Protein: Q00987

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q00987 (Uniprot) MDM2_HUMAN MDM2 E3 ubiquitin-protein ligase Mdm2 human No
Uniprot: E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 1, 187 GO:0006725 cellular aromatic compound metabolic process 53, 222, 342 5.44e-126 5.27e-27
GO:0009056 catabolic process 125 GO:0009059 macromolecule biosynthetic process 270, 874 6.37e-04 1.88e-40
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
1 GO:0035556 intracellular signal transduction
1 GO:0032268 regulation of cellular protein metabolic process
1 GO:0043067 regulation of programmed cell death
1 GO:0009966 regulation of signal transduction
53 GO:0006139 nucleobase-containing compound metabolic process
53 GO:0016567 protein ubiquitination
53 GO:0060255 regulation of macromolecule metabolic process
99 GO:0031325 positive regulation of cellular metabolic process
99 GO:0010628 positive regulation of gene expression
99 GO:0051173 positive regulation of nitrogen compound metabolic process
99 GO:0019538 protein metabolic process
99 GO:0006357 regulation of transcription from RNA polymerase II promoter
99 GO:0007165 signal transduction
125 GO:0044248 cellular catabolic process
125 GO:0016567 protein ubiquitination
125 GO:0060255 regulation of macromolecule metabolic process
131 GO:0070647 protein modification by small protein conjugation or removal
131 GO:0006355 regulation of transcription, DNA-templated
187 GO:0007166 cell surface receptor signaling pathway
187 GO:0006464 cellular protein modification process
187 GO:0070887 cellular response to chemical stimulus
187 GO:0035556 intracellular signal transduction
187 GO:0006928 movement of cell or subcellular component
187 GO:0006796 phosphate-containing compound metabolic process
187 GO:0010647 positive regulation of cell communication
187 GO:0048584 positive regulation of response to stimulus
187 GO:0023056 positive regulation of signaling
187 GO:0060255 regulation of macromolecule metabolic process
187 GO:0009966 regulation of signal transduction
222 GO:0006139 nucleobase-containing compound metabolic process
222 GO:0060255 regulation of macromolecule metabolic process
222 GO:0007165 signal transduction
261 GO:0006355 regulation of transcription, DNA-templated
270 GO:0034645 cellular macromolecule biosynthetic process
270 GO:0010467 gene expression
270 GO:0090304 nucleic acid metabolic process
270 GO:0032446 protein modification by small protein conjugation
270 GO:0060255 regulation of macromolecule metabolic process
270 GO:0007165 signal transduction
342 GO:0006139 nucleobase-containing compound metabolic process
342 GO:0060255 regulation of macromolecule metabolic process
393 GO:0044267 cellular protein metabolic process
475 GO:0031325 positive regulation of cellular metabolic process
475 GO:0060255 regulation of macromolecule metabolic process
655 GO:0006464 cellular protein modification process
655 GO:0071310 cellular response to organic substance
655 GO:0035556 intracellular signal transduction
655 GO:0031325 positive regulation of cellular metabolic process
655 GO:0010604 positive regulation of macromolecule metabolic process
655 GO:0051173 positive regulation of nitrogen compound metabolic process
655 GO:0032268 regulation of cellular protein metabolic process
655 GO:0009966 regulation of signal transduction
655 GO:0006355 regulation of transcription, DNA-templated
655 GO:0009719 response to endogenous stimulus
656 GO:0016070 RNA metabolic process
