Protein: P38936

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P38936 (Uniprot) CDN1A_HUMAN CDKN1A Cyclin-dependent kinase inhibitor 1 human No
Uniprot: May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0006793 phosphorus metabolic process 491 GO:0009059 macromolecule biosynthetic process 6 1.25e-35 4.53e-23
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
2 GO:0044267 cellular protein metabolic process
2 GO:0010467 gene expression
2 GO:0006139 nucleobase-containing compound metabolic process
2 GO:0060255 regulation of macromolecule metabolic process
2 GO:0007165 signal transduction
6 GO:0034645 cellular macromolecule biosynthetic process
6 GO:0010467 gene expression
6 GO:0090304 nucleic acid metabolic process
6 GO:0060255 regulation of macromolecule metabolic process
27 GO:0090304 nucleic acid metabolic process
27 GO:0060255 regulation of macromolecule metabolic process
42 GO:0031325 positive regulation of cellular metabolic process
42 GO:0010604 positive regulation of macromolecule metabolic process
42 GO:0051173 positive regulation of nitrogen compound metabolic process
42 GO:0006355 regulation of transcription, DNA-templated
42 GO:0007165 signal transduction
51 GO:0060255 regulation of macromolecule metabolic process
73 GO:0006355 regulation of transcription, DNA-templated
120 GO:0006464 cellular protein modification process
120 GO:0070887 cellular response to chemical stimulus
120 GO:0031324 negative regulation of cellular metabolic process
120 GO:0010605 negative regulation of macromolecule metabolic process
120 GO:0051172 negative regulation of nitrogen compound metabolic process
120 GO:0031325 positive regulation of cellular metabolic process
120 GO:0010604 positive regulation of macromolecule metabolic process
120 GO:0051173 positive regulation of nitrogen compound metabolic process
120 GO:0006355 regulation of transcription, DNA-templated
120 GO:0007165 signal transduction
181 GO:0044267 cellular protein metabolic process
181 GO:0010467 gene expression
181 GO:0009059 macromolecule biosynthetic process
181 GO:0090304 nucleic acid metabolic process
181 GO:0060255 regulation of macromolecule metabolic process
181 GO:0007165 signal transduction
198 GO:0060255 regulation of macromolecule metabolic process
198 GO:0007165 signal transduction
218 GO:0060255 regulation of macromolecule metabolic process
267 GO:0044271 cellular nitrogen compound biosynthetic process
267 GO:0010467 gene expression
267 GO:0009059 macromolecule biosynthetic process
267 GO:0090304 nucleic acid metabolic process
267 GO:0019538 protein metabolic process
267 GO:0060255 regulation of macromolecule metabolic process
330 GO:0006464 cellular protein modification process
330 GO:0006796 phosphate-containing compound metabolic process
330 GO:0031325 positive regulation of cellular metabolic process
330 GO:0010604 positive regulation of macromolecule metabolic process
330 GO:0051173 positive regulation of nitrogen compound metabolic process
330 GO:2000112 regulation of cellular macromolecule biosynthetic process
330 GO:0010468 regulation of gene expression
330 GO:0019219 regulation of nucleobase-containing compound metabolic process
330 GO:0051246 regulation of protein metabolic process
330 GO:0007165 signal transduction
330 GO:0006351 transcription, DNA-templated
344 GO:0010467 gene expression
344 GO:0019538 protein metabolic process
344 GO:0060255 regulation of macromolecule metabolic process
344 GO:0007165 signal transduction
351 GO:0022402 cell cycle process
351 GO:0034645 cellular macromolecule biosynthetic process
