Protein: Q13404

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q13404 (Uniprot) UB2V1_HUMAN UBE2V1 Ubiquitin-conjugating enzyme E2 variant 1 human No
Uniprot: Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 4 GO:0006725 cellular aromatic compound metabolic process 53 5.44e-126 5.27e-27
GO:0009056 catabolic process 125 GO:0009059 macromolecule biosynthetic process 192 6.37e-04 1.88e-40
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
4 GO:0035556 intracellular signal transduction
4 GO:0031399 regulation of protein modification process
4 GO:0009966 regulation of signal transduction
53 GO:0006139 nucleobase-containing compound metabolic process
53 GO:0016567 protein ubiquitination
53 GO:0060255 regulation of macromolecule metabolic process
125 GO:0044248 cellular catabolic process
125 GO:0016567 protein ubiquitination
125 GO:0060255 regulation of macromolecule metabolic process
134 GO:0044267 cellular protein metabolic process
134 GO:0060255 regulation of macromolecule metabolic process
134 GO:0007165 signal transduction
172 GO:0060255 regulation of macromolecule metabolic process
192 GO:0034645 cellular macromolecule biosynthetic process
192 GO:0006464 cellular protein modification process
192 GO:0010467 gene expression
192 GO:0090304 nucleic acid metabolic process
192 GO:0009893 positive regulation of metabolic process
192 GO:0060255 regulation of macromolecule metabolic process
192 GO:0007165 signal transduction
204 GO:0044267 cellular protein metabolic process
358 GO:0006464 cellular protein modification process
358 GO:0060255 regulation of macromolecule metabolic process
358 GO:0007165 signal transduction
359 GO:0044248 cellular catabolic process
359 GO:0000209 protein polyubiquitination
359 GO:0007165 signal transduction
375 GO:0070647 protein modification by small protein conjugation or removal
375 GO:0060255 regulation of macromolecule metabolic process
381 GO:0006464 cellular protein modification process
381 GO:0010467 gene expression
381 GO:0016310 phosphorylation
381 GO:0010604 positive regulation of macromolecule metabolic process
381 GO:0050790 regulation of catalytic activity
381 GO:0032268 regulation of cellular protein metabolic process
381 GO:0007165 signal transduction
425 GO:0006464 cellular protein modification process
474 GO:0044267 cellular protein metabolic process
474 GO:0090304 nucleic acid metabolic process
474 GO:0060255 regulation of macromolecule metabolic process
531 GO:0019538 protein metabolic process
575 GO:0016567 protein ubiquitination
575 GO:0060255 regulation of macromolecule metabolic process
763 GO:0060255 regulation of macromolecule metabolic process
774 GO:0006464 cellular protein modification process
774 GO:0060255 regulation of macromolecule metabolic process
775 GO:0044267 cellular protein metabolic process
775 GO:0010467 gene expression
775 GO:0006139 nucleobase-containing compound metabolic process
775 GO:0060255 regulation of macromolecule metabolic process
803 GO:0007166 cell surface receptor signaling pathway
803 GO:0044267 cellular protein metabolic process
803 GO:0071310 cellular response to organic substance
803 GO:0035556 intracellular signal transduction
803 GO:0009966 regulation of signal transduction
807 GO:0070647 protein modification by small protein conjugation or removal
824 GO:0044267 cellular protein metabolic process
824 GO:0010467 gene expression
824 GO:0007165 signal transduction
829 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
4 GO:0005829 cytosol
4 GO:0005634 nucleus
53 GO:0005829 cytosol
53 GO:0005654 nucleoplasm
125 GO:0005829 cytosol
125 GO:0005634 nucleus
134 GO:0005829 cytosol
134 GO:0005634 nucleus
192 GO:0005829 cytosol
192 GO:0005654 nucleoplasm
204 GO:0005634 nucleus
227 GO:0005634 nucleus
358 GO:0012505 endomembrane system
358 GO:0005615 extracellular space
358 GO:0005886 plasma membrane
358 GO:0031982 vesicle
359 GO:0005634 nucleus
368 GO:0005829 cytosol
368 GO:0005634 nucleus
368 GO:0031982 vesicle
375 GO:0005829 cytosol
375 GO:0005634 nucleus
381 GO:0005829 cytosol
381 GO:0005634 nucleus
425 GO:0005634 nucleus
575 GO:0005654 nucleoplasm
763 GO:0005634 nucleus
774 GO:0005634 nucleus
775 GO:0005829 cytosol
775 GO:0005634 nucleus
803 GO:0016021 integral component of membrane
803 GO:0005886 plasma membrane
829 GO:0005829 cytosol
829 GO:0031982 vesicle
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000187 activation of MAPK activity TAS
