Protein: P58340

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P58340 (Uniprot) MLF1_HUMAN MLF1 Myeloid leukemia factor 1 human No
Uniprot: Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 1, 534 GO:0006725 cellular aromatic compound metabolic process 395 5.44e-126 5.27e-27
GO:0007165 signal transduction 1, 534 GO:0006139 nucleobase-containing compound metabolic process 616 1.10e-111 5.07e-25
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
1 GO:0035556 intracellular signal transduction
1 GO:0032268 regulation of cellular protein metabolic process
1 GO:0043067 regulation of programmed cell death
1 GO:0009966 regulation of signal transduction
24 GO:0016070 RNA metabolic process
24 GO:0006464 cellular protein modification process
24 GO:0034654 nucleobase-containing compound biosynthetic process
24 GO:0006796 phosphate-containing compound metabolic process
24 GO:0031325 positive regulation of cellular metabolic process
24 GO:0010604 positive regulation of macromolecule metabolic process
24 GO:0051173 positive regulation of nitrogen compound metabolic process
24 GO:2000112 regulation of cellular macromolecule biosynthetic process
24 GO:0010468 regulation of gene expression
24 GO:0019219 regulation of nucleobase-containing compound metabolic process
24 GO:0051246 regulation of protein metabolic process
24 GO:0007165 signal transduction
155 GO:0006464 cellular protein modification process
155 GO:0060255 regulation of macromolecule metabolic process
157 GO:0034645 cellular macromolecule biosynthetic process
157 GO:0044267 cellular protein metabolic process
157 GO:0090304 nucleic acid metabolic process
192 GO:0034645 cellular macromolecule biosynthetic process
192 GO:0006464 cellular protein modification process
192 GO:0010467 gene expression
192 GO:0090304 nucleic acid metabolic process
192 GO:0009893 positive regulation of metabolic process
192 GO:0060255 regulation of macromolecule metabolic process
192 GO:0007165 signal transduction
211 GO:0034645 cellular macromolecule biosynthetic process
211 GO:0044271 cellular nitrogen compound biosynthetic process
211 GO:0090304 nucleic acid metabolic process
211 GO:0060255 regulation of macromolecule metabolic process
326 GO:0044267 cellular protein metabolic process
381 GO:0006464 cellular protein modification process
381 GO:0010467 gene expression
381 GO:0016310 phosphorylation
381 GO:0010604 positive regulation of macromolecule metabolic process
381 GO:0050790 regulation of catalytic activity
381 GO:0032268 regulation of cellular protein metabolic process
381 GO:0007165 signal transduction
395 GO:0006139 nucleobase-containing compound metabolic process
395 GO:0019538 protein metabolic process
434 GO:0044267 cellular protein metabolic process
485 GO:0034645 cellular macromolecule biosynthetic process
485 GO:0090304 nucleic acid metabolic process
534 GO:0007166 cell surface receptor signaling pathway
534 GO:0006464 cellular protein modification process
534 GO:0033554 cellular response to stress
534 GO:0010467 gene expression
534 GO:0006796 phosphate-containing compound metabolic process
534 GO:0060255 regulation of macromolecule metabolic process
534 GO:0009966 regulation of signal transduction
534 GO:0009628 response to abiotic stimulus
545 GO:0044267 cellular protein metabolic process
545 GO:0006139 nucleobase-containing compound metabolic process
551 GO:0034645 cellular macromolecule biosynthetic process
551 GO:0090304 nucleic acid metabolic process
551 GO:0034654 nucleobase-containing compound biosynthetic process
551 GO:0010604 positive regulation of macromolecule metabolic process
551 GO:0051173 positive regulation of nitrogen compound metabolic process
588 GO:0006355 regulation of transcription, DNA-templated
616 GO:0090304 nucleic acid metabolic process
676 GO:0016070 RNA metabolic process
676 GO:0044267 cellular protein metabolic process
676 GO:0010467 gene expression
676 GO:0060255 regulation of macromolecule metabolic process
769 GO:0007165 signal transduction
774 GO:0006464 cellular protein modification process
774 GO:0060255 regulation of macromolecule metabolic process
824 GO:0044267 cellular protein metabolic process
824 GO:0010467 gene expression
824 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
1 GO:0005829 cytosol
1 GO:0005634 nucleus
24 GO:0005829 cytosol
24 GO:0005654 nucleoplasm
155 GO:0005634 nucleus
157 GO:0005654 nucleoplasm
162 GO:0005634 nucleus
192 GO:0005829 cytosol
192 GO:0005654 nucleoplasm
211 GO:0005829 cytosol
211 GO:0031981 nuclear lumen
241 GO:0005829 cytosol
241 GO:0005634 nucleus
326 GO:0005829 cytosol
326 GO:0005634 nucleus
346 GO:0043232 intracellular non-membrane-bounded organelle
346 GO:0005634 nucleus
381 GO:0005829 cytosol
381 GO:0005634 nucleus
395 GO:0005634 nucleus
434 GO:0005829 cytosol
434 GO:0070062 extracellular exosome
434 GO:0005634 nucleus
485 GO:0043232 intracellular non-membrane-bounded organelle
485 GO:0005634 nucleus
534 GO:0005829 cytosol
534 GO:0012505 endomembrane system
534 GO:0005654 nucleoplasm
545 GO:0005829 cytosol
545 GO:0005634 nucleus
545 GO:0031982 vesicle
551 GO:0005829 cytosol
551 GO:0005615 extracellular space
551 GO:0043232 intracellular non-membrane-bounded organelle
551 GO:0005654 nucleoplasm
551 GO:0031982 vesicle
588 GO:0031981 nuclear lumen
616 GO:0005654 nucleoplasm
676 GO:0070013 intracellular organelle lumen
676 GO:0044428 nuclear part
774 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0002318 myeloid progenitor cell differentiation ISS
GO:0006351 transcription, DNA-templated ISS
GO:0007050 cell cycle arrest IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005737 cytoplasm ISS
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
8570204 The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15116101 cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15861129 Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3.
16641997 The DNA sequence, annotation and analysis of human chromosome 3.
22151054 Structural insights of the MLF1/14-3-3 interaction.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
No results found.
Domain Name Domain ID Source
Myeloid_leukemia_factor IPR019376 InterPro
Mlf1IP PF10248 Pfam
PTHR13105 PTHR13105 PANTHER