351 GO:0044267 cellular protein metabolic process
351 GO:0090304 nucleic acid metabolic process
491 GO:0006796 phosphate-containing compound metabolic process
539 GO:0000082 G1/S transition of mitotic cell cycle
539 GO:0034645 cellular macromolecule biosynthetic process
539 GO:0090304 nucleic acid metabolic process
539 GO:0060255 regulation of macromolecule metabolic process
550 GO:0006355 regulation of transcription, DNA-templated
655 GO:0006464 cellular protein modification process
655 GO:0071310 cellular response to organic substance
655 GO:0035556 intracellular signal transduction
655 GO:0031325 positive regulation of cellular metabolic process
655 GO:0010604 positive regulation of macromolecule metabolic process
655 GO:0051173 positive regulation of nitrogen compound metabolic process
655 GO:0032268 regulation of cellular protein metabolic process
655 GO:0009966 regulation of signal transduction
655 GO:0006355 regulation of transcription, DNA-templated
655 GO:0009719 response to endogenous stimulus
752 GO:0016070 RNA metabolic process
752 GO:0034645 cellular macromolecule biosynthetic process
752 GO:0044267 cellular protein metabolic process
752 GO:0034654 nucleobase-containing compound biosynthetic process
752 GO:0010468 regulation of gene expression
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
2 GO:0005829 cytosol
2 GO:0005634 nucleus
6 GO:0043232 intracellular non-membrane-bounded organelle
6 GO:0005654 nucleoplasm
27 GO:0031981 nuclear lumen
42 GO:0005829 cytosol
42 GO:0005654 nucleoplasm
51 GO:0005634 nucleus
73 GO:0005634 nucleus
120 GO:0005829 cytosol
120 GO:0043232 intracellular non-membrane-bounded organelle
120 GO:0005654 nucleoplasm
181 GO:0005829 cytosol
181 GO:0005654 nucleoplasm
198 GO:0005829 cytosol
218 GO:0005634 nucleus
267 GO:0005829 cytosol
267 GO:0070013 intracellular organelle lumen
267 GO:0005634 nucleus
330 GO:0005829 cytosol
330 GO:0005654 nucleoplasm
344 GO:0070013 intracellular organelle lumen
344 GO:0005634 nucleus
351 GO:0043232 intracellular non-membrane-bounded organelle
351 GO:0005654 nucleoplasm
491 GO:0005829 cytosol
491 GO:0043232 intracellular non-membrane-bounded organelle
491 GO:0005634 nucleus
539 GO:0043232 intracellular non-membrane-bounded organelle
539 GO:0005654 nucleoplasm
550 GO:0005634 nucleus
655 GO:0005829 cytosol
655 GO:0005654 nucleoplasm
752 GO:0005829 cytosol
752 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS
GO:0000082 G1/S transition of mitotic cell cycle TAS
GO:0000086 G2/M transition of mitotic cell cycle IMP
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS
GO:0006367 transcription initiation from RNA polymerase II promoter TAS
GO:0006974 cellular response to DNA damage stimulus IMP
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IEA
GO:0007050 cell cycle arrest IMP
GO:0007265 Ras protein signal transduction IEP
GO:0008285 negative regulation of cell proliferation IMP
GO:0009636 response to toxic substance IEA
GO:0010165 response to X-ray IEA
GO:0010243 response to organonitrogen compound IEA
GO:0010629 negative regulation of gene expression IEA
GO:0030308 negative regulation of cell growth IDA
GO:0030890 positive regulation of B cell proliferation IEA
GO:0031100 animal organ regeneration IEA
GO:0031668 cellular response to extracellular stimulus IMP
GO:0033158 regulation of protein import into nucleus, translocation IEA
GO:0034198 cellular response to amino acid starvation IMP
GO:0034605 cellular response to heat IEA
GO:0042326 negative regulation of phosphorylation IDA
