Protein: Q05516

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q05516 (Uniprot) ZBT16_HUMAN ZBTB16 Zinc finger and BTB domain-containing protein 16 human No
Uniprot: Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 169 GO:0006725 cellular aromatic compound metabolic process 345 5.44e-126 5.27e-27
GO:0007165 signal transduction 169 GO:0006139 nucleobase-containing compound metabolic process 497 1.10e-111 5.07e-25
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
17 GO:0006355 regulation of transcription, DNA-templated
51 GO:0060255 regulation of macromolecule metabolic process
59 GO:0016070 RNA metabolic process
59 GO:0006464 cellular protein modification process
59 GO:0010467 gene expression
59 GO:2000112 regulation of cellular macromolecule biosynthetic process
67 GO:0060255 regulation of macromolecule metabolic process
102 GO:0044267 cellular protein metabolic process
102 GO:0031325 positive regulation of cellular metabolic process
102 GO:0010604 positive regulation of macromolecule metabolic process
102 GO:0051173 positive regulation of nitrogen compound metabolic process
102 GO:0006355 regulation of transcription, DNA-templated
102 GO:0007165 signal transduction
155 GO:0006464 cellular protein modification process
155 GO:0060255 regulation of macromolecule metabolic process
167 GO:0016070 RNA metabolic process
167 GO:0010467 gene expression
167 GO:0060255 regulation of macromolecule metabolic process
169 GO:0030522 intracellular receptor signaling pathway
169 GO:0045892 negative regulation of transcription, DNA-templated
169 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
169 GO:0043401 steroid hormone mediated signaling pathway
280 GO:0016070 RNA metabolic process
280 GO:0010467 gene expression
345 GO:0006139 nucleobase-containing compound metabolic process
345 GO:0060255 regulation of macromolecule metabolic process
351 GO:0022402 cell cycle process
351 GO:0034645 cellular macromolecule biosynthetic process
351 GO:0044267 cellular protein metabolic process
351 GO:0090304 nucleic acid metabolic process
362 GO:0006464 cellular protein modification process
362 GO:0060255 regulation of macromolecule metabolic process
394 GO:0006464 cellular protein modification process
394 GO:0031325 positive regulation of cellular metabolic process
394 GO:0010604 positive regulation of macromolecule metabolic process
394 GO:0051173 positive regulation of nitrogen compound metabolic process
394 GO:0032268 regulation of cellular protein metabolic process
394 GO:0006355 regulation of transcription, DNA-templated
394 GO:0007165 signal transduction
497 GO:0090304 nucleic acid metabolic process
497 GO:0060255 regulation of macromolecule metabolic process
547 GO:0060255 regulation of macromolecule metabolic process
581 GO:0031326 regulation of cellular biosynthetic process
581 GO:0060255 regulation of macromolecule metabolic process
581 GO:0019219 regulation of nucleobase-containing compound metabolic process
581 GO:0006351 transcription, DNA-templated
593 GO:0034645 cellular macromolecule biosynthetic process
593 GO:0006464 cellular protein modification process
593 GO:0060255 regulation of macromolecule metabolic process
602 GO:0006464 cellular protein modification process
603 GO:0060255 regulation of macromolecule metabolic process
606 GO:0019538 protein metabolic process
606 GO:0006355 regulation of transcription, DNA-templated
606 GO:0007165 signal transduction
606 GO:0006366 transcription from RNA polymerase II promoter
753 GO:0044267 cellular protein metabolic process
