Protein: Q05513

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q05513 (Uniprot) KPCZ_HUMAN PRKCZ Protein kinase C zeta type human No
Uniprot: Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Necessary and sufficient for LTP maintenance in hippocampal CA1 pyramidal cells. In vein endothelial cells treated with the oxidant peroxynitrite, phosphorylates STK11 leading to nuclear export of STK11, subsequent inhibition of PI3K/Akt signaling, and increased apoptosis. Phosphorylates VAMP2 in vitro (PubMed:17313651). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 1 GO:0006725 cellular aromatic compound metabolic process 484 5.44e-126 5.27e-27
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
1 GO:0035556 intracellular signal transduction
1 GO:0032268 regulation of cellular protein metabolic process
1 GO:0043067 regulation of programmed cell death
1 GO:0009966 regulation of signal transduction
337 GO:0022607 cellular component assembly
337 GO:0035556 intracellular signal transduction
337 GO:0006468 protein phosphorylation
337 GO:0060255 regulation of macromolecule metabolic process
484 GO:0006139 nucleobase-containing compound metabolic process
484 GO:1901362 organic cyclic compound biosynthetic process
484 GO:0019538 protein metabolic process
484 GO:0060255 regulation of macromolecule metabolic process
484 GO:0007165 signal transduction
535 GO:0008219 cell death
535 GO:0044267 cellular protein metabolic process
535 GO:0071495 cellular response to endogenous stimulus
535 GO:0071310 cellular response to organic substance
535 GO:0010605 negative regulation of macromolecule metabolic process
535 GO:0045893 positive regulation of transcription, DNA-templated
535 GO:0006357 regulation of transcription from RNA polymerase II promoter
535 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
1 GO:0005829 cytosol
1 GO:0005634 nucleus
337 GO:0005829 cytosol
337 GO:0043232 intracellular non-membrane-bounded organelle
337 GO:0005634 nucleus
484 GO:0070013 intracellular organelle lumen
484 GO:0005634 nucleus
535 GO:0005829 cytosol
535 GO:0043232 intracellular non-membrane-bounded organelle
535 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000226 microtubule cytoskeleton organization IEA
GO:0001954 positive regulation of cell-matrix adhesion IEA
GO:0006468 protein phosphorylation IDA
GO:0006954 inflammatory response IEA
GO:0007165 signal transduction TAS
GO:0007179 transforming growth factor beta receptor signaling pathway TAS
GO:0007616 long-term memory IEA
GO:0008284 positive regulation of cell proliferation IEA
GO:0008286 insulin receptor signaling pathway IEA
GO:0016477 cell migration IEA
GO:0018105 peptidyl-serine phosphorylation IDA
GO:0030010 establishment of cell polarity ISS
GO:0031333 negative regulation of protein complex assembly IMP
GO:0031532 actin cytoskeleton reorganization IEA
GO:0031584 activation of phospholipase D activity IEA
GO:0032148 activation of protein kinase B activity IEA
GO:0032753 positive regulation of interleukin-4 production ISS
GO:0043066 negative regulation of apoptotic process IEA
GO:0045630 positive regulation of T-helper 2 cell differentiation ISS
GO:0046326 positive regulation of glucose import IEA
GO:0046627 negative regulation of insulin receptor signaling pathway IMP
GO:0046628 positive regulation of insulin receptor signaling pathway ISS
GO:0047496 vesicle transport along microtubule IEA
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation IMP
GO:0051092 positive regulation of NF-kappaB transcription factor activity ISS
GO:0051291 protein heterooligomerization IEA
GO:0051346 negative regulation of hydrolase activity IEA
GO:0051899 membrane depolarization IEA
GO:0060081 membrane hyperpolarization IEA
GO:0060291 long-term synaptic potentiation ISS
GO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
GO:0070528 protein kinase C signaling IEA
GO:0072659 protein localization to plasma membrane IEA
GO:1990138 neuron projection extension IEA
GO:2000463 positive regulation of excitatory postsynaptic potential ISS
GO:2000553 positive regulation of T-helper 2 cell cytokine production ISS
GO:2000664 positive regulation of interleukin-5 secretion ISS
GO:2000667 positive regulation of interleukin-13 secretion ISS
GO:2001181 positive regulation of interleukin-10 secretion ISS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005635 nuclear envelope IEA
GO:0005737 cytoplasm TAS
GO:0005768 endosome IEA
GO:0005815 microtubule organizing center IEA
GO:0005829 cytosol TAS
GO:0005886 plasma membrane IDA
GO:0005911 cell-cell junction IDA
GO:0005923 bicellular tight junction IEA
GO:0016020 membrane TAS
GO:0016324 apical plasma membrane IEA
GO:0016363 nuclear matrix IEA
GO:0030054 cell junction TAS
GO:0031252 cell leading edge IEA
GO:0031941 filamentous actin IEA
GO:0031982 vesicle IDA
GO:0035748 myelin sheath abaxonal region IEA
GO:0043203 axon hillock IEA
GO:0045121 membrane raft IEA
GO:0045179 apical cortex IEA
GO:0048471 perinuclear region of cytoplasm IEA
GO:0070062 extracellular exosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005815 microtubule organizing center GO:0005886 plasma membrane 3.20e-06 1.55e-21
