Protein: Q9NRD5

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9NRD5 (Uniprot) PICK1_HUMAN PICK1 PRKCA-binding protein human No
Uniprot: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009059 macromolecule biosynthetic process 31, 401 GO:0006793 phosphorus metabolic process 491 1.25e-35 4.53e-23
GO:0006139 nucleobase-containing compound metabolic process 132, 142, 219, 354, 527, 694 GO:0007165 signal transduction 831 1.10e-111 5.07e-25
GO:0006725 cellular aromatic compound metabolic process 152 GO:0007165 signal transduction 831 5.44e-126 5.27e-27
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
31 GO:0034645 cellular macromolecule biosynthetic process
31 GO:0044271 cellular nitrogen compound biosynthetic process
31 GO:0090304 nucleic acid metabolic process
31 GO:0010468 regulation of gene expression
63 GO:0010467 gene expression
63 GO:0090304 nucleic acid metabolic process
63 GO:0060255 regulation of macromolecule metabolic process
73 GO:0006355 regulation of transcription, DNA-templated
132 GO:0090304 nucleic acid metabolic process
132 GO:0060255 regulation of macromolecule metabolic process
142 GO:0090304 nucleic acid metabolic process
142 GO:0060255 regulation of macromolecule metabolic process
152 GO:0006139 nucleobase-containing compound metabolic process
194 GO:0044267 cellular protein metabolic process
194 GO:0006355 regulation of transcription, DNA-templated
219 GO:0090304 nucleic acid metabolic process
268 GO:0006355 regulation of transcription, DNA-templated
280 GO:0016070 RNA metabolic process
280 GO:0010467 gene expression
340 GO:0016070 RNA metabolic process
340 GO:0010467 gene expression
340 GO:0060255 regulation of macromolecule metabolic process
354 GO:0090304 nucleic acid metabolic process
401 GO:0034645 cellular macromolecule biosynthetic process
401 GO:0060255 regulation of macromolecule metabolic process
476 GO:0010467 gene expression
476 GO:0060255 regulation of macromolecule metabolic process
478 GO:0060255 regulation of macromolecule metabolic process
491 GO:0006796 phosphate-containing compound metabolic process
511 GO:0010467 gene expression
511 GO:0051252 regulation of RNA metabolic process
527 GO:0090304 nucleic acid metabolic process
527 GO:0060255 regulation of macromolecule metabolic process
530 GO:0016070 RNA metabolic process
530 GO:0060255 regulation of macromolecule metabolic process
544 GO:0016070 RNA metabolic process
544 GO:0006464 cellular protein modification process
544 GO:0006796 phosphate-containing compound metabolic process
544 GO:0031325 positive regulation of cellular metabolic process
544 GO:0010604 positive regulation of macromolecule metabolic process
544 GO:0051173 positive regulation of nitrogen compound metabolic process
544 GO:0032268 regulation of cellular protein metabolic process
544 GO:0010468 regulation of gene expression
544 GO:0023051 regulation of signaling
544 GO:0007165 signal transduction
554 GO:0016070 RNA metabolic process
554 GO:0010468 regulation of gene expression
581 GO:0031326 regulation of cellular biosynthetic process
