Protein: P38936 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P38936 (Uniprot)	CDN1A_HUMAN	CDKN1A	Cyclin-dependent kinase inhibitor 1	human	No

Protein Function

Uniprot: May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and asse more..

MoonDB Dissimilar Functions

Showing 1 to 1 of 1 entries

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006793	phosphorus metabolic process	491	GO:0009059	macromolecule biosynthetic process	6	1.25e-35	4.53e-23

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MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 83 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
2	GO:0044267	cellular protein metabolic process
2	GO:0010467	gene expression
2	GO:0006139	nucleobase-containing compound metabolic process
2	GO:0060255	regulation of macromolecule metabolic process
2	GO:0007165	signal transduction
6	GO:0034645	cellular macromolecule biosynthetic process
6	GO:0010467	gene expression
6	GO:0090304	nucleic acid metabolic process
6	GO:0060255	regulation of macromolecule metabolic process
27	GO:0090304	nucleic acid metabolic process

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Cellular Components

Showing 1 to 10 of 35 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
2	GO:0005829	cytosol
2	GO:0005634	nucleus
6	GO:0043232	intracellular non-membrane-bounded organelle
6	GO:0005654	nucleoplasm
27	GO:0031981	nuclear lumen
42	GO:0005829	cytosol
42	GO:0005654	nucleoplasm
51	GO:0005634	nucleus
73	GO:0005634	nucleus
120	GO:0005829	cytosol

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Protein GO Annotations

Biological Processes

Showing 1 to 10 of 49 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	TAS
GO:0000082	G1/S transition of mitotic cell cycle	TAS
GO:0000086	G2/M transition of mitotic cell cycle	IMP
GO:0006357	regulation of transcription from RNA polymerase II promoter	TAS
GO:0006367	transcription initiation from RNA polymerase II promoter	TAS
GO:0006974	cellular response to DNA damage stimulus	IMP
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	TAS
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IEA
GO:0007050	cell cycle arrest	IMP
GO:0007265	Ras protein signal transduction	IEP

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Cellular Components

Showing 1 to 9 of 9 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IDA
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	TAS
GO:0005730	nucleolus	IDA
GO:0005829	cytosol	TAS
GO:0016604	nuclear body	IDA
GO:0043234	protein complex	IDA
GO:0048471	perinuclear region of cytoplasm	IEA
GO:0070557	PCNA-p21 complex	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 167 entries

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Interactor	Also a MoonDB EMF protein
A1BG_HUMAN	No
A2MG_HUMAN	Yes: P01023 (MoonDB)
ACL6B_HUMAN	No
ACTB_HUMAN	No
AKT1_HUMAN	No
ANGP2_HUMAN	No
APLP1_HUMAN	No
ATPB_HUMAN	No
ATS10_HUMAN	No
ATX3_HUMAN	No

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Publications Associated

Showing 1 to 10 of 31 entries

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PMID	Article Title
7655464	Two variants of the CIP1/WAF1 gene occur together and are associated with human cancer.
7753561	The melanoma differentiation-associated gene mda-6, which encodes the cyclin-dependent kinase inhibitor p21, is differentially expressed during growth, differentiation and progression in human melanoma cells.
8125163	Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen.
8242751	The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
8242752	WAF1, a potential mediator of p53 tumor suppression.
8259214	p21 is a universal inhibitor of cyclin kinases.
8861913	Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA.
9106657	New functional activities for the p21 family of CDK inhibitors.
10753973	Reversible phosphorylation at the C-terminal regulatory domain of p21(Waf1/Cip1) modulates proliferating cell nuclear antigen binding.
11350925	A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 7 of 7 entries

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Domain Name	Domain ID	Source
CDI	IPR003175	InterPro
CDI	PF02234	Pfam
CDKN1A_vertebrate	IPR029841	InterPro
I54380	I54380	PIR
I68674	I68674	PIR
PTHR10265	PTHR10265	PANTHER
PTHR10265:SF16	PTHR10265:SF16	PANTHER

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