Protein: O43639

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
O43639 (Uniprot) NCK2_HUMAN NCK2 Cytoplasmic protein NCK2 human No
Uniprot: Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0002376 immune system process 111 GO:0006396 RNA processing 681 1.36e-06 3.84e-29
GO:0007165 signal transduction 187 GO:0006396 RNA processing 681 3.78e-31 3.47e-84
GO:0010646 regulation of cell communication 284 GO:0006396 RNA processing 681 4.71e-17 5.67e-104
GO:0036211 protein modification process 423, 555 GO:0006396 RNA processing 681 5.60e-03 3.14e-16
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
44 GO:0010467 gene expression
44 GO:0031324 negative regulation of cellular metabolic process
44 GO:0009889 regulation of biosynthetic process
44 GO:0060255 regulation of macromolecule metabolic process
111 GO:0006955 immune response
111 GO:0035556 intracellular signal transduction
111 GO:0009967 positive regulation of signal transduction
111 GO:0006468 protein phosphorylation
111 GO:0060255 regulation of macromolecule metabolic process
111 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
187 GO:0007166 cell surface receptor signaling pathway
187 GO:0006464 cellular protein modification process
187 GO:0070887 cellular response to chemical stimulus
187 GO:0035556 intracellular signal transduction
187 GO:0006928 movement of cell or subcellular component
187 GO:0006796 phosphate-containing compound metabolic process
187 GO:0010647 positive regulation of cell communication
187 GO:0048584 positive regulation of response to stimulus
187 GO:0023056 positive regulation of signaling
187 GO:0060255 regulation of macromolecule metabolic process
187 GO:0009966 regulation of signal transduction
254 GO:0044267 cellular protein metabolic process
254 GO:0048584 positive regulation of response to stimulus
254 GO:0010468 regulation of gene expression
254 GO:0007165 signal transduction
284 GO:0009966 regulation of signal transduction
423 GO:0006464 cellular protein modification process
423 GO:0090304 nucleic acid metabolic process
423 GO:0060255 regulation of macromolecule metabolic process
555 GO:0006464 cellular protein modification process
555 GO:0060255 regulation of macromolecule metabolic process
555 GO:0007165 signal transduction
603 GO:0060255 regulation of macromolecule metabolic process
649 GO:0016070 RNA metabolic process
649 GO:0010468 regulation of gene expression
664 GO:0044267 cellular protein metabolic process
664 GO:0010467 gene expression
664 GO:0090304 nucleic acid metabolic process
664 GO:0060255 regulation of macromolecule metabolic process
664 GO:0007165 signal transduction
681 GO:0008380 RNA splicing
681 GO:0006397 mRNA processing
681 GO:0051252 regulation of RNA metabolic process
681 GO:0010468 regulation of gene expression
834 GO:0051252 regulation of RNA metabolic process
834 GO:2000112 regulation of cellular macromolecule biosynthetic process
834 GO:0010468 regulation of gene expression
834 GO:0006351 transcription, DNA-templated
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
