Protein: O94906

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
O94906 (Uniprot) PRP6_HUMAN PRPF6 Pre-mRNA-processing factor 6 human No
Uniprot: Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 282 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 353 4.83e-02 1.79e-71
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 353 GO:0019538 protein metabolic process 775 1.88e-02 4.66e-37
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
282 GO:0035556 intracellular signal transduction
282 GO:0043085 positive regulation of catalytic activity
282 GO:0031325 positive regulation of cellular metabolic process
282 GO:0051173 positive regulation of nitrogen compound metabolic process
282 GO:0060255 regulation of macromolecule metabolic process
282 GO:0019220 regulation of phosphate metabolic process
353 GO:0000398 mRNA splicing, via spliceosome
747 GO:0010467 gene expression
747 GO:0090304 nucleic acid metabolic process
775 GO:0044267 cellular protein metabolic process
775 GO:0010467 gene expression
775 GO:0006139 nucleobase-containing compound metabolic process
775 GO:0060255 regulation of macromolecule metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
282 GO:0005829 cytosol
282 GO:0005886 plasma membrane
353 GO:0005654 nucleoplasm
747 GO:0070013 intracellular organelle lumen
747 GO:0005634 nucleus
775 GO:0005829 cytosol
775 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000244 spliceosomal tri-snRNP complex assembly IMP
GO:0000245 spliceosomal complex assembly NAS
GO:0000375 RNA splicing, via transesterification reactions NAS
GO:0000398 mRNA splicing, via spliceosome TAS
GO:0006403 RNA localization IMP
GO:0008380 RNA splicing NAS
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005681 spliceosomal complex NAS
GO:0005682 U5 snRNP IDA
GO:0016020 membrane IDA
GO:0016607 nuclear speck IDA
GO:0046540 U4/U6 x U5 tri-snRNP complex IDA
GO:0071013 catalytic step 2 spliceosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0016020 membrane 0.00e+00 4.39e-236
GO:0005654 nucleoplasm GO:0016020 membrane 5.76e-255 1.32e-206
GO:0005681 spliceosomal complex GO:0016020 membrane 6.04e-13 3.30e-19
GO:0016020 membrane GO:0016607 nuclear speck 9.49e-26 4.88e-97
PMID Article Title
10561546 A novel mammalian nuclear protein similar to Schizosaccharomyces pombe Prp1p/Zer1p and Saccharomyces cerevisiae Prp6p pre-mRNA splicing factors.
10788320 The human homologue of the yeast splicing factor Prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions.
10848612 Isoform-specific localization of A-RAF in mitochondria.
11780052 The DNA sequence and comparative analysis of human chromosome 20.
11991638 Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.
12039962 Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16723661 The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP.
17974005 The full-ORF clone resource of the German cDNA consortium.
18669648 A quantitative atlas of mitotic phosphorylation.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21269460 Initial characterization of the human central proteome.
21549338 A missense mutation in PRPF6 causes impairment of pre-mRNA splicing and autosomal-dominant retinitis pigmentosa.
22235333 Mutations in the gene DNAJC5 cause autosomal dominant Kufs disease in a proportion of cases: study of the Parry family and 8 other families.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
OMIM ID Disease Name
613983 Retinitis pigmentosa 60
Domain Name Domain ID Source
HAT IPR003107 InterPro
PRP1_N IPR010491 InterPro
TPR-like_helical_dom_sf IPR011990 InterPro
TPR-contain_dom IPR013026 InterPro
TPR_repeat IPR019734 InterPro
Prp6/Prp1/STA1 IPR027108 InterPro
PRP1_N PF06424 Pfam
TPR_8 PF13181 Pfam
PTHR11246:SF1 PTHR11246:SF1 PANTHER
TPR SM00028 SMART
HAT SM00386 SMART
SSF48452 SSF48452 SUPFAM
T46386 T46386 PIR