 cellular response to growth factor stimulus
869 GO:0072359 circulatory system development
869 GO:0009059 macromolecule biosynthetic process
869 GO:0022008 neurogenesis
869 GO:0019637 organophosphate metabolic process
869 GO:0018108 peptidyl-tyrosine phosphorylation
869 GO:0120036 plasma membrane bounded cell projection organization
869 GO:1902533 positive regulation of intracellular signal transduction
869 GO:0045860 positive regulation of protein kinase activity
869 GO:0043408 regulation of MAPK cascade
869 GO:2000145 regulation of cell motility
869 GO:0042127 regulation of cell proliferation
869 GO:0010468 regulation of gene expression
869 GO:2000026 regulation of multicellular organismal development
869 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
24 GO:0005829 cytosol
24 GO:0005654 nucleoplasm
28 GO:0005829 cytosol
28 GO:0043232 intracellular non-membrane-bounded organelle
28 GO:0005654 nucleoplasm
29 GO:0005634 nucleus
30 GO:0005829 cytosol
30 GO:0043232 intracellular non-membrane-bounded organelle
35 GO:0005829 cytosol
35 GO:0005634 nucleus
35 GO:0005886 plasma membrane
108 GO:0005829 cytosol
108 GO:0005634 nucleus
108 GO:0005886 plasma membrane
111 GO:0005829 cytosol
111 GO:0005886 plasma membrane
128 GO:0012505 endomembrane system
128 GO:0016021 integral component of membrane
128 GO:0005886 plasma membrane
136 GO:0005829 cytosol
136 GO:0005634 nucleus
138 GO:0005634 nucleus
155 GO:0005634 nucleus
162 GO:0005634 nucleus
166 GO:0005829 cytosol
166 GO:0070013 intracellular organelle lumen
166 GO:0044428 nuclear part
166 GO:0005886 plasma membrane
171 GO:0005829 cytosol
171 GO:0005886 plasma membrane
175 GO:0005829 cytosol
175 GO:0005634 nucleus
186 GO:0005829 cytosol
186 GO:0005886 plasma membrane
186 GO:0031982 vesicle
187 GO:0005829 cytosol
187 GO:0005886 plasma membrane
200 GO:0070013 intracellular organelle lumen
202 GO:0005829 cytosol
202 GO:0005886 plasma membrane
205 GO:0005829 cytosol
205 GO:0005634 nucleus
205 GO:0005886 plasma membrane
214 GO:0044428 nuclear part
215 GO:0012505 endomembrane system
215 GO:0005886 plasma membrane
215 GO:0031982 vesicle
232 GO:0005829 cytosol
232 GO:0043232 intracellular non-membrane-bounded organelle
237 GO:0005829 cytosol
237 GO:0012505 endomembrane system
237 GO:0005615 extracellular space
237 GO:0043232 intracellular non-membrane-bounded organelle
237 GO:0070013 intracellular organelle lumen
237 GO:0044428 nuclear part
237 GO:0031982 vesicle
238 GO:0005829 cytosol
238 GO:0005634 nucleus
245 GO:0005634 nucleus
259 GO:0005886 plasma membrane
282 GO:0005829 cytosol
282 GO:0005886 plasma membrane
283 GO:0012505 endomembrane system
283 GO:0044428 nuclear part
284 GO:0005829 cytosol
284 GO:0005886 plasma membrane
297 GO:0005634 nucleus
301 GO:0005829 cytosol
301 GO:0005634 nucleus
308 GO:0005829 cytosol
308 GO:0070013 intracellular organelle lumen
308 GO:0044428 nuclear part
308 GO:0005886 plasma membrane
316 GO:0005634 nucleus