44 GO:0005829 cytosol
44 GO:0005634 nucleus
104 GO:0005829 cytosol
104 GO:0005815 microtubule organizing center
105 GO:0005634 nucleus
111 GO:0005829 cytosol
111 GO:0005886 plasma membrane
187 GO:0005829 cytosol
187 GO:0005886 plasma membrane
254 GO:0005829 cytosol
254 GO:0005634 nucleus
260 GO:0005829 cytosol
284 GO:0005829 cytosol
284 GO:0005886 plasma membrane
423 GO:0005829 cytosol
423 GO:0005634 nucleus
555 GO:0005634 nucleus
603 GO:0005634 nucleus
633 GO:0005829 cytosol
633 GO:0031982 vesicle
649 GO:0070013 intracellular organelle lumen
649 GO:0005634 nucleus
664 GO:0005829 cytosol
664 GO:0043232 intracellular non-membrane-bounded organelle
664 GO:0005634 nucleus
681 GO:0005654 nucleoplasm
735 GO:0005829 cytosol
834 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0001771 immunological synapse formation IEA
GO:0007015 actin filament organization IEA
GO:0007165 signal transduction TAS
GO:0007172 signal complex assembly NAS
GO:0007173 epidermal growth factor receptor signaling pathway TAS
GO:0007176 regulation of epidermal growth factor-activated receptor activity TAS
GO:0008285 negative regulation of cell proliferation TAS
GO:0016477 cell migration IEA
GO:0030032 lamellipodium assembly IEA
GO:0030838 positive regulation of actin filament polymerization IMP
GO:0033137 negative regulation of peptidyl-serine phosphorylation IDA
GO:0036493 positive regulation of translation in response to endoplasmic reticulum stress IEA
GO:0042102 positive regulation of T cell proliferation IMP
GO:0042110 T cell activation NAS
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA
GO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
GO:0048013 ephrin receptor signaling pathway TAS
GO:0060996 dendritic spine development IEA
GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
GO:1903898 negative regulation of PERK-mediated unfolded protein response IEA
GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IDA
GO:1990441 negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005737 cytoplasm IDA
GO:0005783 endoplasmic reticulum IDA
GO:0005829 cytosol TAS
GO:0012506 vesicle membrane IEA
GO:0014069 postsynaptic density IEA
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
SHD_HUMAN No
ZN526_HUMAN No
PR20D_HUMAN No
MEOX2_HUMAN Yes: P50222 (MoonDB)
HSF2B_HUMAN No
TRI27_HUMAN Yes: P14373 (MoonDB)
ITF2_HUMAN No
REL_HUMAN No
NHSL2_HUMAN No
ABI2_HUMAN Yes: Q9NYB9 (MoonDB)
FXR2_HUMAN No
KPRP_HUMAN No
TRIP6_HUMAN No
A0A0C4DGW7_HUMAN No
ABI3_HUMAN No
ANR55_HUMAN No
ATN1_HUMAN No
BC11A_HUMAN No
BCAP_HUMAN No
BCAR1_HUMAN No
CBLB_HUMAN No
CC120_HUMAN No
CCD33_HUMAN No
CD017_HUMAN No
CD3E_HUMAN No
CE170_HUMAN No
CEP19_HUMAN Yes: Q96LK0 (MoonDB)
CEP44_HUMAN No
CHIN_HUMAN No
CHIO_HUMAN No
CL17A_HUMAN No
CPSF6_HUMAN No
CPSF7_HUMAN No
DB124_HUMAN No
DDR1_HUMAN No
DISC1_HUMAN Yes: Q9NRI5 (MoonDB)
DLGP4_HUMAN No
DOCK1_HUMAN No
DTX3_HUMAN No
DVL1_HUMAN No
EF1G_HUMAN No
EFHC2_HUMAN No
EFNB2_HUMAN No
EGFR_HUMAN Yes: P00533 (MoonDB)
EIF3H_HUMAN No
ERBB2_HUMAN Yes: P04626 (MoonDB)
