Protein: P02649

Uniprot: Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0034641 cellular nitrogen compound metabolic process 267 GO:0007165 signal transduction 803 4.22e-144 6.90e-18
Module ID (MoonGO) GO ID (BP) GO Name
129 GO:0044267 cellular protein metabolic process
129 GO:0007165 signal transduction
170 GO:0070887 cellular response to chemical stimulus
170 GO:0034654 nucleobase-containing compound biosynthetic process
170 GO:0031326 regulation of cellular biosynthetic process
170 GO:0010468 regulation of gene expression
170 GO:0007165 signal transduction
267 GO:0044271 cellular nitrogen compound biosynthetic process
267 GO:0010467 gene expression
267 GO:0009059 macromolecule biosynthetic process
267 GO:0090304 nucleic acid metabolic process
267 GO:0019538 protein metabolic process
267 GO:0060255 regulation of macromolecule metabolic process
383 GO:0044267 cellular protein metabolic process
383 GO:0006355 regulation of transcription, DNA-templated
622 GO:0007165 signal transduction
803 GO:0007166 cell surface receptor signaling pathway
803 GO:0044267 cellular protein metabolic process
803 GO:0071310 cellular response to organic substance
803 GO:0035556 intracellular signal transduction
803 GO:0009966 regulation of signal transduction
827 GO:0060255 regulation of macromolecule metabolic process
Module ID (MoonGO) GO ID (CC) GO Name
129 GO:0005829 cytosol
129 GO:0070013 intracellular organelle lumen
170 GO:0005634 nucleus
216 GO:0005829 cytosol
267 GO:0005829 cytosol
267 GO:0070013 intracellular organelle lumen
267 GO:0005634 nucleus
293 GO:0005634 nucleus
365 GO:0015630 microtubule cytoskeleton
383 GO:0070013 intracellular organelle lumen
383 GO:0044428 nuclear part
600 GO:0005634 nucleus
622 GO:0005829 cytosol
622 GO:0070013 intracellular organelle lumen
622 GO:0005634 nucleus
717 GO:0005829 cytosol
717 GO:0043232 intracellular non-membrane-bounded organelle
717 GO:0005634 nucleus
803 GO:0016021 integral component of membrane
803 GO:0005886 plasma membrane
827 GO:0012505 endomembrane system
827 GO:0031982 vesicle
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000302 response to reactive oxygen species NAS
GO:0001523 retinoid metabolic process TAS
GO:0001937 negative regulation of endothelial cell proliferation IDA
GO:0002021 response to dietary excess IEA
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS
GO:0006641 triglyceride metabolic process IDA
GO:0006707 cholesterol catabolic process IBA
GO:0006874 cellular calcium ion homeostasis IEA
GO:0006898 receptor-mediated endocytosis TAS
GO:0007010 cytoskeleton organization TAS
GO:0007186 G-protein coupled receptor signaling pathway IDA
GO:0007263 nitric oxide mediated signal transduction IDA
GO:0007271 synaptic transmission, cholinergic TAS
GO:0007616 long-term memory IGI
GO:0008203 cholesterol metabolic process IDA
GO:0010544 negative regulation of platelet activation IDA
GO:0010873 positive regulation of cholesterol esterification IDA
GO:0010875 positive regulation of cholesterol efflux IDA
GO:0010877 lipid transport involved in lipid storage ISS
GO:0010976 positive regulation of neuron projection development IDA
GO:0010977 negative regulation of neuron projection development IDA
GO:0015909 long-chain fatty acid transport IDA
GO:0017038 protein import IDA
GO:0019068 virion assembly IMP
GO:0019433 triglyceride catabolic process IBA
GO:0019934 cGMP-mediated signaling IDA
GO:0030195 negative regulation of blood coagulation IDA
GO:0030516 regulation of axon extension TAS
GO:0030828 positive regulation of cGMP biosynthetic process IDA
GO:0031102 neuron projection regeneration IBA
GO:0032269 negative regulation of cellular protein metabolic process IGI
GO:0032462 regulation of protein homooligomerization IDA
GO:0032489 regulation of Cdc42 protein signal transduction IDA
GO:0032805 positive regulation of low-density lipoprotein particle receptor catabolic process IDA
GO:0033344 cholesterol efflux IDA
GO:0033700 phospholipid efflux IDA
GO:0034371 chylomicron remodeling TAS
GO:0034372 very-low-density lipoprotein particle remodeling IDA
GO:0034374 low-density lipoprotein particle remodeling IEA
GO:0034375 high-density lipoprotein particle remodeling TAS
GO:0034378 chylomicron assembly TAS
GO:0034380 high-density lipoprotein particle assembly IDA
GO:0034382 chylomicron remnant clearance TAS
GO:0034384 high-density lipoprotein particle clearance IDA
GO:0034447 very-low-density lipoprotein particle clearance IMP
GO:0035641 locomotory exploration behavior IMP
GO:0042158 lipoprotein biosynthetic process IEA
GO:0042159 lipoprotein catabolic process IBA
GO:0042311 vasodilation IEA
GO:0042632 cholesterol homeostasis IDA