753 GO:0034654 nucleobase-containing compound biosynthetic process
753 GO:0031325 positive regulation of cellular metabolic process
753 GO:0010604 positive regulation of macromolecule metabolic process
753 GO:0051173 positive regulation of nitrogen compound metabolic process
753 GO:0031326 regulation of cellular biosynthetic process
753 GO:0019219 regulation of nucleobase-containing compound metabolic process
753 GO:0009966 regulation of signal transduction
859 GO:0010467 gene expression
859 GO:0090304 nucleic acid metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
17 GO:0005829 cytosol
17 GO:0005654 nucleoplasm
51 GO:0005634 nucleus
59 GO:0005634 nucleus
67 GO:0005634 nucleus
82 GO:0005634 nucleus
84 GO:0005634 nucleus
102 GO:0005634 nucleus
155 GO:0005634 nucleus
167 GO:0005654 nucleoplasm
169 GO:0005654 nucleoplasm
231 GO:0005634 nucleus
280 GO:0005634 nucleus
345 GO:0070013 intracellular organelle lumen
345 GO:0005634 nucleus
347 GO:0005829 cytosol
347 GO:0012505 endomembrane system
351 GO:0043232 intracellular non-membrane-bounded organelle
351 GO:0005654 nucleoplasm
362 GO:0070013 intracellular organelle lumen
362 GO:0005634 nucleus
394 GO:0005654 nucleoplasm
497 GO:0005634 nucleus
547 GO:0005654 nucleoplasm
581 GO:0005634 nucleus
593 GO:0005634 nucleus
602 GO:0005634 nucleus
603 GO:0005634 nucleus
606 GO:0005829 cytosol
606 GO:0031981 nuclear lumen
641 GO:0005634 nucleus
710 GO:0005829 cytosol
710 GO:0070013 intracellular organelle lumen
710 GO:0005634 nucleus
753 GO:0005634 nucleus
859 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA
GO:0001823 mesonephros development ISS
GO:0006351 transcription, DNA-templated IEA
GO:0006915 apoptotic process NAS
GO:0007417 central nervous system development ISS
GO:0008285 negative regulation of cell proliferation IEA
GO:0009880 embryonic pattern specification IEA
GO:0009952 anterior/posterior pattern specification IEA
GO:0016567 protein ubiquitination IEA
GO:0030097 hemopoiesis TAS
GO:0030099 myeloid cell differentiation TAS
GO:0032332 positive regulation of chondrocyte differentiation IMP
GO:0034504 protein localization to nucleus IEA
GO:0035116 embryonic hindlimb morphogenesis IEA
GO:0035136 forelimb morphogenesis IEA
GO:0042733 embryonic digit morphogenesis IEA
GO:0043065 positive regulation of apoptotic process IEA
GO:0043687 post-translational protein modification TAS
GO:0045600 positive regulation of fat cell differentiation IMP
GO:0045638 negative regulation of myeloid cell differentiation ISS
GO:0045778 positive regulation of ossification IDA
GO:0045892 negative regulation of transcription, DNA-templated NAS
GO:0045893 positive regulation of transcription, DNA-templated IDA
GO:0048133 male germ-line stem cell asymmetric division IEA
GO:0051138 positive regulation of NK T cell differentiation IEA
GO:0051216 cartilage development IDA
GO:0061036 positive regulation of cartilage development IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005829 cytosol TAS
GO:0005886 plasma membrane IEA
GO:0016604 nuclear body IDA
GO:0016605 PML body IDA
GO:0016607 nuclear speck IDA
GO:0017053 transcriptional repressor complex IDA
GO:0043234 protein complex IMP
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
GO:0005886 plasma membrane GO:0016604 nuclear body 1.42e-38 3.32e-172
GO:0005886 plasma membrane GO:0016607 nuclear speck 2.37e-16 9.27e-101
GO:0005886 plasma membrane GO:0017053 transcriptional repressor complex 7.73e-04 1.11e-30
Interactor Also a MoonDB EMF protein
TRAF1_HUMAN No
CEP70_HUMAN No
