Protein: P14373 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P14373 (Uniprot)	TRI27_HUMAN	TRIM27	Zinc finger protein RFP	human	No

Protein Function

Uniprot: E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked p more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0009056	catabolic process	359	GO:0009059	macromolecule biosynthetic process	5, 797	6.37e-04	1.88e-40

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
5	GO:0034645	cellular macromolecule biosynthetic process
5	GO:0006464	cellular protein modification process
5	GO:0090304	nucleic acid metabolic process
5	GO:0034654	nucleobase-containing compound biosynthetic process
5	GO:0060255	regulation of macromolecule metabolic process
44	GO:0010467	gene expression
44	GO:0031324	negative regulation of cellular metabolic process
44	GO:0009889	regulation of biosynthetic process
44	GO:0060255	regulation of macromolecule metabolic process
53	GO:0006139	nucleobase-containing compound metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
5	GO:0005829	cytosol
5	GO:0005634	nucleus
44	GO:0005829	cytosol
44	GO:0005634	nucleus
53	GO:0005829	cytosol
53	GO:0005654	nucleoplasm
59	GO:0005634	nucleus
67	GO:0005634	nucleus
82	GO:0005634	nucleus
84	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA
GO:0002820	negative regulation of adaptive immune response	IMP
GO:0006351	transcription, DNA-templated	IEA
GO:0006469	negative regulation of protein kinase activity	IDA
GO:0007283	spermatogenesis	TAS
GO:0008283	cell proliferation	TAS
GO:0018108	peptidyl-tyrosine phosphorylation	IEA
GO:0032720	negative regulation of tumor necrosis factor production	IMP
GO:0032897	negative regulation of viral transcription	IDA
GO:0034314	Arp2/3 complex-mediated actin nucleation	IDA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0001650	fibrillar center	IDA
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	IDA
GO:0005730	nucleolus	IDA
GO:0005737	cytoplasm	IDA
GO:0005768	endosome	IDA
GO:0005769	early endosome	IEA
GO:0005829	cytosol	TAS
GO:0005887	integral component of plasma membrane	TAS
GO:0016020	membrane	TAS

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0005768	endosome	4.09e-12	7.34e-15
GO:0005634	nucleus	GO:0005887	integral component of plasma membrane	6.41e-134	1.88e-259
GO:0005634	nucleus	GO:0016020	membrane	0.00e+00	4.39e-236
GO:0005654	nucleoplasm	GO:0005768	endosome	1.29e-11	1.85e-14
GO:0005654	nucleoplasm	GO:0005769	early endosome	5.29e-05	1.04e-19
GO:0005654	nucleoplasm	GO:0005887	integral component of plasma membrane	3.07e-87	3.74e-184
GO:0005654	nucleoplasm	GO:0016020	membrane	5.76e-255	1.32e-206
GO:0005730	nucleolus	GO:0005887	integral component of plasma membrane	3.40e-17	3.71e-07
GO:0005730	nucleolus	GO:0016020	membrane	8.89e-46	1.83e-10
GO:0005737	cytoplasm	GO:0005887	integral component of plasma membrane	4.51e-73	1.63e-08

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
A0A024R8L2_HUMAN	No
AAPK1_HUMAN	No
AB17A_HUMAN	No
ABCF3_HUMAN	No
ACSF3_HUMAN	No
AEN_HUMAN	No
AES_HUMAN	Yes: Q08117 (MoonDB)
AMOL2_HUMAN	No
AP1M1_HUMAN	No
ARHG3_HUMAN	No

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Publications Associated

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PMID	Article Title
1437549	RFP is a DNA binding protein associated with the nuclear matrix.
3037315	ret transforming gene encodes a fusion protein homologous to tyrosine kinases.
3380101	Developmentally regulated expression of a human 'finger'-containing gene encoded by the 5' half of the ret transforming gene.
9247190	Involvement of the rfp tripartite motif in protein-protein interactions and subcellular distribution.
9570750	Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML.
10504338	Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies.
10976108	RET finger protein is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functions.
11331580	The tripartite motif family identifies cell compartments.
12445133	Differential expression of RET finger protein in testicular germ cell tumors.
12787916	Novel tumorigenic rearrangement, Delta rfp/ret, in a papillary thyroid carcinoma from externally irradiated patient.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
B30.2/SPRY	IPR001870	InterPro
B302_SPRY	PS50188	PROSITE
BBOX	SM00336	SMART
BBOX	cd00021	CDD
BBOXZNFINGER	PR01406	PRINTS
BUTYPHLNCDUF	PR01407	PRINTS
Butyrophylin_SPRY	IPR003879	InterPro
ConA-like_dom_sf	IPR013320	InterPro
PRY	IPR006574	InterPro
PRY	PF13765	Pfam

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