Protein: P62993 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P62993 (Uniprot)	GRB2_HUMAN	GRB2	Growth factor receptor-bound protein 2	human	No

Protein Function

Uniprot: Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative pro more..

MoonDB Dissimilar Functions

Showing 1 to 10 of 15 entries

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006139	nucleobase-containing compound metabolic process	698	GO:0022610	biological adhesion	869	2.30e-55	4.36e-110
GO:0007165	signal transduction	187, 355, 486	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	467	4.83e-02	1.79e-71
GO:0007165	signal transduction	187, 355, 486	GO:0006139	nucleobase-containing compound metabolic process	698	1.10e-111	5.07e-25
GO:0007166	cell surface receptor signaling pathway	108	GO:0034641	cellular nitrogen compound metabolic process	35, 180, 327, 492	5.53e-55	9.57e-64
GO:0007166	cell surface receptor signaling pathway	108	GO:0009059	macromolecule biosynthetic process	682	2.49e-18	9.18e-29
GO:0007166	cell surface receptor signaling pathway	108	GO:0006139	nucleobase-containing compound metabolic process	698	6.88e-41	1.21e-84
GO:0009059	macromolecule biosynthetic process	682	GO:0022610	biological adhesion	869	2.22e-23	6.08e-57
GO:0010646	regulation of cell communication	284	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	467	2.08e-06	5.20e-107
GO:0010646	regulation of cell communication	284	GO:0006139	nucleobase-containing compound metabolic process	698	6.71e-28	7.52e-07
GO:0019538	protein metabolic process	15, 166, 177, 202, 215, 254, 306	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	467	1.88e-02	4.66e-37

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
15	GO:0044267	cellular protein metabolic process
20	GO:0019538	protein metabolic process
20	GO:0007165	signal transduction
21	GO:0060255	regulation of macromolecule metabolic process
35	GO:0044271	cellular nitrogen compound biosynthetic process
35	GO:0044267	cellular protein metabolic process
35	GO:0090304	nucleic acid metabolic process
35	GO:0010468	regulation of gene expression
35	GO:0009966	regulation of signal transduction
38	GO:0007165	signal transduction

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Cellular Components

Showing 1 to 10 of 98 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
18	GO:0005829	cytosol
18	GO:0070062	extracellular exosome
20	GO:0005886	plasma membrane
35	GO:0005829	cytosol
35	GO:0005634	nucleus
35	GO:0005886	plasma membrane
108	GO:0005829	cytosol
108	GO:0005634	nucleus
108	GO:0005886	plasma membrane
111	GO:0005829	cytosol

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Protein GO Annotations

Biological Processes

Showing 1 to 10 of 36 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000165	MAPK cascade	TAS
GO:0007173	epidermal growth factor receptor signaling pathway	TAS
GO:0007265	Ras protein signal transduction	TAS
GO:0007267	cell-cell signaling	TAS
GO:0007411	axon guidance	TAS
GO:0007568	aging	IEA
GO:0008286	insulin receptor signaling pathway	TAS
GO:0008543	fibroblast growth factor receptor signaling pathway	TAS
GO:0016032	viral process	IEA
GO:0016477	cell migration	IBA

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Cellular Components

Showing 1 to 10 of 14 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	IDA
GO:0005730	nucleolus	IDA
GO:0005737	cytoplasm	IDA
GO:0005768	endosome	IDA
GO:0005794	Golgi apparatus	IEA
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	TAS
GO:0005911	cell-cell junction	IEA
GO:0008180	COP9 signalosome	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0005768	endosome	4.09e-12	7.34e-15
GO:0005634	nucleus	GO:0005794	Golgi apparatus	4.39e-25	2.14e-64
GO:0005634	nucleus	GO:0005886	plasma membrane	5.35e-300	7.52e-165
GO:0005634	nucleus	GO:0012506	vesicle membrane	9.35e-29	3.51e-48
GO:0005634	nucleus	GO:0070062	extracellular exosome	6.30e-13	4.54e-26
GO:0005654	nucleoplasm	GO:0005768	endosome	1.29e-11	1.85e-14
GO:0005654	nucleoplasm	GO:0005794	Golgi apparatus	1.14e-11	3.23e-62
GO:0005654	nucleoplasm	GO:0005886	plasma membrane	9.14e-199	6.17e-196
GO:0005654	nucleoplasm	GO:0005911	cell-cell junction	3.44e-02	2.10e-14
GO:0005654	nucleoplasm	GO:0012506	vesicle membrane	4.66e-23	1.85e-52

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
A2MG_HUMAN	Yes: P01023 (MoonDB)
A2RU56_HUMAN	No
AAKB1_HUMAN	No
ABI3_HUMAN	No
ABL1_HUMAN	Yes: P00519 (MoonDB)
ABL2_HUMAN	Yes: P42684 (MoonDB)
ACAP1_HUMAN	No
ACK1_HUMAN	No
ACKR3_HUMAN	No
ADA15_HUMAN	No

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Publications Associated

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PMID	Article Title
1322798	The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling.
1384039	Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries.
7664271	Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein.
7716522	Crystal structure of the mammalian Grb2 adaptor.
7881903	Solution structure and ligand-binding site of the carboxy-terminal SH3 domain of GRB2.
8178156	Cloning of a Grb2 isoform with apoptotic properties.
8262059	Mutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblasts.
8388384	Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2.
8491186	The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.
8493579	Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 21 entries

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Domain Name	Domain ID	Source
A43321	A43321	PIR
Grb2	IPR030219	InterPro
GRB2_C_SH3	IPR035643	InterPro
GRB2_N_SH3	IPR035641	InterPro
PTHR24418:SF290	PTHR24418:SF290	PANTHER
SH2	IPR000980	InterPro
SH2	PF00017	Pfam
SH2	PS50001	PROSITE
SH2	SM00252	SMART
SH2_dom_sf	IPR036860	InterPro

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