Protein: Q08117

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q08117 (Uniprot) AES_HUMAN AES Amino-terminal enhancer of split human No
Uniprot: Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0006139 nucleobase-containing compound metabolic process 153 GO:0007165 signal transduction 355 1.10e-111 5.07e-25
GO:0007165 signal transduction 355 GO:0006396 RNA processing 426 3.78e-31 3.47e-84
GO:0006396 RNA processing 426 GO:0048869 cellular developmental process 745 2.41e-03 1.32e-38
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
31 GO:0034645 cellular macromolecule biosynthetic process
31 GO:0044271 cellular nitrogen compound biosynthetic process
31 GO:0090304 nucleic acid metabolic process
31 GO:0010468 regulation of gene expression
59 GO:0016070 RNA metabolic process
59 GO:0006464 cellular protein modification process
59 GO:0010467 gene expression
59 GO:2000112 regulation of cellular macromolecule biosynthetic process
64 GO:0016070 RNA metabolic process
64 GO:0010467 gene expression
64 GO:0060255 regulation of macromolecule metabolic process
67 GO:0060255 regulation of macromolecule metabolic process
127 GO:0016070 RNA metabolic process
127 GO:0010467 gene expression
153 GO:0090304 nucleic acid metabolic process
153 GO:0060255 regulation of macromolecule metabolic process
154 GO:0006915 apoptotic process
154 GO:0007166 cell surface receptor signaling pathway
154 GO:0006464 cellular protein modification process
154 GO:0071310 cellular response to organic substance
154 GO:0060429 epithelium development
154 GO:0006796 phosphate-containing compound metabolic process
154 GO:0009966 regulation of signal transduction
154 GO:0006355 regulation of transcription, DNA-templated
160 GO:0006355 regulation of transcription, DNA-templated
209 GO:0031324 negative regulation of cellular metabolic process
209 GO:0010605 negative regulation of macromolecule metabolic process
209 GO:0051172 negative regulation of nitrogen compound metabolic process
209 GO:0009893 positive regulation of metabolic process
209 GO:0006357 regulation of transcription from RNA polymerase II promoter
209 GO:0007165 signal transduction
238 GO:0060255 regulation of macromolecule metabolic process
268 GO:0006355 regulation of transcription, DNA-templated
280 GO:0016070 RNA metabolic process
280 GO:0010467 gene expression
303 GO:0007165 signal transduction
355 GO:0007166 cell surface receptor signaling pathway
355 GO:0006464 cellular protein modification process
355 GO:0035556 intracellular signal transduction
355 GO:0016310 phosphorylation
355 GO:0010647 positive regulation of cell communication
355 GO:0048584 positive regulation of response to stimulus
355 GO:0023056 positive regulation of signaling
355 GO:0060255 regulation of macromolecule metabolic process
355 GO:0009966 regulation of signal transduction
