Protein: P04626

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P04626 (Uniprot) ERBB2_HUMAN ERBB2 Receptor tyrosine-protein kinase erbB-2 human No
Uniprot: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0044260 cellular macromolecule metabolic process 24, 821 GO:0022610 biological adhesion 869 6.74e-23 3.02e-10
GO:0034641 cellular nitrogen compound metabolic process 35, 327, 477 GO:0007165 signal transduction 355, 486, 803, 828, 831 4.22e-144 6.90e-18
GO:0034641 cellular nitrogen compound metabolic process 35, 327, 477 GO:0006928 movement of cell or subcellular component 496 7.55e-40 5.63e-168
GO:0034641 cellular nitrogen compound metabolic process 35, 327, 477 GO:0022610 biological adhesion 869 6.87e-63 4.34e-65
GO:0007166 cell surface receptor signaling pathway 108 GO:0034641 cellular nitrogen compound metabolic process 35, 327, 477 5.53e-55 9.57e-64
GO:0007166 cell surface receptor signaling pathway 108 GO:0006139 nucleobase-containing compound metabolic process 356 6.88e-41 1.21e-84
GO:0007166 cell surface receptor signaling pathway 108 GO:0009059 macromolecule biosynthetic process 779 2.49e-18 9.18e-29
GO:0007165 signal transduction 187, 282, 308, 355 GO:0006139 nucleobase-containing compound metabolic process 356 1.10e-111 5.07e-25
GO:0010646 regulation of cell communication 284 GO:0034641 cellular nitrogen compound metabolic process 35, 327, 477 1.59e-39 2.52e-03
GO:0010646 regulation of cell communication 284 GO:0006139 nucleobase-containing compound metabolic process 356 6.71e-28 7.52e-07
GO:0006139 nucleobase-containing compound metabolic process 356 GO:0006928 movement of cell or subcellular component 496 1.95e-31 6.36e-195
GO:0006139 nucleobase-containing compound metabolic process 356 GO:0022610 biological adhesion 869 2.30e-55 4.36e-110
GO:0043170 macromolecule metabolic process 410 GO:0022610 biological adhesion 869 2.68e-16 4.92e-03
GO:0009059 macromolecule biosynthetic process 779 GO:0022610 biological adhesion 869 2.22e-23 6.08e-57
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
24 GO:0016070 RNA metabolic process
24 GO:0006464 cellular protein modification process
24 GO:0034654 nucleobase-containing compound biosynthetic process
24 GO:0006796 phosphate-containing compound metabolic process
24 GO:0031325 positive regulation of cellular metabolic process
24 GO:0010604 positive regulation of macromolecule metabolic process
24 GO:0051173 positive regulation of nitrogen compound metabolic process
24 GO:2000112 regulation of cellular macromolecule biosynthetic process
24 GO:0010468 regulation of gene expression
24 GO:0019219 regulation of nucleobase-containing compound metabolic process
24 GO:0051246 regulation of protein metabolic process
24 GO:0007165 signal transduction
29 GO:0060255 regulation of macromolecule metabolic process
29 GO:0007165 signal transduction
35 GO:0044271 cellular nitrogen compound biosynthetic process
35 GO:0044267 cellular protein metabolic process
35 GO:0090304 nucleic acid metabolic process
35 GO:0010468 regulation of gene expression
35 GO:0009966 regulation of signal transduction
108 GO:0007167 enzyme linked receptor protein signaling pathway
108 GO:0006139 nucleobase-containing compound metabolic process
108 GO:0031325 positive regulation of cellular metabolic process
108 GO:1902533 positive regulation of intracellular signal transduction
