Protein: Q6UWE0

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q6UWE0 (Uniprot) LRSM1_HUMAN LRSAM1 E3 ubiquitin-protein ligase LRSAM1 human No
Uniprot: E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos (PubMed:15256501). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (PubMed:23245322). Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (PubMed:23245322, PubMed:25484098). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009056 catabolic process 125 GO:0009059 macromolecule biosynthetic process 192, 391 6.37e-04 1.88e-40
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
125 GO:0044248 cellular catabolic process
125 GO:0016567 protein ubiquitination
125 GO:0060255 regulation of macromolecule metabolic process
192 GO:0034645 cellular macromolecule biosynthetic process
192 GO:0006464 cellular protein modification process
192 GO:0010467 gene expression
192 GO:0090304 nucleic acid metabolic process
192 GO:0009893 positive regulation of metabolic process
192 GO:0060255 regulation of macromolecule metabolic process
192 GO:0007165 signal transduction
391 GO:0034645 cellular macromolecule biosynthetic process
391 GO:0090304 nucleic acid metabolic process
391 GO:0034654 nucleobase-containing compound biosynthetic process
391 GO:0060255 regulation of macromolecule metabolic process
391 GO:0019219 regulation of nucleobase-containing compound metabolic process
425 GO:0006464 cellular protein modification process
807 GO:0070647 protein modification by small protein conjugation or removal
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
125 GO:0005829 cytosol
125 GO:0005634 nucleus
192 GO:0005829 cytosol
192 GO:0005654 nucleoplasm
391 GO:0070013 intracellular organelle lumen
391 GO:0005634 nucleus
425 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000209 protein polyubiquitination IDA
GO:0006914 autophagy IEA
GO:0007165 signal transduction IBA
GO:0030163 protein catabolic process IMP
GO:0045806 negative regulation of endocytosis IMP
GO:0046755 viral budding IMP
GO:0051865 protein autoubiquitination IDA
GO:0070086 ubiquitin-dependent endocytosis IDA
GO:0098656 anion transmembrane transport IBA
GO:1904417 positive regulation of xenophagy IMP
GO:2000786 positive regulation of autophagosome assembly IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005737 cytoplasm IDA
GO:0005829 cytosol IDA
GO:0005886 plasma membrane IBA
GO:0016020 membrane IDA
GO:0034702 ion channel complex IBA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005829 cytosol GO:0034702 ion channel complex 6.28e-12 5.86e-10
PMID Article Title
12975309 The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15164053 DNA sequence and analysis of human chromosome 9.
15256501 Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
17556548 Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery.
18669648 A quantitative atlas of mitotic phosphorylation.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20865121 Mutation in the gene encoding ubiquitin ligase LRSAM1 in patients with Charcot-Marie-Tooth disease.
21269460 Initial characterization of the human central proteome.
22012984 A frameshift mutation in LRSAM1 is responsible for a dominant hereditary polyneuropathy.
23245322 The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular Salmonella Typhimurium.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25484098 PHF23 (plant homeodomain finger protein 23) negatively regulates cell autophagy by promoting ubiquitination and degradation of E3 ligase LRSAM1.
27615052 A novel missense mutation of CMT2P alters transcription machinery.
27686364 Charcot-Marie-Tooth disease type 2G redefined by a novel mutation in LRSAM1.
OMIM ID Disease Name
614436 Charcot-Marie-Tooth disease 2P
Domain Name Domain ID Source
Leu-rich_rpt IPR001611 InterPro
SAM IPR001660 InterPro
Znf_RING IPR001841 InterPro
Leu-rich_rpt_typical-subtyp IPR003591 InterPro
SAM/pointed_sf IPR013761 InterPro
LRR_dom_sf IPR032675 InterPro
SAM_2 PF07647 Pfam
LRR_8 PF13855 Pfam
ZF_RING_2 PS50089 PROSITE
SAM_DOMAIN PS50105 PROSITE
LRR PS51450 PROSITE
LRR_TYP SM00369 SMART
SAM SM00454 SMART
SSF47769 SSF47769 SUPFAM
SSF52058 SSF52058 SUPFAM