ERBB3_HUMAN Yes: P21860 (MoonDB)
FA53C_HUMAN No
FA83A_HUMAN No
FCRL2_HUMAN No
FGFR1_HUMAN No
FOSB_HUMAN No
FYB1_HUMAN No
GAB1_HUMAN Yes: Q13480 (MoonDB)
GARE1_HUMAN No
GGN_HUMAN No
HNRPK_HUMAN Yes: P61978 (MoonDB)
HOMEZ_HUMAN No
HXC4_HUMAN No
INCA1_HUMAN No
K0408_HUMAN No
KAT6B_HUMAN Yes: Q8WYB5 (MoonDB)
KCD17_HUMAN No
KIT_HUMAN No
KLH24_HUMAN No
KLH35_HUMAN No
LCP2_HUMAN No
LIMS1_HUMAN No
LNX1_HUMAN Yes: Q8TBB1 (MoonDB)
LRIQ3_HUMAN No
LZTS2_HUMAN No
MAGA6_HUMAN No
MASP1_HUMAN No
MBD6_HUMAN No
MET_HUMAN No
MNT_HUMAN No
MYPOP_HUMAN No
NC2A_HUMAN No
NPAS2_HUMAN No
NTM2F_HUMAN No
NTRK2_HUMAN No
PAK1_HUMAN Yes: Q13153 (MoonDB)
PAK2_HUMAN No
PBX4_HUMAN No
PGFRB_HUMAN No
PKHN1_HUMAN No
PKN2_HUMAN No
PR20A_HUMAN No
PR20C_HUMAN No
Q86TH3_HUMAN No
RASF7_HUMAN No
RB8NL_HUMAN No
RBM26_HUMAN No
RHG32_HUMAN No
RHOU_HUMAN No
RHOV_HUMAN No
RTN4_HUMAN No
SCML2_HUMAN No
SF3A2_HUMAN No
SF3B4_HUMAN No
SKT_HUMAN No
SOCS7_HUMAN No
SPA2L_HUMAN No
SPC1L_HUMAN No
SPN90_HUMAN No
SPY2_HUMAN No
SRBS2_HUMAN No
SRPK1_HUMAN Yes: Q96SB4 (MoonDB)
SRPK2_HUMAN Yes: P78362 (MoonDB)
STF1_HUMAN No
SYGP1_HUMAN No
SYVM_HUMAN No
TENR_HUMAN No
TGO1_HUMAN No
TM121_HUMAN No
TNFL6_HUMAN No
TRI15_HUMAN Yes: Q9C019 (MoonDB)
TRI41_HUMAN Yes: Q8WV44 (MoonDB)
TXK_HUMAN No
UBC_HUMAN Yes: P0CG48 (MoonDB)
UBP32_HUMAN No
VP37B_HUMAN No
WASF1_HUMAN No
WASL_HUMAN No
WASP_HUMAN No
WBP11_HUMAN No
WIPF1_HUMAN No
ZBT12_HUMAN No
ZBT42_HUMAN No
ZBT7B_HUMAN No
ZC21A_HUMAN No
ZN341_HUMAN No
PMID Article Title
9737977 Identification of Nck family genes, chromosomal localization, expression, and signaling specificity.
9843575 Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways.
10026169 Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck.
10330411 Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: a role in cytoskeletal remodeling.
11240126 Identification and kinetic analysis of the interaction between Nck-2 and DOCK180.
12470648 Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16337946 Pinpointing phosphotyrosine-dependent interactions downstream of the collagen receptor DDR1.
16835242 Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress.
18088087 Phosphoproteome of resting human platelets.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19807924 Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
22223895 Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
No results found.
Domain Name Domain ID Source
SH2 IPR000980 InterPro
SH3_domain IPR001452 InterPro
NCK IPR017304 InterPro
Nck2_SH3_1 IPR035559 InterPro
Nck2_SH3_2 IPR035560 InterPro
Nck2_SH3_3 IPR035561 InterPro
Nck2_SH2 IPR035883 InterPro
SH3-like_dom_sf IPR036028 InterPro
SH2_dom_sf IPR036860 InterPro
SH2 PF00017 Pfam
SH3_1 PF00018 Pfam
SH3_9 PF14604 Pfam
Cytoplasmic_NCK PIRSF037874 PIRSF
SH2DOMAIN PR00401 PRINTS
SH3DOMAIN PR00452 PRINTS
SH2 PS50001 PROSITE
SH3 PS50002 PROSITE
SH2 SM00252 SMART
SH3 SM00326 SMART
SSF50044 SSF50044 SUPFAM
SSF55550 SSF55550 SUPFAM
SH2_Nck2 cd10409 CDD
SH3_Nck2_1 cd11899 CDD
SH3_Nck2_2 cd11902 CDD
SH3_Nck2_3 cd11903 CDD