108 GO:0010604 positive regulation of macromolecule metabolic process
108 GO:0006468 protein phosphorylation
111 GO:0006955 immune response
111 GO:0035556 intracellular signal transduction
111 GO:0009967 positive regulation of signal transduction
111 GO:0006468 protein phosphorylation
111 GO:0060255 regulation of macromolecule metabolic process
111 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
138 GO:0006464 cellular protein modification process
138 GO:0007165 signal transduction
155 GO:0006464 cellular protein modification process
155 GO:0060255 regulation of macromolecule metabolic process
171 GO:0006464 cellular protein modification process
171 GO:0035556 intracellular signal transduction
171 GO:0009966 regulation of signal transduction
181 GO:0044267 cellular protein metabolic process
181 GO:0010467 gene expression
181 GO:0009059 macromolecule biosynthetic process
181 GO:0090304 nucleic acid metabolic process
181 GO:0060255 regulation of macromolecule metabolic process
181 GO:0007165 signal transduction
186 GO:0048468 cell development
186 GO:0007166 cell surface receptor signaling pathway
186 GO:0044267 cellular protein metabolic process
186 GO:0035556 intracellular signal transduction
186 GO:0030182 neuron differentiation
186 GO:0006796 phosphate-containing compound metabolic process
186 GO:0120036 plasma membrane bounded cell projection organization
186 GO:0060255 regulation of macromolecule metabolic process
186 GO:0009966 regulation of signal transduction
187 GO:0007166 cell surface receptor signaling pathway
187 GO:0006464 cellular protein modification process
187 GO:0070887 cellular response to chemical stimulus
187 GO:0035556 intracellular signal transduction
187 GO:0006928 movement of cell or subcellular component
187 GO:0006796 phosphate-containing compound metabolic process
187 GO:0010647 positive regulation of cell communication
187 GO:0048584 positive regulation of response to stimulus
187 GO:0023056 positive regulation of signaling
187 GO:0060255 regulation of macromolecule metabolic process
187 GO:0009966 regulation of signal transduction
205 GO:0071310 cellular response to organic substance
205 GO:0007167 enzyme linked receptor protein signaling pathway
205 GO:0090304 nucleic acid metabolic process
205 GO:0034654 nucleobase-containing compound biosynthetic process
205 GO:0043085 positive regulation of catalytic activity
205 GO:0031325 positive regulation of cellular metabolic process
205 GO:0010604 positive regulation of macromolecule metabolic process
205 GO:0051173 positive regulation of nitrogen compound metabolic process
205 GO:0009967 positive regulation of signal transduction
205 GO:0006468 protein phosphorylation
205 GO:2000112 regulation of cellular macromolecule biosynthetic process
205 GO:0032268 regulation of cellular protein metabolic process
205 GO:0010468 regulation of gene expression
205 GO:1902531 regulation of intracellular signal transduction
205 GO:0019219 regulation of nucleobase-containing compound metabolic process
205 GO:0042325 regulation of phosphorylation
205 GO:0051049 regulation of transport
215 GO:0044267 cellular protein metabolic process
215 GO:0007167 enzyme linked receptor protein signaling pathway
215 GO:0010467 gene expression
215 GO:0016310 phosphorylation
215 GO:1902531 regulation of intracellular signal transduction
215 GO:0060255 regulation of macromolecule metabolic process