GO:0042982 amyloid precursor protein metabolic process IDA
GO:0043407 negative regulation of MAP kinase activity IDA
GO:0043524 negative regulation of neuron apoptotic process IBA
GO:0043537 negative regulation of blood vessel endothelial cell migration IDA
GO:0043687 post-translational protein modification TAS
GO:0043691 reverse cholesterol transport IDA
GO:0044267 cellular protein metabolic process TAS
GO:0044794 positive regulation by host of viral process IMP
GO:0045541 negative regulation of cholesterol biosynthetic process IDA
GO:0045807 positive regulation of endocytosis IDA
GO:0046889 positive regulation of lipid biosynthetic process IDA
GO:0046907 intracellular transport TAS
GO:0048168 regulation of neuronal synaptic plasticity TAS
GO:0048844 artery morphogenesis IEA
GO:0050728 negative regulation of inflammatory response IC
GO:0051000 positive regulation of nitric-oxide synthase activity IDA
GO:0051044 positive regulation of membrane protein ectodomain proteolysis IGI
GO:0051246 regulation of protein metabolic process IGI
GO:0051651 maintenance of location in cell IEA
GO:0055089 fatty acid homeostasis IDA
GO:0060999 positive regulation of dendritic spine development IDA
GO:0061771 response to caloric restriction IGI
GO:0070328 triglyceride homeostasis ISS
GO:0090090 negative regulation of canonical Wnt signaling pathway TAS
GO:0090181 regulation of cholesterol metabolic process IGI
GO:0090209 negative regulation of triglyceride metabolic process IEA
GO:0097113 AMPA glutamate receptor clustering IDA
GO:0097114 NMDA glutamate receptor clustering IDA
GO:0098869 cellular oxidant detoxification IEA
GO:1900221 regulation of amyloid-beta clearance IDA
GO:1900272 negative regulation of long-term synaptic potentiation IDA
GO:1901215 negative regulation of neuron death IDA
GO:1901628 positive regulation of postsynaptic membrane organization IDA
GO:1901630 negative regulation of presynaptic membrane organization IDA
GO:1902430 negative regulation of amyloid-beta formation IDA
GO:1902952 positive regulation of dendritic spine maintenance IDA
GO:1902995 positive regulation of phospholipid efflux IDA
GO:1903002 positive regulation of lipid transport across blood brain barrier IDA
GO:1905855 positive regulation of heparan sulfate binding IDA
GO:1905860 positive regulation of heparan sulfate proteoglycan binding IDA
GO:1905890 regulation of cellular response to very-low-density lipoprotein particle stimulus IDA
GO:1905906 regulation of amyloid fibril formation IDA
GO:1905908 positive regulation of amyloid fibril formation TAS
GO:2000822 regulation of behavioral fear response IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005576 extracellular region TAS
GO:0005615 extracellular space IDA
GO:0005634 nucleus IDA
GO:0005737 cytoplasm TAS
GO:0005769 early endosome TAS
GO:0005783 endoplasmic reticulum IDA
GO:0005788 endoplasmic reticulum lumen TAS
GO:0005794 Golgi apparatus IDA
GO:0005886 plasma membrane TAS
GO:0016020 membrane IDA
GO:0030425 dendrite NAS
GO:0030669 clathrin-coated endocytic vesicle membrane TAS
GO:0031012 extracellular matrix IDA
GO:0034361 very-low-density lipoprotein particle IDA
GO:0034362 low-density lipoprotein particle IDA
GO:0034363 intermediate-density lipoprotein particle IDA
GO:0034364 high-density lipoprotein particle IDA
GO:0034365 discoidal high-density lipoprotein particle TAS
GO:0042627 chylomicron IDA
GO:0043025 neuronal cell body NAS
GO:0070062 extracellular exosome IDA
GO:0071682 endocytic vesicle lumen TAS
GO:0072562 blood microparticle IDA
GO:0106003 amyloid-beta complex IDA
GO:1903561 extracellular vesicle IDA
GO:1990777 lipoprotein particle IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005576 extracellular region GO:0005634 nucleus 4.48e-91 1.28e-107
GO:0005615 extracellular space GO:0005634 nucleus 6.26e-54 1.10e-77
GO:0005634 nucleus GO:0005783 endoplasmic reticulum 8.26e-33 3.22e-89
GO:0005634 nucleus GO:0005788 endoplasmic reticulum lumen 1.02e-17 1.08e-83
GO:0005634 nucleus GO:0005794 Golgi apparatus 4.39e-25 2.14e-64
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
GO:0005634 nucleus GO:0016020 membrane 0.00e+00 4.39e-236
GO:0005634 nucleus GO:0030669 clathrin-coated endocytic vesicle membrane 3.06e-04 2.78e-36
GO:0005634 nucleus GO:0031012 extracellular matrix 1.58e-13 4.18e-03
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
GO:0005634 nucleus GO:1903561 extracellular vesicle 1.85e-13 4.00e-27
PMID Article Title
1674745 Apolipoprotein E-4 Philadelphia (Glu-13-->Lys,Arg-145-->Cys). Homozygosity for two rare point mutations in the apolipoprotein E gene combined with severe type III hyperlipoproteinemia.
