Protein: P78362

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P78362 (Uniprot) SRPK2_HUMAN SRPK2 SRSF protein kinase 2 human No
Uniprot: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0016070 RNA metabolic process 75, 689, 715 GO:0002376 immune system process 811 5.68e-23 7.16e-26
GO:0019538 protein metabolic process 129, 376, 474, 563, 728 GO:0016070 RNA metabolic process 75, 689, 715 5.15e-08 2.82e-13
GO:0019538 protein metabolic process 129, 376, 474, 563, 728 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 467 1.88e-02 4.66e-37
GO:0007165 signal transduction 141 GO:0034641 cellular nitrogen compound metabolic process 47 4.22e-144 6.90e-18
GO:0007165 signal transduction 141 GO:0016070 RNA metabolic process 75, 689, 715 3.11e-78 2.75e-26
GO:0007165 signal transduction 141 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 467 4.83e-02 1.79e-71
GO:0007165 signal transduction 141 GO:0006396 RNA processing 681 3.78e-31 3.47e-84
GO:0036211 protein modification process 483, 560 GO:0016070 RNA metabolic process 75, 689, 715 5.81e-04 8.44e-05
GO:0036211 protein modification process 483, 560 GO:0006396 RNA processing 681 5.60e-03 3.14e-16
GO:0006396 RNA processing 681 GO:0002376 immune system process 811 1.36e-06 3.84e-29
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
38 GO:0007165 signal transduction
47 GO:0044271 cellular nitrogen compound biosynthetic process
47 GO:0051252 regulation of RNA metabolic process
47 GO:0010468 regulation of gene expression
70 GO:0051252 regulation of RNA metabolic process
70 GO:0010468 regulation of gene expression
70 GO:0006351 transcription, DNA-templated
75 GO:0016071 mRNA metabolic process
75 GO:0051252 regulation of RNA metabolic process
75 GO:0010468 regulation of gene expression
75 GO:0006351 transcription, DNA-templated
80 GO:0051252 regulation of RNA metabolic process
80 GO:0010468 regulation of gene expression
93 GO:0034645 cellular macromolecule biosynthetic process
93 GO:0034654 nucleobase-containing compound biosynthetic process
93 GO:0019538 protein metabolic process
93 GO:0051252 regulation of RNA metabolic process
93 GO:0010468 regulation of gene expression
96 GO:0016070 RNA metabolic process
96 GO:0010467 gene expression
124 GO:0010467 gene expression
124 GO:0090304 nucleic acid metabolic process
129 GO:0044267 cellular protein metabolic process
129 GO:0007165 signal transduction
141 GO:0035556 intracellular signal transduction
141 GO:0006468 protein phosphorylation
141 GO:0060255 regulation of macromolecule metabolic process
160 GO:0006355 regulation of transcription, DNA-templated
196 GO:0034645 cellular macromolecule biosynthetic process
196 GO:0006464 cellular protein modification process
196 GO:0090304 nucleic acid metabolic process
196 GO:0031326 regulation of cellular biosynthetic process
196 GO:0010468 regulation of gene expression
196 GO:0010556 regulation of macromolecule biosynthetic process
196 GO:0007165 signal transduction
203 GO:0016070 RNA metabolic process
203 GO:0010468 regulation of gene expression
217 GO:0060255 regulation of macromolecule metabolic process
217 GO:0007165 signal transduction
252 GO:0060255 regulation of macromolecule metabolic process
273 GO:0034645 cellular macromolecule biosynthetic process
273 GO:0044271 cellular nitrogen compound biosynthetic process
273 GO:0006464 cellular protein modification process
273 GO:0051252 regulation of RNA metabolic process
273 GO:0010468 regulation of gene expression
281 GO:0060255 regulation of macromolecule metabolic process
331 GO:0016070 RNA metabolic process
