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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: Q96HA8
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
Q96HA8 (Uniprot)
NTAQ1_HUMAN
WDYHV1
Protein N-terminal glutamine amidohydrolase
human
No
Protein Function
Uniprot:
Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N
-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.
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MoonDB Dissimilar Functions
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GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0009056
catabolic process
125
GO:0009059
macromolecule biosynthetic process
5
6.37e-04
1.88e-40
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MoonDB Network Modules
Biological Processes
Showing 1 to 10 of 30 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
5
GO:0034645
cellular macromolecule biosynthetic process
5
GO:0006464
cellular protein modification process
5
GO:0090304
nucleic acid metabolic process
5
GO:0034654
nucleobase-containing compound biosynthetic process
5
GO:0060255
regulation of macromolecule metabolic process
57
GO:0006139
nucleobase-containing compound metabolic process
67
GO:0060255
regulation of macromolecule metabolic process
103
GO:0006139
nucleobase-containing compound metabolic process
125
GO:0044248
cellular catabolic process
125
GO:0016567
protein ubiquitination
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Cellular Components
Showing 1 to 10 of 46 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
5
GO:0005829
cytosol
5
GO:0005634
nucleus
34
GO:0005634
nucleus
50
GO:0005829
cytosol
50
GO:0005634
nucleus
57
GO:0005634
nucleus
60
GO:0005634
nucleus
67
GO:0005634
nucleus
82
GO:0005634
nucleus
103
GO:0070013
intracellular organelle lumen
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Protein GO Annotations
Biological Processes
Showing 1 to 1 of 1 entries
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GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0006464
cellular protein modification process
ISS
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Cellular Components
Showing 1 to 2 of 2 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0005634
nucleus
ISS
GO:0005829
cytosol
ISS
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Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Showing 1 to 10 of 314 entries
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Interactor
Also a MoonDB EMF protein
1433S_HUMAN
No
5NT1A_HUMAN
No
A0A087WZT3_HUMAN
No
A0A0A0MR80_HUMAN
No
AARD_HUMAN
No
ACD_HUMAN
Yes:
Q96AP0 (MoonDB)
ACO13_HUMAN
No
ACPM_HUMAN
No
ACTB_HUMAN
No
ACTG_HUMAN
No
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Publications Associated
Showing 1 to 3 of 3 entries
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PMID
Article Title
14702039
Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16421571
DNA sequence and analysis of human chromosome 8.
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OMIM Diseases Associated
No results found.
Protein Domains Associated
Showing 1 to 3 of 3 entries
Search:
Domain Name
Domain ID
Source
N_Gln_amidohydro_ab_roll_sf
IPR037132
InterPro
Nt_Gln_amidase
PF09764
Pfam
Prot_N_Gln_amidohydro_ab_roll
IPR023128
InterPro
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