PMID Article Title
7597083 Regulated assembly of tight junctions by protein kinase C.
8224878 The cDNA sequence encoding human protein kinase C-zeta.
8375396 Activation and substrate specificity of the human protein kinase C alpha and zeta isoenzymes.
9447975 Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes.
9566925 Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62.
9768361 Regulation of protein kinase C zeta by PI 3-kinase and PDK-1.
10356400 The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation.
11035106 Protein kinase C zeta plays a central role in activation of the p42/44 mitogen-activated protein kinase by endotoxin in alveolar macrophages.
11260256 Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C.
11755531 p62 forms a ternary complex with PKCzeta and PAR-4 and antagonizes PAR-4-induced PKCzeta inhibition.
11781095 Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment.
12162751 Characterization of PDK2 activity against protein kinase B gamma.
12234671 Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties.
12761192 Protein kinase Czeta (PKCzeta): activation mechanisms and cellular functions.
12887891 PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62.
12893243 Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15084291 Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity.
15314172 Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells.
15324659 aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16322752 PKCzeta at the crossroad of NF-kappaB and Jak1/Stat6 signaling pathways.
16710414 The DNA sequence and biological annotation of human chromosome 1.
16792529 A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda.
16903823 Protein kinase Czeta and glucose uptake.
16959974 The consensus coding sequences of human breast and colorectal cancers.
17313651 WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta.
17344846 Patterns of somatic mutation in human cancer genomes.
18190796 KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling.
18321849 Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells.
18669648 A quantitative atlas of mitotic phosphorylation.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
20332120 CCM1 regulates vascular-lumen organization by inducing endothelial polarity.
21269460 Initial characterization of the human central proteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
No results found.
Domain Name Domain ID Source
PB1_dom IPR000270 InterPro
Prot_kinase_dom IPR000719 InterPro
AGC-kinase_C IPR000961 InterPro
PE/DAG-bd IPR002219 InterPro
Ser/Thr_kinase_AS IPR008271 InterPro
Kinase-like_dom_sf IPR011009 InterPro
PKC IPR012233 InterPro
Protein_kinase_ATP_BS IPR017441 InterPro
Pkinase_C IPR017892 InterPro
DAG/PE-bd IPR020454 InterPro
aPKC_zeta IPR034662 InterPro
PB1_aPKC IPR034877 InterPro
JN0877 JN0877 PIR
Pkinase PF00069 Pfam
C1_1 PF00130 Pfam
Pkinase_C PF00433 Pfam
PB1 PF00564 Pfam
PKC_zeta PIRSF000554 PIRSF
DAGPEDOMAIN PR00008 PRINTS
PROTEIN_KINASE_ATP PS00107 PROSITE
PROTEIN_KINASE_ST PS00108 PROSITE
ZF_DAG_PE_1 PS00479 PROSITE
PROTEIN_KINASE_DOM PS50011 PROSITE
ZF_DAG_PE_2 PS50081 PROSITE
AGC_KINASE_CTER PS51285 PROSITE
PB1 PS51745 PROSITE
C1 SM00109 SMART
S_TK_X SM00133 SMART
S_TKc SM00220 SMART
PB1 SM00666 SMART
SSF56112 SSF56112 SUPFAM
C1 cd00029 CDD
STKc_aPKC_zeta cd05617 CDD
PB1_aPKC cd06404 CDD