331 GO:0006464 cellular protein modification process
331 GO:0010467 gene expression
331 GO:0060255 regulation of macromolecule metabolic process
331 GO:0019219 regulation of nucleobase-containing compound metabolic process
376 GO:0044267 cellular protein metabolic process
376 GO:0007165 signal transduction
430 GO:0019538 protein metabolic process
467 GO:0000398 mRNA splicing, via spliceosome
467 GO:0060255 regulation of macromolecule metabolic process
473 GO:0060255 regulation of macromolecule metabolic process
473 GO:0007165 signal transduction
474 GO:0044267 cellular protein metabolic process
474 GO:0090304 nucleic acid metabolic process
474 GO:0060255 regulation of macromolecule metabolic process
483 GO:0006464 cellular protein modification process
483 GO:0010467 gene expression
483 GO:0009059 macromolecule biosynthetic process
483 GO:0090304 nucleic acid metabolic process
483 GO:0060255 regulation of macromolecule metabolic process
483 GO:0007165 signal transduction
493 GO:0016070 RNA metabolic process
493 GO:0010467 gene expression
507 GO:0010467 gene expression
507 GO:0006139 nucleobase-containing compound metabolic process
511 GO:0010467 gene expression
511 GO:0051252 regulation of RNA metabolic process
559 GO:0006355 regulation of transcription, DNA-templated
560 GO:0006464 cellular protein modification process
560 GO:0060255 regulation of macromolecule metabolic process
560 GO:0007165 signal transduction
563 GO:0044267 cellular protein metabolic process
563 GO:0006139 nucleobase-containing compound metabolic process
563 GO:0010646 regulation of cell communication
563 GO:0060255 regulation of macromolecule metabolic process
563 GO:0023051 regulation of signaling
563 GO:0007165 signal transduction
588 GO:0006355 regulation of transcription, DNA-templated
649 GO:0016070 RNA metabolic process
649 GO:0010468 regulation of gene expression
657 GO:0006355 regulation of transcription, DNA-templated
657 GO:0007165 signal transduction
681 GO:0008380 RNA splicing
681 GO:0006397 mRNA processing
681 GO:0051252 regulation of RNA metabolic process
681 GO:0010468 regulation of gene expression
689 GO:0006396 RNA processing
689 GO:0051252 regulation of RNA metabolic process
689 GO:0010468 regulation of gene expression
714 GO:0016070 RNA metabolic process
714 GO:0010468 regulation of gene expression
715 GO:0006396 RNA processing
715 GO:0060255 regulation of macromolecule metabolic process
728 GO:0044267 cellular protein metabolic process
728 GO:0031325 positive regulation of cellular metabolic process
728 GO:0010604 positive regulation of macromolecule metabolic process
728 GO:0051173 positive regulation of nitrogen compound metabolic process
728 GO:0051252 regulation of RNA metabolic process
728 GO:0010468 regulation of gene expression
728 GO:0007165 signal transduction
749 GO:0007165 signal transduction
754 GO:0010605 negative regulation of macromolecule metabolic process
754 GO:0051252 regulation of RNA metabolic process
754 GO:0010468 regulation of gene expression
754 GO:0006366 transcription from RNA polymerase II promoter
811 GO:0006955 immune response
811 GO:0019538 protein metabolic process
811 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
47 GO:0005654 nucleoplasm
65 GO:0012505 endomembrane system
65 GO:0016021 integral component of membrane
70 GO:0005654 nucleoplasm
75 GO:0005829 cytosol
75 GO:0005654 nucleoplasm
80 GO:0005634 nucleus
93 GO:0005829 cytosol
93 GO:0005634 nucleus
96 GO:0005654 nucleoplasm
117 GO:0005634 nucleus
124 GO:0031981 nuclear lumen
129 GO:0005829 cytosol
129 GO:0070013 intracellular organelle lumen