401 GO:0034645 cellular macromolecule biosynthetic process
401 GO:0060255 regulation of macromolecule metabolic process
426 GO:0008380 RNA splicing
426 GO:0006397 mRNA processing
426 GO:0051252 regulation of RNA metabolic process
426 GO:2000112 regulation of cellular macromolecule biosynthetic process
426 GO:0010468 regulation of gene expression
426 GO:0006351 transcription, DNA-templated
450 GO:0051252 regulation of RNA metabolic process
450 GO:0010646 regulation of cell communication
450 GO:2000112 regulation of cellular macromolecule biosynthetic process
450 GO:0010468 regulation of gene expression
450 GO:0023051 regulation of signaling
450 GO:0007165 signal transduction
454 GO:0031326 regulation of cellular biosynthetic process
454 GO:0060255 regulation of macromolecule metabolic process
462 GO:0090304 nucleic acid metabolic process
509 GO:0010467 gene expression
509 GO:0060255 regulation of macromolecule metabolic process
527 GO:0090304 nucleic acid metabolic process
527 GO:0060255 regulation of macromolecule metabolic process
589 GO:0016070 RNA metabolic process
589 GO:0010467 gene expression
589 GO:0031325 positive regulation of cellular metabolic process
589 GO:2000112 regulation of cellular macromolecule biosynthetic process
589 GO:0019219 regulation of nucleobase-containing compound metabolic process
603 GO:0060255 regulation of macromolecule metabolic process
610 GO:0008219 cell death
610 GO:0007166 cell surface receptor signaling pathway
610 GO:0006464 cellular protein modification process
610 GO:0031324 negative regulation of cellular metabolic process
610 GO:0051172 negative regulation of nitrogen compound metabolic process
610 GO:0016310 phosphorylation
610 GO:0010604 positive regulation of macromolecule metabolic process
610 GO:0051173 positive regulation of nitrogen compound metabolic process
610 GO:0008104 protein localization
610 GO:0051128 regulation of cellular component organization
610 GO:0032268 regulation of cellular protein metabolic process
610 GO:0009966 regulation of signal transduction
610 GO:0006355 regulation of transcription, DNA-templated
657 GO:0006355 regulation of transcription, DNA-templated
657 GO:0007165 signal transduction
664 GO:0044267 cellular protein metabolic process
664 GO:0010467 gene expression
664 GO:0090304 nucleic acid metabolic process
664 GO:0060255 regulation of macromolecule metabolic process
664 GO:0007165 signal transduction
743 GO:0007165 signal transduction
745 GO:0048468 cell development
745 GO:0007166 cell surface receptor signaling pathway
745 GO:0010467 gene expression
745 GO:0048699 generation of neurons
745 GO:0006139 nucleobase-containing compound metabolic process
745 GO:0060255 regulation of macromolecule metabolic process
782 GO:0006355 regulation of transcription, DNA-templated
791 GO:0060255 regulation of macromolecule metabolic process