GO:0042493 response to drug IEA
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
GO:0043066 negative regulation of apoptotic process IEA
GO:0043068 positive regulation of programmed cell death IEA
GO:0043491 protein kinase B signaling TAS
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IEA
GO:0045860 positive regulation of protein kinase activity IDA
GO:0046685 response to arsenic-containing substance IEA
GO:0048146 positive regulation of fibroblast proliferation IMP
GO:0050821 protein stabilization TAS
GO:0051412 response to corticosterone IEA
GO:0055093 response to hyperoxia IEA
GO:0060574 intestinal epithelial cell maturation IEA
GO:0071479 cellular response to ionizing radiation IMP
GO:0071480 cellular response to gamma radiation IEA
GO:0071493 cellular response to UV-B ISS
GO:0071850 mitotic cell cycle arrest IEA
GO:0090398 cellular senescence IMP
GO:0090399 replicative senescence IEA
GO:0090400 stress-induced premature senescence TAS
GO:0097193 intrinsic apoptotic signaling pathway TAS
GO:1904030 negative regulation of cyclin-dependent protein kinase activity IMP
GO:1904031 positive regulation of cyclin-dependent protein kinase activity IEA
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle IGI
GO:2000278 regulation of DNA biosynthetic process IEA
GO:2000379 positive regulation of reactive oxygen species metabolic process IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IDA
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005730 nucleolus IDA
GO:0005829 cytosol TAS
GO:0016604 nuclear body IDA
GO:0043234 protein complex IDA
GO:0048471 perinuclear region of cytoplasm IEA
GO:0070557 PCNA-p21 complex IDA
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
TRAF1_HUMAN No
TFP11_HUMAN No
MEOX2_HUMAN Yes: P50222 (MoonDB)
ITF2_HUMAN No
KAP1_HUMAN No
REL_HUMAN No
MTUS2_HUMAN No
KIFC3_HUMAN No
TRI54_HUMAN No
IKZF3_HUMAN No
HEM1_HUMAN No
GOGA2_HUMAN Yes: Q08379 (MoonDB)
SKP1_HUMAN Yes: P63208 (MoonDB)
ING5_HUMAN No
TEX11_HUMAN No
USBP1_HUMAN No
ZBT16_HUMAN Yes: Q05516 (MoonDB)
K1H1_HUMAN No
OPTN_HUMAN No
TNIP1_HUMAN No
NEMO_HUMAN Yes: Q9Y6K9 (MoonDB)
TS101_HUMAN Yes: Q99816 (MoonDB)
KRA31_HUMAN No
PCNA_HUMAN Yes: P12004 (MoonDB)
SUMO3_HUMAN No
GNB5_HUMAN No
LZTS2_HUMAN No
BAG6_HUMAN No
TYB4_HUMAN Yes: P62328 (MoonDB)
SYQ_HUMAN No
CDK3_HUMAN No
CDK5_HUMAN No
CELF3_HUMAN No
SKP2_HUMAN No
SETB1_HUMAN No
P53_HUMAN Yes: P04637 (MoonDB)
GBB2_HUMAN No
GET4_HUMAN Yes: Q7L5D6 (MoonDB)
HNRPK_HUMAN Yes: P61978 (MoonDB)
MYOME_HUMAN No
AKT1_HUMAN No
VIME_HUMAN Yes: P08670 (MoonDB)
RACK1_HUMAN No
GA45G_HUMAN No
A2MG_HUMAN Yes: P01023 (MoonDB)
TZAP_HUMAN No
FBN3_HUMAN No
GDF9_HUMAN No
EF1A1_HUMAN No
TLE1_HUMAN No
U119A_HUMAN No
SMAD4_HUMAN No
RBM48_HUMAN No
CSN6_HUMAN No
MED31_HUMAN No
TNIP2_HUMAN No
UB2D1_HUMAN Yes: P51668 (MoonDB)
CASP3_HUMAN No
CDC7_HUMAN No
CDK4_HUMAN No
A1BG_HUMAN No
ACL6B_HUMAN No
ACTB_HUMAN No
ANGP2_HUMAN No
APLP1_HUMAN No
ATPB_HUMAN No
ATS10_HUMAN No
ATX3_HUMAN No
BAD_HUMAN No
BCCIP_HUMAN No
CA123_HUMAN No
CAB45_HUMAN No
CATB_HUMAN No
CBP_HUMAN No
CC85B_HUMAN No
CCNA1_HUMAN No
CCNA2_HUMAN No
CCNB1_HUMAN No
CCNB2_HUMAN No
CCND1_HUMAN No
CCND2_HUMAN No
CCND3_HUMAN No
CCNE1_HUMAN No
CCNE2_HUMAN No
CDC45_HUMAN No
CDC5L_HUMAN No
CDC6_HUMAN No
CDK14_HUMAN No
CDK1_HUMAN No
CDK2_HUMAN No
CDK6_HUMAN Yes: Q00534 (MoonDB)
CDN1B_HUMAN Yes: P46527 (MoonDB)
CEBPA_HUMAN No
CENPB_HUMAN No
CIZ1_HUMAN No
CO4A5_HUMAN No
CPNE2_HUMAN No
CPNE6_HUMAN No
CREL2_HUMAN No
CSAD_HUMAN No
DC1I1_HUMAN No
DDAH2_HUMAN No
DEAF1_HUMAN No
DOCK7_HUMAN No
ECHB_HUMAN No
EXT2_HUMAN No
F13A_HUMAN No
