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A Database of Extreme Multifunctional and Moonlighting Proteins
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About
Protein: Q9BZR9
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
Q9BZR9 (Uniprot)
TRIM8_HUMAN
TRIM8
Probable E3 ubiquitin-protein ligase TRIM8
human
No
Protein Function
Uniprot:
Probable E3 ubiquitin-protein ligase which may promote proteasomal degradation of SOCS1.
MoonDB Dissimilar Functions
GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0009056
catabolic process
125
GO:0009059
macromolecule biosynthetic process
5
,
384
6.37e-04
1.88e-40
MoonDB Network Modules
Biological Processes
Module ID
(MoonGO)
GO ID (BP)
GO Name
5
GO:0034645
cellular macromolecule biosynthetic process
5
GO:0006464
cellular protein modification process
5
GO:0090304
nucleic acid metabolic process
5
GO:0034654
nucleobase-containing compound biosynthetic process
5
GO:0060255
regulation of macromolecule metabolic process
53
GO:0006139
nucleobase-containing compound metabolic process
53
GO:0016567
protein ubiquitination
53
GO:0060255
regulation of macromolecule metabolic process
79
GO:0007165
signal transduction
125
GO:0044248
cellular catabolic process
125
GO:0016567
protein ubiquitination
125
GO:0060255
regulation of macromolecule metabolic process
131
GO:0070647
protein modification by small protein conjugation or removal
131
GO:0006355
regulation of transcription, DNA-templated
134
GO:0044267
cellular protein metabolic process
134
GO:0060255
regulation of macromolecule metabolic process
134
GO:0007165
signal transduction
375
GO:0070647
protein modification by small protein conjugation or removal
375
GO:0060255
regulation of macromolecule metabolic process
384
GO:0034645
cellular macromolecule biosynthetic process
384
GO:0006464
cellular protein modification process
384
GO:0090304
nucleic acid metabolic process
384
GO:0031326
regulation of cellular biosynthetic process
384
GO:0060255
regulation of macromolecule metabolic process
384
GO:0007165
signal transduction
419
GO:0022607
cellular component assembly
575
GO:0016567
protein ubiquitination
575
GO:0060255
regulation of macromolecule metabolic process
688
GO:0006355
regulation of transcription, DNA-templated
688
GO:0007165
signal transduction
713
GO:0090304
nucleic acid metabolic process
713
GO:0070647
protein modification by small protein conjugation or removal
713
GO:0007165
signal transduction
Cellular Components
Module ID
(MoonGO)
GO ID (CC)
GO Name
5
GO:0005829
cytosol
5
GO:0005634
nucleus
53
GO:0005829
cytosol
53
GO:0005654
nucleoplasm
79
GO:0005634
nucleus
125
GO:0005829
cytosol
125
GO:0005634
nucleus
131
GO:0005829
cytosol
131
GO:0043232
intracellular non-membrane-bounded organelle
131
GO:0005634
nucleus
134
GO:0005829
cytosol
134
GO:0005634
nucleus
375
GO:0005829
cytosol
375
GO:0005634
nucleus
384
GO:0005829
cytosol
384
GO:0031981
nuclear lumen
419
GO:0044430
cytoskeletal part
419
GO:0005829
