Protein: Q13114 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q13114 (Uniprot)	TRAF3_HUMAN	TRAF3	TNF receptor-associated factor 3	human	No

Protein Function

Uniprot: Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	609	GO:0006725	cellular aromatic compound metabolic process	683	5.44e-126	5.27e-27

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
121	GO:0010467	gene expression
121	GO:0060255	regulation of macromolecule metabolic process
121	GO:0007165	signal transduction
131	GO:0070647	protein modification by small protein conjugation or removal
131	GO:0006355	regulation of transcription, DNA-templated
380	GO:0010467	gene expression
380	GO:0019538	protein metabolic process
380	GO:0060255	regulation of macromolecule metabolic process
420	GO:0006464	cellular protein modification process
476	GO:0010467	gene expression

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
121	GO:0005634	nucleus
131	GO:0005829	cytosol
131	GO:0043232	intracellular non-membrane-bounded organelle
131	GO:0005634	nucleus
380	GO:0005634	nucleus
420	GO:0005829	cytosol
420	GO:0005634	nucleus
476	GO:0005634	nucleus
487	GO:0005634	nucleus
511	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0001817	regulation of cytokine production	ISS
GO:0002224	toll-like receptor signaling pathway	ISS
GO:0006915	apoptotic process	IEA
GO:0007165	signal transduction	TAS
GO:0008063	Toll signaling pathway	IEA
GO:0016567	protein ubiquitination	IEA
GO:0016579	protein deubiquitination	TAS
GO:0030162	regulation of proteolysis	IMP
GO:0032088	negative regulation of NF-kappaB transcription factor activity	IMP
GO:0032480	negative regulation of type I interferon production	TAS

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005739	mitochondrion	IEA
GO:0005768	endosome	IEA
GO:0005829	cytosol	TAS
GO:0009898	cytoplasmic side of plasma membrane	ISS
GO:0035631	CD40 receptor complex	ISS

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ABC3C_HUMAN	No
ASCC1_HUMAN	No
BIVM_HUMAN	No
CC184_HUMAN	No
CCD13_HUMAN	No
CDC37_HUMAN	Yes: Q16543 (MoonDB)
CJ062_HUMAN	No
DAXX_HUMAN	No
EWS_HUMAN	No
GMEB2_HUMAN	No

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Publications Associated

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PMID	Article Title
7527023	A novel RING finger protein interacts with the cytoplasmic domain of CD40.
7530216	A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40.
7533327	Involvement of CRAF1, a relative of TRAF, in CD40 signaling.
7859281	The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family.
8663299	TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor.
8710854	I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction.
9162022	Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1.
9168896	Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily.
9275204	Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2.
9418902	4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB.

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OMIM Diseases Associated

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OMIM ID	Disease Name
614849	Herpes simplex encephalitis 3

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Protein Domains Associated

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Domain Name	Domain ID	Source
A55960	A55960	PIR
MATH	PS50144	PROSITE
MATH	SM00061	SMART
MATH/TRAF_dom	IPR002083	InterPro
MATH_TRAF3	cd03777	CDD
PTHR10131:SF76	PTHR10131:SF76	PANTHER
S68467	S68467	PIR
SSF49599	SSF49599	SUPFAM
TNF_rcpt--assoc_TRAF	IPR012227	InterPro
TRAF	PIRSF015614	PIRSF

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