FAD1_HUMAN No
FAF1_HUMAN No
FIBB_HUMAN No
FOXO1_HUMAN No
GCKR_HUMAN No
GEMI_HUMAN No
HDA11_HUMAN No
HDAC1_HUMAN No
HMGX3_HUMAN No
HOOK2_HUMAN No
HPPD_HUMAN No
HXD8_HUMAN No
INP5K_HUMAN No
KLH23_HUMAN No
KMT2B_HUMAN No
KPYM_HUMAN Yes: P14618 (MoonDB)
LRIF1_HUMAN No
M2OM_HUMAN No
MCM10_HUMAN No
MDM2_HUMAN Yes: Q00987 (MoonDB)
MSH2_HUMAN No
NKD2_HUMAN No
NPRL2_HUMAN No
NR1H2_HUMAN Yes: P55055 (MoonDB)
NRBP_HUMAN No
NRK2_HUMAN No
ODPB_HUMAN No
OTUB1_HUMAN No
PRS7_HUMAN No
RAB1A_HUMAN No
RAI1_HUMAN No
RBBP4_HUMAN No
RL18_HUMAN No
RL35_HUMAN No
RS2_HUMAN No
S10A8_HUMAN No
SCG1_HUMAN No
SIPA1_HUMAN No
SP110_HUMAN No
SPRE1_HUMAN No
STAT3_HUMAN Yes: P40763 (MoonDB)
TAF5L_HUMAN No
TBA1A_HUMAN No
TBB2B_HUMAN No
TBB3_HUMAN No
TCPH_HUMAN No
TETN_HUMAN No
THIO_HUMAN No
TNR16_HUMAN No
TRM2A_HUMAN No
TTLL5_HUMAN No
TXD11_HUMAN No
UBB_HUMAN Yes: P0CG47 (MoonDB)
UBP4_HUMAN No
VATA_HUMAN No
VPS51_HUMAN No
WDR73_HUMAN No
WIZ_HUMAN No
ZN135_HUMAN No
ZN431_HUMAN No
PMID Article Title
7655464 Two variants of the CIP1/WAF1 gene occur together and are associated with human cancer.
7753561 The melanoma differentiation-associated gene mda-6, which encodes the cyclin-dependent kinase inhibitor p21, is differentially expressed during growth, differentiation and progression in human melanoma cells.
8125163 Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen.
8242751 The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
8242752 WAF1, a potential mediator of p53 tumor suppression.
8259214 p21 is a universal inhibitor of cyclin kinases.
8861913 Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA.
9106657 New functional activities for the p21 family of CDK inhibitors.
10753973 Reversible phosphorylation at the C-terminal regulatory domain of p21(Waf1/Cip1) modulates proliferating cell nuclear antigen binding.
11350925 A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome.
11463845 Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells.
11595739 Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta.
12431783 Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase.
14574404 The DNA sequence and analysis of human chromosome 6.
15226418 N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15574338 N-acetylation and ubiquitin-independent proteasomal degradation of p21(Cip1).
16964243 A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
16982699 Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding.
18669648 A quantitative atlas of mitotic phosphorylation.
18703516 CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation.
18794347 PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.
18794348 The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing.
19054851 Human protein factory for converting the transcriptome into an in vitro-expressed proteome.
19332548 Ionizing radiation induces ATM-independent degradation of p21Cip1 in transformed cells.
19445729 A dual role of Cdk2 in DNA damage response.
19536131 Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis.
20307683 Pim-2 phosphorylation of p21(Cip1/WAF1) enhances its stability and inhibits cell proliferation in HCT116 cells.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23645206 ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.).
25329316 A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation.
No results found.
Domain Name Domain ID Source
I54380 I54380 PIR
I68674 I68674 PIR
CDI IPR003175 InterPro
CDKN1A_vertebrate IPR029841 InterPro
CDI PF02234 Pfam
PTHR10265 PTHR10265 PANTHER
PTHR10265:SF16 PTHR10265:SF16 PANTHER