247 GO:0006464 cellular protein modification process
247 GO:0060255 regulation of macromolecule metabolic process
247 GO:0007165 signal transduction
258 GO:0006464 cellular protein modification process
258 GO:0031325 positive regulation of cellular metabolic process
258 GO:0060255 regulation of macromolecule metabolic process
282 GO:0035556 intracellular signal transduction
282 GO:0043085 positive regulation of catalytic activity
282 GO:0031325 positive regulation of cellular metabolic process
282 GO:0051173 positive regulation of nitrogen compound metabolic process
282 GO:0060255 regulation of macromolecule metabolic process
282 GO:0019220 regulation of phosphate metabolic process
284 GO:0009966 regulation of signal transduction
308 GO:0007166 cell surface receptor signaling pathway
308 GO:0071310 cellular response to organic substance
308 GO:0035556 intracellular signal transduction
308 GO:0043085 positive regulation of catalytic activity
308 GO:0031328 positive regulation of cellular biosynthetic process
308 GO:0010604 positive regulation of macromolecule metabolic process
308 GO:0045935 positive regulation of nucleobase-containing compound metabolic process
308 GO:0009967 positive regulation of signal transduction
308 GO:0006468 protein phosphorylation
308 GO:0031399 regulation of protein modification process
308 GO:0006355 regulation of transcription, DNA-templated
316 GO:0044267 cellular protein metabolic process
316 GO:0060255 regulation of macromolecule metabolic process
327 GO:0044271 cellular nitrogen compound biosynthetic process
327 GO:0044267 cellular protein metabolic process
327 GO:0006139 nucleobase-containing compound metabolic process
327 GO:0031325 positive regulation of cellular metabolic process
327 GO:0031326 regulation of cellular biosynthetic process
327 GO:0010468 regulation of gene expression
327 GO:0007165 signal transduction
355 GO:0007166 cell surface receptor signaling pathway
355 GO:0006464 cellular protein modification process
355 GO:0035556 intracellular signal transduction
355 GO:0016310 phosphorylation
355 GO:0010647 positive regulation of cell communication
355 GO:0048584 positive regulation of response to stimulus
355 GO:0023056 positive regulation of signaling
355 GO:0060255 regulation of macromolecule metabolic process
355 GO:0009966 regulation of signal transduction
356 GO:0034654 nucleobase-containing compound biosynthetic process
356 GO:0006468 protein phosphorylation
356 GO:0051252 regulation of RNA metabolic process
356 GO:2000112 regulation of cellular macromolecule biosynthetic process
356 GO:0010468 regulation of gene expression
356 GO:0007165 signal transduction
410 GO:0010467 gene expression
410 GO:0007165 signal transduction
477 GO:0044271 cellular nitrogen compound biosynthetic process
477 GO:0090304 nucleic acid metabolic process
477 GO:1901362 organic cyclic compound biosynthetic process
477 GO:2000112 regulation of cellular macromolecule biosynthetic process
477 GO:0007165 signal transduction
486 GO:0007166 cell surface receptor signaling pathway
486 GO:0006464 cellular protein modification process
486 GO:0060255 regulation of macromolecule metabolic process
496 GO:0048870 cell motility
496 GO:0071310 cellular response to organic substance
496 GO:0090304 nucleic acid metabolic process
496 GO:0034654 nucleobase-containing compound biosynthetic process