2063194 Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E.
2556398 Apolipoprotein E3-Leiden contains a seven-amino acid insertion that is a tandem repeat of residues 121-127.
2760009 Molecular cloning of a human apolipoprotein E variant: E5 (Glu-3-->Lys).
2987927 Nucleotide sequence and structure of the human apolipoprotein E gene.
3243553 Genotyping and sequence analysis of apolipoprotein E isoforms.
3283935 Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.
3947350 Binding of a high reactive heparin to human apolipoprotein E: identification of two heparin-binding domains.
6325438 Synthesis, intracellular processing, and signal peptide of human apolipoprotein E.
6327682 Human apolipoprotein E mRNA. cDNA cloning and nucleotide sequencing of a new variant.
6897404 Identification and DNA sequence of a human apolipoprotein E cDNA clone.
7068630 Human apolipoprotein E. The complete amino acid sequence.
7833947 Genetic heterogeneity of apolipoprotein E and its influence on plasma lipid and lipoprotein levels.
8287539 Common and rare genotypes of human apolipoprotein E determined by specific restriction profiles of polymerase chain reaction-amplified DNA.
8346443 Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.
8488843 Characterization of five new mutants in the carboxyl-terminal domain of human apolipoprotein E: no cosegregation with severe hyperlipidemia.
8756331 Novel mechanism for defective receptor binding of apolipoprotein E2 in type III hyperlipoproteinemia.
9176854 Apolipoprotein E Sendai (arginine 145-->proline): a new variant associated with lipoprotein glomerulopathy.
9360638 Apolipoprotein E R112; R251G: a carboxy-terminal variant found in patients with hyperlipidemia and coronary heart disease.
10432380 A novel apolipoprotein E mutation, E2 (Arg25Cys), in lipoprotein glomerulopathy.
10452964 Glycation of apolipoprotein E impairs its binding to heparin: identification of the major glycation site.
10520737 Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1.
10850798 Conformational flexibility in the apolipoprotein E amino-terminal domain structure determined from three new crystal forms: implications for lipid binding.
11042151 Sequence diversity and large-scale typing of SNPs in the human apolipoprotein E gene.
11095479 Familial splenomegaly: macrophage hypercatabolism of lipoproteins associated with apolipoprotein E mutation [apolipoprotein E (delta149 Leu)].
12864777 Apolipoprotein E3Basel: new insights into a highly conserved protein region.
12966036 Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16094309 Variable expressivity of the clinical and biochemical phenotype associated with the apolipoprotein E p.Leu149del mutation.
18077821 APOE Kyoto mutation in European Americans with lipoprotein glomerulopathy.
19838169 Enrichment of glycopeptides for glycan structure and attachment site identification.
21269460 Initial characterization of the human central proteome.
22028381 Quantitative detection of single amino acid polymorphisms by targeted proteomics.
22481068 Apolipoprotein E gene mutations in subjects with mixed hyperlipidemia and a clinical diagnosis of familial combined hyperlipidemia.
22905912 Resveratrol-induced changes of the human adipocyte secretion profile.
22949395 Description of a large family with autosomal dominant hypercholesterolemia associated with the APOE p.Leu167del mutation.
23234360 LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.
24267230 APOE p.Leu167del mutation in familial hypercholesterolemia.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
26091039 A single kinase generates the majority of the secreted phosphoproteome.
26802169 Global molecular analysis and APOE mutations in a cohort of autosomal dominant hypercholesterolemia patients in France.
OMIM ID Disease Name
104310 Alzheimer disease 2
143890 Familial hypercholesterolemia
269600 Sea-blue histiocyte disease
611771 Lipoprotein glomerulopathy
617347 Hyperlipoproteinemia 3
Domain Name Domain ID Source
ApoA_E IPR000074 InterPro
Apolipoprotein PF01442 Pfam