Protein: Q13200

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q13200 (Uniprot) PSMD2_HUMAN PSMD2 26S proteasome non-ATPase regulatory subunit 2 human No
Uniprot: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 1 GO:0006725 cellular aromatic compound metabolic process 345 5.44e-126 5.27e-27
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
1 GO:0035556 intracellular signal transduction
1 GO:0032268 regulation of cellular protein metabolic process
1 GO:0043067 regulation of programmed cell death
1 GO:0009966 regulation of signal transduction
24 GO:0016070 RNA metabolic process
24 GO:0006464 cellular protein modification process
24 GO:0034654 nucleobase-containing compound biosynthetic process
24 GO:0006796 phosphate-containing compound metabolic process
24 GO:0031325 positive regulation of cellular metabolic process
24 GO:0010604 positive regulation of macromolecule metabolic process
24 GO:0051173 positive regulation of nitrogen compound metabolic process
24 GO:2000112 regulation of cellular macromolecule biosynthetic process
24 GO:0010468 regulation of gene expression
24 GO:0019219 regulation of nucleobase-containing compound metabolic process
24 GO:0051246 regulation of protein metabolic process
24 GO:0007165 signal transduction
155 GO:0006464 cellular protein modification process
155 GO:0060255 regulation of macromolecule metabolic process
157 GO:0034645 cellular macromolecule biosynthetic process
157 GO:0044267 cellular protein metabolic process
157 GO:0090304 nucleic acid metabolic process
197 GO:0044267 cellular protein metabolic process
197 GO:0060255 regulation of macromolecule metabolic process
258 GO:0006464 cellular protein modification process
258 GO:0031325 positive regulation of cellular metabolic process
258 GO:0060255 regulation of macromolecule metabolic process
283 GO:0006464 cellular protein modification process
283 GO:0060255 regulation of macromolecule metabolic process
326 GO:0044267 cellular protein metabolic process
345 GO:0006139 nucleobase-containing compound metabolic process
345 GO:0060255 regulation of macromolecule metabolic process
381 GO:0006464 cellular protein modification process
381 GO:0010467 gene expression
381 GO:0016310 phosphorylation
381 GO:0010604 positive regulation of macromolecule metabolic process
381 GO:0050790 regulation of catalytic activity
381 GO:0032268 regulation of cellular protein metabolic process
381 GO:0007165 signal transduction
434 GO:0044267 cellular protein metabolic process
469 GO:0060255 regulation of macromolecule metabolic process
485 GO:0034645 cellular macromolecule biosynthetic process
485 GO:0090304 nucleic acid metabolic process
534 GO:0007166 cell surface receptor signaling pathway
534 GO:0006464 cellular protein modification process
534 GO:0033554 cellular response to stress
534 GO:0010467 gene expression
534 GO:0006796 phosphate-containing compound metabolic process
534 GO:0060255 regulation of macromolecule metabolic process
534 GO:0009966 regulation of signal transduction
534 GO:0009628 response to abiotic stimulus
545 GO:0044267 cellular protein metabolic process
545 GO:0006139 nucleobase-containing compound metabolic process
551 GO:0034645 cellular macromolecule biosynthetic process
551 GO:0090304 nucleic acid metabolic process
551 GO:0034654 nucleobase-containing compound biosynthetic process
551 GO:0010604 positive regulation of macromolecule metabolic process
551 GO:0051173 positive regulation of nitrogen compound metabolic process
553 GO:0019538 protein metabolic process
588 GO:0006355 regulation of transcription, DNA-templated
676 GO:0016070 RNA metabolic process
676 GO:0044267 cellular protein metabolic process
676 GO:0010467 gene expression
676 GO:0060255 regulation of macromolecule metabolic process
