Protein: Q63HR2

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q63HR2 (Uniprot) TNS2_HUMAN TNS2 Tensin-2 human No
Uniprot: Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 187 GO:0006139 nucleobase-containing compound metabolic process 462, 612 1.10e-111 5.07e-25
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
129 GO:0044267 cellular protein metabolic process
129 GO:0007165 signal transduction
139 GO:0023051 regulation of signaling
139 GO:0007165 signal transduction
187 GO:0007166 cell surface receptor signaling pathway
187 GO:0006464 cellular protein modification process
187 GO:0070887 cellular response to chemical stimulus
187 GO:0035556 intracellular signal transduction
187 GO:0006928 movement of cell or subcellular component
187 GO:0006796 phosphate-containing compound metabolic process
187 GO:0010647 positive regulation of cell communication
187 GO:0048584 positive regulation of response to stimulus
187 GO:0023056 positive regulation of signaling
187 GO:0060255 regulation of macromolecule metabolic process
187 GO:0009966 regulation of signal transduction
209 GO:0031324 negative regulation of cellular metabolic process
209 GO:0010605 negative regulation of macromolecule metabolic process
209 GO:0051172 negative regulation of nitrogen compound metabolic process
209 GO:0009893 positive regulation of metabolic process
209 GO:0006357 regulation of transcription from RNA polymerase II promoter
209 GO:0007165 signal transduction
376 GO:0044267 cellular protein metabolic process
376 GO:0007165 signal transduction
462 GO:0090304 nucleic acid metabolic process
474 GO:0044267 cellular protein metabolic process
474 GO:0090304 nucleic acid metabolic process
474 GO:0060255 regulation of macromolecule metabolic process
536 GO:0010604 positive regulation of macromolecule metabolic process
536 GO:0051173 positive regulation of nitrogen compound metabolic process
536 GO:0019538 protein metabolic process
536 GO:0007165 signal transduction
612 GO:0090304 nucleic acid metabolic process
612 GO:0031325 positive regulation of cellular metabolic process
612 GO:0010604 positive regulation of macromolecule metabolic process
612 GO:0051173 positive regulation of nitrogen compound metabolic process
612 GO:0006468 protein phosphorylation
612 GO:0032268 regulation of cellular protein metabolic process
612 GO:0010468 regulation of gene expression
612 GO:0010556 regulation of macromolecule biosynthetic process
612 GO:0019219 regulation of nucleobase-containing compound metabolic process
612 GO:0042325 regulation of phosphorylation
612 GO:0009966 regulation of signal transduction
688 GO:0006355 regulation of transcription, DNA-templated
688 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
60 GO:0005634 nucleus
119 GO:0005829 cytosol
129 GO:0005829 cytosol
129 GO:0070013 intracellular organelle lumen
187 GO:0005829 cytosol
187 GO:0005886 plasma membrane
209 GO:0005654 nucleoplasm
264 GO:0012505 endomembrane system
346 GO:0043232 intracellular non-membrane-bounded organelle
346 GO:0005634 nucleus
376 GO:0005829 cytosol
376 GO:0005634 nucleus
462 GO:0005634 nucleus
536 GO:0005829 cytosol
536 GO:0005634 nucleus
612 GO:0005634 nucleus
651 GO:0005829 cytosol
688 GO:0005634 nucleus
726 GO:0005634 nucleus
746 GO:0043232 intracellular non-membrane-bounded organelle
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0001822 kidney development IEA
GO:0006470 protein dephosphorylation IEA
GO:0008285 negative regulation of cell proliferation IMP
GO:0014850 response to muscle activity IEA
GO:0019725 cellular homeostasis IEA
GO:0032963 collagen metabolic process IEA
GO:0035264 multicellular organism growth IEA
GO:0035556 intracellular signal transduction IEA
GO:0048871 multicellular organismal homeostasis IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005622 intracellular IEA
GO:0005886 plasma membrane IEA