656 GO:0034645 cellular macromolecule biosynthetic process
656 GO:0044271 cellular nitrogen compound biosynthetic process
656 GO:0010467 gene expression
656 GO:0060255 regulation of macromolecule metabolic process
706 GO:0044267 cellular protein metabolic process
706 GO:0090304 nucleic acid metabolic process
706 GO:0034654 nucleobase-containing compound biosynthetic process
706 GO:2000112 regulation of cellular macromolecule biosynthetic process
706 GO:0010468 regulation of gene expression
706 GO:0019219 regulation of nucleobase-containing compound metabolic process
706 GO:0007165 signal transduction
731 GO:0044267 cellular protein metabolic process
731 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
731 GO:0010629 negative regulation of gene expression
731 GO:0045934 negative regulation of nucleobase-containing compound metabolic process
731 GO:0010604 positive regulation of macromolecule metabolic process
731 GO:0006357 regulation of transcription from RNA polymerase II promoter
731 GO:0007165 signal transduction
737 GO:0006464 cellular protein modification process
737 GO:0009059 macromolecule biosynthetic process
737 GO:0006139 nucleobase-containing compound metabolic process
737 GO:0031325 positive regulation of cellular metabolic process
737 GO:0010604 positive regulation of macromolecule metabolic process
737 GO:0051173 positive regulation of nitrogen compound metabolic process
737 GO:0032268 regulation of cellular protein metabolic process
737 GO:0007165 signal transduction
776 GO:0006464 cellular protein modification process
776 GO:0035556 intracellular signal transduction
776 GO:0031325 positive regulation of cellular metabolic process
776 GO:0032268 regulation of cellular protein metabolic process
776 GO:0009966 regulation of signal transduction
823 GO:0044267 cellular protein metabolic process
823 GO:0071310 cellular response to organic substance
823 GO:0010629 negative regulation of gene expression
823 GO:0031325 positive regulation of cellular metabolic process
823 GO:0010628 positive regulation of gene expression
823 GO:0051173 positive regulation of nitrogen compound metabolic process
823 GO:0006357 regulation of transcription from RNA polymerase II promoter
823 GO:0007165 signal transduction
874 GO:0034645 cellular macromolecule biosynthetic process
874 GO:0010646 regulation of cell communication
874 GO:0023051 regulation of signaling
874 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
1 GO:0005829 cytosol
1 GO:0005634 nucleus
53 GO:0005829 cytosol
53 GO:0005654 nucleoplasm
99 GO:0005654 nucleoplasm
125 GO:0005829 cytosol
125 GO:0005634 nucleus
131 GO:0005829 cytosol
131 GO:0043232 intracellular non-membrane-bounded organelle
131 GO:0005634 nucleus
162 GO:0005634 nucleus
187 GO:0005829 cytosol
187 GO:0005886 plasma membrane
222 GO:0070013 intracellular organelle lumen
222 GO:0044428 nuclear part
261 GO:0031981 nuclear lumen
270 GO:0005829 cytosol
270 GO:0070013 intracellular organelle lumen
270 GO:0005634 nucleus
342 GO:0012505 endomembrane system
342 GO:0044428 nuclear part
393 GO:0043232 intracellular non-membrane-bounded organelle
393 GO:0005634 nucleus
475 GO:0070013 intracellular organelle lumen
475 GO:0005634 nucleus
655 GO:0005829 cytosol
655 GO:0005654 nucleoplasm
656 GO:0043232 intracellular non-membrane-bounded organelle
656 GO:0005634 nucleus
706 GO:0005829 cytosol
706 GO:0031981 nuclear lumen
731 GO:0005654 nucleoplasm
737 GO:0005829 cytosol
