Protein: Q9UJV3

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9UJV3 (Uniprot) TRIM1_HUMAN MID2 Probable E3 ubiquitin-protein ligase MID2 human No
Uniprot: May play a role in microtubule stabilization.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009056 catabolic process 359 GO:0009059 macromolecule biosynthetic process 401, 593 6.37e-04 1.88e-40
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
63 GO:0010467 gene expression
63 GO:0090304 nucleic acid metabolic process
63 GO:0060255 regulation of macromolecule metabolic process
67 GO:0060255 regulation of macromolecule metabolic process
73 GO:0006355 regulation of transcription, DNA-templated
127 GO:0016070 RNA metabolic process
127 GO:0010467 gene expression
132 GO:0090304 nucleic acid metabolic process
132 GO:0060255 regulation of macromolecule metabolic process
151 GO:0060255 regulation of macromolecule metabolic process
280 GO:0016070 RNA metabolic process
280 GO:0010467 gene expression
359 GO:0044248 cellular catabolic process
359 GO:0000209 protein polyubiquitination
359 GO:0007165 signal transduction
375 GO:0070647 protein modification by small protein conjugation or removal
375 GO:0060255 regulation of macromolecule metabolic process
401 GO:0034645 cellular macromolecule biosynthetic process
401 GO:0060255 regulation of macromolecule metabolic process
464 GO:0016070 RNA metabolic process
464 GO:0010467 gene expression
478 GO:0060255 regulation of macromolecule metabolic process
572 GO:0090304 nucleic acid metabolic process
581 GO:0031326 regulation of cellular biosynthetic process
581 GO:0060255 regulation of macromolecule metabolic process
581 GO:0019219 regulation of nucleobase-containing compound metabolic process
581 GO:0006351 transcription, DNA-templated
593 GO:0034645 cellular macromolecule biosynthetic process
593 GO:0006464 cellular protein modification process
593 GO:0060255 regulation of macromolecule metabolic process
596 GO:0006464 cellular protein modification process
603 GO:0060255 regulation of macromolecule metabolic process
605 GO:0007165 signal transduction
648 GO:0016070 RNA metabolic process
648 GO:0034645 cellular macromolecule biosynthetic process
648 GO:0010467 gene expression
648 GO:0031326 regulation of cellular biosynthetic process
648 GO:0010556 regulation of macromolecule biosynthetic process
648 GO:0019219 regulation of nucleobase-containing compound metabolic process
782 GO:0006355 regulation of transcription, DNA-templated
827 GO:0060255 regulation of macromolecule metabolic process
829 GO:0007165 signal transduction
848 GO:0007165 signal transduction
863 GO:0016070 RNA metabolic process
863 GO:0010467 gene expression
863 GO:0031326 regulation of cellular biosynthetic process
863 GO:0010556 regulation of macromolecule biosynthetic process
866 GO:0010646 regulation of cell communication
866 GO:0060255 regulation of macromolecule metabolic process
866 GO:0023051 regulation of signaling
866 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
63 GO:0005634 nucleus
67 GO:0005634 nucleus
73 GO:0005634 nucleus
82 GO:0005634 nucleus
84 GO:0005634 nucleus
89 GO:0005634 nucleus
127 GO:0005634 nucleus
132 GO:0005634 nucleus
151 GO:0005634 nucleus
231 GO:0005634 nucleus
280 GO:0005634 nucleus
322 GO:0005634 nucleus
359 GO:0005634 nucleus
375 GO:0005829 cytosol
375 GO:0005634 nucleus
401 GO:0005634 nucleus
464 GO:0070013 intracellular organelle lumen