581 GO:0060255 regulation of macromolecule metabolic process
581 GO:0019219 regulation of nucleobase-containing compound metabolic process
581 GO:0006351 transcription, DNA-templated
605 GO:0007165 signal transduction
608 GO:0060255 regulation of macromolecule metabolic process
657 GO:0006355 regulation of transcription, DNA-templated
657 GO:0007165 signal transduction
680 GO:0016070 RNA metabolic process
680 GO:0009059 macromolecule biosynthetic process
680 GO:0060255 regulation of macromolecule metabolic process
694 GO:0090304 nucleic acid metabolic process
694 GO:0060255 regulation of macromolecule metabolic process
699 GO:0022607 cellular component assembly
699 GO:0051649 establishment of localization in cell
699 GO:0071705 nitrogen compound transport
699 GO:0008104 protein localization
699 GO:0019538 protein metabolic process
737 GO:0006464 cellular protein modification process
737 GO:0009059 macromolecule biosynthetic process
737 GO:0006139 nucleobase-containing compound metabolic process
737 GO:0031325 positive regulation of cellular metabolic process
737 GO:0010604 positive regulation of macromolecule metabolic process
737 GO:0051173 positive regulation of nitrogen compound metabolic process
737 GO:0032268 regulation of cellular protein metabolic process
737 GO:0007165 signal transduction
782 GO:0006355 regulation of transcription, DNA-templated
788 GO:0006464 cellular protein modification process
788 GO:0060255 regulation of macromolecule metabolic process
831 GO:0007166 cell surface receptor signaling pathway
831 GO:0044271 cellular nitrogen compound biosynthetic process
831 GO:0006139 nucleobase-containing compound metabolic process
831 GO:0006796 phosphate-containing compound metabolic process
831 GO:0010646 regulation of cell communication
831 GO:0060255 regulation of macromolecule metabolic process
831 GO:0023051 regulation of signaling
832 GO:0060255 regulation of macromolecule metabolic process
832 GO:0006351 transcription, DNA-templated
866 GO:0010646 regulation of cell communication
866 GO:0060255 regulation of macromolecule metabolic process
866 GO:0023051 regulation of signaling
866 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
31 GO:0005634 nucleus
63 GO:0005634 nucleus
73 GO:0005634 nucleus
82 GO:0005634 nucleus
84 GO:0005634 nucleus
89 GO:0005634 nucleus
95 GO:0005634 nucleus
132 GO:0005634 nucleus
135 GO:0005634 nucleus
142 GO:0005634 nucleus
152 GO:0005829 cytosol
152 GO:0005634 nucleus
194 GO:0043232 intracellular non-membrane-bounded organelle
194 GO:0031981 nuclear lumen
208 GO:0005634 nucleus
219 GO:0005634 nucleus
268 GO:0005634 nucleus
280 GO:0005634 nucleus
322 GO:0005634 nucleus
340 GO:0005634 nucleus
354 GO:0005634 nucleus
401 GO:0005634 nucleus
468 GO:0005634 nucleus
476 GO:0005634 nucleus
478 GO:0005634 nucleus
491 GO:0005829 cytosol
491 GO:0043232 intracellular non-membrane-bounded organelle
491 GO:0005634 nucleus
511 GO:0005634 nucleus
523 GO:0005829 cytosol
523 GO:0031982 vesicle
527 GO:0005634 nucleus
530 GO:0070013 intracellular organelle lumen
