Protein: O75400 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
O75400 (Uniprot)	PR40A_HUMAN	PRPF40A	Pre-mRNA-processing factor 40 homolog A	human	No

Protein Function

Uniprot: Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	294, 353	GO:0019538	protein metabolic process	56, 413	1.88e-02	4.66e-37

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
51	GO:0060255	regulation of macromolecule metabolic process
56	GO:0044267	cellular protein metabolic process
56	GO:0060255	regulation of macromolecule metabolic process
96	GO:0016070	RNA metabolic process
96	GO:0010467	gene expression
167	GO:0016070	RNA metabolic process
167	GO:0010467	gene expression
167	GO:0060255	regulation of macromolecule metabolic process
199	GO:0006464	cellular protein modification process
199	GO:0060255	regulation of macromolecule metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
51	GO:0005634	nucleus
56	GO:0005829	cytosol
91	GO:0005576	extracellular region
96	GO:0005654	nucleoplasm
167	GO:0005654	nucleoplasm
199	GO:0012505	endomembrane system
199	GO:0005576	extracellular region
199	GO:0070013	intracellular organelle lumen
294	GO:0030529	intracellular ribonucleoprotein complex
294	GO:0005654	nucleoplasm

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000398	mRNA splicing, via spliceosome	TAS
GO:0007010	cytoskeleton organization	IMP
GO:0007049	cell cycle	IEA
GO:0008360	regulation of cell shape	IMP
GO:0016477	cell migration	IMP
GO:0032465	regulation of cytokinesis	IMP
GO:0051301	cell division	IEA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005654	nucleoplasm	TAS
GO:0005685	U1 snRNP	IBA
GO:0005829	cytosol	IDA
GO:0016020	membrane	IDA
GO:0016363	nuclear matrix	IDA
GO:0016607	nuclear speck	IDA
GO:0071004	U2-type prespliceosome	IBA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005654	nucleoplasm	GO:0016020	membrane	5.76e-255	1.32e-206
GO:0016020	membrane	GO:0016607	nuclear speck	9.49e-26	4.88e-97

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ASXL2_HUMAN	No
BAG6_HUMAN	No
BEND7_HUMAN	No
BIG2_HUMAN	No
BRD4_HUMAN	No
CAP2_HUMAN	No
CCNL1_HUMAN	No
CD045_HUMAN	No
CDK12_HUMAN	No
CDK13_HUMAN	No

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Publications Associated

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PMID	Article Title
9700202	Huntingtin interacts with a family of WW domain proteins.
10508479	Antigens recognized by autologous antibody in patients with renal-cell carcinoma.
11042152	Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
12381297	The structure of an FF domain from human HYPA/FBP11.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15815621	Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
16391387	Interaction of the nuclear matrix protein NAKAP with HypA and huntingtin: implications for nuclear toxicity in Huntington's disease pathogenesis.
17081983	Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
18220336	Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
FF	PF01846	Pfam
FF	PS51676	PROSITE
FF	SM00441	SMART
FF_domain	IPR002713	InterPro
FF_domain_sf	IPR036517	InterPro
SSF51045	SSF51045	SUPFAM
SSF81698	SSF81698	SUPFAM
WW	PF00397	Pfam
WW	SM00456	SMART
WW	cd00201	CDD

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