496 GO:0043085 positive regulation of catalytic activity
496 GO:0031325 positive regulation of cellular metabolic process
496 GO:1902533 positive regulation of intracellular signal transduction
496 GO:0010604 positive regulation of macromolecule metabolic process
496 GO:0051173 positive regulation of nitrogen compound metabolic process
496 GO:0051128 regulation of cellular component organization
496 GO:2000112 regulation of cellular macromolecule biosynthetic process
496 GO:0010468 regulation of gene expression
496 GO:0043549 regulation of kinase activity
496 GO:0019219 regulation of nucleobase-containing compound metabolic process
496 GO:0001932 regulation of protein phosphorylation
496 GO:0009719 response to endogenous stimulus
496 GO:1901700 response to oxygen-containing compound
496 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
555 GO:0006464 cellular protein modification process
555 GO:0060255 regulation of macromolecule metabolic process
555 GO:0007165 signal transduction
655 GO:0006464 cellular protein modification process
655 GO:0071310 cellular response to organic substance
655 GO:0035556 intracellular signal transduction
655 GO:0031325 positive regulation of cellular metabolic process
655 GO:0010604 positive regulation of macromolecule metabolic process
655 GO:0051173 positive regulation of nitrogen compound metabolic process
655 GO:0032268 regulation of cellular protein metabolic process
655 GO:0009966 regulation of signal transduction
655 GO:0006355 regulation of transcription, DNA-templated
655 GO:0009719 response to endogenous stimulus
679 GO:0031325 positive regulation of cellular metabolic process
679 GO:0010604 positive regulation of macromolecule metabolic process
679 GO:0051173 positive regulation of nitrogen compound metabolic process
679 GO:0006357 regulation of transcription from RNA polymerase II promoter
679 GO:0007165 signal transduction
685 GO:0060255 regulation of macromolecule metabolic process
685 GO:0007165 signal transduction
704 GO:0007165 signal transduction
779 GO:0034645 cellular macromolecule biosynthetic process
779 GO:0090304 nucleic acid metabolic process
779 GO:0034654 nucleobase-containing compound biosynthetic process
779 GO:0060255 regulation of macromolecule metabolic process
803 GO:0007166 cell surface receptor signaling pathway
803 GO:0044267 cellular protein metabolic process
803 GO:0071310 cellular response to organic substance
803 GO:0035556 intracellular signal transduction
803 GO:0009966 regulation of signal transduction
821 GO:0006259 DNA metabolic process
821 GO:0007166 cell surface receptor signaling pathway
821 GO:0034613 cellular protein localization
821 GO:0071495 cellular response to endogenous stimulus
821 GO:0071310 cellular response to organic substance
821 GO:0031324 negative regulation of cellular metabolic process
821 GO:0010605 negative regulation of macromolecule metabolic process
821 GO:0051172 negative regulation of nitrogen compound metabolic process
821 GO:0031328 positive regulation of cellular biosynthetic process
821 GO:0010557 positive regulation of macromolecule biosynthetic process
821 GO:0045935 positive regulation of nucleobase-containing compound metabolic process
821 GO:0048584 positive regulation of response to stimulus
821 GO:0006468 protein phosphorylation
821 GO:0031399 regulation of protein modification process