530 GO:0005634 nucleus
544 GO:0005829 cytosol
544 GO:0005634 nucleus
554 GO:0005634 nucleus
581 GO:0005634 nucleus
608 GO:0043232 intracellular non-membrane-bounded organelle
608 GO:0005634 nucleus
634 GO:0005829 cytosol
634 GO:0005634 nucleus
642 GO:0005634 nucleus
657 GO:0005634 nucleus
680 GO:0005634 nucleus
694 GO:0005634 nucleus
699 GO:0005829 cytosol
699 GO:0012505 endomembrane system
699 GO:0043232 intracellular non-membrane-bounded organelle
699 GO:0005634 nucleus
699 GO:0031982 vesicle
737 GO:0005829 cytosol
737 GO:0043232 intracellular non-membrane-bounded organelle
737 GO:0005634 nucleus
782 GO:0005634 nucleus
788 GO:0005829 cytosol
831 GO:0042995 cell projection
831 GO:0005829 cytosol
831 GO:0005634 nucleus
831 GO:0005886 plasma membrane
832 GO:0005829 cytosol
832 GO:0005634 nucleus
866 GO:0005829 cytosol
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0002092 positive regulation of receptor internalization ISS
GO:0006468 protein phosphorylation ISS
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER NAS
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IDA
GO:0015844 monoamine transport IDA
GO:0021782 glial cell development ISS
GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation IBA
GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation ISS
GO:0036294 cellular response to decreased oxygen levels ISS
GO:0042149 cellular response to glucose starvation ISS
GO:0043045 DNA methylation involved in embryo development NAS
GO:0043046 DNA methylation involved in gamete generation TAS
GO:0043113 receptor clustering ISS
GO:0045161 neuronal ion channel clustering TAS
GO:0060292 long term synaptic depression ISS
GO:0097061 dendritic spine organization ISS
GO:0097062 dendritic spine maintenance ISS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005737 cytoplasm IDA
GO:0005739 mitochondrion IDA
GO:0005794 Golgi apparatus ISS
GO:0005829 cytosol IDA
GO:0005856 cytoskeleton IEA
GO:0005886 plasma membrane TAS
GO:0014069 postsynaptic density IEA
GO:0016235 aggresome IDA
GO:0030054 cell junction IEA
GO:0030666 endocytic vesicle membrane TAS
GO:0042734 presynaptic membrane IDA
GO:0043005 neuron projection ISS
GO:0045202 synapse ISS
GO:0045211 postsynaptic membrane IEA
GO:0048471 perinuclear region of cytoplasm ISS
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
PRP31_HUMAN No
TFP11_HUMAN No
A0A024R4Z4_HUMAN No
FAM9A_HUMAN No
4EBP1_HUMAN No
A4D1I3_HUMAN No
ABT1_HUMAN No
AEBP2_HUMAN No
AES_HUMAN Yes: Q08117 (MoonDB)
AKT1_HUMAN No
AKT2_HUMAN No
ALKB8_HUMAN No
AP1M1_HUMAN No
AP1S1_HUMAN No
APTX_HUMAN No
AR6P1_HUMAN No
ARHG3_HUMAN No
ARHG5_HUMAN No
ARMX1_HUMAN No
ASIC1_HUMAN No
AT7L3_HUMAN No
ATIF1_HUMAN No
ATX1L_HUMAN No
ATX3_HUMAN No
ATX7_HUMAN No
AVPI1_HUMAN No
B2L14_HUMAN No
B7ZLI8_HUMAN No
BAHD1_HUMAN No
BEX1_HUMAN No
BL1S2_HUMAN No
BLK_HUMAN No
BNC1_HUMAN No
BOLA3_HUMAN No
BORG1_HUMAN No
BRD1_HUMAN No
BUD31_HUMAN No
BYST_HUMAN No
C102B_HUMAN No
C2CD5_HUMAN No
CARD9_HUMAN No
CATG_HUMAN No
CBX8_HUMAN No
CC103_HUMAN No
CCNH_HUMAN No
CD046_HUMAN No
CDA7L_HUMAN No
CDC73_HUMAN No