317 GO:0005829 cytosol
323 GO:0005829 cytosol
323 GO:0043232 intracellular non-membrane-bounded organelle
323 GO:0070013 intracellular organelle lumen
323 GO:0044428 nuclear part
327 GO:0005829 cytosol
327 GO:0043232 intracellular non-membrane-bounded organelle
327 GO:0005634 nucleus
327 GO:0005886 plasma membrane
333 GO:0016021 integral component of membrane
333 GO:0098590 plasma membrane region
350 GO:0012505 endomembrane system
350 GO:0031224 intrinsic component of membrane
355 GO:0044459 plasma membrane part
367 GO:0005829 cytosol
367 GO:0070013 intracellular organelle lumen
367 GO:0005634 nucleus
381 GO:0005829 cytosol
381 GO:0005634 nucleus
388 GO:0016021 integral component of membrane
404 GO:0005829 cytosol
404 GO:0012505 endomembrane system
404 GO:0031982 vesicle
410 GO:0005634 nucleus
440 GO:0005829 cytosol
440 GO:0005634 nucleus
440 GO:0005886 plasma membrane
440 GO:0031982 vesicle
475 GO:0070013 intracellular organelle lumen
475 GO:0005634 nucleus
477 GO:0005829 cytosol
477 GO:0070013 intracellular organelle lumen
477 GO:0044428 nuclear part
484 GO:0070013 intracellular organelle lumen
484 GO:0005634 nucleus
486 GO:0005829 cytosol
486 GO:0005634 nucleus
486 GO:0031982 vesicle
488 GO:0005634 nucleus
488 GO:0031982 vesicle
492 GO:0044428 nuclear part
496 GO:0005829 cytosol
496 GO:0005634 nucleus
496 GO:0005886 plasma membrane
512 GO:0005829 cytosol
517 GO:0005829 cytosol
517 GO:0012505 endomembrane system
517 GO:0031982 vesicle
524 GO:0005856 cytoskeleton
524 GO:0005829 cytosol
524 GO:0120025 plasma membrane bounded cell projection
551 GO:0005829 cytosol
551 GO:0005615 extracellular space
551 GO:0043232 intracellular non-membrane-bounded organelle
551 GO:0005654 nucleoplasm
551 GO:0031982 vesicle
555 GO:0005634 nucleus
577 GO:0005829 cytosol
577 GO:0043232 intracellular non-membrane-bounded organelle
577 GO:0070013 intracellular organelle lumen
577 GO:0044428 nuclear part
577 GO:0031982 vesicle
590 GO:0005829 cytosol
590 GO:0005634 nucleus
590 GO:0005886 plasma membrane
614 GO:0005829 cytosol
614 GO:0005634 nucleus
655 GO:0005829 cytosol
655 GO:0005654 nucleoplasm
682 GO:0005634 nucleus
698 GO:0043232 intracellular non-membrane-bounded organelle
698 GO:0031981 nuclear lumen
698 GO:0005886 plasma membrane
705 GO:0070013 intracellular organelle lumen
706 GO:0005829 cytosol
706 GO:0031981 nuclear lumen
731 GO:0005654 nucleoplasm
761 GO:0005654 nucleoplasm
779 GO:0043232 intracellular non-membrane-bounded organelle
779 GO:0070013 intracellular organelle lumen
779 GO:0044428 nuclear part
803 GO:0016021 integral component of membrane
803 GO:0005886 plasma membrane
821 GO:0005829 cytosol
821 GO:0005654 nucleoplasm
821 GO:0005886 plasma membrane
869 GO:0012505 endomembrane system
869 GO:0005615 extracellular space
869 GO:0044459 plasma membrane part
869 GO:0031982 vesicle
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000165 MAPK cascade TAS
GO:0000186 activation of MAPKK activity IEA