821 GO:0006355 regulation of transcription, DNA-templated
821 GO:1901700 response to oxygen-containing compound
828 GO:0007166 cell surface receptor signaling pathway
831 GO:0007166 cell surface receptor signaling pathway
831 GO:0044271 cellular nitrogen compound biosynthetic process
831 GO:0006139 nucleobase-containing compound metabolic process
831 GO:0006796 phosphate-containing compound metabolic process
831 GO:0010646 regulation of cell communication
831 GO:0060255 regulation of macromolecule metabolic process
831 GO:0023051 regulation of signaling
869 GO:0007155 cell adhesion
869 GO:0048468 cell development
869 GO:0016477 cell migration
869 GO:0000902 cell morphogenesis
869 GO:0044255 cellular lipid metabolic process
869 GO:0071363 cellular response to growth factor stimulus
869 GO:0072359 circulatory system development
869 GO:0009059 macromolecule biosynthetic process
869 GO:0022008 neurogenesis
869 GO:0019637 organophosphate metabolic process
869 GO:0018108 peptidyl-tyrosine phosphorylation
869 GO:0120036 plasma membrane bounded cell projection organization
869 GO:1902533 positive regulation of intracellular signal transduction
869 GO:0045860 positive regulation of protein kinase activity
869 GO:0043408 regulation of MAPK cascade
869 GO:2000145 regulation of cell motility
869 GO:0042127 regulation of cell proliferation
869 GO:0010468 regulation of gene expression
869 GO:2000026 regulation of multicellular organismal development
869 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
24 GO:0005829 cytosol
24 GO:0005654 nucleoplasm
29 GO:0005634 nucleus
35 GO:0005829 cytosol
35 GO:0005634 nucleus
35 GO:0005886 plasma membrane
108 GO:0005829 cytosol
108 GO:0005634 nucleus
108 GO:0005886 plasma membrane
111 GO:0005829 cytosol
111 GO:0005886 plasma membrane
138 GO:0005634 nucleus
155 GO:0005634 nucleus
162 GO:0005634 nucleus
171 GO:0005829 cytosol
171 GO:0005886 plasma membrane
181 GO:0005829 cytosol
181 GO:0005654 nucleoplasm
186 GO:0005829 cytosol
186 GO:0005886 plasma membrane
186 GO:0031982 vesicle
187 GO:0005829 cytosol
187 GO:0005886 plasma membrane
205 GO:0005829 cytosol
205 GO:0005634 nucleus
205 GO:0005886 plasma membrane
215 GO:0012505 endomembrane system
215 GO:0005886 plasma membrane
215 GO:0031982 vesicle
247 GO:0005634 nucleus
282 GO:0005829 cytosol
282 GO:0005886 plasma membrane
284 GO:0005829 cytosol
284 GO:0005886 plasma membrane
308 GO:0005829 cytosol
308 GO:0070013 intracellular organelle lumen
308 GO:0044428 nuclear part
308 GO:0005886 plasma membrane
316 GO:0005634 nucleus
327 GO:0005829 cytosol
327 GO:0043232 intracellular non-membrane-bounded organelle
327 GO:0005634 nucleus
327 GO:0005886 plasma membrane
355 GO:0044459 plasma membrane part
356 GO:0005634 nucleus
410 GO:0005634 nucleus
477 GO:0005829 cytosol
477 GO:0070013 intracellular organelle lumen
477 GO:0044428 nuclear part
486 GO:0005829 cytosol
486 GO:0005634 nucleus
486 GO:0031982 vesicle
496 GO:0005829 cytosol
496 GO:0005634 nucleus
496 GO:0005886 plasma membrane
555 GO:0005634 nucleus
655 GO:0005829 cytosol
655 GO:0005654 nucleoplasm
679 GO:0031981 nuclear lumen
685 GO:0005829 cytosol
779 GO:0043232 intracellular non-membrane-bounded organelle
779 GO:0070013 intracellular organelle lumen
779 GO:0044428 nuclear part
803 GO:0016021 integral component of membrane
803 GO:0005886 plasma membrane
821 GO:0005829 cytosol
821 GO:0005654 nucleoplasm
