Protein: Q16543 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q16543 (Uniprot)	CDC37_HUMAN	CDC37	Hsp90 co-chaperone Cdc37	human	No

Protein Function

Uniprot: Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206).

MoonDB Dissimilar Functions

Showing 1 to 3 of 3 entries

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006464	cellular protein modification process	195	GO:0016070	RNA metabolic process	689	5.81e-04	8.44e-05
GO:0019538	protein metabolic process	434	GO:0016070	RNA metabolic process	689	5.15e-08	2.82e-13
GO:0036211	protein modification process	32, 155, 221, 290, 301	GO:0016070	RNA metabolic process	689	5.81e-04	8.44e-05

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MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 79 entries

Search:

Module ID (MoonGO)	GO ID (BP)	GO Name
24	GO:0016070	RNA metabolic process
24	GO:0006464	cellular protein modification process
24	GO:0034654	nucleobase-containing compound biosynthetic process
24	GO:0006796	phosphate-containing compound metabolic process
24	GO:0031325	positive regulation of cellular metabolic process
24	GO:0010604	positive regulation of macromolecule metabolic process
24	GO:0051173	positive regulation of nitrogen compound metabolic process
24	GO:2000112	regulation of cellular macromolecule biosynthetic process
24	GO:0010468	regulation of gene expression
24	GO:0019219	regulation of nucleobase-containing compound metabolic process

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Cellular Components

Showing 1 to 10 of 53 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
24	GO:0005829	cytosol
24	GO:0005654	nucleoplasm
31	GO:0005634	nucleus
32	GO:0005886	plasma membrane
32	GO:0031982	vesicle
50	GO:0005829	cytosol
50	GO:0005634	nucleus
54	GO:0070013	intracellular organelle lumen
54	GO:0005634	nucleus
81	GO:0005829	cytosol

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	TAS
GO:0006457	protein folding	IBA
GO:0006605	protein targeting	TAS
GO:0010608	posttranscriptional regulation of gene expression	IEA
GO:0018108	peptidyl-tyrosine phosphorylation	IEA
GO:0038128	ERBB2 signaling pathway	TAS
GO:0050821	protein stabilization	IBA
GO:0060334	regulation of interferon-gamma-mediated signaling pathway	IMP
GO:0060338	regulation of type I interferon-mediated signaling pathway	IMP
GO:0098779	positive regulation of mitophagy in response to mitochondrial depolarization	IEA

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Cellular Components

Showing 1 to 4 of 4 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005737	cytoplasm	IDA
GO:0005829	cytosol	TAS
GO:0070062	extracellular exosome	IDA
GO:1990565	HSP90-CDC37 chaperone complex	IEA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 254 entries

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Interactor	Also a MoonDB EMF protein
2AAA_HUMAN	No
5NT1A_HUMAN	No
A2MG_HUMAN	Yes: P01023 (MoonDB)
A4_HUMAN	No
AAPK1_HUMAN	No
ACTB_HUMAN	No
ACTG_HUMAN	No
AKT1_HUMAN	No
AKT3_HUMAN	No
ALS2_HUMAN	No

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Publications Associated

Showing 1 to 10 of 22 entries

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PMID	Article Title
8666233	Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4.
8703009	Physical interaction of mammalian CDC37 with CDK4.
9150368	Interaction between Cdc37 and Cdk4 in human cells.
9482106	Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells.
10409742	Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization.
10858314	p50(cdc37) is a nonexclusive Hsp90 cohort which participates intimately in Hsp90-mediated folding of immature kinase molecules.
11036079	Hsp90 regulates p50(cdc37) function during the biogenesis of the active conformation of the heme-regulated eIF2 alpha kinase.
11085988	Functional interaction of human Cdc37 with the androgen receptor but not with the glucocorticoid receptor.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15592455	Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 12 entries

Search:

Domain Name	Domain ID	Source
Cdc37	IPR004918	InterPro
Cdc37_C	IPR013873	InterPro
CDC37_C	PF08564	Pfam
CDC37_C	SM01069	SMART
Cdc37_Hsp90-bd	IPR013874	InterPro
CDC37_M	PF08565	Pfam
CDC37_M	SM01070	SMART
CDC37_N	PF03234	Pfam
CDC37_N	SM01071	SMART
Cdc37_N_dom	IPR013855	InterPro

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