GO:0001503 ossification NAS
GO:0001892 embryonic placenta development IEA
GO:0001934 positive regulation of protein phosphorylation IDA
GO:0001942 hair follicle development IEA
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS
GO:0006412 translation IEA
GO:0006950 response to stress NAS
GO:0006970 response to osmotic stress IEA
GO:0007165 signal transduction TAS
GO:0007166 cell surface receptor signaling pathway IDA
GO:0007173 epidermal growth factor receptor signaling pathway TAS
GO:0007202 activation of phospholipase C activity TAS
GO:0007435 salivary gland morphogenesis IEA
GO:0007494 midgut development IEA
GO:0007611 learning or memory ISS
GO:0007623 circadian rhythm IEA
GO:0008283 cell proliferation IDA
GO:0008284 positive regulation of cell proliferation IDA
GO:0010960 magnesium ion homeostasis IEA
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling IMP
GO:0016101 diterpenoid metabolic process IEA
GO:0018108 peptidyl-tyrosine phosphorylation IDA
GO:0021795 cerebral cortex cell migration IEA
GO:0030307 positive regulation of cell growth IDA
GO:0030324 lung development IEA
GO:0030335 positive regulation of cell migration IMP
GO:0031659 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle IDA
GO:0032930 positive regulation of superoxide anion generation IEA
GO:0033138 positive regulation of peptidyl-serine phosphorylation IMP
GO:0033590 response to cobalamin IEA
GO:0033594 response to hydroxyisoflavone IEA
GO:0034614 cellular response to reactive oxygen species IMP
GO:0035413 positive regulation of catenin import into nucleus IMP
GO:0035690 cellular response to drug IEA
GO:0038083 peptidyl-tyrosine autophosphorylation TAS
GO:0038128 ERBB2 signaling pathway TAS
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway TAS
GO:0042060 wound healing IEA
GO:0042177 negative regulation of protein catabolic process IDA
GO:0042327 positive regulation of phosphorylation IDA
GO:0042698 ovulation cycle IEA
GO:0042743 hydrogen peroxide metabolic process IEA
GO:0043006 activation of phospholipase A2 activity by calcium-mediated signaling TAS
GO:0043066 negative regulation of apoptotic process IMP
GO:0043406 positive regulation of MAP kinase activity IDA
GO:0043586 tongue development IEA
GO:0045429 positive regulation of nitric oxide biosynthetic process IDA
GO:0045739 positive regulation of DNA repair IDA
GO:0045740 positive regulation of DNA replication IDA
GO:0045780 positive regulation of bone resorption IEA
GO:0045893 positive regulation of transcription, DNA-templated IMP
GO:0045907 positive regulation of vasoconstriction IEA
GO:0045930 negative regulation of mitotic cell cycle IEA
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA
GO:0046328 regulation of JNK cascade IMP
GO:0046718 viral entry into host cell IEA
GO:0046777 protein autophosphorylation IMP
GO:0046854 phosphatidylinositol phosphorylation IEA
GO:0048143 astrocyte activation IEA
GO:0048146 positive regulation of fibroblast proliferation IEA
