Protein: P01023

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P01023 (Uniprot) A2MG_HUMAN A2M Alpha-2-macroglobulin human No
Uniprot: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0006139 nucleobase-containing compound metabolic process 27 GO:0007165 signal transduction 803 1.10e-111 5.07e-25
GO:0034641 cellular nitrogen compound metabolic process 267 GO:0007165 signal transduction 803 4.22e-144 6.90e-18
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
27 GO:0090304 nucleic acid metabolic process
27 GO:0060255 regulation of macromolecule metabolic process
129 GO:0044267 cellular protein metabolic process
129 GO:0007165 signal transduction
170 GO:0070887 cellular response to chemical stimulus
170 GO:0034654 nucleobase-containing compound biosynthetic process
170 GO:0031326 regulation of cellular biosynthetic process
170 GO:0010468 regulation of gene expression
170 GO:0007165 signal transduction
198 GO:0060255 regulation of macromolecule metabolic process
198 GO:0007165 signal transduction
267 GO:0044271 cellular nitrogen compound biosynthetic process
267 GO:0010467 gene expression
267 GO:0009059 macromolecule biosynthetic process
267 GO:0090304 nucleic acid metabolic process
267 GO:0019538 protein metabolic process
267 GO:0060255 regulation of macromolecule metabolic process
410 GO:0010467 gene expression
410 GO:0007165 signal transduction
622 GO:0007165 signal transduction
803 GO:0007166 cell surface receptor signaling pathway
803 GO:0044267 cellular protein metabolic process
803 GO:0071310 cellular response to organic substance
803 GO:0035556 intracellular signal transduction
803 GO:0009966 regulation of signal transduction
827 GO:0060255 regulation of macromolecule metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
18 GO:0005829 cytosol
18 GO:0070062 extracellular exosome
27 GO:0031981 nuclear lumen
129 GO:0005829 cytosol
129 GO:0070013 intracellular organelle lumen
136 GO:0005829 cytosol
136 GO:0005634 nucleus
148 GO:0005829 cytosol
170 GO:0005634 nucleus
198 GO:0005829 cytosol
216 GO:0005829 cytosol
267 GO:0005829 cytosol
267 GO:0070013 intracellular organelle lumen
267 GO:0005634 nucleus
293 GO:0005634 nucleus
410 GO:0005634 nucleus
622 GO:0005829 cytosol
622 GO:0070013 intracellular organelle lumen
622 GO:0005634 nucleus
717 GO:0005829 cytosol
717 GO:0043232 intracellular non-membrane-bounded organelle
717 GO:0005634 nucleus
803 GO:0016021 integral component of membrane
803 GO:0005886 plasma membrane
827 GO:0012505 endomembrane system
827 GO:0031982 vesicle
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0001869 negative regulation of complement activation, lectin pathway IDA
GO:0002576 platelet degranulation TAS
GO:0007597 blood coagulation, intrinsic pathway TAS
GO:0010951 negative regulation of endopeptidase activity IEA
GO:0022617 extracellular matrix disassembly TAS
GO:0043547 positive regulation of GTPase activity IEA
GO:0048863 stem cell differentiation IEA
GO:0051056 regulation of small GTPase mediated signal transduction TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005576 extracellular region TAS
GO:0005829 cytosol TAS
GO:0031093 platelet alpha granule lumen TAS
GO:0070062 extracellular exosome IDA
GO:0072562 blood microparticle IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
1370808 Cloning of the human alpha 2-macroglobulin gene and detection of mutations in two functional domains: the bait region and the thiolester site.
1374237 Structure of the human alpha-2 macroglobulin gene and its promotor.
1692292 A genetic polymorphism in a functional domain of human pregnancy zone protein: the bait region. Genomic structure of the bait domains of human pregnancy zone protein and alpha 2 macroglobulin.
1707161 Sequence polymorphism in the human alpha2-macroglobulin (A2M) gene.
2408344 Human alpha 2-macroglobulin gene is located on chromosome 12.
2430963 Primary structure of human alpha 2-macroglobulin. Complete disulfide bridge assignment and localization of two interchain bridges in the dimeric proteinase binding unit.
2581245 Nucleotide sequence of cDNA encoding human alpha 2-macroglobulin and assignment of the chromosomal locus.
6165619 Primary structure of the 'bait' region for proteinases in alpha 2-macroglobulin. Nature of the complex.
6167263 Proteolytic cleavage sites on alpha 2-macroglobulin resulting in proteinase binding are different for trypsin and Staphylococcus aureus V-8 proteinase.
6172288 Primary and secondary cleavage sites in the bait region of alpha 2-macroglobulin.
6195065 Human neutrophil elastase and cathepsin G cleavage sites in the bait region of alpha 2-macroglobulin. Proposed structural limits of the bait region.
6203908 Primary structure of human alpha 2-macroglobulin. V. The complete structure.
9865955 Localization of basic residues required for receptor binding to the single alpha-helix of the receptor binding domain of human alpha2-macroglobulin.
12754519 Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.
14760718 Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15611997 Alpha(2) macroglobulin, a PSA-binding protein, is expressed in human prostate stroma.
16335952 Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
16541075 The finished DNA sequence of human chromosome 12.
17608619 Human alpha2-macroglobulin is composed of multiple domains, as predicted by homology with complement component C3.
17974005 The full-ORF clone resource of the German cDNA consortium.
19139490 A strategy for precise and large scale identification of core fucosylated glycoproteins.
19159218 Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
21269460 Initial characterization of the human central proteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
No results found.
Domain Name Domain ID Source
MAHU A94033 PIR
Macroglobln_a2 IPR001599 InterPro
A2M_N IPR002890 InterPro
Terpenoid_cyclase/PrenylTrfase IPR008930 InterPro
A-macroglobulin_rcpt-bd IPR009048 InterPro
TonB_box_CS IPR010916 InterPro
A2M_N_2 IPR011625 InterPro
A2M_comp IPR011626 InterPro
Ig-like_fold IPR013783 InterPro
Ig_E-set IPR014756 InterPro
MacrogloblnA2_thiol-ester-bond IPR019565 InterPro
MacrogloblnA2_CS IPR019742 InterPro
A-macroglobulin_rcpt-bd_sf IPR036595 InterPro
A2M PF00207 Pfam
A2M_N PF01835 Pfam
A2M_recep PF07677 Pfam
A2M_comp PF07678 Pfam
A2M_N_2 PF07703 Pfam
Thiol-ester_cl PF10569 Pfam
ALPHA_2_MACROGLOBULIN PS00477 PROSITE
A2M_N_2 SM01359 SMART
A2M SM01360 SMART
A2M_recep SM01361 SMART
SSF48239 SSF48239 SUPFAM
SSF49410 SSF49410 SUPFAM
SSF81296 SSF81296 SUPFAM