CDKA1_HUMAN No
CDKL3_HUMAN No
CDN2B_HUMAN No
CDN2D_HUMAN No
CE290_HUMAN No
CE57L_HUMAN No
CEP19_HUMAN Yes: Q96LK0 (MoonDB)
CEP89_HUMAN No
CEP95_HUMAN No
CGBP1_HUMAN No
CH033_HUMAN No
CHM1B_HUMAN No
CIC_HUMAN No
COIL_HUMAN No
CPNE2_HUMAN No
CPNE7_HUMAN No
CRY2_HUMAN No
CSK22_HUMAN No
CUTC_HUMAN No
DCNL5_HUMAN No
DCTD_HUMAN No
DDX55_HUMAN No
DDX6_HUMAN No
DHB14_HUMAN No
DJB13_HUMAN No
DMC1_HUMAN No
DMD_HUMAN No
DPOLL_HUMAN No
DTNB_HUMAN No
DUPD1_HUMAN No
EAF1_HUMAN No
ECHP_HUMAN No
EF2KT_HUMAN No
EFHC2_HUMAN No
EHD2_HUMAN No
EIF1A_HUMAN No
EIF3D_HUMAN No
ENKD1_HUMAN No
EPMIP_HUMAN No
ERBB2_HUMAN Yes: P04626 (MoonDB)
ERBIN_HUMAN No
ESCO2_HUMAN No
EXOS5_HUMAN No
F161A_HUMAN No
F161B_HUMAN No
F207A_HUMAN No
F214B_HUMAN No
F219B_HUMAN No
F90A1_HUMAN No
FBXL3_HUMAN No
FBXL8_HUMAN No
FGF16_HUMAN No
FKBP6_HUMAN No
FRDA_HUMAN No
FWCH1_HUMAN No
G45IP_HUMAN No
GA2L2_HUMAN No
GFI1B_HUMAN No
GFI1_HUMAN No
GLCTK_HUMAN No
GLYR1_HUMAN No
GMCLL_HUMAN No
GOR_HUMAN No
GPC4_HUMAN No
GPKOW_HUMAN No
GPR37_HUMAN No
GPT11_HUMAN No
GPTC2_HUMAN No
GRB10_HUMAN No
GRB7_HUMAN No
GRCR1_HUMAN No
GRIA2_HUMAN No
GRIA3_HUMAN No
GRIA4_HUMAN No
GRIK1_HUMAN No
GRIK2_HUMAN No
GRM3_HUMAN No
GRM7_HUMAN No
GTPB2_HUMAN No
HDAC4_HUMAN No
HEM3_HUMAN No
HEXI2_HUMAN No
HM20A_HUMAN No
HMBX1_HUMAN No
HOP_HUMAN No
HSF2B_HUMAN No
HSF2_HUMAN No
HXA5_HUMAN No
ID2_HUMAN No
IF4A3_HUMAN No
IF4H_HUMAN No
IF5A1_HUMAN No
IHO1_HUMAN No
IL16_HUMAN No
ILF2_HUMAN No
IN80B_HUMAN No
IN80E_HUMAN No
IP6K1_HUMAN No
ISCU_HUMAN No
K1328_HUMAN No
KAT5_HUMAN No
KCTD1_HUMAN No
KCTD6_HUMAN No
KCTD9_HUMAN No
KPCG_HUMAN No
LCLT1_HUMAN No
LMBL2_HUMAN No
LMO3_HUMAN No
LONF1_HUMAN No
LRC73_HUMAN No
LZTL1_HUMAN No
LZTS1_HUMAN No
MAGA4_HUMAN No
MAGB4_HUMAN No
MARE3_HUMAN No
MAZ_HUMAN No
MBD3_HUMAN No
MCM10_HUMAN No
MEOX2_HUMAN Yes: P50222 (MoonDB)
MGME1_HUMAN No
MK09_HUMAN No
MMTA2_HUMAN No
MNS1_HUMAN No
MO4L1_HUMAN No
MO4L2_HUMAN No
MOB3C_HUMAN No
MORN3_HUMAN No
MOS_HUMAN No
MP2K6_HUMAN No
MRNIP_HUMAN No
MSRB3_HUMAN No
MSS51_HUMAN No
MTA1_HUMAN No
MTG1_HUMAN No
MTNA_HUMAN No
NATD1_HUMAN No
NC2A_HUMAN No
NDEL1_HUMAN Yes: Q9GZM8 (MoonDB)
NDK7_HUMAN No
NECA2_HUMAN No
NECT1_HUMAN No
NEK6_HUMAN No
NGAL_HUMAN Yes: P80188 (MoonDB)
NMNA1_HUMAN No
NOC4L_HUMAN No
OARD1_HUMAN No
OPTN_HUMAN No
OSBP2_HUMAN No
OSGI1_HUMAN No
PA1B3_HUMAN No
PAIRB_HUMAN No
PAX6_HUMAN No
PBX4_HUMAN No
PDCD5_HUMAN No
PDS5A_HUMAN No
PEBP1_HUMAN No
PEPL_HUMAN No
PHF19_HUMAN No
PHS_HUMAN Yes: P61457 (MoonDB)
PI5PA_HUMAN No
PIBF1_HUMAN No
PKHA7_HUMAN No
PKN1_HUMAN No
PKNX2_HUMAN No
PNKP_HUMAN No
PNO1_HUMAN No
PPL13_HUMAN No
PR40A_HUMAN Yes: O75400 (MoonDB)
PROP1_HUMAN No
PRP18_HUMAN No
PSA1_HUMAN No
PSME3_HUMAN No
PTH_HUMAN No
Q08AG9_HUMAN No
Q86XJ5_HUMAN No
Q8IVT4_HUMAN No
Q8N9J2_HUMAN No
RA51D_HUMAN No
RASL3_HUMAN No
RBTN1_HUMAN No
REEP6_HUMAN No
REL_HUMAN No
REQU_HUMAN No
RFC3_HUMAN No
RIMS3_HUMAN No
RIN1_HUMAN No
RNF8_HUMAN No
RNPS1_HUMAN No
ROBO3_HUMAN No
ROP1A_HUMAN No
RPC3_HUMAN No
RPIA_HUMAN No
RPP25_HUMAN No
RRP8_HUMAN No
RU2A_HUMAN No
RU2B_HUMAN No
RXRB_HUMAN Yes: P28702 (MoonDB)
RXRG_HUMAN No
