Protein: P63104 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P63104 (Uniprot)	1433Z_HUMAN	YWHAZ	14-3-3 protein zeta/delta	human	No

Protein Function

Uniprot: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

MoonDB Dissimilar Functions

Showing 1 to 5 of 5 entries

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006725	cellular aromatic compound metabolic process	484	GO:0033036	macromolecule localization	517	1.29e-20	6.46e-74
GO:0007165	signal transduction	1, 4, 187, 282, 308	GO:0006725	cellular aromatic compound metabolic process	484	5.44e-126	5.27e-27
GO:0009059	macromolecule biosynthetic process	471	GO:0033036	macromolecule localization	517	2.32e-08	6.09e-30
GO:0033036	macromolecule localization	517	GO:0044260	cellular macromolecule metabolic process	544, 724	4.56e-06	3.25e-28
GO:0043170	macromolecule metabolic process	310, 367	GO:0033036	macromolecule localization	517	2.48e-08	1.95e-27

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
1	GO:0035556	intracellular signal transduction
1	GO:0032268	regulation of cellular protein metabolic process
1	GO:0043067	regulation of programmed cell death
1	GO:0009966	regulation of signal transduction
2	GO:0044267	cellular protein metabolic process
2	GO:0010467	gene expression
2	GO:0006139	nucleobase-containing compound metabolic process
2	GO:0060255	regulation of macromolecule metabolic process
2	GO:0007165	signal transduction
4	GO:0035556	intracellular signal transduction

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Cellular Components

Showing 1 to 10 of 67 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
1	GO:0005829	cytosol
1	GO:0005634	nucleus
2	GO:0005829	cytosol
2	GO:0005634	nucleus
4	GO:0005829	cytosol
4	GO:0005634	nucleus
7	GO:0005654	nucleoplasm
11	GO:0005634	nucleus
37	GO:0005829	cytosol
123	GO:0043232	intracellular non-membrane-bounded organelle

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Protein GO Annotations

Biological Processes

Showing 1 to 9 of 9 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006605	protein targeting	IEA
GO:0007165	signal transduction	TAS
GO:0030168	platelet activation	TAS
GO:0043066	negative regulation of apoptotic process	TAS
GO:0043488	regulation of mRNA stability	TAS
GO:0051683	establishment of Golgi localization	IMP
GO:0061024	membrane organization	TAS
GO:0090168	Golgi reassembly	IMP
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	TAS

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Cellular Components

Showing 1 to 10 of 12 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005615	extracellular space	IDA
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	TAS
GO:0005737	cytoplasm	TAS
GO:0005739	mitochondrion	IEA
GO:0005829	cytosol	TAS
GO:0005925	focal adhesion	IDA
GO:0030659	cytoplasmic vesicle membrane	TAS
GO:0031982	vesicle	IDA
GO:0042470	melanosome	IEA

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Dissimilar Cellular Components (PrOnto)

Showing 1 to 8 of 8 entries

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005615	extracellular space	GO:0005634	nucleus	6.26e-54	1.10e-77
GO:0005615	extracellular space	GO:0005654	nucleoplasm	1.00e-49	3.88e-77
GO:0005634	nucleus	GO:0030659	cytoplasmic vesicle membrane	4.71e-30	7.28e-80
GO:0005634	nucleus	GO:0031982	vesicle	1.94e-54	3.27e-93
GO:0005634	nucleus	GO:0070062	extracellular exosome	6.30e-13	4.54e-26
GO:0005654	nucleoplasm	GO:0030659	cytoplasmic vesicle membrane	1.28e-24	2.03e-103
GO:0005654	nucleoplasm	GO:0031982	vesicle	4.01e-60	1.21e-165
GO:0005654	nucleoplasm	GO:0070062	extracellular exosome	3.37e-20	1.23e-35

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All Protein Interactions

Showing 1 to 10 of 115 entries

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Interactor	Also a MoonDB EMF protein
1433E_HUMAN	Yes: P62258 (MoonDB)
ADA22_HUMAN	No
ADA23_HUMAN	No
ADIP_HUMAN	Yes: Q9Y2D8 (MoonDB)
ANM5_HUMAN	No
ARAF_HUMAN	No
ATX1_HUMAN	Yes: P54253 (MoonDB)
BAD_HUMAN	No
BAIP2_HUMAN	No
BCAR1_HUMAN	No

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Publications Associated

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PMID	Article Title
1577711	Cloning and expression of a human 14-3-3 protein mediating phospholipolysis. Identification of an arachidonoyl-enzyme intermediate during catalysis.
9360956	14-3-3 is phosphorylated by casein kinase I on residue 233. Phosphorylation at this site in vivo regulates Raf/14-3-3 interaction.
9512661	Two unique 5' untranslated regions in mRNAs encoding human 14-3-3 zeta: differential expression in hemopoietic cells.
10455159	Nuclear localization of protein kinase U-alpha is regulated by 14-3-3.
10488331	Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding.
11336675	Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation.
11427721	Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis.
11956222	Identification of 14-3-3zeta as a protein kinase B/Akt substrate.
12665801	Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
12865427	The dimeric versus monomeric status of 14-3-3zeta is controlled by phosphorylation of Ser58 at the dimer interface.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 13 entries

Search:

Domain Name	Domain ID	Source
14-3-3	IPR000308	InterPro
14-3-3	PF00244	Pfam
14-3-3	PIRSF000868	PIRSF
14-3-3_CS	IPR023409	InterPro
14-3-3_dom_sf	IPR036815	InterPro
14-3-3_domain	IPR023410	InterPro
1433_1	PS00796	PROSITE
1433_2	PS00797	PROSITE
1433ZETA	PR00305	PRINTS
14_3_3	SM00101	SMART

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