MEOX2_HUMAN Yes: P50222 (MoonDB)
HSF2B_HUMAN No
PROP1_HUMAN No
TRI27_HUMAN Yes: P14373 (MoonDB)
KAP1_HUMAN No
REL_HUMAN No
TRAF2_HUMAN No
FHL2_HUMAN No
MTUS2_HUMAN No
KIFC3_HUMAN No
TRI54_HUMAN No
CARD9_HUMAN No
AES_HUMAN Yes: Q08117 (MoonDB)
HXA1_HUMAN No
HDX_HUMAN No
GOGA2_HUMAN Yes: Q08379 (MoonDB)
GRB7_HUMAN No
KR412_HUMAN No
SH24A_HUMAN No
GG6L9_HUMAN No
SMN_HUMAN No
A0A0C4DGV4_HUMAN No
A0A0A0MQW5_HUMAN No
AMOL2_HUMAN No
ANDR_HUMAN Yes: P10275 (MoonDB)
ANXA7_HUMAN No
APC5_HUMAN No
APR_HUMAN No
ATP7B_HUMAN No
ATS4_HUMAN No
BCL6_HUMAN No
CC130_HUMAN No
CC85B_HUMAN No
CCHCR_HUMAN No
CD81_HUMAN No
CDK4_HUMAN No
CDN1A_HUMAN Yes: P38936 (MoonDB)
CEP72_HUMAN No
CFAH_HUMAN No
CIDEA_HUMAN No
COG6_HUMAN No
COQ6_HUMAN No
CTDS1_HUMAN No
DAAF5_HUMAN No
DPM1_HUMAN No
DYN2_HUMAN Yes: P50570 (MoonDB)
EF1A1_HUMAN No
EFHC2_HUMAN No
ENOX1_HUMAN No
F90A1_HUMAN No
FCHO1_HUMAN No
FSHR_HUMAN No
GCSH_HUMAN No
GO45_HUMAN No
GPAN1_HUMAN No
GSTM4_HUMAN No
HBEGF_HUMAN No
HD_HUMAN Yes: P42858 (MoonDB)
HXC5_HUMAN No
ICAM3_HUMAN No
IF2B_HUMAN No
IL32_HUMAN No
IL6_HUMAN No
K1549_HUMAN No
K1C40_HUMAN No
KITH_HUMAN No
LDOC1_HUMAN No
LMTK3_HUMAN No
LSM2_HUMAN No
LTOR5_HUMAN No
LYAR_HUMAN No
LYRIC_HUMAN No
M3K3_HUMAN No
MAGAB_HUMAN Yes: P43364 (MoonDB)
MCUB_HUMAN No
MTG8_HUMAN No
MX1_HUMAN No
MYLIP_HUMAN No
NALP7_HUMAN No
NCOR2_HUMAN No
ODO2_HUMAN No
OSBL3_HUMAN No
PA1B3_HUMAN No
PGAM5_HUMAN No
PHF1_HUMAN No
PIAS2_HUMAN No
PIBF1_HUMAN No
PLS1_HUMAN No
PML_HUMAN No
PNRC2_HUMAN No
PPA5_HUMAN No
PSD11_HUMAN No
PSMD2_HUMAN Yes: Q13200 (MoonDB)
RAB3I_HUMAN No
RARA_HUMAN Yes: P10276 (MoonDB)
RB27A_HUMAN No
RENR_HUMAN No
RFLB_HUMAN No
RINT1_HUMAN No
RO52_HUMAN No
RXRA_HUMAN Yes: P19793 (MoonDB)
SIN3A_HUMAN No
SIN3B_HUMAN No
SMAD3_HUMAN Yes: P84022 (MoonDB)
SPOP_HUMAN No
SPY2_HUMAN No
SUMO1_HUMAN Yes: P63165 (MoonDB)
TAB2_HUMAN No
TERF1_HUMAN No
TGT_HUMAN No
THNS2_HUMAN No
TIMP1_HUMAN No
TOLIP_HUMAN No
TRAF4_HUMAN No
TRI23_HUMAN No
TRIM1_HUMAN Yes: Q9UJV3 (MoonDB)
UBC9_HUMAN Yes: P63279 (MoonDB)
VTA1_HUMAN No
WDR33_HUMAN No
ZBT32_HUMAN No
ZBT42_HUMAN No
ZN281_HUMAN No
ZNF24_HUMAN No
PMID Article Title
8384553 Fusion between a novel Kruppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia.
8387545 Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia.
9770450 Crystal structure of the BTB domain from PLZF.
10500192 Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene.
10537309 Structure-function studies of the BTB/POZ transcriptional repression domain from the promyelocytic leukemia zinc finger oncoprotein.
10572087 A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF.
11161217 Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis.
14528312 Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16676348 A new hepatocytic isoform of PLZF lacking the BTB domain interacts with ATP7B, the Wilson disease protein, and positively regulates ERK signal transduction.
18611983 Biallelic loss of function of the promyelocytic leukaemia zinc finger (PLZF) gene causes severe skeletal defects and genital hypoplasia.
OMIM ID Disease Name
612447 Skeletal defects, genital hypoplasia, and mental retardation
Domain Name Domain ID Source
BTB/POZ_dom IPR000210 InterPro
SKP1/BTB/POZ_sf IPR011333 InterPro
Znf_RING/FYVE/PHD IPR013083 InterPro
Znf_C2H2_type IPR013087 InterPro
Znf_C2H2_sf IPR036236 InterPro
BTB PF00651 Pfam
ZINC_FINGER_C2H2_1 PS00028 PROSITE
BTB PS50097 PROSITE
ZINC_FINGER_C2H2_2 PS50157 PROSITE
S36336 S36336 PIR
BTB SM00225 SMART
ZnF_C2H2 SM00355 SMART
SSF54695 SSF54695 SUPFAM
SSF57667 SSF57667 SUPFAM