Protein: P02649 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P02649 (Uniprot)	APOE_HUMAN	APOE	Apolipoprotein E	human	No

Protein Function

Uniprot: Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0034641	cellular nitrogen compound metabolic process	267	GO:0007165	signal transduction	803	4.22e-144	6.90e-18

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
129	GO:0044267	cellular protein metabolic process
129	GO:0007165	signal transduction
170	GO:0070887	cellular response to chemical stimulus
170	GO:0034654	nucleobase-containing compound biosynthetic process
170	GO:0031326	regulation of cellular biosynthetic process
170	GO:0010468	regulation of gene expression
170	GO:0007165	signal transduction
267	GO:0044271	cellular nitrogen compound biosynthetic process
267	GO:0010467	gene expression
267	GO:0009059	macromolecule biosynthetic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
129	GO:0005829	cytosol
129	GO:0070013	intracellular organelle lumen
170	GO:0005634	nucleus
216	GO:0005829	cytosol
267	GO:0005829	cytosol
267	GO:0070013	intracellular organelle lumen
267	GO:0005634	nucleus
293	GO:0005634	nucleus
365	GO:0015630	microtubule cytoskeleton
383	GO:0070013	intracellular organelle lumen

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000302	response to reactive oxygen species	NAS
GO:0001523	retinoid metabolic process	TAS
GO:0001937	negative regulation of endothelial cell proliferation	IDA
GO:0002021	response to dietary excess	IEA
GO:0006357	regulation of transcription from RNA polymerase II promoter	TAS
GO:0006641	triglyceride metabolic process	IDA
GO:0006707	cholesterol catabolic process	IBA
GO:0006874	cellular calcium ion homeostasis	IEA
GO:0006898	receptor-mediated endocytosis	TAS
GO:0007010	cytoskeleton organization	TAS

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005576	extracellular region	TAS
GO:0005615	extracellular space	IDA
GO:0005634	nucleus	IDA
GO:0005737	cytoplasm	TAS
GO:0005769	early endosome	TAS
GO:0005783	endoplasmic reticulum	IDA
GO:0005788	endoplasmic reticulum lumen	TAS
GO:0005794	Golgi apparatus	IDA
GO:0005886	plasma membrane	TAS
GO:0016020	membrane	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005576	extracellular region	GO:0005634	nucleus	4.48e-91	1.28e-107
GO:0005615	extracellular space	GO:0005634	nucleus	6.26e-54	1.10e-77
GO:0005634	nucleus	GO:0005783	endoplasmic reticulum	8.26e-33	3.22e-89
GO:0005634	nucleus	GO:0005788	endoplasmic reticulum lumen	1.02e-17	1.08e-83
GO:0005634	nucleus	GO:0005794	Golgi apparatus	4.39e-25	2.14e-64
GO:0005634	nucleus	GO:0005886	plasma membrane	5.35e-300	7.52e-165
GO:0005634	nucleus	GO:0016020	membrane	0.00e+00	4.39e-236
GO:0005634	nucleus	GO:0030669	clathrin-coated endocytic vesicle membrane	3.06e-04	2.78e-36
GO:0005634	nucleus	GO:0031012	extracellular matrix	1.58e-13	4.18e-03
GO:0005634	nucleus	GO:0070062	extracellular exosome	6.30e-13	4.54e-26

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
A2MG_HUMAN	Yes: P01023 (MoonDB)
ACTG_HUMAN	No
ANKH_HUMAN	No
ARFG1_HUMAN	No
CDC37_HUMAN	Yes: Q16543 (MoonDB)
CP2C8_HUMAN	No
CP2CI_HUMAN	No
ECSIT_HUMAN	No
ELAV1_HUMAN	No
EPN2_HUMAN	No

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Publications Associated

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PMID	Article Title
1674745	Apolipoprotein E-4 Philadelphia (Glu-13-->Lys,Arg-145-->Cys). Homozygosity for two rare point mutations in the apolipoprotein E gene combined with severe type III hyperlipoproteinemia.
2063194	Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E.
2556398	Apolipoprotein E3-Leiden contains a seven-amino acid insertion that is a tandem repeat of residues 121-127.
2760009	Molecular cloning of a human apolipoprotein E variant: E5 (Glu-3-->Lys).
2987927	Nucleotide sequence and structure of the human apolipoprotein E gene.
3243553	Genotyping and sequence analysis of apolipoprotein E isoforms.
3283935	Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.
3947350	Binding of a high reactive heparin to human apolipoprotein E: identification of two heparin-binding domains.
6325438	Synthesis, intracellular processing, and signal peptide of human apolipoprotein E.
6327682	Human apolipoprotein E mRNA. cDNA cloning and nucleotide sequencing of a new variant.

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OMIM Diseases Associated

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OMIM ID	Disease Name
104310	Alzheimer disease 2
143890	Familial hypercholesterolemia
269600	Sea-blue histiocyte disease
611771	Lipoprotein glomerulopathy
617347	Hyperlipoproteinemia 3

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Protein Domains Associated

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Domain Name	Domain ID	Source
ApoA_E	IPR000074	InterPro
Apolipoprotein	PF01442	Pfam
LPHUE	A92478	PIR

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