141 GO:0005634 nucleus
143 GO:0005634 nucleus
160 GO:0005634 nucleus
185 GO:0005829 cytosol
196 GO:0005634 nucleus
203 GO:0070013 intracellular organelle lumen
203 GO:0005634 nucleus
206 GO:0005829 cytosol
217 GO:0005829 cytosol
217 GO:0043232 intracellular non-membrane-bounded organelle
252 GO:0005634 nucleus
260 GO:0005829 cytosol
273 GO:0043232 intracellular non-membrane-bounded organelle
273 GO:0005654 nucleoplasm
281 GO:0005634 nucleus
331 GO:0005654 nucleoplasm
376 GO:0005829 cytosol
376 GO:0005634 nucleus
411 GO:0005634 nucleus
436 GO:0031224 intrinsic component of membrane
467 GO:0005654 nucleoplasm
473 GO:0005634 nucleus
483 GO:0005829 cytosol
483 GO:0031981 nuclear lumen
493 GO:0031981 nuclear lumen
507 GO:0044428 nuclear part
511 GO:0005634 nucleus
532 GO:0005829 cytosol
532 GO:0043232 intracellular non-membrane-bounded organelle
532 GO:0005634 nucleus
559 GO:0031981 nuclear lumen
560 GO:0005829 cytosol
563 GO:0005634 nucleus
588 GO:0031981 nuclear lumen
639 GO:0005634 nucleus
649 GO:0070013 intracellular organelle lumen
649 GO:0005634 nucleus
657 GO:0005634 nucleus
681 GO:0005654 nucleoplasm
689 GO:0005654 nucleoplasm
714 GO:0031981 nuclear lumen
715 GO:0031981 nuclear lumen
728 GO:0005829 cytosol
728 GO:0005634 nucleus
749 GO:0005829 cytosol
754 GO:0005654 nucleoplasm
811 GO:0005829 cytosol
811 GO:0044428 nuclear part
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000245 spliceosomal complex assembly IDA
GO:0001525 angiogenesis ISS
GO:0006468 protein phosphorylation IDA
GO:0008284 positive regulation of cell proliferation IDA
GO:0008380 RNA splicing IDA
GO:0010628 positive regulation of gene expression ISS
GO:0030154 cell differentiation IEA
GO:0035063 nuclear speck organization ISS
GO:0035556 intracellular signal transduction IDA
GO:0043525 positive regulation of neuron apoptotic process ISS
GO:0045070 positive regulation of viral genome replication IDA
GO:0045071 negative regulation of viral genome replication IDA
GO:0045087 innate immune response IC
GO:0045787 positive regulation of cell cycle ISS
GO:0048024 regulation of mRNA splicing, via spliceosome TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm IDA
GO:0005730 nucleolus IDA
GO:0005737 cytoplasm IDA
GO:0005829 cytosol IDA
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
PSA3_HUMAN Yes: P25788 (MoonDB)
PR20D_HUMAN No
PROP1_HUMAN No
COIL_HUMAN No
RBM39_HUMAN No
MMTA2_HUMAN No
AES_HUMAN Yes: Q08117 (MoonDB)
LCE3D_HUMAN No
ABC3C_HUMAN No
FXR2_HUMAN No
DDX6_HUMAN No
NCK2_HUMAN Yes: O43639 (MoonDB)
EVI5L_HUMAN No
HOME3_HUMAN No
F90A1_HUMAN No
WDR5_HUMAN No
LCA5_HUMAN No
RNPS1_HUMAN No
NXT2_HUMAN No
MB212_HUMAN No
PPIL1_HUMAN No
RU17_HUMAN Yes: P08621 (MoonDB)
CLK1_HUMAN No
SRS11_HUMAN No
U2AFM_HUMAN No
SRRM1_HUMAN No
SNIP1_HUMAN Yes: Q8TAD8 (MoonDB)
RSRC1_HUMAN No
LUZP4_HUMAN No
LC7L2_HUMAN No
ERCC3_HUMAN No
CLD19_HUMAN No
DBF4B_HUMAN No
CLK2_HUMAN No
HNRPC_HUMAN No
RNF4_HUMAN No
GBRL1_HUMAN No
TRI41_HUMAN Yes: Q8WV44 (MoonDB)
1433B_HUMAN No
AAPK1_HUMAN No
ABL1_HUMAN Yes: P00519 (MoonDB)
ACHA5_HUMAN No
ACINU_HUMAN No
ADAP1_HUMAN No
ADPRH_HUMAN No
AGRG5_HUMAN No
ALKB3_HUMAN No
AMERL_HUMAN No
APEX1_HUMAN No
AR6P4_HUMAN No
ARC1B_HUMAN No
ARGL1_HUMAN No
ATAT_HUMAN No
AURKA_HUMAN No
BAIP2_HUMAN No
BCE1_HUMAN No
BORG4_HUMAN No
BRD3_HUMAN No
CA174_HUMAN No
CAND1_HUMAN No
CBLN4_HUMAN No
CBX5_HUMAN Yes: P45973 (MoonDB)
CC28A_HUMAN No
CCD97_HUMAN No
CCG2_HUMAN No
CCM2_HUMAN No
CD046_HUMAN No
CD53_HUMAN No
CDK7_HUMAN No
CHD2_HUMAN No
CHERP_HUMAN Yes: Q8IWX8 (MoonDB)
CHTOP_HUMAN No
CLIC5_HUMAN No
CLK3_HUMAN No
CP078_HUMAN No