GO:0048546 digestive tract morphogenesis IEA
GO:0048661 positive regulation of smooth muscle cell proliferation IEA
GO:0048812 neuron projection morphogenesis IEA
GO:0050679 positive regulation of epithelial cell proliferation IDA
GO:0050729 positive regulation of inflammatory response IEA
GO:0050730 regulation of peptidyl-tyrosine phosphorylation IMP
GO:0050999 regulation of nitric-oxide synthase activity IDA
GO:0051205 protein insertion into membrane TAS
GO:0051592 response to calcium ion IEA
GO:0051897 positive regulation of protein kinase B signaling TAS
GO:0051968 positive regulation of synaptic transmission, glutamatergic IEA
GO:0060571 morphogenesis of an epithelial fold IEA
GO:0061024 membrane organization TAS
GO:0061029 eyelid development in camera-type eye IEA
GO:0070141 response to UV-A IDA
GO:0070372 regulation of ERK1 and ERK2 cascade IMP
GO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
GO:0071230 cellular response to amino acid stimulus IEA
GO:0071260 cellular response to mechanical stimulus IEA
GO:0071276 cellular response to cadmium ion IMP
GO:0071364 cellular response to epidermal growth factor stimulus ISS
GO:0071392 cellular response to estradiol stimulus IDA
GO:0071549 cellular response to dexamethasone stimulus IEA
GO:0097421 liver regeneration IEA
GO:0097755 positive regulation of blood vessel diameter IEA
GO:0098609 cell-cell adhesion IMP
GO:1900020 positive regulation of protein kinase C activity IDA
GO:1901185 negative regulation of ERBB signaling pathway TAS
GO:1901224 positive regulation of NIK/NF-kappaB signaling IMP
GO:1902722 positive regulation of prolactin secretion IEA
GO:1903078 positive regulation of protein localization to plasma membrane IDA
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA IMP
GO:1905208 negative regulation of cardiocyte differentiation IMP
GO:2000145 regulation of cell motility TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000139 Golgi membrane IEA
GO:0005615 extracellular space NAS
GO:0005634 nucleus IDA
GO:0005737 cytoplasm IDA
GO:0005768 endosome IDA
GO:0005789 endoplasmic reticulum membrane IEA
GO:0005886 plasma membrane TAS
GO:0005925 focal adhesion IDA
GO:0009986 cell surface IDA
GO:0010008 endosome membrane IDA
GO:0016020 membrane IDA
GO:0016021 integral component of membrane IEA
GO:0016323 basolateral plasma membrane IDA
GO:0016324 apical plasma membrane IEA
GO:0030122 AP-2 adaptor complex TAS
GO:0030665 clathrin-coated vesicle membrane TAS
GO:0031901 early endosome membrane IDA
GO:0031965 nuclear membrane IEA
GO:0043234 protein complex IDA
GO:0043235 receptor complex IDA
GO:0045121 membrane raft IDA
GO:0045202 synapse IEA
GO:0048471 perinuclear region of cytoplasm IEA
GO:0070435 Shc-EGFR complex ISS
GO:0097489 multivesicular body, internal vesicle lumen IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0000139 Golgi membrane GO:0005634 nucleus 1.09e-30 1.17e-81