737 GO:0043232 intracellular non-membrane-bounded organelle
737 GO:0005634 nucleus
776 GO:0005829 cytosol
776 GO:0043232 intracellular non-membrane-bounded organelle
776 GO:0005634 nucleus
823 GO:0005829 cytosol
823 GO:0005654 nucleoplasm
874 GO:0043232 intracellular non-membrane-bounded organelle
874 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA
GO:0001568 blood vessel development IEA
GO:0001974 blood vessel remodeling IEA
GO:0002027 regulation of heart rate IEA
GO:0003181 atrioventricular valve morphogenesis IEA
GO:0003203 endocardial cushion morphogenesis IEA
GO:0003281 ventricular septum development IEA
GO:0003283 atrial septum development IEA
GO:0006461 protein complex assembly IDA
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
GO:0007089 traversing start control point of mitotic cell cycle IEA
GO:0008284 positive regulation of cell proliferation TAS
GO:0009636 response to toxic substance IEA
GO:0010039 response to iron ion IEA
GO:0010628 positive regulation of gene expression IEA
GO:0010955 negative regulation of protein processing IEA
GO:0010977 negative regulation of neuron projection development IEA
GO:0016032 viral process IEA
GO:0016567 protein ubiquitination IDA
GO:0016579 protein deubiquitination TAS
GO:0016925 protein sumoylation IEA
GO:0018205 peptidyl-lysine modification IMP
GO:0031648 protein destabilization IDA
GO:0032026 response to magnesium ion IEA
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
GO:0034504 protein localization to nucleus IDA
GO:0036369 transcription factor catabolic process TAS
GO:0042176 regulation of protein catabolic process IDA
GO:0042220 response to cocaine IEA
GO:0042493 response to drug IEA
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IMP
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
GO:0043278 response to morphine IEA
GO:0043491 protein kinase B signaling TAS
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
GO:0045184 establishment of protein localization IDA
GO:0045472 response to ether IEA
GO:0045892 negative regulation of transcription, DNA-templated IDA
GO:0045931 positive regulation of mitotic cell cycle IMP
GO:0046677 response to antibiotic IEP
GO:0046827 positive regulation of protein export from nucleus IEA
GO:0048545 response to steroid hormone IEA
GO:0051603 proteolysis involved in cellular protein catabolic process IMP
GO:0051865 protein autoubiquitination IMP
GO:0060411 cardiac septum morphogenesis IEA
GO:0070301 cellular response to hydrogen peroxide IEA
GO:0071157 negative regulation of cell cycle arrest IDA
GO:0071301 cellular response to vitamin B1 IEA
GO:0071312 cellular response to alkaloid IEA
GO:0071363 cellular response to growth factor stimulus IEA
GO:0071375 cellular response to peptide hormone stimulus IEA
GO:0071391 cellular response to estrogen stimulus IEA
GO:0071456 cellular response to hypoxia IEP
GO:0071480 cellular response to gamma radiation IDA
GO:0071494 cellular response to UV-C IEA
GO:0072717 cellular response to actinomycin D IDA
GO:1901796 regulation of signal transduction by p53 class mediator TAS
GO:1901797 negative regulation of signal transduction by p53 class mediator IDA
GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IMP
GO:1904404 response to formaldehyde IEA
GO:1904707 positive regulation of vascular smooth muscle cell proliferation IEA
GO:1904754 positive regulation of vascular associated smooth muscle cell migration IEA
GO:1990000 amyloid fibril formation IMP
