UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P62310 (Uniprot)	LSM3_HUMAN	LSM3	U6 snRNA-associated Sm-like protein LSm3	human	No

Protein Function

Uniprot: Binds specifically to the 3'-terminal U-tract of U6 snRNA.

MoonDB Dissimilar Functions

GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0019538	protein metabolic process	181	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	467	1.88e-02	4.66e-37

MoonDB Network Modules

Biological Processes

Module ID (MoonGO)	GO ID (BP)	GO Name
167	GO:0016070	RNA metabolic process
167	GO:0010467	gene expression
167	GO:0060255	regulation of macromolecule metabolic process
181	GO:0044267	cellular protein metabolic process
181	GO:0010467	gene expression
181	GO:0009059	macromolecule biosynthetic process
181	GO:0090304	nucleic acid metabolic process
181	GO:0060255	regulation of macromolecule metabolic process
181	GO:0007165	signal transduction
467	GO:0000398	mRNA splicing, via spliceosome
467	GO:0060255	regulation of macromolecule metabolic process

Cellular Components

Module ID (MoonGO)	GO ID (CC)	GO Name
167	GO:0005654	nucleoplasm
181	GO:0005829	cytosol
181	GO:0005654	nucleoplasm
208	GO:0005634	nucleus
227	GO:0005634	nucleus
467	GO:0005654	nucleoplasm

Protein GO Annotations

Biological Processes

GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000398	mRNA splicing, via spliceosome	TAS
GO:0006397	mRNA processing	TAS
GO:0033962	cytoplasmic mRNA processing body assembly	IBA
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	TAS

Cellular Components

GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000932	P-body	IBA
GO:0005634	nucleus	TAS
GO:0005654	nucleoplasm	TAS
GO:0005688	U6 snRNP	IBA
GO:0005829	cytosol	TAS
GO:0046540	U4/U6 x U5 tri-snRNP complex	IBA
GO:0071011	precatalytic spliceosome	IBA
GO:0071013	catalytic step 2 spliceosome	IDA
GO:1990726	Lsm1-7-Pat1 complex	IBA

Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Interactor	Also a MoonDB EMF protein
DDT4L_HUMAN	Yes: Q96D03 (MoonDB)
TFP11_HUMAN	No
KEAP1_HUMAN	No
LSM2_HUMAN	No
TCL1A_HUMAN	No
HSPB1_HUMAN	Yes: P04792 (MoonDB)
CEP95_HUMAN	No
SF3B2_HUMAN	No
NACC1_HUMAN	No
GDF9_HUMAN	No
EF1A1_HUMAN	No
LSM1_HUMAN	No
LSM6_HUMAN	No
LSM8_HUMAN	No
SMD3_HUMAN	No
UT14A_HUMAN	No
ICLN_HUMAN	No
SMD1_HUMAN	No
MEP50_HUMAN	No
RUXE_HUMAN	No
RUXF_HUMAN	No
RUXG_HUMAN	No
LSM7_HUMAN	No
WDR83_HUMAN	No
DLX4_HUMAN	No
GSTA1_HUMAN	No
LSM10_HUMAN	No
LSM5_HUMAN	No
THOC5_HUMAN	No
XPC_HUMAN	No
XRN2_HUMAN	No
YBOX1_HUMAN	No

Publications Associated

PMID	Article Title
10369684	Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin.
10523320	A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro.
11991638	Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
19413330	Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
21269460	Initial characterization of the human central proteome.
22814378	N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
25944712	N-terminome analysis of the human mitochondrial proteome.

OMIM Diseases Associated

No results found.

Protein Domains Associated

Domain Name	Domain ID	Source
LSM_dom_euk/arc	IPR001163	InterPro
LSM_dom_sf	IPR010920	InterPro
Lsm3	IPR034105	InterPro
LSM	PF01423	Pfam
Sm	SM00651	SMART
SSF50182	SSF50182	SUPFAM
LSm3	cd01730	CDD