GO:0005615 extracellular space GO:0005634 nucleus 6.26e-54 1.10e-77
GO:0005634 nucleus GO:0005768 endosome 4.09e-12 7.34e-15
GO:0005634 nucleus GO:0005789 endoplasmic reticulum membrane 1.61e-25 3.10e-56
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
GO:0005634 nucleus GO:0009986 cell surface 1.10e-44 1.49e-81
GO:0005634 nucleus GO:0010008 endosome membrane 1.38e-08 8.40e-30
GO:0005634 nucleus GO:0016020 membrane 0.00e+00 4.39e-236
GO:0005634 nucleus GO:0016021 integral component of membrane 0.00e+00 0.00e+00
GO:0005634 nucleus GO:0016324 apical plasma membrane 8.24e-09 4.92e-02
GO:0005634 nucleus GO:0030665 clathrin-coated vesicle membrane 3.06e-05 6.65e-11
GO:0005634 nucleus GO:0045202 synapse 1.10e-08 8.94e-15
GO:0005737 cytoplasm GO:0016021 integral component of membrane 2.01e-156 1.16e-04
GO:0016021 integral component of membrane GO:0043234 protein complex 6.03e-79 2.03e-37
Interactor Also a MoonDB EMF protein
VAPA_HUMAN No
KAP1_HUMAN No
TRAF2_HUMAN No
TGFB1_HUMAN No
BLK_HUMAN No
NCK2_HUMAN Yes: O43639 (MoonDB)
HS90B_HUMAN Yes: P08238 (MoonDB)
P55G_HUMAN Yes: Q92569 (MoonDB)
CHIP_HUMAN Yes: Q9UNE7 (MoonDB)
CALM1_HUMAN Yes: P0DP23 (MoonDB)
NEMO_HUMAN Yes: Q9Y6K9 (MoonDB)
ANS1A_HUMAN No
HSPB1_HUMAN Yes: P04792 (MoonDB)
MK09_HUMAN No
GRB2_HUMAN Yes: P62993 (MoonDB)
GRP75_HUMAN No
PPP5_HUMAN No
1433B_HUMAN No
1433S_HUMAN No
1433T_HUMAN No
1433Z_HUMAN Yes: P63104 (MoonDB)
A4_HUMAN No
AATC_HUMAN No
ABL1_HUMAN Yes: P00519 (MoonDB)
ABL2_HUMAN Yes: P42684 (MoonDB)
ACTN4_HUMAN No
ADRM1_HUMAN No
AHNK_HUMAN No
AHSA1_HUMAN No
AIP_HUMAN No
AKA12_HUMAN No
AKT1_HUMAN No
ALDOA_HUMAN No
AMPO_HUMAN No
ANS1B_HUMAN No
ANXA1_HUMAN No
AP2M1_HUMAN No
APBA3_HUMAN No
APBB1_HUMAN No
APBB2_HUMAN No
APBB3_HUMAN No
ARF4_HUMAN No
ARF6_HUMAN No
ARHG7_HUMAN No
ARPC5_HUMAN No
ARRB1_HUMAN Yes: P49407 (MoonDB)
ARRB2_HUMAN Yes: P32121 (MoonDB)
ATPG_HUMAN No
AURKA_HUMAN No
BAIP2_HUMAN No
BMX_HUMAN No
CADH1_HUMAN No
CADH5_HUMAN No
CAMLG_HUMAN No
CAV1_HUMAN No
CAV2_HUMAN No
CBLC_HUMAN No
CBL_HUMAN No
CBR1_HUMAN No
CD59_HUMAN No
CDC37_HUMAN Yes: Q16543 (MoonDB)
CDK1_HUMAN No
CEND_HUMAN No
CHD5_HUMAN No
CISH_HUMAN No
CLNK_HUMAN No
CNTN2_HUMAN No
CO9A3_HUMAN No
COF1_HUMAN No
CRKL_HUMAN No
CRK_HUMAN Yes: P46108 (MoonDB)
CSK_HUMAN No
CSRP1_HUMAN No
CTNA1_HUMAN No
CTND1_HUMAN No
CYH2_HUMAN No
CYLC2_HUMAN No
DCTN2_HUMAN No
DCUP_HUMAN No
DNJC4_HUMAN No
DOK1_HUMAN No
DOK4_HUMAN No
DOK5_HUMAN No
DOK6_HUMAN No
DP13A_HUMAN Yes: Q9UKG1 (MoonDB)
DYHC1_HUMAN No
EF1G_HUMAN No
EGF_HUMAN No
ENPL_HUMAN No
EPS8_HUMAN No
ERBB2_HUMAN Yes: P04626 (MoonDB)
ERBB3_HUMAN Yes: P21860 (MoonDB)
ERBB4_HUMAN No
ERCC1_HUMAN No
ERRFI_HUMAN No
EZRI_HUMAN No
FAAA_HUMAN No
FAK1_HUMAN No
FANCC_HUMAN No
FES_HUMAN No
FGR_HUMAN No
FINC_HUMAN No
FKBP4_HUMAN No
FKBP5_HUMAN No
FKBP8_HUMAN No
FOS_HUMAN No
FRAT2_HUMAN No
FRK_HUMAN No
G3P_HUMAN Yes: P04406 (MoonDB)
GAB1_HUMAN Yes: Q13480 (MoonDB)
GBRL2_HUMAN Yes: P60520 (MoonDB)
GCR_HUMAN No
GDS1_HUMAN No
GELS_HUMAN No