CR025_HUMAN No
CSAG1_HUMAN No
CSKP_HUMAN No
CTBL1_HUMAN No
D42E1_HUMAN No
DAW1_HUMAN No
DDX21_HUMAN No
DDX46_HUMAN No
DHX8_HUMAN No
DNJB7_HUMAN No
DNJC8_HUMAN No
DPOLB_HUMAN No
DRG1_HUMAN No
E41L1_HUMAN No
E41LA_HUMAN No
EGLN2_HUMAN No
ENOX2_HUMAN No
ERN1_HUMAN No
ES8L3_HUMAN No
FA76B_HUMAN No
FCF1_HUMAN No
FGF12_HUMAN No
FOXN3_HUMAN No
FXR1_HUMAN No
GBRAP_HUMAN Yes: O95166 (MoonDB)
GOG6A_HUMAN No
HBS1L_HUMAN No
HIRP3_HUMAN No
HMCES_HUMAN No
HMGN3_HUMAN No
HXB6_HUMAN No
IF1AY_HUMAN No
IFIT5_HUMAN No
IKKA_HUMAN No
KCNN2_HUMAN No
LRN4L_HUMAN No
LUC7L_HUMAN No
MAGB1_HUMAN No
MAPK5_HUMAN No
MARHA_HUMAN No
MCLN3_HUMAN No
MK_HUMAN No
MPP3_HUMAN No
NC2A_HUMAN No
NCBP3_HUMAN No
NELFE_HUMAN No
NGLY1_HUMAN No
NOM1_HUMAN No
NOP16_HUMAN No
NPM2_HUMAN No
NSE4A_HUMAN No
NSRP1_HUMAN No
NUP50_HUMAN No
OCEL1_HUMAN No
OR5A1_HUMAN No
PABP4_HUMAN No
PAK4_HUMAN No
PDE7B_HUMAN No
PELI1_HUMAN No
PPIA_HUMAN No
PR38A_HUMAN No
PTBP1_HUMAN No
Q7Z3Y4_HUMAN No
RBM15_HUMAN No
RBM23_HUMAN No
RBM8A_HUMAN No
RHG12_HUMAN No
RIT1_HUMAN No
RIT2_HUMAN No
RL22_HUMAN No
RL39L_HUMAN No
RL41_HUMAN No
RSRC2_HUMAN No
RSRP1_HUMAN No
RT06_HUMAN No
RT11_HUMAN No
RTF1_HUMAN No
RWD2B_HUMAN No
SAHH2_HUMAN No
SC23B_HUMAN No
SELS_HUMAN No
SERF1_HUMAN No
SLAI2_HUMAN No
SNR27_HUMAN No
SNURF_HUMAN No
SORCN_HUMAN No
SP16H_HUMAN No
SREK1_HUMAN No
SRS10_HUMAN No
SRS12_HUMAN No
SRSF1_HUMAN No
SRSF3_HUMAN No
SRSF5_HUMAN No
SRSF7_HUMAN No
SRSF8_HUMAN No
SRSF9_HUMAN No
STON1_HUMAN No
T2EA_HUMAN No
TAF7L_HUMAN No
TCOF_HUMAN No
TITIN_HUMAN Yes: Q8WZ42 (MoonDB)
TM14A_HUMAN No
TNIP2_HUMAN No
TPD52_HUMAN No
TR10C_HUMAN No
TRA2A_HUMAN No
TRA2B_HUMAN No
TRUB1_HUMAN No
TYDP2_HUMAN No
U1SBP_HUMAN No
U2AF1_HUMAN No
U2AF2_HUMAN No
UB2E2_HUMAN Yes: Q96LR5 (MoonDB)
UBD_HUMAN No
VAV2_HUMAN Yes: P52735 (MoonDB)
VRK1_HUMAN No
YPEL2_HUMAN No
YPEL3_HUMAN No
YTDC1_HUMAN No
ZMAT4_HUMAN No
ZN321_HUMAN No
ZRAB2_HUMAN No
ZSC12_HUMAN No
ZSC9_HUMAN No
PMID Article Title
9472028 SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells.
12134018 Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein.
12853948 The DNA sequence of human chromosome 7.
15144186 Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16122776 Suppression of hepatitis B virus replication by SRPK1 and SRPK2 via a pathway independent of the phosphorylation of the viral core protein.
16964243 A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
17344846 Patterns of somatic mutation in human cancer genomes.
18425142 Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome.
18559500 Serine/arginine protein-specific kinase 2 promotes leukemia cell proliferation by phosphorylating acinus and regulating cyclin A1.
18669648 A quantitative atlas of mitotic phosphorylation.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19592491 Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21056976 The N-terminal fragment from caspase-cleaved serine/arginine protein-specific kinase2 (SRPK2) translocates into the nucleus and promotes apoptosis.
21157427 Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin.
21205200 Serine-arginine protein kinases: a small protein kinase family with a large cellular presence.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
No results found.
Domain Name Domain ID Source
Prot_kinase_dom IPR000719 InterPro
Ser/Thr_kinase_AS IPR008271 InterPro
Kinase-like_dom_sf IPR011009 InterPro
Protein_kinase_ATP_BS IPR017441 InterPro
Pkinase PF00069 Pfam
PROTEIN_KINASE_ATP PS00107 PROSITE
PROTEIN_KINASE_ST PS00108 PROSITE
PROTEIN_KINASE_DOM PS50011 PROSITE
S_TKc SM00220 SMART
SSF56112 SSF56112 SUPFAM