Protein: Q08117 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q08117 (Uniprot)	AES_HUMAN	AES	Amino-terminal enhancer of split	human	No

Protein Function

Uniprot: Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006139	nucleobase-containing compound metabolic process	153	GO:0007165	signal transduction	355	1.10e-111	5.07e-25
GO:0006396	RNA processing	426	GO:0048869	cellular developmental process	745	2.41e-03	1.32e-38
GO:0007165	signal transduction	355	GO:0006396	RNA processing	426	3.78e-31	3.47e-84

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
31	GO:0034645	cellular macromolecule biosynthetic process
31	GO:0044271	cellular nitrogen compound biosynthetic process
31	GO:0090304	nucleic acid metabolic process
31	GO:0010468	regulation of gene expression
59	GO:0016070	RNA metabolic process
59	GO:0006464	cellular protein modification process
59	GO:0010467	gene expression
59	GO:2000112	regulation of cellular macromolecule biosynthetic process
64	GO:0016070	RNA metabolic process
64	GO:0010467	gene expression

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
31	GO:0005634	nucleus
59	GO:0005634	nucleus
60	GO:0005634	nucleus
64	GO:0005634	nucleus
67	GO:0005634	nucleus
84	GO:0005634	nucleus
89	GO:0005634	nucleus
95	GO:0005634	nucleus
127	GO:0005634	nucleus
153	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IMP
GO:0001501	skeletal system development	IEA
GO:0006351	transcription, DNA-templated	IEA
GO:0007275	multicellular organism development	TAS
GO:0009887	animal organ morphogenesis	TAS
GO:0010629	negative regulation of gene expression	IMP
GO:0016055	Wnt signaling pathway	IEA
GO:0031668	cellular response to extracellular stimulus	IEA
GO:0032091	negative regulation of protein binding	IDA
GO:0040008	regulation of growth	IEA

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Cellular Components

Showing 1 to 1 of 1 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 290 entries

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Interactor	Also a MoonDB EMF protein
A0A024R8L2_HUMAN	No
A0A087WSW0_HUMAN	No
AAKB2_HUMAN	No
AAPK1_HUMAN	No
AAPK2_HUMAN	No
ABI2_HUMAN	Yes: Q9NYB9 (MoonDB)
AEN_HUMAN	No
AF17_HUMAN	No
AGR2_HUMAN	No
AKP8L_HUMAN	No

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Publications Associated

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PMID	Article Title
8365415	Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein.
9809752	Genomic organization and chromosome localization to band 19p13.3 of the human AES gene: gene product exhibits strong similarity to the N-terminal domain of Drosophila enhancer of split Groucho protein.
10660609	Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats.
10748198	Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta.
11390640	Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex.
12441302	Six3 and Six6 activity is modulated by members of the groucho family.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15057824	The DNA sequence and biology of human chromosome 19.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
20068231	Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 5 of 5 entries

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Domain Name	Domain ID	Source
G01236	G01236	PIR
Groucho/TLE_N	IPR005617	InterPro
S35678	S35678	PIR
S35679	S35679	PIR
TLE_N	PF03920	Pfam

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