837 GO:0009887 animal organ morphogenesis
837 GO:0006915 apoptotic process
837 GO:0007166 cell surface receptor signaling pathway
837 GO:0033554 cellular response to stress
837 GO:0018193 peptidyl-amino acid modification
837 GO:0051130 positive regulation of cellular component organization
837 GO:1902533 positive regulation of intracellular signal transduction
837 GO:0001934 positive regulation of protein phosphorylation
837 GO:0045893 positive regulation of transcription, DNA-templated
837 GO:0006357 regulation of transcription from RNA polymerase II promoter
837 GO:0051338 regulation of transferase activity
837 GO:0009628 response to abiotic stimulus
837 GO:0001501 skeletal system development
861 GO:0060255 regulation of macromolecule metabolic process
861 GO:0006351 transcription, DNA-templated
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
31 GO:0005634 nucleus
59 GO:0005634 nucleus
60 GO:0005634 nucleus
64 GO:0005634 nucleus
67 GO:0005634 nucleus
84 GO:0005634 nucleus
89 GO:0005634 nucleus
95 GO:0005634 nucleus
127 GO:0005634 nucleus
153 GO:0005634 nucleus
160 GO:0005634 nucleus
209 GO:0005654 nucleoplasm
231 GO:0005634 nucleus
238 GO:0005829 cytosol
238 GO:0005634 nucleus
268 GO:0005634 nucleus
271 GO:0005634 nucleus
280 GO:0005634 nucleus
355 GO:0044459 plasma membrane part
401 GO:0005634 nucleus
426 GO:0005654 nucleoplasm
450 GO:0005634 nucleus
454 GO:0005634 nucleus
462 GO:0005634 nucleus
509 GO:0005634 nucleus
527 GO:0005634 nucleus
589 GO:0005829 cytosol
589 GO:0005634 nucleus
603 GO:0005634 nucleus
610 GO:0031981 nuclear lumen
611 GO:0005634 nucleus
657 GO:0005634 nucleus
664 GO:0005829 cytosol
664 GO:0043232 intracellular non-membrane-bounded organelle
664 GO:0005634 nucleus
726 GO:0005634 nucleus
743 GO:0012505 endomembrane system
745 GO:0005634 nucleus
746 GO:0043232 intracellular non-membrane-bounded organelle
782 GO:0005634 nucleus
791 GO:0005634 nucleus
837 GO:0005829 cytosol
837 GO:0005654 nucleoplasm
861 GO:0070013 intracellular organelle lumen
861 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP
GO:0001501 skeletal system development IEA
GO:0006351 transcription, DNA-templated IEA
GO:0007275 multicellular organism development TAS
GO:0009887 animal organ morphogenesis TAS
GO:0010629 negative regulation of gene expression IMP
GO:0016055 Wnt signaling pathway IEA
GO:0031668 cellular response to extracellular stimulus IEA
GO:0032091 negative regulation of protein binding IDA
GO:0040008 regulation of growth IEA
GO:0045892 negative regulation of transcription, DNA-templated IDA
GO:0060761 negative regulation of response to cytokine stimulus IMP
GO:0070555 response to interleukin-1 IDA
GO:0090090 negative regulation of canonical Wnt signaling pathway IDA
GO:2000210 positive regulation of anoikis IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
RBPMS_HUMAN Yes: Q93062 (MoonDB)
PRP31_HUMAN No