GO:0005925 focal adhesion IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005622 intracellular GO:0005886 plasma membrane 0.00e+00 9.14e-55
Interactor Also a MoonDB EMF protein
RBPMS_HUMAN Yes: Q93062 (MoonDB)
CRTP1_HUMAN No
KR122_HUMAN No
KR123_HUMAN No
KR108_HUMAN No
DDT4L_HUMAN Yes: Q96D03 (MoonDB)
KR107_HUMAN No
ARI5A_HUMAN No
IHO1_HUMAN No
ENKD1_HUMAN No
CRX_HUMAN No
VINEX_HUMAN No
PROP1_HUMAN No
REL_HUMAN No
NT2NL_HUMAN No
ZCH14_HUMAN No
ZN837_HUMAN No
AES_HUMAN Yes: Q08117 (MoonDB)
OTX1_HUMAN No
HXA1_HUMAN No
CTSR1_HUMAN No
CA094_HUMAN No
KR105_HUMAN No
KR132_HUMAN No
KPRP_HUMAN No
ZN417_HUMAN Yes: Q8TAU3 (MoonDB)
AP2D_HUMAN No
PATZ1_HUMAN No
RHG07_HUMAN No
MYPOP_HUMAN No
KR231_HUMAN No
1433B_HUMAN No
A2RU56_HUMAN No
ADCK5_HUMAN No
AP1S2_HUMAN No
AQP1_HUMAN No
ASB3_HUMAN No
BAHD1_HUMAN No
BRCA1_HUMAN No
CATZ_HUMAN No
CCNK_HUMAN No
CGB2_HUMAN No
CK087_HUMAN No
CNNM3_HUMAN No
CPSF7_HUMAN No
CRKL_HUMAN No
CSK_HUMAN No
CU077_HUMAN No
CX6B2_HUMAN No
DCA11_HUMAN No
DCAF8_HUMAN No
DOK3_HUMAN No
DZIP1_HUMAN No
DZIP3_HUMAN No
E41LA_HUMAN No
EPDR1_HUMAN No
ERBB2_HUMAN Yes: P04626 (MoonDB)
ERBB3_HUMAN Yes: P21860 (MoonDB)
ES8L2_HUMAN No
FA46A_HUMAN No
FA46B_HUMAN No
FABP7_HUMAN No
FGF21_HUMAN No
FGFR1_HUMAN No
FOXO1_HUMAN No
GATA1_HUMAN No
GBA3_HUMAN No
GFI1B_HUMAN No
GO45_HUMAN No
HUWE1_HUMAN No
HXB9_HUMAN No
HXC8_HUMAN No
ID2_HUMAN No
IN80B_HUMAN No
K22O_HUMAN No
KC1E_HUMAN No
KCTD9_HUMAN No
KIF1A_HUMAN No
KIT_HUMAN No
KLH15_HUMAN No
KR103_HUMAN No
KR111_HUMAN No
KRA31_HUMAN No
KRA44_HUMAN No
LASP1_HUMAN No
LPXN_HUMAN No
LUZP4_HUMAN No
MBPHL_HUMAN No
MET_HUMAN No
MPEG1_HUMAN No
MT2_HUMAN No
MYH7B_HUMAN No
NMU_HUMAN No
NT5C_HUMAN No
NUBP2_HUMAN No
NXP20_HUMAN No
OBSL1_HUMAN No
PER1_HUMAN No
PGAM5_HUMAN No
PHF1_HUMAN No
PIN1_HUMAN No
PKP1_HUMAN No
PLB1_HUMAN No
PLS3_HUMAN No
PWP1_HUMAN No
Q8N6X9_HUMAN No
Q8N779_HUMAN No
Q96BA5_HUMAN No
Q9NWL9_HUMAN No
RAM_HUMAN No
RBAK_HUMAN No
REEP6_HUMAN No
RFT1_HUMAN No
RPA12_HUMAN No
RPC6_HUMAN No
RYDEN_HUMAN No
SDCG8_HUMAN No
SH2B3_HUMAN No
SNTB2_HUMAN No
SOCS7_HUMAN No
SPT12_HUMAN No
SPY2_HUMAN No
SPY4_HUMAN No
SRTD2_HUMAN No
SUSD2_HUMAN No
SUV91_HUMAN No
T4S19_HUMAN No
TBC16_HUMAN No
TCP1L_HUMAN No
TEKT3_HUMAN No
TEKT5_HUMAN No
TNFL6_HUMAN No
TRIM8_HUMAN Yes: Q9BZR9 (MoonDB)
TSC1_HUMAN No
TWSG1_HUMAN No
UBP54_HUMAN No
UFO_HUMAN No
UTRO_HUMAN No
WDFY3_HUMAN No
ZIM2_HUMAN No
ZN205_HUMAN No
ZN250_HUMAN No
ZN497_HUMAN No
ZN575_HUMAN No
ZN586_HUMAN No
ZN587_HUMAN No
ZN648_HUMAN No
ZN655_HUMAN No
PMID Article Title
10470851 Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
11792844 Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration.
12168954 Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
12470648 Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15817639 C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration.
17974005 The full-ORF clone resource of the German cDNA consortium.
22019427 The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
No results found.
Domain Name Domain ID Source
SH2 IPR000980 InterPro
PE/DAG-bd IPR002219 InterPro
PTB/PI_dom IPR006020 InterPro
PH-like_dom_sf IPR011993 InterPro
PTB IPR013625 InterPro
Tensin_C2-dom IPR014020 InterPro
Prot-tyrosine_phosphatase-like IPR029021 InterPro
Tensin_phosphatase IPR029023 InterPro
Tensin_PTB IPR033929 InterPro
Tensin_like_SH2 IPR035012 InterPro
C2_domain_sf IPR035892 InterPro
SH2_dom_sf IPR036860 InterPro
SH2 PF00017 Pfam
PTB PF08416 Pfam
PTEN_C2 PF10409 Pfam
ZF_DAG_PE_1 PS00479 PROSITE
SH2 PS50001 PROSITE
ZF_DAG_PE_2 PS50081 PROSITE
PPASE_TENSIN PS51181 PROSITE
C2_TENSIN PS51182 PROSITE
C1 SM00109 SMART
SH2 SM00252 SMART
PTB SM00462 SMART
PTEN_C2 SM01326 SMART
SSF49562 SSF49562 SUPFAM
SSF50729 SSF50729 SUPFAM
SSF52799 SSF52799 SUPFAM
SSF55550 SSF55550 SUPFAM
T46500 T46500 PIR
C1 cd00029 CDD
PTB_tensin cd01213 CDD
SH2_Tensin_like cd09927 CDD