Protein: P50222 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P50222 (Uniprot)	MEOX2_HUMAN	MEOX2	Homeobox protein MOX-2	human	No

Protein Function

Uniprot: Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006139	nucleobase-containing compound metabolic process	219, 354, 480, 527	GO:0007165	signal transduction	828	1.10e-111	5.07e-25
GO:0006725	cellular aromatic compound metabolic process	66, 741	GO:0007165	signal transduction	828	5.44e-126	5.27e-27

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MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 95 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
56	GO:0044267	cellular protein metabolic process
56	GO:0060255	regulation of macromolecule metabolic process
63	GO:0010467	gene expression
63	GO:0090304	nucleic acid metabolic process
63	GO:0060255	regulation of macromolecule metabolic process
66	GO:0006139	nucleobase-containing compound metabolic process
73	GO:0006355	regulation of transcription, DNA-templated
77	GO:0007165	signal transduction
100	GO:0016070	RNA metabolic process
100	GO:0034645	cellular macromolecule biosynthetic process

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Cellular Components

Showing 1 to 10 of 50 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
56	GO:0005829	cytosol
63	GO:0005634	nucleus
73	GO:0005634	nucleus
77	GO:0070013	intracellular organelle lumen
77	GO:0005634	nucleus
95	GO:0005634	nucleus
100	GO:0005829	cytosol
100	GO:0005634	nucleus
102	GO:0005634	nucleus
124	GO:0031981	nuclear lumen

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0001525	angiogenesis	IEA
GO:0001757	somite specification	IEA
GO:0006366	transcription from RNA polymerase II promoter	IEA
GO:0007275	multicellular organism development	TAS
GO:0007519	skeletal muscle tissue development	IEA
GO:0008015	blood circulation	TAS
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IMP
GO:0060021	palate development	IEA
GO:0060173	limb development	IEA
GO:0061053	somite development	IBA

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Cellular Components

Showing 1 to 3 of 3 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005737	cytoplasm	IDA
GO:0016607	nuclear speck	IEA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 684 entries

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Interactor	Also a MoonDB EMF protein
1A01_HUMAN	No
3BHS7_HUMAN	No
5HT1E_HUMAN	No
7B2_HUMAN	No
A0A024R6G0_HUMAN	No
A0A024R8A9_HUMAN	No
A0A087WY75_HUMAN	No
A0A087WZT3_HUMAN	No
A0A0C4DFM2_HUMAN	No
A0A0C4DGQ3_HUMAN	No

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Publications Associated

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PMID	Article Title
7607679	Isolation of the human MOX2 homeobox gene and localization to chromosome 7p22.1-p21.3.
7713505	Molecular cloning and localization of the human GAX gene to 7p21.
12690205	Human chromosome 7: DNA sequence and biology.
12853948	The DNA sequence of human chromosome 7.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16335786	Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10.
19266028	Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment.
19760604	Two candidate tumor suppressor genes, MEOX2 and SOSTDC1, identified in a 7p21 homozygous deletion region in a Wilms tumor.
22206000	Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 13 entries

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Domain Name	Domain ID	Source
A55641	A55641	PIR
A56837	A56837	PIR
Homeobox	PF00046	Pfam
HOMEOBOX	PR00024	PRINTS
Homeobox-like_sf	IPR009057	InterPro
HOMEOBOX_1	PS00027	PROSITE
HOMEOBOX_2	PS50071	PROSITE
Homeobox_CS	IPR017970	InterPro
Homeobox_dom	IPR001356	InterPro
Homeobox_metazoa	IPR020479	InterPro

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