821 GO:0005886 plasma membrane
828 GO:0016021 integral component of membrane
828 GO:0005634 nucleus
831 GO:0042995 cell projection
831 GO:0005829 cytosol
831 GO:0005634 nucleus
831 GO:0005886 plasma membrane
869 GO:0012505 endomembrane system
869 GO:0005615 extracellular space
869 GO:0044459 plasma membrane part
869 GO:0031982 vesicle
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000165 MAPK cascade TAS
GO:0001934 positive regulation of protein phosphorylation ISS
GO:0006351 transcription, DNA-templated IEA
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS
GO:0006468 protein phosphorylation TAS
GO:0007165 signal transduction IDA
GO:0007166 cell surface receptor signaling pathway IDA
GO:0007167 enzyme linked receptor protein signaling pathway TAS
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS
GO:0007422 peripheral nervous system development IEA
GO:0007507 heart development IEA
GO:0007528 neuromuscular junction development IEA
GO:0008045 motor neuron axon guidance IEA
GO:0008283 cell proliferation TAS
GO:0014065 phosphatidylinositol 3-kinase signaling IDA
GO:0018108 peptidyl-tyrosine phosphorylation IEA
GO:0030307 positive regulation of cell growth IMP
GO:0032886 regulation of microtubule-based process IDA
GO:0033088 negative regulation of immature T cell proliferation in thymus IEA
GO:0038128 ERBB2 signaling pathway TAS
GO:0042060 wound healing IDA
GO:0042552 myelination IEA
GO:0043406 positive regulation of MAP kinase activity IDA
GO:0043547 positive regulation of GTPase activity ISS
GO:0045727 positive regulation of translation IMP
GO:0045765 regulation of angiogenesis NAS
GO:0045785 positive regulation of cell adhesion IDA
GO:0045943 positive regulation of transcription from RNA polymerase I promoter IMP
GO:0045945 positive regulation of transcription from RNA polymerase III promoter IDA
GO:0046777 protein autophosphorylation IDA
GO:0046854 phosphatidylinositol phosphorylation IEA
GO:0048709 oligodendrocyte differentiation IEA
GO:0050679 positive regulation of epithelial cell proliferation IDA
GO:0051897 positive regulation of protein kinase B signaling TAS
GO:0070372 regulation of ERK1 and ERK2 cascade IMP
GO:0071363 cellular response to growth factor stimulus IDA
GO:0071364 cellular response to epidermal growth factor stimulus IMP
GO:0090314 positive regulation of protein targeting to membrane IDA
GO:1901185 negative regulation of ERBB signaling pathway TAS
GO:2000145 regulation of cell motility TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005829 cytosol IDA
GO:0005886 plasma membrane TAS
GO:0010008 endosome membrane IDA
GO:0016021 integral component of membrane NAS
GO:0016323 basolateral plasma membrane IDA
GO:0016324 apical plasma membrane IEA
GO:0043209 myelin sheath IEA
GO:0043235 receptor complex TAS
GO:0048471 perinuclear region of cytoplasm IEA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
GO:0005634 nucleus GO:0010008 endosome membrane 1.38e-08 8.40e-30
GO:0005634 nucleus GO:0016021 integral component of membrane 0.00e+00 0.00e+00
GO:0005634 nucleus GO:0016324 apical plasma membrane 8.24e-09 4.92e-02
GO:0005829 cytosol GO:0016021 integral component of membrane 0.00e+00 0.00e+00
Interactor Also a MoonDB EMF protein
PICK1_HUMAN Yes: Q9NRD5 (MoonDB)
DAB1_HUMAN No
TGFB1_HUMAN No
GRB7_HUMAN No
BLK_HUMAN No
NCK2_HUMAN Yes: O43639 (MoonDB)
HS90B_HUMAN Yes: P08238 (MoonDB)
