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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: P78362
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
P78362 (Uniprot)
SRPK2_HUMAN
SRPK2
SRSF protein kinase 2
human
No
Protein Function
Uniprot:
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by u
p-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles.
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MoonDB Dissimilar Functions
Showing 1 to 10 of 10 entries
Search:
GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0006396
RNA processing
681
GO:0002376
immune system process
811
1.36e-06
3.84e-29
GO:0007165
signal transduction
141
GO:0034641
cellular nitrogen compound metabolic process
47
4.22e-144
6.90e-18
GO:0007165
signal transduction
141
GO:0016070
RNA metabolic process
75
,
689
,
715
3.11e-78
2.75e-26
GO:0007165
signal transduction
141
GO:0000377
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
467
4.83e-02
1.79e-71
GO:0007165
signal transduction
141
GO:0006396
RNA processing
681
3.78e-31
3.47e-84
GO:0016070
RNA metabolic process
75
,
689
,
715
GO:0002376
immune system process
811
5.68e-23
7.16e-26
GO:0019538
protein metabolic process
129
,
376
,
474
,
563
,
728
GO:0016070
RNA metabolic process
75
,
689
,
715
5.15e-08
2.82e-13
GO:0019538
protein metabolic process
129
,
376
,
474
,
563
,
728
GO:0000377
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
467
1.88e-02
4.66e-37
GO:0036211
protein modification process
483
,
560
GO:0016070
RNA metabolic process
75
,
689
,
715
5.81e-04
8.44e-05
GO:0036211
protein modification process
483
,
560
GO:0006396
RNA processing
681
5.60e-03
3.14e-16
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MoonDB Network Modules
Biological Processes
Showing 1 to 10 of 114 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
38
GO:0007165
signal transduction
47
GO:0044271
cellular nitrogen compound biosynthetic process
47
GO:0051252
regulation of RNA metabolic process
47
GO:0010468
regulation of gene expression
70
GO:0051252
regulation of RNA metabolic process
70
GO:0010468
regulation of gene expression
70
GO:0006351
transcription, DNA-templated
75
GO:0016071
mRNA metabolic process
75
GO:0051252
regulation of RNA metabolic process
75
GO:0010468
regulation of gene expression
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Cellular Components
Showing 1 to 10 of 62 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
47
GO:0005654
nucleoplasm
65
GO:0012505
endomembrane system
65
GO:0016021
integral component of membrane
70
GO:0005654
nucleoplasm
75
GO:0005829
cytosol
75
GO:0005654
nucleoplasm
80
GO:0005634
nucleus
93
GO:0005829
cytosol
93
GO:0005634
nucleus
96
GO:0005654
nucleoplasm
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Protein GO Annotations
Biological Processes
Showing 1 to 10 of 15 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0000245
spliceosomal complex assembly
IDA
GO:0001525
angiogenesis
ISS
GO:0006468
protein phosphorylation
IDA
GO:0008284
positive regulation of cell proliferation
IDA
GO:0008380
RNA splicing
IDA
GO:0010628
positive regulation of gene expression
ISS
GO:0030154
cell differentiation
IEA
GO:0035063
nuclear speck organization
ISS
GO:0035556
intracellular signal transduction
IDA
GO:0043525
positive regulation of neuron apoptotic process
ISS
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Cellular Components
Showing 1 to 5 of 5 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0005634
nucleus
IDA
GO:0005654
nucleoplasm
IDA
GO:0005730
nucleolus
IDA
GO:0005737
cytoplasm
IDA
GO:0005829
cytosol
IDA
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Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Showing 1 to 10 of 199 entries
Search:
Interactor
Also a MoonDB EMF protein
1433B_HUMAN
No
AAPK1_HUMAN
No
ABC3C_HUMAN
No
ABL1_HUMAN
Yes:
P00519 (MoonDB)
ACHA5_HUMAN
No
ACINU_HUMAN
No
ADAP1_HUMAN
No
ADPRH_HUMAN
No
AES_HUMAN
Yes:
Q08117 (MoonDB)
AGRG5_HUMAN
No
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Publications Associated
Showing 1 to 10 of 23 entries
Search:
PMID
Article Title
9472028
SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells.
12134018
Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein.
12853948
The DNA sequence of human chromosome 7.
15144186
Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
15489334
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16122776
Suppression of hepatitis B virus replication by SRPK1 and SRPK2 via a pathway independent of the phosphorylation of the viral core protein.
16964243
A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
17344846
Patterns of somatic mutation in human cancer genomes.
18425142
Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome.
18559500
Serine/arginine protein-specific kinase 2 promotes leukemia cell proliferation by phosphorylating acinus and regulating cyclin A1.
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OMIM Diseases Associated
No results found.
Protein Domains Associated
Showing 1 to 10 of 10 entries
Search:
Domain Name
Domain ID
Source
Kinase-like_dom_sf
IPR011009
InterPro
Pkinase
PF00069
Pfam
Prot_kinase_dom
IPR000719
InterPro
PROTEIN_KINASE_ATP
PS00107
PROSITE
Protein_kinase_ATP_BS
IPR017441
InterPro
PROTEIN_KINASE_DOM
PS50011
PROSITE
PROTEIN_KINASE_ST
PS00108
PROSITE
S_TKc
SM00220
SMART
Ser/Thr_kinase_AS
IPR008271
InterPro
SSF56112
SSF56112
SUPFAM
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