Protein: Q13064

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q13064 (Uniprot) MKRN3_HUMAN MKRN3 Probable E3 ubiquitin-protein ligase makorin-3 human No
Uniprot: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009056 catabolic process 125 GO:0009059 macromolecule biosynthetic process 5, 384 6.37e-04 1.88e-40
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
5 GO:0034645 cellular macromolecule biosynthetic process
5 GO:0006464 cellular protein modification process
5 GO:0090304 nucleic acid metabolic process
5 GO:0034654 nucleobase-containing compound biosynthetic process
5 GO:0060255 regulation of macromolecule metabolic process
125 GO:0044248 cellular catabolic process
125 GO:0016567 protein ubiquitination
125 GO:0060255 regulation of macromolecule metabolic process
334 GO:0016070 RNA metabolic process
334 GO:0010467 gene expression
334 GO:0060255 regulation of macromolecule metabolic process
354 GO:0090304 nucleic acid metabolic process
384 GO:0034645 cellular macromolecule biosynthetic process
384 GO:0006464 cellular protein modification process
384 GO:0090304 nucleic acid metabolic process
384 GO:0031326 regulation of cellular biosynthetic process
384 GO:0060255 regulation of macromolecule metabolic process
384 GO:0007165 signal transduction
425 GO:0006464 cellular protein modification process
456 GO:0010467 gene expression
456 GO:0090304 nucleic acid metabolic process
643 GO:0044267 cellular protein metabolic process
673 GO:0090304 nucleic acid metabolic process
772 GO:0006464 cellular protein modification process
772 GO:0006796 phosphate-containing compound metabolic process
772 GO:0032268 regulation of cellular protein metabolic process
772 GO:0009966 regulation of signal transduction
807 GO:0070647 protein modification by small protein conjugation or removal
818 GO:0070647 protein modification by small protein conjugation or removal
818 GO:0006355 regulation of transcription, DNA-templated
818 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
5 GO:0005829 cytosol
5 GO:0005634 nucleus
60 GO:0005634 nucleus
84 GO:0005634 nucleus
125 GO:0005829 cytosol
125 GO:0005634 nucleus
334 GO:0031981 nuclear lumen
354 GO:0005634 nucleus
384 GO:0005829 cytosol
384 GO:0031981 nuclear lumen
425 GO:0005634 nucleus
643 GO:0005634 nucleus
673 GO:0005634 nucleus
772 GO:0005886 plasma membrane
818 GO:0005829 cytosol
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0016567 protein ubiquitination IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0030529 intracellular ribonucleoprotein complex TAS
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
RBPMS_HUMAN Yes: Q93062 (MoonDB)
PRP31_HUMAN No
CRTP1_HUMAN No
DDT4L_HUMAN Yes: Q96D03 (MoonDB)
TFP11_HUMAN No
PO6F2_HUMAN No
CEP70_HUMAN No
KRA81_HUMAN No
MEOX2_HUMAN Yes: P50222 (MoonDB)
HSF2B_HUMAN No
ARI5A_HUMAN No
RSPO4_HUMAN No
ENKD1_HUMAN No
VINEX_HUMAN No
KRT34_HUMAN No
K2C75_HUMAN No
TRAF2_HUMAN No
ATL4_HUMAN No
KIFC3_HUMAN No
IKZF3_HUMAN No
AES_HUMAN Yes: Q08117 (MoonDB)
PSB1_HUMAN No
PSA1_HUMAN No
CTSR1_HUMAN No
RPAC1_HUMAN No
TSN4_HUMAN No
TCEA2_HUMAN No
GEM_HUMAN No
USBP1_HUMAN No
RBPS2_HUMAN No
WWOX_HUMAN No
LAGE3_HUMAN No
BPIA1_HUMAN No
SYFM_HUMAN No
TS101_HUMAN Yes: Q99816 (MoonDB)
D3DTF8_HUMAN No
HGS_HUMAN No
Q8N4W5_HUMAN No
WDR25_HUMAN No
FA46B_HUMAN No
HSF4_HUMAN No
PKN1_HUMAN No
AQP1_HUMAN No
AAPK2_HUMAN No
T10IP_HUMAN No
TTC23_HUMAN No
Q8IVT4_HUMAN No
CC120_HUMAN No
ZN587_HUMAN No
F110A_HUMAN No
SCNM1_HUMAN No
BEX2_HUMAN No
G3V1X1_HUMAN No
