Protein: Q9HD42

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9HD42 (Uniprot) CHM1A_HUMAN CHMP1A Charged multivesicular body protein 1a human Yes
Uniprot: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing. more..
Dissimilar Functions Manual Curation

Function 1: Endocytic function, component of the ESCRT-III complex.

Function 2: Chromatin condensation, nuclear matrix protein affecting chromatin structure and cell-cycle progression, gene silencing. Condition: nuclear localisation.

Publications (PMID): 11559748, 16730941, 11559747

Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
699 GO:0022607 cellular component assembly
699 GO:0051649 establishment of localization in cell
699 GO:0071705 nitrogen compound transport
699 GO:0008104 protein localization
699 GO:0019538 protein metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
699 GO:0005829 cytosol
699 GO:0012505 endomembrane system
699 GO:0043232 intracellular non-membrane-bounded organelle
699 GO:0005634 nucleus
699 GO:0031982 vesicle
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000920 cell separation after cytokinesis IMP
GO:0006351 transcription, DNA-templated IEA
GO:0006508 proteolysis IEA
GO:0006997 nucleus organization IMP
GO:0007034 vacuolar transport IEA
GO:0007076 mitotic chromosome condensation IDA
GO:0007080 mitotic metaphase plate congression IMP
GO:0010824 regulation of centrosome duplication IMP
GO:0015031 protein transport IEA
GO:0016192 vesicle-mediated transport IDA
GO:0016458 gene silencing IDA
GO:0036258 multivesicular body assembly NAS
GO:0039702 viral budding via host ESCRT complex NAS
GO:0045014 negative regulation of transcription by glucose IDA
GO:0045892 negative regulation of transcription, DNA-templated IDA
GO:0051301 cell division IMP
GO:1901673 regulation of mitotic spindle assembly IMP
GO:1904903 ESCRT III complex disassembly NAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000794 condensed nuclear chromosome IDA
GO:0000815 ESCRT III complex IEA
GO:0005769 early endosome IDA
GO:0005815 microtubule organizing center IDA
GO:0012505 endomembrane system IDA
GO:0016363 nuclear matrix IDA
GO:0070062 extracellular exosome IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
7584044 Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.
8863740 Molecular cloning, expression and chromosomal localization of a human gene encoding a 33 kDa putative metallopeptidase (PRSM1).
11559747 CHMP1 is a novel nuclear matrix protein affecting chromatin structure and cell-cycle progression.
11559748 CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins.
14505570 The protein network of HIV budding.
14519844 Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15616553 The sequence and analysis of duplication-rich human chromosome 16.
17928862 ESCRT-III recognition by VPS4 ATPases.
19129479 Biochemical analyses of human IST1 and its function in cytokinesis.
19129480 Essential role of hIST1 in cytokinesis.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
21269460 Initial characterization of the human central proteome.
23023333 CHMP1A encodes an essential regulator of BMI1-INK4A in cerebellar development.
23045692 ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
OMIM ID Disease Name
614961 Pontocerebellar hypoplasia 8
Domain Name Domain ID Source
Snf7_fam IPR005024 InterPro
CHMP1A IPR029888 InterPro
JC4963 JC4963 PIR
Snf7 PF03357 Pfam
PTHR10476:SF17 PTHR10476:SF17 PANTHER