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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: Q8TBB1
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
Q8TBB1 (Uniprot)
LNX1_HUMAN
LNX1
E3 ubiquitin-protein ligase LNX
human
No
Protein Function
Uniprot:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66
and isoform p72 of NUMB, but not that of isoform p71 or isoform p65.Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.
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MoonDB Dissimilar Functions
Showing 1 to 7 of 7 entries
Search:
GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0006139
nucleobase-containing compound metabolic process
132
GO:0007165
signal transduction
255
1.10e-111
5.07e-25
GO:0006464
cellular protein modification process
375
GO:0016070
RNA metabolic process
715
5.81e-04
8.44e-05
GO:0006725
cellular aromatic compound metabolic process
103
,
152
GO:0007165
signal transduction
255
5.44e-126
5.27e-27
GO:0007165
signal transduction
255
GO:0034641
cellular nitrogen compound metabolic process
47
4.22e-144
6.90e-18
GO:0007165
signal transduction
255
GO:0016070
RNA metabolic process
715
3.11e-78
2.75e-26
GO:0019538
protein metabolic process
177
,
254
,
664
GO:0016070
RNA metabolic process
715
5.15e-08
2.82e-13
GO:0036211
protein modification process
599
GO:0016070
RNA metabolic process
715
5.81e-04
8.44e-05
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MoonDB Network Modules
Biological Processes
Showing 1 to 10 of 98 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
47
GO:0044271
cellular nitrogen compound biosynthetic process
47
GO:0051252
regulation of RNA metabolic process
47
GO:0010468
regulation of gene expression
79
GO:0007165
signal transduction
80
GO:0051252
regulation of RNA metabolic process
80
GO:0010468
regulation of gene expression
96
GO:0016070
RNA metabolic process
96
GO:0010467
gene expression
103
GO:0006139
nucleobase-containing compound metabolic process
132
GO:0090304
nucleic acid metabolic process
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Cellular Components
Showing 1 to 10 of 70 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
47
GO:0005654
nucleoplasm
79
GO:0005634
nucleus
80
GO:0005634
nucleus
82
GO:0005634
nucleus
89
GO:0005634
nucleus
96
GO:0005654
nucleoplasm
103
GO:0070013
intracellular organelle lumen
103
GO:0005634
nucleus
117
GO:0005634
nucleus
132
GO:0005634
nucleus
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Protein GO Annotations
Biological Processes
Showing 1 to 2 of 2 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0042787
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
IEA
GO:0051260
protein homooligomerization
IEA
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Cellular Components
Showing 1 to 1 of 1 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0005737
cytoplasm
IEA
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Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Showing 1 to 10 of 463 entries
Search:
Interactor
Also a MoonDB EMF protein
1433Z_HUMAN
Yes:
P63104 (MoonDB)
5HT2B_HUMAN
No
A2RRN7_HUMAN
No
ABI2_HUMAN
Yes:
Q9NYB9 (MoonDB)
ABR_HUMAN
No
ACPM_HUMAN
No
ACTN1_HUMAN
No
ACTN3_HUMAN
No
ACTN4_HUMAN
No
ACY3_HUMAN
No
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Publications Associated
Showing 1 to 10 of 10 entries
Search:
PMID
Article Title
11521506
Identification of a human LNX protein containing multiple PDZ domains.
12468544
The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX).
12975309
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
14702039
Complete sequencing and characterization of 21,243 full-length human cDNAs.
15367597
Np9 protein of human endogenous retrovirus K interacts with ligand of numb protein X.
15489334
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15815621
Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
20864041
MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases.
21406692
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
23186163
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
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OMIM Diseases Associated
No results found.
Protein Domains Associated
Showing 1 to 10 of 14 entries
Search:
Domain Name
Domain ID
Source
PDZ
IPR001478
InterPro
PDZ
PF00595
Pfam
PDZ
PS50106
PROSITE
PDZ
SM00228
SMART
PDZ_sf
IPR036034
InterPro
RING
SM00184
SMART
SSF50156
SSF50156
SUPFAM
zf-C3HC4
PF00097
Pfam
ZF_RING_1
PS00518
PROSITE
ZF_RING_2
PS50089
PROSITE
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