Protein: P16885

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P16885 (Uniprot) PLCG2_HUMAN PLCG2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 human No
Uniprot: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007166 cell surface receptor signaling pathway 108 GO:0006725 cellular aromatic compound metabolic process 494 3.09e-47 2.24e-87
GO:0007165 signal transduction 486 GO:0006725 cellular aromatic compound metabolic process 494 5.44e-126 5.27e-27
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
108 GO:0007167 enzyme linked receptor protein signaling pathway
108 GO:0006139 nucleobase-containing compound metabolic process
108 GO:0031325 positive regulation of cellular metabolic process
108 GO:1902533 positive regulation of intracellular signal transduction
108 GO:0010604 positive regulation of macromolecule metabolic process
108 GO:0006468 protein phosphorylation
111 GO:0006955 immune response
111 GO:0035556 intracellular signal transduction
111 GO:0009967 positive regulation of signal transduction
111 GO:0006468 protein phosphorylation
111 GO:0060255 regulation of macromolecule metabolic process
111 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
486 GO:0007166 cell surface receptor signaling pathway
486 GO:0006464 cellular protein modification process
486 GO:0060255 regulation of macromolecule metabolic process
494 GO:0006139 nucleobase-containing compound metabolic process
583 GO:0060255 regulation of macromolecule metabolic process
688 GO:0006355 regulation of transcription, DNA-templated
688 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
108 GO:0005829 cytosol
108 GO:0005634 nucleus
108 GO:0005886 plasma membrane
111 GO:0005829 cytosol
111 GO:0005886 plasma membrane
486 GO:0005829 cytosol
486 GO:0005634 nucleus
486 GO:0031982 vesicle
494 GO:0005634 nucleus
583 GO:0043232 intracellular non-membrane-bounded organelle
583 GO:0005634 nucleus
688 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0002092 positive regulation of receptor internalization IEA
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0002316 follicular B cell differentiation IEA
GO:0006661 phosphatidylinositol biosynthetic process IDA
GO:0009395 phospholipid catabolic process IEA
GO:0010468 regulation of gene expression IEA
GO:0016055 Wnt signaling pathway TAS
GO:0019722 calcium-mediated signaling NAS
GO:0030168 platelet activation TAS
GO:0030183 B cell differentiation ISS
GO:0032237 activation of store-operated calcium channel activity IEA
GO:0032481 positive regulation of type I interferon production IEA
GO:0032496 response to lipopolysaccharide IEA
GO:0032959 inositol trisphosphate biosynthetic process IEA
GO:0038095 Fc-epsilon receptor signaling pathway TAS
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
GO:0043069 negative regulation of programmed cell death IEA
GO:0043647 inositol phosphate metabolic process TAS
GO:0050852 T cell receptor signaling pathway ISS
GO:0050853 B cell receptor signaling pathway ISS
GO:0051209 release of sequestered calcium ion into cytosol IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005829 cytosol TAS
GO:0005886 plasma membrane TAS
GO:0070062 extracellular exosome IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
2849563 Complete cDNA encoding a putative phospholipase C from transformed human lymphocytes.
11606584 Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling.
12181444 Activation of phospholipase Cgamma2 by tyrosine phosphorylation.
15144186 Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15616553 The sequence and analysis of duplication-rich human chromosome 16.
16533400 NovelFam3000 -- uncharacterized human protein domains conserved across model organisms.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
21269460 Initial characterization of the human central proteome.
22236196 Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions.
23000145 A hypermorphic missense mutation in PLCG2, encoding phospholipase Cgamma2, causes a dominantly inherited autoinflammatory disease with immunodeficiency.
24869598 Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib.
OMIM ID Disease Name
614468 Familial cold autoinflammatory syndrome 3
614878 Autoinflammation, antibody deficiency, and immune dysregulation PLCG2-associated
Domain Name Domain ID Source
C2_dom IPR000008 InterPro
PLipase_C_PInositol-sp_X_dom IPR000909 InterPro
SH2 IPR000980 InterPro
PI-PLC_fam IPR001192 InterPro
SH3_domain IPR001452 InterPro
PLipase_C_Pinositol-sp_Y IPR001711 InterPro
PH_domain IPR001849 InterPro
EF-hand-dom_pair IPR011992 InterPro
PH-like_dom_sf IPR011993 InterPro
PLC-gamma IPR016279 InterPro
PLC-like_Pdiesterase_TIM-brl IPR017946 InterPro
PLC-gamma2 IPR028381 InterPro
PLC-gamma_C-SH2 IPR035023 InterPro
PLC-gamma_N-SH2 IPR035024 InterPro
PLCgamma2_SH3 IPR035723 InterPro
C2_domain_sf IPR035892 InterPro
SH3-like_dom_sf IPR036028 InterPro
SH2_dom_sf IPR036860 InterPro
SH2 PF00017 Pfam
SH3_1 PF00018 Pfam
C2 PF00168 Pfam
PI-PLC-Y PF00387 Pfam
PI-PLC-X PF00388 Pfam
PLC-gamma PIRSF000952 PIRSF
PHPHLIPASEC PR00390 PRINTS
SH2DOMAIN PR00401 PRINTS
SH3DOMAIN PR00452 PRINTS
SH2 PS50001 PROSITE
SH3 PS50002 PROSITE
PH_DOMAIN PS50003 PROSITE
C2 PS50004 PROSITE
PIPLC_X_DOMAIN PS50007 PROSITE
PIPLC_Y_DOMAIN PS50008 PROSITE
PTHR10336 PTHR10336 PANTHER
PTHR10336:SF25 PTHR10336:SF25 PANTHER
S02004 S02004 PIR
PLCXc SM00148 SMART
PLCYc SM00149 SMART
PH SM00233 SMART
C2 SM00239 SMART
SH2 SM00252 SMART
SH3 SM00326 SMART
SSF47473 SSF47473 SUPFAM
SSF49562 SSF49562 SUPFAM
SSF50044 SSF50044 SUPFAM
SSF50729 SSF50729 SUPFAM
SSF51695 SSF51695 SUPFAM
SSF55550 SSF55550 SUPFAM
SH2_C-SH2_PLC_gamma_like cd09932 CDD
SH2_N-SH2_PLC_gamma_like cd10341 CDD
SH3_PLCgamma2 cd11969 CDD