464 GO:0005634 nucleus
478 GO:0005634 nucleus
495 GO:0043232 intracellular non-membrane-bounded organelle
495 GO:0005634 nucleus
572 GO:0005634 nucleus
581 GO:0005634 nucleus
593 GO:0005634 nucleus
596 GO:0005634 nucleus
603 GO:0005634 nucleus
648 GO:0005634 nucleus
697 GO:0043232 intracellular non-membrane-bounded organelle
697 GO:0005634 nucleus
782 GO:0005634 nucleus
827 GO:0012505 endomembrane system
827 GO:0031982 vesicle
829 GO:0005829 cytosol
829 GO:0031982 vesicle
866 GO:0005829 cytosol
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0010508 positive regulation of autophagy IMP
GO:0016567 protein ubiquitination IEA
GO:0032897 negative regulation of viral transcription IDA
GO:0035372 protein localization to microtubule IMP
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
GO:0045087 innate immune response IDA
GO:0046597 negative regulation of viral entry into host cell IDA
GO:0051091 positive regulation of DNA binding transcription factor activity IMP
GO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
GO:1902187 negative regulation of viral release from host cell IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005737 cytoplasm IEA
GO:0005874 microtubule IDA
GO:0070062 extracellular exosome IDA
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
PRP31_HUMAN No
PICK1_HUMAN Yes: Q9NRD5 (MoonDB)
MEOX2_HUMAN Yes: P50222 (MoonDB)
IHO1_HUMAN No
ENKD1_HUMAN No
ZN408_HUMAN No
K2C75_HUMAN No
TRI27_HUMAN Yes: P14373 (MoonDB)
REL_HUMAN No
ATL4_HUMAN No
KIFC3_HUMAN No
TRI54_HUMAN No
CARD9_HUMAN No
IKZF3_HUMAN No
SDCB1_HUMAN Yes: O00560 (MoonDB)
MMTA2_HUMAN No
LMO4_HUMAN No
AP1M1_HUMAN No
PSA1_HUMAN No
FBXW5_HUMAN No
HDX_HUMAN No
ZRAN1_HUMAN No
ZGPAT_HUMAN No
GOGA2_HUMAN Yes: Q08379 (MoonDB)
ZBT24_HUMAN No
PRPF3_HUMAN No
BYST_HUMAN No
ELOA1_HUMAN No
TCEA2_HUMAN No
TRI42_HUMAN No
TEANC_HUMAN No
GMCLL_HUMAN No
PPL13_HUMAN No
GEM_HUMAN No
ZN417_HUMAN Yes: Q8TAU3 (MoonDB)
CBX8_HUMAN No
BLK_HUMAN No
Q49AR9_HUMAN No
LAGE3_HUMAN No
GMCL1_HUMAN No
ZBT16_HUMAN Yes: Q05516 (MoonDB)
K1H1_HUMAN No
K1C40_HUMAN No
SYFM_HUMAN No
MOS_HUMAN No
PPR18_HUMAN No
CE57L_HUMAN No
CCHCR_HUMAN No
FBF1_HUMAN No
HXB9_HUMAN No
PKN1_HUMAN No
GOR_HUMAN No
K1C27_HUMAN No
FSD2_HUMAN No
DCX_HUMAN No
F107A_HUMAN No
AQP1_HUMAN No
HDAC4_HUMAN No
CDK18_HUMAN No
ZN124_HUMAN No
F161A_HUMAN No
ZC21C_HUMAN No
ZN648_HUMAN No
TTC23_HUMAN No
ZN774_HUMAN No
ZN410_HUMAN No
F90A1_HUMAN No
Q8IVT4_HUMAN No
LNX1_HUMAN Yes: Q8TBB1 (MoonDB)
LENG1_HUMAN No
CC120_HUMAN No
ZN587_HUMAN No
THAP7_HUMAN No
SCNM1_HUMAN No
RCOR3_HUMAN No
A0A024R857_HUMAN No
A8KA13_HUMAN No
ADT3_HUMAN No
AEN_HUMAN No
AL3B1_HUMAN No
ARHG5_HUMAN No
ATRIP_HUMAN No
BAHD1_HUMAN No
BCL6B_HUMAN No
BRCA1_HUMAN No
BRM1L_HUMAN No
CACO2_HUMAN No
CATZ_HUMAN No
CC185_HUMAN No
CCD42_HUMAN No
CHD2_HUMAN No
CHSP1_HUMAN No
CL033_HUMAN No
CNNM3_HUMAN No
COX5B_HUMAN No
CPSF4_HUMAN No
CRERF_HUMAN No
DGC6L_HUMAN No
DGCR6_HUMAN No
DIEXF_HUMAN No
DMRT3_HUMAN No
DYDC1_HUMAN No
EFC4B_HUMAN No
EFHC2_HUMAN No
EGFL7_HUMAN No
EIF1A_HUMAN No
EKI2_HUMAN No
EPN2_HUMAN No
F161B_HUMAN No
F208B_HUMAN No
F214A_HUMAN No
F214B_HUMAN No
FA50B_HUMAN No
FAKD5_HUMAN No
FRMD6_HUMAN No
FX4L3_HUMAN No
GA2L2_HUMAN No
GAS8_HUMAN No
GCC1_HUMAN No
GFI1B_HUMAN No
GO45_HUMAN No
GOGA7_HUMAN No
GORS2_HUMAN No
GPAN1_HUMAN No
GPKOW_HUMAN No
HCK_HUMAN No
HPLN2_HUMAN No
HXB2_HUMAN No
HXB5_HUMAN No
IGBP1_HUMAN No
IGFN1_HUMAN No
IL16_HUMAN No
IN80B_HUMAN No
ISCU_HUMAN No