GPM6B_HUMAN No
GRAP2_HUMAN No
GRB10_HUMAN No
HCK_HUMAN No
HDAC6_HUMAN No
HDAC7_HUMAN No
HEMGN_HUMAN No
HEXI1_HUMAN No
HS71A_HUMAN No
HS90A_HUMAN Yes: P07900 (MoonDB)
HSP74_HUMAN No
HSP76_HUMAN No
HSP7C_HUMAN Yes: P11142 (MoonDB)
HUMMR_HUMAN No
IBP3_HUMAN No
IRS1_HUMAN No
IRS4_HUMAN No
ITB1_HUMAN No
ITB2_HUMAN No
ITK_HUMAN No
ITSN2_HUMAN No
JAK2_HUMAN No
JIP1_HUMAN No
JIP2_HUMAN Yes: Q13387 (MoonDB)
KCTD9_HUMAN No
KPCA_HUMAN No
KPCE_HUMAN No
KPCZ_HUMAN Yes: Q05513 (MoonDB)
KPYM_HUMAN Yes: P14618 (MoonDB)
KSYK_HUMAN Yes: P43405 (MoonDB)
LAT_HUMAN No
LCP2_HUMAN No
LRP1_HUMAN No
LRRK1_HUMAN No
LYN_HUMAN No
M3K12_HUMAN No
M3K3_HUMAN No
M4K1_HUMAN No
MAPK3_HUMAN No
MAST1_HUMAN No
MATR3_HUMAN No
MDHC_HUMAN No
MEGF6_HUMAN No
MK08_HUMAN No
MK14_HUMAN No
MPIP3_HUMAN No
MUC1_HUMAN No
NCK1_HUMAN Yes: P16333 (MoonDB)
NECD_HUMAN No
NOE1_HUMAN No
NRG1_HUMAN No
NTRK2_HUMAN No
NUDC3_HUMAN No
NUMBL_HUMAN No
NUMB_HUMAN No
OAZ1_HUMAN No
P3C2B_HUMAN No
P85A_HUMAN Yes: P27986 (MoonDB)
P85B_HUMAN No
PAK1_HUMAN Yes: Q13153 (MoonDB)
PDC6I_HUMAN Yes: Q8WUM4 (MoonDB)
PDK3_HUMAN No
PGFRA_HUMAN No
PGS2_HUMAN No
PHOCN_HUMAN No
PIM1_HUMAN No
PIN4_HUMAN No
PLAK_HUMAN No
PLCG1_HUMAN Yes: P19174 (MoonDB)
PLCG2_HUMAN Yes: P16885 (MoonDB)
PLCH1_HUMAN No
PLPL2_HUMAN No
PP2AB_HUMAN No
PRCC_HUMAN No
PRDX1_HUMAN No
PRKDC_HUMAN No
PSA7_HUMAN No
PSMD4_HUMAN No
PTGDS_HUMAN No
PTK6_HUMAN No
PTN11_HUMAN Yes: Q06124 (MoonDB)
PTN12_HUMAN No
PTN18_HUMAN No
PTN1_HUMAN No
PTN22_HUMAN No
PTPRB_HUMAN No
PTPRC_HUMAN No
PTPRJ_HUMAN No
PUR9_HUMAN No
Q59EJ3_HUMAN No
Q59G22_HUMAN No
Q59GR8_HUMAN No
RAB3A_HUMAN No
RAF1_HUMAN Yes: P04049 (MoonDB)
RASA1_HUMAN No
RET_HUMAN No
RGS4_HUMAN No
RIN2_HUMAN No
RPGF1_HUMAN No
RUSC2_HUMAN No
S10A4_HUMAN No
SEPP1_HUMAN No
SGSM2_HUMAN No
SH21A_HUMAN No
SH22A_HUMAN Yes: Q9NP31 (MoonDB)
SH23A_HUMAN No
SH2B1_HUMAN No
SH2B3_HUMAN No
SH2D3_HUMAN No
SH321_HUMAN No
SH3G2_HUMAN No
SH3G3_HUMAN No
SH3L1_HUMAN No
SH3L3_HUMAN No
SHC1_HUMAN No
SHC2_HUMAN No
SHC3_HUMAN No
SHC4_HUMAN No
SIAS_HUMAN No
SLAP1_HUMAN No
SLAP2_HUMAN No
SNP25_HUMAN No
SNX1_HUMAN Yes: Q13596 (MoonDB)
SNX9_HUMAN No
SOCS3_HUMAN No
SOCS6_HUMAN No
SOS2_HUMAN No
SPCS2_HUMAN No
SPRL1_HUMAN No
SRBS2_HUMAN No
SRC8_HUMAN Yes: Q14247 (MoonDB)
SRC_HUMAN Yes: P12931 (MoonDB)
STA5A_HUMAN No
STAP2_HUMAN No
STAT1_HUMAN No
STAT2_HUMAN No
STAT3_HUMAN Yes: P40763 (MoonDB)
STIP1_HUMAN No
STX17_HUMAN No
SYN1_HUMAN No
SYUA_HUMAN No
TAB1_HUMAN Yes: Q15750 (MoonDB)
TAU_HUMAN No
TBA1A_HUMAN No
TENS3_HUMAN No
TENS4_HUMAN No
TGFA_HUMAN No
THIO_HUMAN No
TLN1_HUMAN No
TLR2_HUMAN No
TMCO3_HUMAN No
TNR1A_HUMAN No
TPIS_HUMAN No
TPM1_HUMAN No
TRMO_HUMAN No
TSTD2_HUMAN No
UB2V2_HUMAN No
UCHL1_HUMAN No
UFO_HUMAN No
VAV_HUMAN No
WASF3_HUMAN No
WASL_HUMAN No
ZAP70_HUMAN No
ZN510_HUMAN No
PMID Article Title
1988448 Contributory effects of de novo transcription and premature transcript termination in the regulation of human epidermal growth factor receptor proto-oncogene RNA synthesis.
