Protein: P78362 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P78362 (Uniprot)	SRPK2_HUMAN	SRPK2	SRSF protein kinase 2	human	No

Protein Function

Uniprot: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by u more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006396	RNA processing	681	GO:0002376	immune system process	811	1.36e-06	3.84e-29
GO:0007165	signal transduction	141	GO:0034641	cellular nitrogen compound metabolic process	47	4.22e-144	6.90e-18
GO:0007165	signal transduction	141	GO:0016070	RNA metabolic process	75, 689, 715	3.11e-78	2.75e-26
GO:0007165	signal transduction	141	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	467	4.83e-02	1.79e-71
GO:0007165	signal transduction	141	GO:0006396	RNA processing	681	3.78e-31	3.47e-84
GO:0016070	RNA metabolic process	75, 689, 715	GO:0002376	immune system process	811	5.68e-23	7.16e-26
GO:0019538	protein metabolic process	129, 376, 474, 563, 728	GO:0016070	RNA metabolic process	75, 689, 715	5.15e-08	2.82e-13
GO:0019538	protein metabolic process	129, 376, 474, 563, 728	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	467	1.88e-02	4.66e-37
GO:0036211	protein modification process	483, 560	GO:0016070	RNA metabolic process	75, 689, 715	5.81e-04	8.44e-05
GO:0036211	protein modification process	483, 560	GO:0006396	RNA processing	681	5.60e-03	3.14e-16

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MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 114 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
38	GO:0007165	signal transduction
47	GO:0044271	cellular nitrogen compound biosynthetic process
47	GO:0051252	regulation of RNA metabolic process
47	GO:0010468	regulation of gene expression
70	GO:0051252	regulation of RNA metabolic process
70	GO:0010468	regulation of gene expression
70	GO:0006351	transcription, DNA-templated
75	GO:0016071	mRNA metabolic process
75	GO:0051252	regulation of RNA metabolic process
75	GO:0010468	regulation of gene expression

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Cellular Components

Showing 1 to 10 of 62 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
47	GO:0005654	nucleoplasm
65	GO:0012505	endomembrane system
65	GO:0016021	integral component of membrane
70	GO:0005654	nucleoplasm
75	GO:0005829	cytosol
75	GO:0005654	nucleoplasm
80	GO:0005634	nucleus
93	GO:0005829	cytosol
93	GO:0005634	nucleus
96	GO:0005654	nucleoplasm

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000245	spliceosomal complex assembly	IDA
GO:0001525	angiogenesis	ISS
GO:0006468	protein phosphorylation	IDA
GO:0008284	positive regulation of cell proliferation	IDA
GO:0008380	RNA splicing	IDA
GO:0010628	positive regulation of gene expression	ISS
GO:0030154	cell differentiation	IEA
GO:0035063	nuclear speck organization	ISS
GO:0035556	intracellular signal transduction	IDA
GO:0043525	positive regulation of neuron apoptotic process	ISS

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Cellular Components

Showing 1 to 5 of 5 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	IDA
GO:0005730	nucleolus	IDA
GO:0005737	cytoplasm	IDA
GO:0005829	cytosol	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 199 entries

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Interactor	Also a MoonDB EMF protein
1433B_HUMAN	No
AAPK1_HUMAN	No
ABC3C_HUMAN	No
ABL1_HUMAN	Yes: P00519 (MoonDB)
ACHA5_HUMAN	No
ACINU_HUMAN	No
ADAP1_HUMAN	No
ADPRH_HUMAN	No
AES_HUMAN	Yes: Q08117 (MoonDB)
AGRG5_HUMAN	No

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Publications Associated

Showing 1 to 10 of 23 entries

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PMID	Article Title
9472028	SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells.
12134018	Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein.
12853948	The DNA sequence of human chromosome 7.
15144186	Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16122776	Suppression of hepatitis B virus replication by SRPK1 and SRPK2 via a pathway independent of the phosphorylation of the viral core protein.
16964243	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
17344846	Patterns of somatic mutation in human cancer genomes.
18425142	Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome.
18559500	Serine/arginine protein-specific kinase 2 promotes leukemia cell proliferation by phosphorylating acinus and regulating cyclin A1.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 10 entries

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Domain Name	Domain ID	Source
Kinase-like_dom_sf	IPR011009	InterPro
Pkinase	PF00069	Pfam
Prot_kinase_dom	IPR000719	InterPro
PROTEIN_KINASE_ATP	PS00107	PROSITE
Protein_kinase_ATP_BS	IPR017441	InterPro
PROTEIN_KINASE_DOM	PS50011	PROSITE
PROTEIN_KINASE_ST	PS00108	PROSITE
S_TKc	SM00220	SMART
Ser/Thr_kinase_AS	IPR008271	InterPro
SSF56112	SSF56112	SUPFAM

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