753 GO:0044267 cellular protein metabolic process
753 GO:0034654 nucleobase-containing compound biosynthetic process
753 GO:0031325 positive regulation of cellular metabolic process
753 GO:0010604 positive regulation of macromolecule metabolic process
753 GO:0051173 positive regulation of nitrogen compound metabolic process
753 GO:0031326 regulation of cellular biosynthetic process
753 GO:0019219 regulation of nucleobase-containing compound metabolic process
753 GO:0009966 regulation of signal transduction
774 GO:0006464 cellular protein modification process
774 GO:0060255 regulation of macromolecule metabolic process
775 GO:0044267 cellular protein metabolic process
775 GO:0010467 gene expression
775 GO:0006139 nucleobase-containing compound metabolic process
775 GO:0060255 regulation of macromolecule metabolic process
824 GO:0044267 cellular protein metabolic process
824 GO:0010467 gene expression
824 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
1 GO:0005829 cytosol
1 GO:0005634 nucleus
24 GO:0005829 cytosol
24 GO:0005654 nucleoplasm
155 GO:0005634 nucleus
157 GO:0005654 nucleoplasm
162 GO:0005634 nucleus
283 GO:0012505 endomembrane system
283 GO:0044428 nuclear part
291 GO:0043232 intracellular non-membrane-bounded organelle
291 GO:0005634 nucleus
326 GO:0005829 cytosol
326 GO:0005634 nucleus
345 GO:0070013 intracellular organelle lumen
345 GO:0005634 nucleus
381 GO:0005829 cytosol
381 GO:0005634 nucleus
434 GO:0005829 cytosol
434 GO:0070062 extracellular exosome
434 GO:0005634 nucleus
469 GO:0043232 intracellular non-membrane-bounded organelle
469 GO:0005634 nucleus
485 GO:0043232 intracellular non-membrane-bounded organelle
485 GO:0005634 nucleus
534 GO:0005829 cytosol
534 GO:0012505 endomembrane system
534 GO:0005654 nucleoplasm
545 GO:0005829 cytosol
545 GO:0005634 nucleus
545 GO:0031982 vesicle
551 GO:0005829 cytosol
551 GO:0005615 extracellular space
551 GO:0043232 intracellular non-membrane-bounded organelle
551 GO:0005654 nucleoplasm
551 GO:0031982 vesicle
588 GO:0031981 nuclear lumen
676 GO:0070013 intracellular organelle lumen
676 GO:0044428 nuclear part
729 GO:0005829 cytosol
729 GO:0005634 nucleus
753 GO:0005634 nucleus
774 GO:0005634 nucleus
775 GO:0005829 cytosol
775 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000165 MAPK cascade TAS
GO:0000209 protein polyubiquitination TAS
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
GO:0006521 regulation of cellular amino acid metabolic process TAS
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle TAS
GO:0016579 protein deubiquitination TAS
GO:0031145 anaphase-promoting complex-dependent catabolic process TAS
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process TAS
GO:0033209 tumor necrosis factor-mediated signaling pathway TAS
GO:0038061 NIK/NF-kappaB signaling TAS
GO:0038095 Fc-epsilon receptor signaling pathway TAS
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS
GO:0043312 neutrophil degranulation TAS
GO:0043488 regulation of mRNA stability TAS
GO:0043687 post-translational protein modification TAS
GO:0050852 T cell receptor signaling pathway TAS
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
GO:0055085 transmembrane transport TAS
GO:0060071 Wnt signaling pathway, planar cell polarity pathway TAS
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
GO:0090090 negative regulation of canonical Wnt signaling pathway TAS
GO:0090263 positive regulation of canonical Wnt signaling pathway TAS
GO:1902036 regulation of hematopoietic stem cell differentiation TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000502 proteasome complex IDA
GO:0005576 extracellular region TAS
GO:0005634 nucleus IBA
GO:0005654 nucleoplasm TAS
GO:0005829 cytosol TAS
GO:0005838 proteasome regulatory particle TAS