CRTP1_HUMAN No
FBLN4_HUMAN No
KR122_HUMAN No
KR108_HUMAN No
TRAF1_HUMAN No
KR107_HUMAN No
KR109_HUMAN Yes: P60411 (MoonDB)
PICK1_HUMAN Yes: Q9NRD5 (MoonDB)
HNRPF_HUMAN No
DAZP2_HUMAN Yes: Q15038 (MoonDB)
MDFI_HUMAN No
ZN408_HUMAN No
A0A024R8L2_HUMAN No
CRX_HUMAN No
KRT34_HUMAN No
K1C13_HUMAN No
TRI27_HUMAN Yes: P14373 (MoonDB)
ITF2_HUMAN No
K1C15_HUMAN No
REL_HUMAN No
TRAF2_HUMAN No
MTUS2_HUMAN No
NT2NL_HUMAN No
KRT35_HUMAN No
KIFC3_HUMAN No
CARD9_HUMAN No
ABI2_HUMAN Yes: Q9NYB9 (MoonDB)
IKZF3_HUMAN No
T22D4_HUMAN No
SDCB1_HUMAN Yes: O00560 (MoonDB)
A0A087WSW0_HUMAN No
VP37C_HUMAN Yes: A5D8V6 (MoonDB)
LMO4_HUMAN No
AAKB2_HUMAN No
AAPK1_HUMAN No
AAPK2_HUMAN No
AEN_HUMAN No
AF17_HUMAN No
AGR2_HUMAN No
AKP8L_HUMAN No
ANDR_HUMAN Yes: P10275 (MoonDB)
AP2D_HUMAN No
APC11_HUMAN No
ASB3_HUMAN No
ATN1_HUMAN No
ATX1L_HUMAN No
BAHD1_HUMAN No
BCL6_HUMAN No
BHE40_HUMAN Yes: O14503 (MoonDB)
BIRC7_HUMAN No
BPIA1_HUMAN No
BYST_HUMAN No
CA094_HUMAN No
CA109_HUMAN No
CA216_HUMAN No
CABP4_HUMAN No
CABP5_HUMAN No
CACO2_HUMAN No
CAN1_HUMAN No
CC120_HUMAN No
CCD57_HUMAN No
CCL7_HUMAN No
CCNJL_HUMAN No
CCNK_HUMAN No
CCNO_HUMAN No
CF195_HUMAN No
CF206_HUMAN No
CIB3_HUMAN No
CJ055_HUMAN No
CNFN_HUMAN No
CPSF7_HUMAN No
CR018_HUMAN No
CSTF2_HUMAN No
CSTFT_HUMAN No
CTBP2_HUMAN No
CTGE5_HUMAN No
DCNL1_HUMAN No
DDX6_HUMAN No
DGCR6_HUMAN No
DIP2A_HUMAN No
DMRT3_HUMAN No
DSC10_HUMAN No
DVL2_HUMAN No
DYDC1_HUMAN No
EAF1_HUMAN No
EAF2_HUMAN No
EFC4B_HUMAN No
EFHC1_HUMAN No
EIF1A_HUMAN No
EXOS5_HUMAN No
EYA2_HUMAN No
F124A_HUMAN No
F124B_HUMAN No
F168B_HUMAN No
F214B_HUMAN No
F90A1_HUMAN No
FA46B_HUMAN No
FANCG_HUMAN Yes: O15287 (MoonDB)
FBF1_HUMAN No
FHL3_HUMAN No
FOSB_HUMAN No
FOXN1_HUMAN No
FOXP2_HUMAN No
FRS3_HUMAN No
FSD2_HUMAN No
GATA1_HUMAN No
GBRAP_HUMAN Yes: O95166 (MoonDB)
GCC1_HUMAN No
GFAP_HUMAN No
GFI1B_HUMAN No
GG6L9_HUMAN No
GGYF1_HUMAN No
GLIS2_HUMAN No
GLRX3_HUMAN No
GOGA2_HUMAN Yes: Q08379 (MoonDB)
GORS2_HUMAN No
GPT2L_HUMAN No
GRAP2_HUMAN No
GRB2_HUMAN Yes: P62993 (MoonDB)
GUSP1_HUMAN No
GYS1_HUMAN No
HDAC4_HUMAN No
HDHD3_HUMAN No
HEXI2_HUMAN No
HGS_HUMAN No
HNF1A_HUMAN No
HNRH2_HUMAN No
HNRPK_HUMAN Yes: P61978 (MoonDB)
HOMEZ_HUMAN No
HXA1_HUMAN No
HXB5_HUMAN No
HXC8_HUMAN No
HXC9_HUMAN No
IF4E2_HUMAN No
IN80B_HUMAN No
IN80E_HUMAN No
IRX2_HUMAN No
IRX6_HUMAN No
K1C40_HUMAN No
K1H1_HUMAN No
KANK2_HUMAN No
KLD7B_HUMAN No
KR103_HUMAN No
KR111_HUMAN No
KR133_HUMAN No
KR171_HUMAN No
LDOC1_HUMAN No
LENG8_HUMAN No
LHX3_HUMAN No
LMBL2_HUMAN No
LSM2_HUMAN No
LZTS2_HUMAN No
MARE3_HUMAN No
MBNL1_HUMAN No
MCRS1_HUMAN No
MD12L_HUMAN No
MED31_HUMAN No
MED4_HUMAN No
MFAP1_HUMAN No
MGN2_HUMAN No
MIIP_HUMAN No
MK01_HUMAN Yes: P28482 (MoonDB)
MK14_HUMAN No
MKRN3_HUMAN Yes: Q13064 (MoonDB)
MLX_HUMAN No
MO4L1_HUMAN No
MO4L2_HUMAN No
MSS51_HUMAN No
MSX2_HUMAN No
MVP_HUMAN No
MY15B_HUMAN No
MYH7B_HUMAN No
MYOG_HUMAN No
NAB2_HUMAN No
NAF1_HUMAN No
