Protein: P51965

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P51965 (Uniprot) UB2E1_HUMAN UBE2E1 Ubiquitin-conjugating enzyme E2 E1 human No
Uniprot: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009056 catabolic process 125 GO:0009059 macromolecule biosynthetic process 192, 270 6.37e-04 1.88e-40
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
53 GO:0006139 nucleobase-containing compound metabolic process
53 GO:0016567 protein ubiquitination
53 GO:0060255 regulation of macromolecule metabolic process
125 GO:0044248 cellular catabolic process
125 GO:0016567 protein ubiquitination
125 GO:0060255 regulation of macromolecule metabolic process
192 GO:0034645 cellular macromolecule biosynthetic process
192 GO:0006464 cellular protein modification process
192 GO:0010467 gene expression
192 GO:0090304 nucleic acid metabolic process
192 GO:0009893 positive regulation of metabolic process
192 GO:0060255 regulation of macromolecule metabolic process
192 GO:0007165 signal transduction
270 GO:0034645 cellular macromolecule biosynthetic process
270 GO:0010467 gene expression
270 GO:0090304 nucleic acid metabolic process
270 GO:0032446 protein modification by small protein conjugation
270 GO:0060255 regulation of macromolecule metabolic process
270 GO:0007165 signal transduction
359 GO:0044248 cellular catabolic process
359 GO:0000209 protein polyubiquitination
359 GO:0007165 signal transduction
375 GO:0070647 protein modification by small protein conjugation or removal
375 GO:0060255 regulation of macromolecule metabolic process
575 GO:0016567 protein ubiquitination
575 GO:0060255 regulation of macromolecule metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
53 GO:0005829 cytosol
53 GO:0005654 nucleoplasm
125 GO:0005829 cytosol
125 GO:0005634 nucleus
192 GO:0005829 cytosol
192 GO:0005654 nucleoplasm
270 GO:0005829 cytosol
270 GO:0070013 intracellular organelle lumen
270 GO:0005634 nucleus
359 GO:0005634 nucleus
375 GO:0005829 cytosol
375 GO:0005634 nucleus
575 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000209 protein polyubiquitination IDA
GO:0006511 ubiquitin-dependent protein catabolic process TAS
GO:0010390 histone monoubiquitination IDA
GO:0016567 protein ubiquitination TAS
GO:0031145 anaphase-promoting complex-dependent catabolic process TAS
GO:0032020 ISG15-protein conjugation IDA
GO:0033523 histone H2B ubiquitination IDA
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process TAS
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
GO:0070936 protein K48-linked ubiquitination IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000151 ubiquitin ligase complex IDA
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005829 cytosol TAS
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
8576257 Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16428300 Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme.
16641997 The DNA sequence, annotation and analysis of human chromosome 3.
17588522 E3-independent monoubiquitination of ubiquitin-binding proteins.
18845142 The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
20061386 The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
22496338 A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.
No results found.
Domain Name Domain ID Source
UBQ-conjugat_E2 IPR000608 InterPro
UBQ-conjugating_enzyme/RWD IPR016135 InterPro
UBQ-conjugating_AS IPR023313 InterPro
UQ_con PF00179 Pfam
UBIQUITIN_CONJUGAT_1 PS00183 PROSITE
UBIQUITIN_CONJUGAT_2 PS50127 PROSITE
SSF54495 SSF54495 SUPFAM
UBCc cd00195 CDD