GO:1990785 response to water-immersion restraint stress IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IMP
GO:0005654 nucleoplasm TAS
GO:0005730 nucleolus IDA
GO:0005737 cytoplasm IMP
GO:0005829 cytosol TAS
GO:0005886 plasma membrane TAS
GO:0016604 nuclear body IDA
GO:0030666 endocytic vesicle membrane TAS
GO:0043234 protein complex IDA
GO:0045202 synapse IEA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
GO:0005634 nucleus GO:0030666 endocytic vesicle membrane 1.59e-05 7.63e-18
GO:0005634 nucleus GO:0045202 synapse 1.10e-08 8.94e-15
GO:0005654 nucleoplasm GO:0005886 plasma membrane 9.14e-199 6.17e-196
GO:0005654 nucleoplasm GO:0045202 synapse 3.30e-10 4.22e-25
GO:0005730 nucleolus GO:0005886 plasma membrane 7.70e-47 3.09e-07
GO:0005886 plasma membrane GO:0016604 nuclear body 1.42e-38 3.32e-172
Interactor Also a MoonDB EMF protein
PSME3_HUMAN No
STX1A_HUMAN No
RNF8_HUMAN No
UBP2_HUMAN Yes: O75604 (MoonDB)
ATF4_HUMAN No
HSP7C_HUMAN Yes: P11142 (MoonDB)
PLK1_HUMAN Yes: P53350 (MoonDB)
SRBS2_HUMAN No
DAXX_HUMAN No
UB2D2_HUMAN Yes: P62837 (MoonDB)
CTBP1_HUMAN No
RS27A_HUMAN No
PRP6_HUMAN Yes: O94906 (MoonDB)
RCN2_HUMAN No
SETB1_HUMAN No
P53_HUMAN Yes: P04637 (MoonDB)
RASF5_HUMAN No
GSTP1_HUMAN No
WT1_HUMAN No
MKRN3_HUMAN Yes: Q13064 (MoonDB)
POTE1_HUMAN Yes: Q9NUX5 (MoonDB)
AKT1_HUMAN No
DYR_HUMAN No
UBE2K_HUMAN Yes: P61086 (MoonDB)
TRI23_HUMAN No
HIF1A_HUMAN No
NACAM_HUMAN No
EF1G_HUMAN No
TRAF5_HUMAN No
RS3_HUMAN No
A4_HUMAN No
TF65_HUMAN No
UB2D1_HUMAN Yes: P51668 (MoonDB)
UBE2Z_HUMAN No
JUND_HUMAN No
CASP3_HUMAN No
UBP7_HUMAN No
CDN1A_HUMAN Yes: P38936 (MoonDB)
EP300_HUMAN Yes: Q09472 (MoonDB)
BAIP2_HUMAN No
IGF1R_HUMAN No
ARRB1_HUMAN Yes: P49407 (MoonDB)
ACM3_HUMAN No
ANR17_HUMAN No
ARF_HUMAN No
ARHG6_HUMAN No
ARRB2_HUMAN Yes: P32121 (MoonDB)
BCD1_HUMAN No
C560_HUMAN No
CASP2_HUMAN No
CLUS_HUMAN No
CSTN1_HUMAN No
CWC25_HUMAN No
DAAM2_HUMAN No
DMB_HUMAN No
DNJB1_HUMAN No
DNJB4_HUMAN No
ENPL_HUMAN No
EPS15_HUMAN Yes: P42566 (MoonDB)
ERIC3_HUMAN No
ESR1_HUMAN Yes: P03372 (MoonDB)
EZRI_HUMAN No
F1711_HUMAN No
FEZ1_HUMAN No
FKBP3_HUMAN No
GBRA2_HUMAN No
JUN_HUMAN No
KBL_HUMAN No
KIF5A_HUMAN No
KPYM_HUMAN Yes: P14618 (MoonDB)
LATS2_HUMAN No
LMO7_HUMAN No
M4K4_HUMAN No
MDM4_HUMAN Yes: O15151 (MoonDB)
MEA1_HUMAN No
MTAP2_HUMAN No
MTBP_HUMAN No
MYD88_HUMAN No
NACA_HUMAN No
NDKB_HUMAN No
NDUAC_HUMAN No
NFM_HUMAN No
NOP53_HUMAN No
NP1L1_HUMAN No
NSD2_HUMAN No
NUCKS_HUMAN No
NUCL_HUMAN No
NUDT9_HUMAN No
NUMB_HUMAN No
OGA_HUMAN No
P73_HUMAN No
PFD6_HUMAN No
PHF7_HUMAN No
PIM1_HUMAN No
PIM2_HUMAN No
PIM3_HUMAN No
PPM1D_HUMAN No
PRC2C_HUMAN No
PTPRD_HUMAN No
RGRF1_HUMAN No
RIDA_HUMAN No
RL11_HUMAN No
RL23_HUMAN No
RL26_HUMAN No
RL27A_HUMAN No
RN126_HUMAN No
RNF10_HUMAN No
RS7_HUMAN No
RT33_HUMAN No
RYBP_HUMAN No
RYR2_HUMAN No
S100B_HUMAN No
S10A1_HUMAN No
S10A2_HUMAN No
S10A4_HUMAN No
S10A6_HUMAN No
SEC63_HUMAN No
SESN2_HUMAN No
SET_HUMAN No
SHPK_HUMAN No
SMC3_HUMAN Yes: Q9UQE7 (MoonDB)
SREK1_HUMAN No
SRP19_HUMAN No
SYMC_HUMAN No
TBB5_HUMAN No
TBCA_HUMAN No
TELT_HUMAN No
TM87A_HUMAN No
TRIM4_HUMAN No
TRIM9_HUMAN No
TSNAX_HUMAN No
UB2G2_HUMAN No
UBE2U_HUMAN Yes: Q5VVX9 (MoonDB)
WIPI4_HUMAN No
YYAP1_HUMAN No
ZBTB1_HUMAN No
ZN133_HUMAN No
ZN326_HUMAN No
ZN766_HUMAN No
PMID Article Title
1614537 Amplification of a gene encoding a p53-associated protein in human sarcomas.
7651818 A functional p53-responsive intronic promoter is contained within the human mdm2 gene.
7689721 Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes.