GO:0000209 protein polyubiquitination TAS
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0006282 regulation of DNA repair TAS
GO:0006301 postreplication repair IBA
GO:0006355 regulation of transcription, DNA-templated TAS
GO:0007254 JNK cascade TAS
GO:0030154 cell differentiation NAS
GO:0038095 Fc-epsilon receptor signaling pathway TAS
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling TAS
GO:0045893 positive regulation of transcription, DNA-templated TAS
GO:0050852 T cell receptor signaling pathway TAS
GO:0051092 positive regulation of NF-kappaB transcription factor activity TAS
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway TAS
GO:0070534 protein K63-linked ubiquitination IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000151 ubiquitin ligase complex IDA
GO:0005634 nucleus TAS
GO:0005654 nucleoplasm IDA
GO:0005737 cytoplasm IDA
GO:0005829 cytosol TAS
GO:0031371 ubiquitin conjugating enzyme complex IDA
GO:0035370 UBC13-UEV1A complex IDA
GO:0043234 protein complex IDA
GO:0070062 extracellular exosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
GO:0005654 nucleoplasm GO:0070062 extracellular exosome 3.37e-20 1.23e-35
Interactor Also a MoonDB EMF protein
DAZP2_HUMAN Yes: Q15038 (MoonDB)
CTG1B_HUMAN No
UBQL2_HUMAN Yes: Q9UHD9 (MoonDB)
UBQL1_HUMAN No
XIAP_HUMAN Yes: P98170 (MoonDB)
BIRC7_HUMAN No
CHIP_HUMAN Yes: Q9UNE7 (MoonDB)
CALM1_HUMAN Yes: P0DP23 (MoonDB)
HG2A_HUMAN No
RNF5_HUMAN No
HGS_HUMAN No
F168A_HUMAN No
UBE3A_HUMAN Yes: Q05086 (MoonDB)
TRI39_HUMAN No
ARI2_HUMAN No
CCD69_HUMAN No
UBA1_HUMAN No
UBE2N_HUMAN Yes: P61088 (MoonDB)
ACOX1_HUMAN No
AN13A_HUMAN No
AN13D_HUMAN No
APEX2_HUMAN No
ASCC2_HUMAN No
ATX3_HUMAN No
BAP1_HUMAN No
BIRC3_HUMAN No
BIRC8_HUMAN No
CAR14_HUMAN No
CBLB_HUMAN No
CEP85_HUMAN No
CF106_HUMAN No
CREL1_HUMAN No
CUED1_HUMAN No
DBF4B_HUMAN No
DCNL1_HUMAN No
DCNL2_HUMAN No
DEN6B_HUMAN No
DNJB2_HUMAN No
DNJB6_HUMAN No
DP13A_HUMAN Yes: Q9UKG1 (MoonDB)
DTX3_HUMAN No
DZIP3_HUMAN No
EPHA1_HUMAN No
EPN1_HUMAN Yes: Q9Y6I3 (MoonDB)
F184A_HUMAN No
FAF2_HUMAN No
FKBP6_HUMAN No
G3V219_HUMAN No
GGA2_HUMAN No
GRAP1_HUMAN No
HBS1L_HUMAN No
HIP1R_HUMAN No
HIP1_HUMAN Yes: O00291 (MoonDB)
HOIL1_HUMAN No
IMPCT_HUMAN No
INT3_HUMAN No
KRT36_HUMAN No
LRSM1_HUMAN Yes: Q6UWE0 (MoonDB)
MFSD6_HUMAN No
MKRN3_HUMAN Yes: Q13064 (MoonDB)
NUDT6_HUMAN No
PELI1_HUMAN No
PELI2_HUMAN No
POLI_HUMAN No
R144A_HUMAN No
RET2_HUMAN No
RFWD3_HUMAN No
RHBL4_HUMAN No
RING2_HUMAN No
RIOK3_HUMAN No
RN111_HUMAN Yes: Q6ZNA4 (MoonDB)
RN122_HUMAN No
RN135_HUMAN No
RN182_HUMAN No
RN185_HUMAN No
RNF10_HUMAN No
RNF13_HUMAN No
RNF14_HUMAN No
RNF34_HUMAN No
RNF37_HUMAN No
RNF4_HUMAN No
RO52_HUMAN No
SL9B2_HUMAN No
SMUF1_HUMAN No
THA_HUMAN No
TRI11_HUMAN No
TRI18_HUMAN No
TRI23_HUMAN No
TRI32_HUMAN No
TRI52_HUMAN No
TRIM5_HUMAN Yes: Q9C035 (MoonDB)
TRIM8_HUMAN Yes: Q9BZR9 (MoonDB)
TSN17_HUMAN No
UB2D3_HUMAN Yes: P61077 (MoonDB)
UB2E1_HUMAN Yes: P51965 (MoonDB)
UB2E2_HUMAN Yes: Q96LR5 (MoonDB)
UBE2C_HUMAN No
UBE2O_HUMAN Yes: Q9C0C9 (MoonDB)
UBE2S_HUMAN No
UBE2T_HUMAN No
UBQL4_HUMAN No
ZNRF1_HUMAN No
PMID Article Title
9305758 CROC-1 encodes a protein which mediates transcriptional activation of the human FOS promoter.
9418904 Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells.
9580084 Role of UEV-1A, a homologue of the tumor suppressor protein TSG101, in protection from DNA damage.
9705497 The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family.
11057907 Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain.
11076860 Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene.
11780052 The DNA sequence and comparative analysis of human chromosome 20.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16307917 Chaperoned ubiquitylation -- crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex.
16893187 Structure and interactions of the ubiquitin-conjugating enzyme variant human Uev1a: implications for enzymatic synthesis of polyubiquitin chains.
20061386 The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.
21512573 TRIM5 is an innate immune sensor for the retrovirus capsid lattice.
22496338 A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
25944712 N-terminome analysis of the human mitochondrial proteome.
No results found.
Domain Name Domain ID Source
UBQ-conjugat_E2 IPR000608 InterPro
UBQ-conjugating_enzyme/RWD IPR016135 InterPro
UQ_con PF00179 Pfam
UBIQUITIN_CONJUGAT_2 PS50127 PROSITE
SSF54495 SSF54495 SUPFAM