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A Database of Extreme Multifunctional and Moonlighting Proteins
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About
Protein: Q96D03
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
Q96D03 (Uniprot)
DDT4L_HUMAN
DDIT4L
DNA damage-inducible transcript 4-like protein
human
No
Protein Function
Uniprot:
Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1.
MoonDB Dissimilar Functions
GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0019538
protein metabolic process
181
GO:0016070
RNA metabolic process
719
5.15e-08
2.82e-13
MoonDB Network Modules
Biological Processes
Module ID
(MoonGO)
GO ID (BP)
GO Name
181
GO:0044267
cellular protein metabolic process
181
GO:0010467
gene expression
181
GO:0009059
macromolecule biosynthetic process
181
GO:0090304
nucleic acid metabolic process
181
GO:0060255
regulation of macromolecule metabolic process
181
GO:0007165
signal transduction
364
GO:0016070
RNA metabolic process
364
GO:0010468
regulation of gene expression
719
GO:0006401
RNA catabolic process
719
GO:0016071
mRNA metabolic process
719
GO:0010629
negative regulation of gene expression
719
GO:0019219
regulation of nucleobase-containing compound metabolic process
Cellular Components
Module ID
(MoonGO)
GO ID (CC)
GO Name
181
GO:0005829
cytosol
181
GO:0005654
nucleoplasm
208
GO:0005634
nucleus
364
GO:0005634
nucleus
634
GO:0005829
cytosol
634
GO:0005634
nucleus
719
GO:0005829
cytosol
719
GO:0043232
intracellular non-membrane-bounded organelle
719
GO:0005634
nucleus
Protein GO Annotations
Biological Processes
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0009968
negative regulation of signal transduction
IEA
Cellular Components
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0005737
cytoplasm
ISS
Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Interactor
Also a MoonDB EMF protein
A0A024R4Q5_HUMAN
No
4EBP1_HUMAN
No
AAKB2_HUMAN
No
ACBP_HUMAN
No
ACY3_HUMAN
No
AIDA_HUMAN
No
AKT1_HUMAN
No
AP4A_HUMAN
No
ARPIN_HUMAN
No
B2L14_HUMAN
No
BAFL_HUMAN
No
BAG4_HUMAN
No
BID_HUMAN
No
CABP5_HUMAN
No
CACO2_HUMAN
No
CALM1_HUMAN
Yes:
P0DP23 (MoonDB)
CATIP_HUMAN
No
CCNK_HUMAN
No
CDD_HUMAN
No
CDN2D_HUMAN
No
CDPF1_HUMAN
No
CE022_HUMAN
No
CHM1A_HUMAN
Yes:
Q9HD42 (MoonDB)
CLIC3_HUMAN
No
CLK2_HUMAN
No
CLK3_HUMAN
No
CN119_HUMAN
No
COAC_HUMAN
No
CPNE7_HUMAN
No
CRBB1_HUMAN
No
CRLF3_HUMAN
No
CS025_HUMAN
No
DNPH1_HUMAN
No
DUPD1_HUMAN
No
DUS23_HUMAN
No
EPHB6_HUMAN
No
EXOS1_HUMAN
No
EXOS5_HUMAN
No
EXOS8_HUMAN
