Function 1: Transport, part of the ESCRT complex (endocytosis). Condition: mainly cytoplasmic, membrane-associated when active and soluble when inactive.
Function 2: Transcriptional repressor protein, decreasing GR-dependent transcriptional activation by binding and repressing AF-1. Condition: nuclear localisation (cell cycle dependant, nuclear localisation increased through binding of nuclear proteins AATF, Daxx or RTA).
Publications (PMID): 10508170, 9588212, 9465061, 17182691