cytosol
575
GO:0005654
nucleoplasm
688
GO:0005634
nucleus
713
GO:0005829
cytosol
713
GO:0005634
nucleus
Protein GO Annotations
Biological Processes
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0010508
positive regulation of autophagy
IMP
GO:0016567
protein ubiquitination
IEA
GO:0019827
stem cell population maintenance
IEA
GO:0032897
negative regulation of viral transcription
IEA
GO:0043123
positive regulation of I-kappaB kinase/NF-kappaB signaling
IDA
GO:0045087
innate immune response
IDA
GO:0046597
negative regulation of viral entry into host cell
IEA
GO:0051091
positive regulation of DNA binding transcription factor activity
IDA
GO:0051092
positive regulation of NF-kappaB transcription factor activity
IDA
GO:0060333
interferon-gamma-mediated signaling pathway
TAS
GO:1900182
positive regulation of protein localization to nucleus
IEA
GO:1902187
negative regulation of viral release from host cell
IDA
Cellular Components
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0005829
cytosol
TAS
GO:0016605
PML body
IDA
Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Interactor
Also a MoonDB EMF protein
TRI27_HUMAN
Yes:
P14373 (MoonDB)
HXA1_HUMAN
No
CTSR1_HUMAN
No
XIAP_HUMAN
Yes:
P98170 (MoonDB)
RNF41_HUMAN
No
TNPO2_HUMAN
No
TNS2_HUMAN
Yes:
Q63HR2 (MoonDB)
HGS_HUMAN
No
LNX1_HUMAN
Yes:
Q8TBB1 (MoonDB)
SIAH1_HUMAN
Yes:
Q8IUQ4 (MoonDB)
UBP2_HUMAN
Yes:
O75604 (MoonDB)
TRI39_HUMAN
No
UBS3A_HUMAN
No
UB2V1_HUMAN
Yes:
Q13404 (MoonDB)
UB2D2_HUMAN
Yes:
P62837 (MoonDB)
UBXN7_HUMAN
No
MKRN3_HUMAN
Yes:
Q13064 (MoonDB)
LONF1_HUMAN
No
TNIP3_HUMAN
No
F124B_HUMAN
No
RN111_HUMAN
Yes:
Q6ZNA4 (MoonDB)
RN138_HUMAN
No
TRI43_HUMAN
No
UHRF2_HUMAN
No
TRIM2_HUMAN
No
RD23A_HUMAN
No
TRAF5_HUMAN
No
UB2D1_HUMAN
Yes:
P51668 (MoonDB)
UB2D3_HUMAN
Yes:
P61077 (MoonDB)
UBE2W_HUMAN
Yes:
Q96B02 (MoonDB)
UB2D4_HUMAN
Yes:
Q9Y2X8 (MoonDB)
RO52_HUMAN
No
UBP7_HUMAN
No
CBL_HUMAN
No
BRAP_HUMAN
No
CCNH_HUMAN
No
DCNL1_HUMAN
No
ITSN1_HUMAN
No
MAGC2_HUMAN
No
MSL2_HUMAN
No
MTURN_HUMAN
No
NOD2_HUMAN
No
NUD10_HUMAN
No
OTU1_HUMAN
No
OTUB2_HUMAN
No
PCGF5_HUMAN
No
R113A_HUMAN
No
RAD18_HUMAN
No
RBX2_HUMAN
No
RC3H2_HUMAN
No
RN141_HUMAN
No
RN181_HUMAN
No
SNUT2_HUMAN
No
TIF1A_HUMAN
No
TNAP3_HUMAN
No
TRI15_HUMAN
Yes:
Q9C019 (MoonDB)
TRI25_HUMAN
No
TRI47_HUMAN
No
TRIM9_HUMAN
No
UB2L6_HUMAN
No
UBP21_HUMAN
No
UBP5_HUMAN
No
ZN363_HUMAN
No
Publications Associated
PMID
Article Title
11118312
A novel RING finger-B box-coiled-coil protein, GERP.
11331580
The tripartite motif family identifies cell compartments.
15164054
The DNA sequence and comparative analysis of human chromosome 10.
15489334
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
OMIM Diseases Associated
No results found.
Protein Domains Associated
Domain Name
Domain ID
Source
Znf_B-box
IPR000315
InterPro
Znf_RING
IPR001841
InterPro
Znf_RING/FYVE/PHD
IPR013083
InterPro
Znf_RING_CS
IPR017907
InterPro
JC7562
JC7562
PIR
ZF_RING_1
PS00518
PROSITE
ZF_RING_2
PS50089
PROSITE
RING
SM00184
SMART
BBOX
cd00021
CDD