No
F261_HUMAN
No
FA84B_HUMAN
No
FADD_HUMAN
No
FAP20_HUMAN
No
FHIT_HUMAN
No
FHL2_HUMAN
No
FKBP6_HUMAN
No
FLNA_HUMAN
Yes:
P21333 (MoonDB)
GA45G_HUMAN
No
GEMI6_HUMAN
No
GPKOW_HUMAN
No
GRB2_HUMAN
Yes:
P62993 (MoonDB)
GUC1A_HUMAN
No
HDAC7_HUMAN
No
HM20A_HUMAN
No
HSPB7_HUMAN
No
I36RA_HUMAN
No
IF4A3_HUMAN
No
IF4H_HUMAN
No
IMDH1_HUMAN
No
KANK2_HUMAN
No
KCTD9_HUMAN
No
KDM8_HUMAN
No
KFA_HUMAN
No
KRA56_HUMAN
No
KRT34_HUMAN
No
LEGL_HUMAN
No
LENG1_HUMAN
No
LSM3_HUMAN
Yes:
P62310 (MoonDB)
LSM5_HUMAN
No
LSM7_HUMAN
No
M3KCL_HUMAN
No
MARE2_HUMAN
No
MARE3_HUMAN
No
MEMO1_HUMAN
No
MIEN1_HUMAN
No
MKRN3_HUMAN
Yes:
Q13064 (MoonDB)
MLX_HUMAN
No
MO4L2_HUMAN
No
MT1M_HUMAN
No
MYG1_HUMAN
No
MYLIP_HUMAN
No
NAA10_HUMAN
No
NAV1_HUMAN
No
NDK7_HUMAN
No
NEK6_HUMAN
No
NGB_HUMAN
No
NQO2_HUMAN
No
NR2CA_HUMAN
No
NUD22_HUMAN
No
NXT2_HUMAN
No
OTU1_HUMAN
No
P20D2_HUMAN
No
PARVG_HUMAN
No
PCBP3_HUMAN
No
PDE4C_HUMAN
No
PLS4_HUMAN
No
PMVK_HUMAN
No
PPIL1_HUMAN
No
PPL13_HUMAN
No
PPR27_HUMAN
No
PR40A_HUMAN
Yes:
O75400 (MoonDB)
PSA1_HUMAN
No
PSB9_HUMAN
No
PTPS_HUMAN
No
PUF60_HUMAN
No
Q3SXR9_HUMAN
No
Q5BIX2_HUMAN
No
Q8TCW6_HUMAN
No
RAB32_HUMAN
No
RBTN1_HUMAN
No
RFC5_HUMAN
No
RFPL3_HUMAN
No
RL22_HUMAN
No
RPIA_HUMAN
No
RPR1B_HUMAN
No
RUXG_HUMAN
No
SC22A_HUMAN
No
SCOC_HUMAN
No
SEN15_HUMAN
No
SEPT1_HUMAN
No
SEPT3_HUMAN
No
SEPT5_HUMAN
No
SH3L3_HUMAN
No
SNRPA_HUMAN
No
SR1IP_HUMAN
No
ST2B1_HUMAN
Yes:
O00204 (MoonDB)
STK16_HUMAN
No
STK4_HUMAN
No
T11L1_HUMAN
No
TB22B_HUMAN
No
TCL1A_HUMAN
No
TEKT4_HUMAN
No
TEX14_HUMAN
No
THIO_HUMAN
No
TNS2_HUMAN
Yes:
Q63HR2 (MoonDB)
TOLIP_HUMAN
No
TSSK3_HUMAN
No
TTC5_HUMAN
No
TXN4A_HUMAN
No
TXND5_HUMAN
No
TYW3_HUMAN
No
UBS3A_HUMAN
No
YES_HUMAN
No
YPEL5_HUMAN
No
ZBED8_HUMAN
No
ZN593_HUMAN
No
ZN765_HUMAN
No
ZNF76_HUMAN
No
ZSC23_HUMAN
No
Publications Associated
PMID
Article Title
12453409
REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species.
14702039
Complete sequencing and characterization of 21,243 full-length human cDNAs.
15308555
REDD2 gene is upregulated by modified LDL or hypoxia and mediates human macrophage cell death.
15489334
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15545625
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex.
15632201
The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway.
17974005
The full-ORF clone resource of the German cDNA consortium.
OMIM Diseases Associated
No results found.
Protein Domains Associated
Domain Name
Domain ID
Source
RTP801-like
IPR012918
InterPro
RTP801_C
PF07809
Pfam
PTHR12478
PTHR12478
PANTHER