2543678 All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptor.
2790960 Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation.
2985580 Identification of residues in the nucleotide binding site of the epidermal growth factor receptor/kinase.
2991899 Characterization and sequence of the promoter region of the human epidermal growth factor receptor gene.
3039909 Receptors for epidermal growth factor and other polypeptide mitogens.
3138233 Epidermal growth factor receptor threonine and serine residues phosphorylated in vivo.
3329716 The human EGF receptor gene: structure of the 110 kb locus and identification of sequences regulating its transcription.
6093780 Isolation of an evolutionarily conserved epidermal growth factor receptor cDNA from human A431 carcinoma cells.
6324343 Production of an epidermal growth factor receptor-related protein.
6325948 ATP-stimulated interaction between epidermal growth factor receptor and supercoiled DNA.
6326261 Expression cloning of human EGF receptor complementary DNA: gene amplification and three related messenger RNA products in A431 cells.
6328312 Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells.
6330563 Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells.
7654368 Possible role of variant RNA transcripts in the regulation of epidermal growth factor receptor expression in human placenta.
7657591 Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation.
7679104 Amphiregulin induces tyrosine phosphorylation of the epidermal growth factor receptor and p185erbB2. Evidence that amphiregulin acts exclusively through the epidermal growth factor receptor at the surface of human epithelial cells.
8144591 Recombinant human betacellulin. Molecular structure, biological activities, and receptor interaction.
8650580 Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor.
8918811 A 1.8 kb alternative transcript from the human epidermal growth factor receptor gene encodes a truncated form of the receptor.
8962717 Analysis of the glycosylation patterns of the extracellular domain of the epidermal growth factor receptor expressed in Chinese hamster ovary fibroblasts.
9103388 Expression of a truncated epidermal growth factor receptor-like protein (TEGFR) in ovarian cancer.
9419975 Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4.
9488479 Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase.
9556602 Disulfide bond structure of human epidermal growth factor receptor.
9852145 Interaction of ZPR1 with translation elongation factor-1alpha in proliferating cells.
10026169 Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck.
10228163 Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant mu2 subunit and its effects on endocytosis.
10523301 Cell-type specific phosphorylation of threonines T654 and T669 by PKD defines the signal capacity of the EGF receptor.
10731668 Characterization of the N-oligosaccharides attached to the atypical Asn-X-Cys sequence of recombinant human epidermal growth factor receptor.
10805725 Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors.
11116146 The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome.
11161793 Comparative genomic sequence analysis and isolation of human and mouse alternative EGFR transcripts encoding truncated receptor isoforms.
11483589 The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin.
11602604 RGS16 function is regulated by epidermal growth factor receptor-mediated tyrosine phosphorylation.
12297050 Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains.
12620237 EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization.
12731890 Characterization of glycosylation sites of the epidermal growth factor receptor.
12873986 Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor.
15118125 EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.
15282549 LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation.
15340161 Signal peptide prediction based on analysis of experimentally verified cleavage sites.
15374980 A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells.
15590694 Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling.
15611079 Epigen, the last ligand of ErbB receptors, reveals intricate relationships between affinity and mitogenicity.
15623594 High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness in Taiwan.
15837620 Structural basis for inhibition of the epidermal growth factor receptor by cetuximab.
15840573 A structural model for the membrane-bound form of the juxtamembrane domain of the epidermal growth factor receptor.