GO:0008540 proteasome regulatory particle, base subcomplex IBA
GO:0016020 membrane IDA
GO:0022624 proteasome accessory complex ISS
GO:0034515 proteasome storage granule IBA
GO:0034774 secretory granule lumen TAS
GO:0070062 extracellular exosome IDA
GO:1904813 ficolin-1-rich granule lumen TAS
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005576 extracellular region GO:0005634 nucleus 4.48e-91 1.28e-107
GO:0005576 extracellular region GO:0005654 nucleoplasm 6.62e-72 7.68e-98
GO:0005634 nucleus GO:0016020 membrane 0.00e+00 4.39e-236
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
GO:0005654 nucleoplasm GO:0016020 membrane 5.76e-255 1.32e-206
GO:0005654 nucleoplasm GO:0070062 extracellular exosome 3.37e-20 1.23e-35
Interactor Also a MoonDB EMF protein
UBQL2_HUMAN Yes: Q9UHD9 (MoonDB)
BAG3_HUMAN No
SGTA_HUMAN No
ZBT16_HUMAN Yes: Q05516 (MoonDB)
CHIP_HUMAN Yes: Q9UNE7 (MoonDB)
MOS_HUMAN No
PPP5_HUMAN No
AGO2_HUMAN No
MLF2_HUMAN Yes: Q15773 (MoonDB)
AASD1_HUMAN No
ADA2A_HUMAN No
AP3D1_HUMAN No
B4DE84_HUMAN No
BAG1_HUMAN No
BAG2_HUMAN No
BAG5_HUMAN No
CDK9_HUMAN No
CFLAR_HUMAN No
CLCN2_HUMAN No
CNR2_HUMAN No
CYFP1_HUMAN No
DDX11_HUMAN No
DNJB2_HUMAN No
DNJB6_HUMAN No
DNJC7_HUMAN No
DYN3_HUMAN No
E2AK4_HUMAN No
EIPR1_HUMAN No
ERBB2_HUMAN Yes: P04626 (MoonDB)
ERF1_HUMAN No
FKBP8_HUMAN No
GBB1_HUMAN No
GBB2_HUMAN No
GET4_HUMAN Yes: Q7L5D6 (MoonDB)
GLR_HUMAN No
GNA15_HUMAN No
GNAZ_HUMAN No
GNB5_HUMAN No
GTD2A_HUMAN No
HAX1_HUMAN No
HDAC6_HUMAN No
HSP72_HUMAN No
HSP76_HUMAN No
HSP7C_HUMAN Yes: P11142 (MoonDB)
HUS1B_HUMAN No
IFRD2_HUMAN No
KC1E_HUMAN No
KPSH2_HUMAN No
LRIF1_HUMAN No
MCM5_HUMAN No
MKS3_HUMAN No
MLF1_HUMAN Yes: P58340 (MoonDB)
MTR1A_HUMAN No
NAL12_HUMAN No
NOD1_HUMAN No
OFD1_HUMAN No
PRAME_HUMAN No
PRP6_HUMAN Yes: O94906 (MoonDB)
PRS4_HUMAN No
PRS6B_HUMAN No
PSMD3_HUMAN No
PSMD4_HUMAN No
PTN_HUMAN No
Q16221_HUMAN No
Q1JUL4_HUMAN No
Q59FP4_HUMAN No
Q5ULA9_HUMAN No
Q8IZN1_HUMAN No
Q96P23_HUMAN No
Q96S08_HUMAN No
RAF1_HUMAN Yes: P04049 (MoonDB)
REC8_HUMAN No
RGS11_HUMAN No
RGS6_HUMAN No
RGS9_HUMAN No
RIF1_HUMAN No
RMP_HUMAN No
SIM2_HUMAN No
SIR6_HUMAN No
SMRD2_HUMAN No
STEA1_HUMAN No
STIP1_HUMAN No
SYFA_HUMAN No
TBB1_HUMAN No
TBB4A_HUMAN No
TBC3B_HUMAN No
TET3_HUMAN No
TF3C5_HUMAN No
TLR7_HUMAN No
TNR1A_HUMAN No
TP4A1_HUMAN No
TSSK6_HUMAN No
U119A_HUMAN No
UBCP1_HUMAN No
UBP19_HUMAN No
VP9D1_HUMAN No
ZBT39_HUMAN No
PMID Article Title
1317798 Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms.
7601280 A protein related to a proteasomal subunit binds to the intracellular domain of the p55 TNF receptor upstream to its 'death domain'.
8774743 cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11.
9126987 Two-hybrid cloning of a gene encoding TNF receptor-associated protein 2, a protein that interacts with the intracellular domain of the type 1 TNF receptor: identity with subunit 2 of the 26S protease.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16641997 The DNA sequence, annotation and analysis of human chromosome 3.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
17323924 Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.
17924679 Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
18669648 A quantitative atlas of mitotic phosphorylation.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25944712 N-terminome analysis of the human mitochondrial proteome.
27342858 Structure of the human 26S proteasome at a resolution of 3.9 Aa.
27428775 An atomic structure of the human 26S proteasome.
No results found.
Domain Name Domain ID Source
Proteasome/cyclosome_rpt IPR002015 InterPro
ARM-like IPR011989 InterPro
ARM-type_fold IPR016024 InterPro
26S_Psome_Rpn1 IPR016643 InterPro
PC_rep PF01851 Pfam
26S_Psome_Rpn1 PIRSF015965 PIRSF
PTHR10943:SF1 PTHR10943:SF1 PANTHER
SSF48371 SSF48371 SUPFAM