P55G_HUMAN Yes: Q92569 (MoonDB)
3BP2_HUMAN No
ANS1A_HUMAN No
TNS2_HUMAN Yes: Q63HR2 (MoonDB)
B4DYC6_HUMAN No
GRB2_HUMAN Yes: P62993 (MoonDB)
NUDC_HUMAN No
PPP5_HUMAN No
EGFR_HUMAN Yes: P00533 (MoonDB)
MLF2_HUMAN Yes: Q15773 (MoonDB)
PSMD2_HUMAN Yes: Q13200 (MoonDB)
FKBP5_HUMAN No
NUDC3_HUMAN No
HSP7C_HUMAN Yes: P11142 (MoonDB)
AASD1_HUMAN No
CRKL_HUMAN No
RIN1_HUMAN No
CDC37_HUMAN Yes: Q16543 (MoonDB)
SHC3_HUMAN No
JIP2_HUMAN Yes: Q13387 (MoonDB)
FYN_HUMAN Yes: P06241 (MoonDB)
IRS4_HUMAN No
ABL1_HUMAN Yes: P00519 (MoonDB)
ABL2_HUMAN Yes: P42684 (MoonDB)
AGRB1_HUMAN No
ANS1B_HUMAN No
ANXA6_HUMAN No
APBB1_HUMAN No
APBB3_HUMAN No
ARY2_HUMAN No
BAAT_HUMAN No
BAIP3_HUMAN No
BCAR3_HUMAN No
BLNK_HUMAN No
BMX_HUMAN No
BTC_HUMAN No
CC180_HUMAN No
CDK8_HUMAN No
CHIN_HUMAN No
CISH_HUMAN No
CLCN6_HUMAN No
CLNK_HUMAN No
CP17A_HUMAN No
CRK_HUMAN Yes: P46108 (MoonDB)
CSK_HUMAN No
CTNB1_HUMAN No
CYBP_HUMAN No
CYLC2_HUMAN No
DHB3_HUMAN No
DLG4_HUMAN Yes: P78352 (MoonDB)
DOK1_HUMAN No
DOK4_HUMAN No
DOK6_HUMAN No
DPOD2_HUMAN No
ERBB3_HUMAN Yes: P21860 (MoonDB)
ERBB4_HUMAN No
ERBIN_HUMAN No
ERRFI_HUMAN No
EZRI_HUMAN No
F16P1_HUMAN No
FAK1_HUMAN No
FAK2_HUMAN No
FER_HUMAN No
FGR_HUMAN No
FRAT2_HUMAN No
G3P_HUMAN Yes: P04406 (MoonDB)
GLCE_HUMAN No
GMPR2_HUMAN No
GRAP2_HUMAN No
HDAC6_HUMAN No
HOP2_HUMAN No
HS90A_HUMAN Yes: P07900 (MoonDB)
HSP76_HUMAN No
I13R2_HUMAN No
IRS1_HUMAN No
ITK_HUMAN No
JAK1_HUMAN No
JIP1_HUMAN No
KLK5_HUMAN No
KPYM_HUMAN Yes: P14618 (MoonDB)
KSYK_HUMAN Yes: P43405 (MoonDB)
LYPD3_HUMAN No
MATK_HUMAN No
MLF1_HUMAN Yes: P58340 (MoonDB)
MP2K1_HUMAN No
MTCH1_HUMAN No
MUCL1_HUMAN No
OSMR_HUMAN No
P85A_HUMAN Yes: P27986 (MoonDB)
P85B_HUMAN No
PHF23_HUMAN No
PLAK_HUMAN No
PLCG1_HUMAN Yes: P19174 (MoonDB)
PLCG2_HUMAN Yes: P16885 (MoonDB)
PPAP_HUMAN No
PRD14_HUMAN No
PTK6_HUMAN No
PTN11_HUMAN Yes: Q06124 (MoonDB)
PTN12_HUMAN No
PTN18_HUMAN No
PTN22_HUMAN No
PTN3_HUMAN No
PTPRB_HUMAN No
PTPRC_HUMAN No
PTPRG_HUMAN No
PTPRJ_HUMAN No
PTPRK_HUMAN No
PTPRO_HUMAN No
PTPRZ_HUMAN No
Q8IW90_HUMAN No
RASA1_HUMAN No
RHBT2_HUMAN No
RIN2_HUMAN No
SAP_HUMAN No
SFRP4_HUMAN No
SH21B_HUMAN No
SH22A_HUMAN Yes: Q9NP31 (MoonDB)
SH23A_HUMAN No
SH2B2_HUMAN No
SH2B3_HUMAN No
SH2D5_HUMAN No
SHC1_HUMAN No
SHC2_HUMAN No
SLAP1_HUMAN No
SLAP2_HUMAN No
SMAD1_HUMAN Yes: Q15797 (MoonDB)
SOCS1_HUMAN No
SPT6H_HUMAN No
SRPK1_HUMAN Yes: Q96SB4 (MoonDB)
STAT1_HUMAN No
STAT3_HUMAN Yes: P40763 (MoonDB)
STIP1_HUMAN No
STK24_HUMAN No
SYIC_HUMAN No
TCAL2_HUMAN No
TEC_HUMAN No
TENS3_HUMAN No
TGFA_HUMAN No
THRSP_HUMAN No
TLN1_HUMAN No
TRMO_HUMAN No
TTC9B_HUMAN No
TXK_HUMAN No
UN45B_HUMAN No
UTP18_HUMAN No
VAS1_HUMAN No
VAV2_HUMAN Yes: P52735 (MoonDB)
VAV3_HUMAN No
VAV_HUMAN No
VIGLN_HUMAN No
ZN189_HUMAN No
PMID Article Title
2992089 Amplification of a novel v-erbB-related gene in a human mammary carcinoma.
2995967 A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma.
2999974 Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.
3003577 Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor.
3039351 Human HER2 (neu) promoter: evidence for multiple mechanisms for transcriptional initiation.
8095488 Characterization of a new allele of the human ERBB2 gene by allele-specific competition hybridization.
8104414 Molecular cloning and sequencing of an intron of Her-2/neu (ERBB2) gene.
10358079 ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases.