RYDEN_HUMAN No
SACS_HUMAN No
SAS10_HUMAN No
SC6A2_HUMAN No
SC6A3_HUMAN No
SC6A4_HUMAN No
SCND1_HUMAN Yes: P57086 (MoonDB)
SCNM1_HUMAN No
SEM3B_HUMAN No
SEPT1_HUMAN No
SH24A_HUMAN No
SHLB2_HUMAN No
SLIRP_HUMAN No
SMRD1_HUMAN No
SNF5_HUMAN No
SNR25_HUMAN No
SNW1_HUMAN No
SPC1L_HUMAN No
SPEG_HUMAN No
SPXN2_HUMAN No
SRTD1_HUMAN No
SRTD3_HUMAN No
SSNA1_HUMAN No
STK4_HUMAN No
SYNCI_HUMAN No
SYQ_HUMAN No
SYT17_HUMAN No
T10IP_HUMAN No
T23O_HUMAN No
T2EB_HUMAN No
TB22B_HUMAN No
TBCD7_HUMAN No
TCEA2_HUMAN No
TDIF1_HUMAN No
TDIF2_HUMAN No
TEAN2_HUMAN No
TEANC_HUMAN No
THAP6_HUMAN No
THAP7_HUMAN No
TLRN1_HUMAN No
TPM4_HUMAN No
TRAF4_HUMAN No
TRAF5_HUMAN No
TRI44_HUMAN No
TRI54_HUMAN No
TRIM1_HUMAN Yes: Q9UJV3 (MoonDB)
TRIMM_HUMAN No
TRM2A_HUMAN No
TSN_HUMAN No
TSTD2_HUMAN No
TT23L_HUMAN No
TTC23_HUMAN No
TX101_HUMAN No
TXN4B_HUMAN No
TXND9_HUMAN No
TYW3_HUMAN No
UB2E3_HUMAN Yes: Q969T4 (MoonDB)
UBE2K_HUMAN Yes: P61086 (MoonDB)
UBP2_HUMAN Yes: O75604 (MoonDB)
UBP7_HUMAN No
UBQL4_HUMAN No
USBP1_HUMAN No
VAX1_HUMAN No
VEZF1_HUMAN No
VPS25_HUMAN No
WT1_HUMAN No
XPA_HUMAN No
YES_HUMAN No
YPEL2_HUMAN No
YTDC1_HUMAN No
Z286A_HUMAN No
ZBED1_HUMAN No
ZBT24_HUMAN No
ZBT49_HUMAN No
ZBTB2_HUMAN No
ZFHX3_HUMAN No
ZFP2_HUMAN No
ZMAT2_HUMAN No
ZMY12_HUMAN No
ZN165_HUMAN No
ZN205_HUMAN No
ZN250_HUMAN No
ZN264_HUMAN No
ZN276_HUMAN No
ZN329_HUMAN No
ZN330_HUMAN No
ZN408_HUMAN No
ZN410_HUMAN No
ZN414_HUMAN No
ZN417_HUMAN Yes: Q8TAU3 (MoonDB)
ZN438_HUMAN No
ZN497_HUMAN No
ZN524_HUMAN No
ZN575_HUMAN No
ZN576_HUMAN No
ZN593_HUMAN No
ZN624_HUMAN No
ZN691_HUMAN No
ZN697_HUMAN No
ZN764_HUMAN No
ZN774_HUMAN No
ZNF17_HUMAN No
ZNF35_HUMAN No
ZNF71_HUMAN No
ZSC21_HUMAN No
ZSC23_HUMAN No
ZZZ3_HUMAN No
PMID Article Title
10591208 The DNA sequence of human chromosome 22.
10623590 Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors.
11343649 Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1.
11641419 The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering.
11802773 Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel).
12529303 Reevaluating human gene annotation: a second-generation analysis of chromosome 22.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15247289 The PDZ domain of PICK1 differentially accepts protein kinase C-alpha and GluR2 as interacting ligands.
15304526 A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth.
15461802 A genome annotation-driven approach to cloning the human ORFeome.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
17384233 Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions.
20403402 Threonine 82 at the PDZ domain of PICK1 is critical for AMPA receptor interaction and localization.
No results found.
Domain Name Domain ID Source
PDZ IPR001478 InterPro
AH_dom IPR010504 InterPro
AH/BAR_dom_sf IPR027267 InterPro
Arfaptin_fam IPR030798 InterPro
PDZ_sf IPR036034 InterPro
JC7167 JC7167 PIR
PDZ PF00595 Pfam
Arfaptin PF06456 Pfam
PDZ PS50106 PROSITE
AH PS50870 PROSITE
PTHR12141 PTHR12141 PANTHER
PDZ SM00228 SMART
Arfaptin SM01015 SMART
SSF103657 SSF103657 SUPFAM
SSF50156 SSF50156 SUPFAM