16083266 Extended Range Proteomic Analysis (ERPA): a new and sensitive LC-MS platform for high sequence coverage of complex proteins with extensive post-translational modifications-comprehensive analysis of beta-casein and epidermal growth factor receptor (EGFR).
16140940 Functional implications of altered subcellular localization of PELP1 in breast cancer cells.
16205628 Distinctive activation patterns in constitutively active and gefitinib-sensitive EGFR mutants.
16533793 Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features.
16543144 Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain.
16672372 Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
17115032 Tyrosine phosphorylation controls PCNA function through protein stability.
17182860 Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation.
17344846 Patterns of somatic mutation in human cancer genomes.
17349580 Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity.
17671655 Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia.
18046415 Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.
18220336 Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
18227510 The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP.
18602463 Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking.
18669648 A quantitative atlas of mitotic phosphorylation.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
19159218 Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
19172738 Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.
19369195 Large-scale proteomics analysis of the human kinome.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19509291 GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling.
19560417 The juxtamembrane region of the EGF receptor functions as an activation domain.
19563760 Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment.
19749156 G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha-positive cancer cells.
19836242 An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20471394 Spatial structure of the transmembrane domain heterodimer of ErbB1 and ErbB2 receptor tyrosine kinases.
20551055 Nuclear alternate estrogen receptor GPR30 mediates 17beta-estradiol-induced gene expression and migration in breast cancer-associated fibroblasts.
20674546 COPI-mediated retrograde trafficking from the Golgi to the ER regulates EGFR nuclear transport.
20837704 Structural evidence for loose linkage between ligand binding and kinase activation in the epidermal growth factor receptor.
21258366 Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation.
21269460 Initial characterization of the human central proteome.
21487020 Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells.
21516087 EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy.
21518868 FER tyrosine kinase (FER) overexpression mediates resistance to quinacrine through EGF-dependent activation of NF-kappaB.
22179831 Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression.
22298428 The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane.
22888118 Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23418353 The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor.
23912460 Hyperactivation of EGFR and downstream effector phospholipase D1 by oncogenic FAM83B.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24691054 Epithelial inflammation resulting from an inherited loss-of-function mutation in EGFR.
25311788 EGFR phosphorylates and inhibits lung tumor suppressor GPRC5A in lung cancer.
28479384 Beclin1 antagonizes LAPTM4B-mediated EGFR overactivation in gastric cancer cells.
OMIM ID Disease Name
211980 Lung cancer
616069 Inflammatory skin and bowel disease, neonatal, 2
Domain Name Domain ID Source
GQHUE A00641 PIR
Rcpt_L-dom IPR000494 InterPro
Prot_kinase_dom IPR000719 InterPro
Ser-Thr/Tyr_kinase_cat_dom IPR001245 InterPro
Furin-like_Cys-rich_dom IPR006211 InterPro
Furin_repeat IPR006212 InterPro
Tyr_kinase_AS IPR008266 InterPro
Growth_fac_rcpt_cys_sf IPR009030 InterPro
Kinase-like_dom_sf IPR011009 InterPro
Tyr_kinase_EGF/ERB/XmrK_rcpt IPR016245 InterPro
Protein_kinase_ATP_BS IPR017441 InterPro
Tyr_kinase_cat_dom IPR020635 InterPro
Cyt_c1_TM_anchor_C IPR021157 InterPro
LRR_dom_sf IPR032675 InterPro
GF_recep_IV IPR032778 InterPro
Rcpt_L-dom_sf IPR036941 InterPro
Furin-like PF00757 Pfam
Recep_L_domain PF01030 Pfam
Pkinase_Tyr PF07714 Pfam
GF_recep_IV PF14843 Pfam
TyrPK_EGF-R PIRSF000619 PIRSF
TYRKINASE PR00109 PRINTS
PROTEIN_KINASE_ATP PS00107 PROSITE
PROTEIN_KINASE_TYR PS00109 PROSITE
PROTEIN_KINASE_DOM PS50011 PROSITE
TyrKc SM00219 SMART
FU SM00261 SMART
SSF52058 SSF52058 SUPFAM
SSF56112 SSF56112 SUPFAM
SSF57184 SSF57184 SUPFAM