10593938 Poor binding of a HER-2/neu epitope (GP2) to HLA-A2.1 is due to a lack of interactions with the center of the peptide.
10805725 Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors.
12444095 Novel mode of ligand recognition by the Erbin PDZ domain.
12610629 Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab.
12939402 Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein.
12975581 Solution structure of the human Grb7-SH2 domain/erbB2 peptide complex and structural basis for Grb7 binding to ErbB2.
15093539 Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex.
15156151 Memo mediates ErbB2-driven cell motility.
15210733 Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2.
15380516 Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2.
15457249 Lung cancer: intragenic ERBB2 kinase mutations in tumours.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16314522 Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor.
16794579 Biosynthesis of tumorigenic HER2 C-terminal fragments by alternative initiation of translation.
16978839 Neuregulin-1 only induces trans-phosphorylation between ErbB receptor heterodimer partners.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
17344846 Patterns of somatic mutation in human cancer genomes.
17554007 Plexin-B2, but not Plexin-B1, critically modulates neuronal migration and patterning of the developing nervous system in vivo.
18669648 A quantitative atlas of mitotic phosphorylation.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
18719096 Brk is coamplified with ErbB2 to promote proliferation in breast cancer.
19299620 Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site.
19372587 ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells.
20010870 Copine-III interacts with ErbB2 and promotes tumor cell migration.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20696930 Structural basis for high-affinity HER2 receptor binding by an engineered protein.
20937854 ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells.
21097718 Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing.
21190959 Dissociation of epidermal growth factor receptor and ErbB2 heterodimers in the presence of somatostatin receptor 5 modulate signaling pathways.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21454582 Structural analysis of the mechanism of inhibition and allosteric activation of the kinase domain of HER2 protein.
21555369 Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24722188 Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
26517842 Client proteins and small molecule inhibitors display distinct binding preferences for constitutive and stress-induced HSP90 isoforms and their conformationally restricted mutants.
27134172 Crystal structure and substrate specificity of PTPN12.
OMIM ID Disease Name
137800 Glioma
167000 Ovarian cancer
211980 Lung cancer
613659 Gastric cancer
Domain Name Domain ID Source
A24571 A24571 PIR
Rcpt_L-dom IPR000494 InterPro
Prot_kinase_dom IPR000719 InterPro
Ser-Thr/Tyr_kinase_cat_dom IPR001245 InterPro
Furin-like_Cys-rich_dom IPR006211 InterPro
Furin_repeat IPR006212 InterPro
Tyr_kinase_AS IPR008266 InterPro
Growth_fac_rcpt_cys_sf IPR009030 InterPro
Kinase-like_dom_sf IPR011009 InterPro
Tyr_kinase_EGF/ERB/XmrK_rcpt IPR016245 InterPro
Protein_kinase_ATP_BS IPR017441 InterPro
Tyr_kinase_cat_dom IPR020635 InterPro
Cyt_c1_TM_anchor_C IPR021157 InterPro
LRR_dom_sf IPR032675 InterPro
GF_recep_IV IPR032778 InterPro
Rcpt_L-dom_sf IPR036941 InterPro
Furin-like PF00757 Pfam
Recep_L_domain PF01030 Pfam
Pkinase_Tyr PF07714 Pfam
GF_recep_IV PF14843 Pfam
TyrPK_EGF-R PIRSF000619 PIRSF
TYRKINASE PR00109 PRINTS
PROTEIN_KINASE_ATP PS00107 PROSITE
PROTEIN_KINASE_TYR PS00109 PROSITE
PROTEIN_KINASE_DOM PS50011 PROSITE
TyrKc SM00219 SMART
FU SM00261 SMART
SSF52058 SSF52058 SUPFAM
SSF56112 SSF56112 SUPFAM
SSF57184 SSF57184 SUPFAM