8705862 Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer.
8875929 Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.
9270029 Translational enhancement of mdm2 oncogene expression in human tumor cells containing a stabilized wild-type p53 protein.
9450543 Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53.
10597303 A novel exon within the mdm2 gene modulates translation initiation in vitro and disrupts the p53-binding domain of mdm2 protein.
10608892 Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein.
10611322 Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage.
10707090 Identification of a cryptic nucleolar-localization signal in MDM2.
10722742 Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.
10723139 Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase.
11087894 A MboII polymorphism in exon 11 of the human MDM2 gene occurring in normal blood donors and in soft tissue sarcoma patients: an indication for an increased cancer susceptibility?
11351297 Analysis of the molecular species generated by MDM2 gene amplification in liposarcomas.
12167711 Hypophosphorylation of Mdm2 augments p53 stability.
12821780 Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor.
12883554 A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15053880 A dynamic role of HAUSP in the p53-Mdm2 pathway.
15195100 PML regulates p53 stability by sequestering Mdm2 to the nucleolus.
15313915 Synergistic tumor suppression by coexpression of FHIT and p53 coincides with FHIT-mediated MDM2 inactivation and p53 stabilization in human non-small cell lung cancer cells.
15315825 Genomic organisation of the human MDM2 oncogene and relationship to its alternatively spliced mRNAs.
15364927 Negative regulation of p53 functions by Daxx and the involvement of MDM2.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15550242 A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans.
15632057 Regulation of p53 and MDM2 activity by MTBP.
15878855 {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase.
16173922 A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2.
16219768 WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53.
16337594 MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein.
16402859 Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway.
16474402 Molecular recognition of p53 and MDM2 by USP7/HAUSP.
16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
16541075 The finished DNA sequence of human chromosome 12.
16845383 Critical role for Daxx in regulating Mdm2.
17003841 The single-nucleotide polymorphism 309 in the MDM2 gene contributes to the Li-Fraumeni syndrome and related phenotypes.
17110379 A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability.
17290220 The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2.
17460193 CARF binds to three members (ARF, p53, and HDM2) of the p53 tumor-suppressor pathway.
17470788 PACT is a negative regulator of p53 and essential for cell growth and embryonic development.
18382127 CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2.
18566590 The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex.
18768758 AAA ATPase p97 and adaptor UBXD1 suppress MDM2 ubiquitination and degradation and promote constitutive p53 turnover.
19098711 RYBP stabilizes p53 by modulating MDM2.
19139490 A strategy for precise and large scale identification of core fucosylated glycoproteins.
19219073 Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53-MDM2 signaling pathway.
19369353 Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19756449 Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation.
19816404 ATM activates p53 by regulating MDM2 oligomerization and E3 processivity.
19837670 MTA1 coregulator regulates p53 stability and function.
19838211 MdmX is a substrate for the deubiquitinating enzyme USP2a.
19965871 ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage.
20173098 RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage.
20385133 p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma.
20858735 Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways.
21333377 Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2.
22128911 Notch1 binds and induces degradation of Snail in hepatocellular carcinoma.
22869143 BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24120868 The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress.
No results found.
Domain Name Domain ID Source
Znf_RING IPR001841 InterPro
Znf_RanBP2 IPR001876 InterPro
SWIB_MDM2_domain IPR003121 InterPro
Znf_RING/FYVE/PHD IPR013083 InterPro
MDM2_E3_ligase IPR015459 InterPro
p53_neg-reg_MDM_2/4 IPR016495 InterPro
Mdm2 IPR028340 InterPro
Znf_RanBP2_sf IPR036443 InterPro
SWIB_MDM2_dom_sf IPR036885 InterPro
zf-RanBP PF00641 Pfam
SWIB PF02201 Pfam
p53_MDM_2/4 PIRSF006748 PIRSF
MDM2 PIRSF500700 PIRSF
ZF_RANBP2_1 PS01358 PROSITE
ZF_RING_2 PS50089 PROSITE
ZF_RANBP2_2 PS50199 PROSITE
PTHR13844:SF15 PTHR13844:SF15 PANTHER
S24354 S24354 PIR
SSF47592 SSF47592 SUPFAM
SSF90209 SSF90209 SUPFAM