ITB4_HUMAN No
JOS1_HUMAN No
K1683_HUMAN No
K22O_HUMAN No
KANK2_HUMAN No
KIF1A_HUMAN No
KIF9_HUMAN No
LEG8_HUMAN No
LMNB2_HUMAN No
LMO3_HUMAN No
LMTD2_HUMAN No
LONF1_HUMAN No
LRC45_HUMAN No
LZTS1_HUMAN No
LZTS2_HUMAN No
M1IP1_HUMAN No
MAGA6_HUMAN No
MEOX1_HUMAN No
MET17_HUMAN No
MFAP1_HUMAN No
MGN2_HUMAN No
MTG8_HUMAN No
MVP_HUMAN No
NCOA4_HUMAN No
NR1D2_HUMAN No
NSMF_HUMAN No
NXF1_HUMAN No
OTUB2_HUMAN No
PROP_HUMAN No
PTCD2_HUMAN No
PTPC1_HUMAN No
Q6NSM0_HUMAN No
Q8WUT1_HUMAN No
Q96D16_HUMAN No
Q9Y260_HUMAN No
RABX5_HUMAN No
REL1_HUMAN No
RNB3L_HUMAN No
RP25L_HUMAN No
RPH3L_HUMAN No
RYDEN_HUMAN No
S2548_HUMAN No
SEPT1_HUMAN No
SNAI1_HUMAN No
SNP47_HUMAN No
SPA24_HUMAN No
SPG21_HUMAN No
SPY2_HUMAN No
STX11_HUMAN No
SYGP1_HUMAN No
SYQ_HUMAN No
SYT17_HUMAN No
TB22B_HUMAN No
TCAF1_HUMAN No
TEKT1_HUMAN No
TM14B_HUMAN No
TOP3B_HUMAN No
TRI18_HUMAN No
TRI29_HUMAN No
TRI32_HUMAN No
TRI41_HUMAN Yes: Q8WV44 (MoonDB)
TRI69_HUMAN No
TRPV6_HUMAN No
TSG10_HUMAN No
TXND5_HUMAN No
UB2D1_HUMAN Yes: P51668 (MoonDB)
UB2D2_HUMAN Yes: P62837 (MoonDB)
UB2D3_HUMAN Yes: P61077 (MoonDB)
UB2D4_HUMAN Yes: Q9Y2X8 (MoonDB)
UB2E1_HUMAN Yes: P51965 (MoonDB)
UB2E2_HUMAN Yes: Q96LR5 (MoonDB)
UB2E3_HUMAN Yes: Q969T4 (MoonDB)
UBE2K_HUMAN Yes: P61086 (MoonDB)
UBE2N_HUMAN Yes: P61088 (MoonDB)
UBE2U_HUMAN Yes: Q5VVX9 (MoonDB)
UBP25_HUMAN No
UBP2_HUMAN Yes: O75604 (MoonDB)
UBP54_HUMAN No
UBTD1_HUMAN No
UN45A_HUMAN No
UTP23_HUMAN No
WIT1_HUMAN No
ZBT42_HUMAN No
ZFY21_HUMAN No
ZIM2_HUMAN No
ZN165_HUMAN No
ZN250_HUMAN No
ZN266_HUMAN No
ZN438_HUMAN No
ZN440_HUMAN No
ZN497_HUMAN No
ZN564_HUMAN No
ZN669_HUMAN No
ZN696_HUMAN No
ZN764_HUMAN No
ZN784_HUMAN No
ZN785_HUMAN No
ZN792_HUMAN No
ZNF24_HUMAN No
ZSC12_HUMAN No
PMID Article Title
10400986 MID2, a homologue of the Opitz syndrome gene MID1: similarities in a sub-cellular localization and differences in expression during development.
10644436 FXY2/MID2, a gene related to the X-linked Opitz syndrome gene FXY/MID1, maps to Xq22 and encodes a FNIII domain-containing protein that associates with microtubules.
11806752 MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, Alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15772651 The DNA sequence of the human X chromosome.
24115387 Targeted deep resequencing identifies MID2 mutation for X-linked intellectual disability with varied disease severity in a large kindred from India.
OMIM ID Disease Name
300928 Mental retardation, X-linked 101
Domain Name Domain ID Source
Znf_B-box IPR000315 InterPro
Znf_RING IPR001841 InterPro
B30.2/SPRY IPR001870 InterPro
Bbox_C IPR003649 InterPro
SPRY_dom IPR003877 InterPro
Butyrophylin_SPRY IPR003879 InterPro
FN3_dom IPR003961 InterPro
Znf_RING/FYVE/PHD IPR013083 InterPro
ConA-like_dom_sf IPR013320 InterPro
Ig-like_fold IPR013783 InterPro
COS_domain IPR017903 InterPro
Znf_RING_CS IPR017907 InterPro
Znf-RING_LisH IPR027370 InterPro
MID2 IPR033491 InterPro
SPRY/PRY_TRIM1 IPR035752 InterPro
FN3_sf IPR036116 InterPro
SPRY PF00622 Pfam
zf-B_box PF00643 Pfam
zf-RING_UBOX PF13445 Pfam
BUTYPHLNCDUF PR01407 PRINTS
ZF_RING_1 PS00518 PROSITE
ZF_RING_2 PS50089 PROSITE
ZF_BBOX PS50119 PROSITE
B302_SPRY PS50188 PROSITE
COS PS51262 PROSITE
PTHR44073:SF2 PTHR44073:SF2 PANTHER
FN3 SM00060 SMART
RING SM00184 SMART
BBOX SM00336 SMART
SPRY SM00449 SMART
BBC SM00502 SMART
SSF49265 SSF49265 SUPFAM
SSF49899 SSF49899 SUPFAM
BBOX cd00021 CDD
FN3 cd00063 CDD
SPRY_PRY_TRIM1 cd13739 CDD