Protein: Q63HR2 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q63HR2 (Uniprot)	TNS2_HUMAN	TNS2	Tensin-2	human	No

Protein Function

Uniprot: Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling.

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	187	GO:0006139	nucleobase-containing compound metabolic process	462, 612	1.10e-111	5.07e-25

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
129	GO:0044267	cellular protein metabolic process
129	GO:0007165	signal transduction
139	GO:0023051	regulation of signaling
139	GO:0007165	signal transduction
187	GO:0007166	cell surface receptor signaling pathway
187	GO:0006464	cellular protein modification process
187	GO:0070887	cellular response to chemical stimulus
187	GO:0035556	intracellular signal transduction
187	GO:0006928	movement of cell or subcellular component
187	GO:0006796	phosphate-containing compound metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
60	GO:0005634	nucleus
119	GO:0005829	cytosol
129	GO:0005829	cytosol
129	GO:0070013	intracellular organelle lumen
187	GO:0005829	cytosol
187	GO:0005886	plasma membrane
209	GO:0005654	nucleoplasm
264	GO:0012505	endomembrane system
346	GO:0043232	intracellular non-membrane-bounded organelle
346	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0001822	kidney development	IEA
GO:0006470	protein dephosphorylation	IEA
GO:0008285	negative regulation of cell proliferation	IMP
GO:0014850	response to muscle activity	IEA
GO:0019725	cellular homeostasis	IEA
GO:0032963	collagen metabolic process	IEA
GO:0035264	multicellular organism growth	IEA
GO:0035556	intracellular signal transduction	IEA
GO:0048871	multicellular organismal homeostasis	IEA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005622	intracellular	IEA
GO:0005886	plasma membrane	IEA
GO:0005925	focal adhesion	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005622	intracellular	GO:0005886	plasma membrane	0.00e+00	9.14e-55

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
1433B_HUMAN	No
A2RU56_HUMAN	No
ADCK5_HUMAN	No
AES_HUMAN	Yes: Q08117 (MoonDB)
AP1S2_HUMAN	No
AP2D_HUMAN	No
AQP1_HUMAN	No
ARI5A_HUMAN	No
ASB3_HUMAN	No
BAHD1_HUMAN	No

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Publications Associated

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PMID	Article Title
10470851	Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
11792844	Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration.
12168954	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
12470648	Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15817639	C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration.
17974005	The full-ORF clone resource of the German cDNA consortium.
22019427	The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2.
22814378	N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23186163	Toward a comprehensive characterization of a human cancer cell phosphoproteome.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
C1	SM00109	SMART
C1	cd00029	CDD
C2_domain_sf	IPR035892	InterPro
C2_TENSIN	PS51182	PROSITE
PE/DAG-bd	IPR002219	InterPro
PH-like_dom_sf	IPR011993	InterPro
PPASE_TENSIN	PS51181	PROSITE
Prot-tyrosine_phosphatase-like	IPR029021	InterPro
PTB	IPR013625	InterPro
PTB	PF08416	Pfam

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