NCDN_HUMAN No
NDOR1_HUMAN No
NEK6_HUMAN No
NTAQ1_HUMAN Yes: Q96HA8 (MoonDB)
NUD22_HUMAN No
OLIG3_HUMAN No
OSGI1_HUMAN No
OXER1_HUMAN No
PARVG_HUMAN No
PATZ1_HUMAN No
PAX8_HUMAN No
PCBP1_HUMAN No
PFD5_HUMAN No
PHF1_HUMAN No
PI5PA_HUMAN No
PITX1_HUMAN No
PITX2_HUMAN No
PP16A_HUMAN No
PP16B_HUMAN No
PRD14_HUMAN No
PRR35_HUMAN No
PRR3_HUMAN No
PSB4_HUMAN No
PSMF1_HUMAN No
PTH2_HUMAN Yes: Q9Y3E5 (MoonDB)
Q499Y1_HUMAN No
Q6ICL0_HUMAN No
RA51D_HUMAN No
RBM10_HUMAN Yes: P98175 (MoonDB)
RBTN1_HUMAN No
RBTN2_HUMAN No
RFX6_HUMAN No
RHG32_HUMAN No
RHXF2_HUMAN No
RIBC1_HUMAN No
RIM3A_HUMAN No
RIPP1_HUMAN No
RL18A_HUMAN No
RNF31_HUMAN No
RPAC1_HUMAN No
RU1C_HUMAN No
RUNX1_HUMAN No
RUSC1_HUMAN No
RYDEN_HUMAN No
SCNM1_HUMAN No
SEN15_HUMAN No
SF3B4_HUMAN No
SH3G3_HUMAN No
SIX1_HUMAN No
SIX3_HUMAN No
SIX6_HUMAN No
SKIL_HUMAN No
SMAD3_HUMAN Yes: P84022 (MoonDB)
SMAD4_HUMAN No
SNCAP_HUMAN No
SNRPA_HUMAN No
SOLH1_HUMAN No
SOX5_HUMAN No
SPG21_HUMAN No
SPT25_HUMAN No
SPT5H_HUMAN No
SRPK2_HUMAN Yes: P78362 (MoonDB)
SRTD3_HUMAN No
STK16_HUMAN No
STX11_HUMAN No
SUFU_HUMAN No
SYQ_HUMAN No
T10IP_HUMAN No
TBX3_HUMAN No
TBX6_HUMAN No
TEAD4_HUMAN No
TEX37_HUMAN No
TF65_HUMAN No
TF7L2_HUMAN No
THAP7_HUMAN No
TIGD3_HUMAN No
TMCC2_HUMAN No
TNR6A_HUMAN No
TNS2_HUMAN Yes: Q63HR2 (MoonDB)
TRI26_HUMAN No
TRI41_HUMAN Yes: Q8WV44 (MoonDB)
TRIP6_HUMAN No
TRM2A_HUMAN No
TSC1_HUMAN No
TSG10_HUMAN No
TSSK3_HUMAN No
TTC23_HUMAN No
U2AF2_HUMAN No
UBE2H_HUMAN Yes: P62256 (MoonDB)
UBP2_HUMAN Yes: O75604 (MoonDB)
UBP54_HUMAN No
UBX11_HUMAN No
VA0D1_HUMAN No
VEZF1_HUMAN No
VIME_HUMAN Yes: P08670 (MoonDB)
VP37B_HUMAN No
YTHD1_HUMAN No
ZBT16_HUMAN Yes: Q05516 (MoonDB)
ZBT24_HUMAN No
ZBT47_HUMAN No
ZFHX3_HUMAN No
ZGPAT_HUMAN No
ZIC1_HUMAN No
ZN330_HUMAN No
ZN414_HUMAN No
ZN417_HUMAN Yes: Q8TAU3 (MoonDB)
ZN467_HUMAN No
ZN503_HUMAN No
ZN524_HUMAN No
ZN576_HUMAN No
ZN792_HUMAN No
ZNF48_HUMAN No
ZRAN1_HUMAN No
PMID Article Title
8365415 Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein.
9809752 Genomic organization and chromosome localization to band 19p13.3 of the human AES gene: gene product exhibits strong similarity to the N-terminal domain of Drosophila enhancer of split Groucho protein.
10660609 Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats.
10748198 Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta.
11390640 Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex.
12441302 Six3 and Six6 activity is modulated by members of the groucho family.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15057824 The DNA sequence and biology of human chromosome 19.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
22304967 XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling.
No results found.
Domain Name Domain ID Source
G01236 G01236 PIR
Groucho/TLE_N IPR005617 InterPro
TLE_N PF03920 Pfam
S35678 S35678 PIR
S35679 S35679 PIR