Protein: P07550 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P07550 (Uniprot)	ADRB2_HUMAN	ADRB2	Beta-2 adrenergic receptor	human	No

Protein Function

Uniprot: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.

MoonDB Dissimilar Functions

Showing 1 to 2 of 2 entries

Search:

GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	187	GO:0006725	cellular aromatic compound metabolic process	222	5.44e-126	5.27e-27
GO:0009059	macromolecule biosynthetic process	401	GO:0009056	catabolic process	48	6.37e-04	1.88e-40

Previous1Next

MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 23 entries

Search:

Module ID (MoonGO)	GO ID (BP)	GO Name
48	GO:0044248	cellular catabolic process
48	GO:0070647	protein modification by small protein conjugation or removal
48	GO:0006508	proteolysis
48	GO:0060255	regulation of macromolecule metabolic process
48	GO:0007165	signal transduction
187	GO:0007166	cell surface receptor signaling pathway
187	GO:0006464	cellular protein modification process
187	GO:0070887	cellular response to chemical stimulus
187	GO:0035556	intracellular signal transduction
187	GO:0006928	movement of cell or subcellular component

Previous1 2 3Next

Cellular Components

Showing 1 to 10 of 15 entries

Search:

Module ID (MoonGO)	GO ID (CC)	GO Name
48	GO:0031410	cytoplasmic vesicle
48	GO:0012505	endomembrane system
48	GO:0005634	nucleus
48	GO:0005886	plasma membrane
187	GO:0005829	cytosol
187	GO:0005886	plasma membrane
222	GO:0070013	intracellular organelle lumen
222	GO:0044428	nuclear part
274	GO:0005829	cytosol
274	GO:0012505	endomembrane system

Previous1 2Next

Protein GO Annotations

Biological Processes

Showing 1 to 10 of 35 entries

Search:

GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0002024	diet induced thermogenesis	IEA
GO:0002025	norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IBA
GO:0002028	regulation of sodium ion transport	IEA
GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin	IDA
GO:0006898	receptor-mediated endocytosis	IDA
GO:0007166	cell surface receptor signaling pathway	TAS
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	TAS
GO:0007186	G-protein coupled receptor signaling pathway	TAS
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	TAS
GO:0007190	activation of adenylate cyclase activity	IDA

Previous1 2 3 4Next

Cellular Components

Showing 1 to 10 of 11 entries

Search:

GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IEA
GO:0005764	lysosome	TAS
GO:0005768	endosome	TAS
GO:0005769	early endosome	IEA
GO:0005886	plasma membrane	TAS
GO:0005887	integral component of plasma membrane	IDA
GO:0010008	endosome membrane	TAS
GO:0016020	membrane	NAS
GO:0016324	apical plasma membrane	IEA
GO:0030665	clathrin-coated vesicle membrane	TAS

Previous1 2Next

Dissimilar Cellular Components (PrOnto)

Showing 1 to 8 of 8 entries

Search:

GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0005764	lysosome	5.88e-10	1.00e-16
GO:0005634	nucleus	GO:0005768	endosome	4.09e-12	7.34e-15
GO:0005634	nucleus	GO:0005886	plasma membrane	5.35e-300	7.52e-165
GO:0005634	nucleus	GO:0005887	integral component of plasma membrane	6.41e-134	1.88e-259
GO:0005634	nucleus	GO:0010008	endosome membrane	1.38e-08	8.40e-30
GO:0005634	nucleus	GO:0016020	membrane	0.00e+00	4.39e-236
GO:0005634	nucleus	GO:0016324	apical plasma membrane	8.24e-09	4.92e-02
GO:0005634	nucleus	GO:0030665	clathrin-coated vesicle membrane	3.06e-05	6.65e-11

Previous1Next

All Protein Interactions

Showing 1 to 10 of 66 entries

Search:

Interactor	Also a MoonDB EMF protein
5HT4R_HUMAN	No
ADCY3_HUMAN	No
AGRG1_HUMAN	No
ALDOA_HUMAN	No
ALEX_HUMAN	No
ARF4_HUMAN	No
ARRB2_HUMAN	Yes: P32121 (MoonDB)
ARRD1_HUMAN	No
ARRD3_HUMAN	No
BACD1_HUMAN	No

Previous1 2 3 4 5 6 7Next

Publications Associated

Showing 1 to 10 of 31 entries

Search:

PMID	Article Title
2540197	Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor.
2823249	Structure of the gene for human beta 2-adrenergic receptor: expression and promoter characterization.
2831218	Site-directed mutagenesis and continuous expression of human beta-adrenergic receptors. Identification of a conserved aspartate residue involved in agonist binding and receptor activation.
3025863	cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.
3026848	Cloning and sequence analysis of the human brain beta-adrenergic receptor. Evolutionary relationship to rodent and avian beta-receptors and porcine muscarinic receptors.
3033609	Primary structure of the human beta-adrenergic receptor gene.
3034889	Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions.
7706471	Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype.
7822302	Arrestin interactions with G protein-coupled receptors. Direct binding studies of wild type and mutant arrestins with rhodopsin, beta 2-adrenergic, and m2 muscarinic cholinergic receptors.
7915137	Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties.

Previous1 2 3 4Next

OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 14 entries

Search:

Domain Name	Domain ID	Source
7tm_1	PF00001	Pfam
7TM_GPCR_Srsx	SM01381	SMART
7tmA_Beta2_AR	cd15957	CDD
ADR_fam	IPR002233	InterPro
ADRB2_rcpt	IPR000332	InterPro
ADRENERGICR	PR01103	PRINTS
ADRENRGCB2AR	PR00562	PRINTS
G_PROTEIN_RECEP_F1_1	PS00237	PROSITE
G_PROTEIN_RECEP_F1_2	PS50262	PROSITE
GPCR_Rhodpsn	IPR000276	InterPro

Previous1 2Next