Protein: Q6UWE0 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q6UWE0 (Uniprot)	LRSM1_HUMAN	LRSAM1	E3 ubiquitin-protein ligase LRSAM1	human	No

Protein Function

Uniprot: E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos (PubMed:15256501). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (Pu more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0009056	catabolic process	125	GO:0009059	macromolecule biosynthetic process	192, 391	6.37e-04	1.88e-40

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
125	GO:0044248	cellular catabolic process
125	GO:0016567	protein ubiquitination
125	GO:0060255	regulation of macromolecule metabolic process
192	GO:0034645	cellular macromolecule biosynthetic process
192	GO:0006464	cellular protein modification process
192	GO:0010467	gene expression
192	GO:0090304	nucleic acid metabolic process
192	GO:0009893	positive regulation of metabolic process
192	GO:0060255	regulation of macromolecule metabolic process
192	GO:0007165	signal transduction

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
125	GO:0005829	cytosol
125	GO:0005634	nucleus
192	GO:0005829	cytosol
192	GO:0005654	nucleoplasm
391	GO:0070013	intracellular organelle lumen
391	GO:0005634	nucleus
425	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000209	protein polyubiquitination	IDA
GO:0006914	autophagy	IEA
GO:0007165	signal transduction	IBA
GO:0030163	protein catabolic process	IMP
GO:0045806	negative regulation of endocytosis	IMP
GO:0046755	viral budding	IMP
GO:0051865	protein autoubiquitination	IDA
GO:0070086	ubiquitin-dependent endocytosis	IDA
GO:0098656	anion transmembrane transport	IBA
GO:1904417	positive regulation of xenophagy	IMP

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005737	cytoplasm	IDA
GO:0005829	cytosol	IDA
GO:0005886	plasma membrane	IBA
GO:0016020	membrane	IDA
GO:0034702	ion channel complex	IBA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005829	cytosol	GO:0034702	ion channel complex	6.28e-12	5.86e-10

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ATX1_HUMAN	Yes: P54253 (MoonDB)
ATX7_HUMAN	No
CCDC6_HUMAN	No
F178B_HUMAN	No
GBRL2_HUMAN	Yes: P60520 (MoonDB)
GP108_HUMAN	No
GRIK5_HUMAN	No
HS90B_HUMAN	Yes: P08238 (MoonDB)
KLC1_HUMAN	No
MAGA1_HUMAN	No

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Publications Associated

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PMID	Article Title
12975309	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15164053	DNA sequence and analysis of human chromosome 9.
15256501	Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
17556548	Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery.
18669648	A quantitative atlas of mitotic phosphorylation.
20068231	Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20865121	Mutation in the gene encoding ubiquitin ligase LRSAM1 in patients with Charcot-Marie-Tooth disease.
21269460	Initial characterization of the human central proteome.

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OMIM Diseases Associated

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OMIM ID	Disease Name
614436	Charcot-Marie-Tooth disease 2P

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Protein Domains Associated

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Domain Name	Domain ID	Source
Leu-rich_rpt	IPR001611	InterPro
Leu-rich_rpt_typical-subtyp	IPR003591	InterPro
LRR	PS51450	PROSITE
LRR_8	PF13855	Pfam
LRR_dom_sf	IPR032675	InterPro
LRR_TYP	SM00369	SMART
SAM	IPR001660	InterPro
SAM	SM00454	SMART
SAM/pointed_sf	IPR013761	InterPro
SAM_2	PF07647	Pfam

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