KANK2_HUMAN No
CC185_HUMAN No
G45IP_HUMAN No
UBE2H_HUMAN Yes: P62256 (MoonDB)
AP2A_HUMAN No
DCTN3_HUMAN No
KR196_HUMAN No
Q6ZP95_HUMAN No
STH_HUMAN No
RIBC1_HUMAN No
F161B_HUMAN No
MBD3_HUMAN No
PRR35_HUMAN No
RTP5_HUMAN No
AVPI1_HUMAN No
CL033_HUMAN No
TPRX1_HUMAN No
SMRD1_HUMAN No
ZN414_HUMAN No
IN80B_HUMAN No
UBE2N_HUMAN Yes: P61088 (MoonDB)
UB2V1_HUMAN Yes: Q13404 (MoonDB)
UB2D2_HUMAN Yes: P62837 (MoonDB)
UB2E3_HUMAN Yes: Q969T4 (MoonDB)
KLH38_HUMAN No
PEX5_HUMAN No
F208B_HUMAN No
KRT86_HUMAN No
FBLN3_HUMAN No
1433S_HUMAN No
ADA2C_HUMAN No
ANR11_HUMAN No
APEX2_HUMAN No
B2L11_HUMAN No
BATF2_HUMAN No
CDCA4_HUMAN No
CF195_HUMAN No
CJ082_HUMAN No
CK057_HUMAN No
COG6_HUMAN No
COLI_HUMAN No
EFC4B_HUMAN No
ERCC1_HUMAN No
F124B_HUMAN No
F214B_HUMAN No
GATA1_HUMAN No
GO45_HUMAN No
GOG6A_HUMAN No
GRAP2_HUMAN No
GT253_HUMAN No
GUSP1_HUMAN No
IGF1_HUMAN No
KIF1A_HUMAN No
LRSM1_HUMAN Yes: Q6UWE0 (MoonDB)
MAGD1_HUMAN No
MAT1_HUMAN Yes: P51948 (MoonDB)
MDM2_HUMAN Yes: Q00987 (MoonDB)
MDM4_HUMAN Yes: O15151 (MoonDB)
MEOX1_HUMAN No
MI4GD_HUMAN No
MORN3_HUMAN No
MYOZ2_HUMAN No
NDE1_HUMAN No
PEX10_HUMAN No
PTH1R_HUMAN No
PTK6_HUMAN No
Q0VAL7_HUMAN No
Q8N0U1_HUMAN No
RASD1_HUMAN No
RBM41_HUMAN No
RBX2_HUMAN No
RN166_HUMAN No
RNF32_HUMAN Yes: Q9H0A6 (MoonDB)
RT06_HUMAN No
SF01_HUMAN Yes: Q15637 (MoonDB)
SMYD3_HUMAN No
SOSB2_HUMAN No
STN1_HUMAN No
SYGP1_HUMAN No
TAD2A_HUMAN No
TCHP_HUMAN No
TCL1B_HUMAN No
TRI23_HUMAN No
TRI31_HUMAN No
TRI34_HUMAN No
TRI65_HUMAN No
TRIM5_HUMAN Yes: Q9C035 (MoonDB)
TRIM8_HUMAN Yes: Q9BZR9 (MoonDB)
TTC25_HUMAN No
TXD11_HUMAN No
UB2D1_HUMAN Yes: P51668 (MoonDB)
UB2D3_HUMAN Yes: P61077 (MoonDB)
UB2D4_HUMAN Yes: Q9Y2X8 (MoonDB)
UB2E1_HUMAN Yes: P51965 (MoonDB)
UB2E2_HUMAN Yes: Q96LR5 (MoonDB)
UB2L3_HUMAN Yes: P68036 (MoonDB)
UB2V2_HUMAN No
UBC9_HUMAN Yes: P63279 (MoonDB)
UBE2K_HUMAN Yes: P61086 (MoonDB)
UBE2U_HUMAN Yes: Q5VVX9 (MoonDB)
UBE2W_HUMAN Yes: Q96B02 (MoonDB)
VP9D1_HUMAN No
YV018_HUMAN No
ZBT42_HUMAN No
ZCH13_HUMAN No
ZFP57_HUMAN No
ZIM2_HUMAN No
PMID Article Title
10196367 A novel imprinted gene, encoding a RING zinc-finger protein, and overlapping antisense transcript in the Prader-Willi syndrome critical region.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16959974 The consensus coding sequences of human breast and colorectal cancers.
19066619 A paternal deletion of MKRN3, MAGEL2 and NDN does not result in Prader-Willi syndrome.
23738509 Central precocious puberty caused by mutations in the imprinted gene MKRN3.
24438377 Central precocious puberty in a girl and early puberty in her brother caused by a novel mutation in the MKRN3 gene.
24628548 Central precocious puberty that appears to be sporadic caused by paternally inherited mutations in the imprinted gene makorin ring finger 3.
25011910 MKRN3 mutations in familial central precocious puberty.
25316453 A novel MKRN3 missense mutation causing familial precocious puberty.
OMIM ID Disease Name
615346 Precocious puberty, central 2
Domain Name Domain ID Source
G01614 G01614 PIR
Znf_CCCH IPR000571 InterPro
Znf_RING IPR001841 InterPro
Znf_RING/FYVE/PHD IPR013083 InterPro
Znf_RING_CS IPR017907 InterPro
Znf_C3HC4_RING-type IPR018957 InterPro
Makorin_3 IPR026294 InterPro
MKRN1_C IPR031644 InterPro
Znf_CCCH_sf IPR036855 InterPro
zf-C3HC4 PF00097 Pfam
MKRN1_C PF15815 Pfam
ZF_RING_1 PS00518 PROSITE
ZF_RING_2 PS50089 PROSITE
ZF_C3H1 PS50103 PROSITE
PTHR11224:SF38 PTHR11224:SF38 PANTHER
RING SM00184 SMART
ZnF_C3H1 SM00356 SMART
SSF90229 SSF90229 SUPFAM