Protein: P16885 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P16885 (Uniprot)	PLCG2_HUMAN	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	human	No

Protein Function

Uniprot: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	486	GO:0006725	cellular aromatic compound metabolic process	494	5.44e-126	5.27e-27
GO:0007166	cell surface receptor signaling pathway	108	GO:0006725	cellular aromatic compound metabolic process	494	3.09e-47	2.24e-87

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
108	GO:0007167	enzyme linked receptor protein signaling pathway
108	GO:0006139	nucleobase-containing compound metabolic process
108	GO:0031325	positive regulation of cellular metabolic process
108	GO:1902533	positive regulation of intracellular signal transduction
108	GO:0010604	positive regulation of macromolecule metabolic process
108	GO:0006468	protein phosphorylation
111	GO:0006955	immune response
111	GO:0035556	intracellular signal transduction
111	GO:0009967	positive regulation of signal transduction
111	GO:0006468	protein phosphorylation

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
108	GO:0005829	cytosol
108	GO:0005634	nucleus
108	GO:0005886	plasma membrane
111	GO:0005829	cytosol
111	GO:0005886	plasma membrane
486	GO:0005829	cytosol
486	GO:0005634	nucleus
486	GO:0031982	vesicle
494	GO:0005634	nucleus
583	GO:0043232	intracellular non-membrane-bounded organelle

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0002092	positive regulation of receptor internalization	IEA
GO:0002223	stimulatory C-type lectin receptor signaling pathway	TAS
GO:0002316	follicular B cell differentiation	IEA
GO:0006661	phosphatidylinositol biosynthetic process	IDA
GO:0009395	phospholipid catabolic process	IEA
GO:0010468	regulation of gene expression	IEA
GO:0016055	Wnt signaling pathway	TAS
GO:0019722	calcium-mediated signaling	NAS
GO:0030168	platelet activation	TAS
GO:0030183	B cell differentiation	ISS

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Cellular Components

Showing 1 to 3 of 3 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	TAS
GO:0070062	extracellular exosome	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ANDR_HUMAN	Yes: P10275 (MoonDB)
ASB9_HUMAN	No
BOP_HUMAN	No
CH60_HUMAN	No
EGFR_HUMAN	Yes: P00533 (MoonDB)
ELK1_HUMAN	No
EPOR_HUMAN	No
EPYC_HUMAN	No
ERBB2_HUMAN	Yes: P04626 (MoonDB)
ESTD_HUMAN	No

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Publications Associated

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PMID	Article Title
2849563	Complete cDNA encoding a putative phospholipase C from transformed human lymphocytes.
11606584	Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling.
12181444	Activation of phospholipase Cgamma2 by tyrosine phosphorylation.
15144186	Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15616553	The sequence and analysis of duplication-rich human chromosome 16.
16533400	NovelFam3000 -- uncharacterized human protein domains conserved across model organisms.
19690332	Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
21269460	Initial characterization of the human central proteome.
22236196	Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions.

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OMIM Diseases Associated

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OMIM ID	Disease Name
614468	Familial cold autoinflammatory syndrome 3
614878	Autoinflammation, antibody deficiency, and immune dysregulation PLCG2-associated

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Protein Domains Associated

Showing 1 to 10 of 51 entries

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Domain Name	Domain ID	Source
C2	PF00168	Pfam
C2	PS50004	PROSITE
C2	SM00239	SMART
C2_dom	IPR000008	InterPro
C2_domain_sf	IPR035892	InterPro
EF-hand-dom_pair	IPR011992	InterPro
PH	SM00233	SMART
PH-like_dom_sf	IPR011993	InterPro
PH_domain	IPR001849	InterPro
PH_DOMAIN	PS50003	PROSITE

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