Protein: Q05516 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q05516 (Uniprot)	ZBT16_HUMAN	ZBTB16	Zinc finger and BTB domain-containing protein 16	human	No

Protein Function

Uniprot: Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target prot more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	169	GO:0006725	cellular aromatic compound metabolic process	345	5.44e-126	5.27e-27
GO:0007165	signal transduction	169	GO:0006139	nucleobase-containing compound metabolic process	497	1.10e-111	5.07e-25

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
17	GO:0006355	regulation of transcription, DNA-templated
51	GO:0060255	regulation of macromolecule metabolic process
59	GO:0016070	RNA metabolic process
59	GO:0006464	cellular protein modification process
59	GO:0010467	gene expression
59	GO:2000112	regulation of cellular macromolecule biosynthetic process
67	GO:0060255	regulation of macromolecule metabolic process
102	GO:0044267	cellular protein metabolic process
102	GO:0031325	positive regulation of cellular metabolic process
102	GO:0010604	positive regulation of macromolecule metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
17	GO:0005829	cytosol
17	GO:0005654	nucleoplasm
51	GO:0005634	nucleus
59	GO:0005634	nucleus
67	GO:0005634	nucleus
82	GO:0005634	nucleus
84	GO:0005634	nucleus
102	GO:0005634	nucleus
155	GO:0005634	nucleus
167	GO:0005654	nucleoplasm

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA
GO:0001823	mesonephros development	ISS
GO:0006351	transcription, DNA-templated	IEA
GO:0006915	apoptotic process	NAS
GO:0007417	central nervous system development	ISS
GO:0008285	negative regulation of cell proliferation	IEA
GO:0009880	embryonic pattern specification	IEA
GO:0009952	anterior/posterior pattern specification	IEA
GO:0016567	protein ubiquitination	IEA
GO:0030097	hemopoiesis	TAS

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	IEA
GO:0016604	nuclear body	IDA
GO:0016605	PML body	IDA
GO:0016607	nuclear speck	IDA
GO:0017053	transcriptional repressor complex	IDA
GO:0043234	protein complex	IMP

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0005886	plasma membrane	5.35e-300	7.52e-165
GO:0005886	plasma membrane	GO:0016604	nuclear body	1.42e-38	3.32e-172
GO:0005886	plasma membrane	GO:0016607	nuclear speck	2.37e-16	9.27e-101
GO:0005886	plasma membrane	GO:0017053	transcriptional repressor complex	7.73e-04	1.11e-30

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
A0A0A0MQW5_HUMAN	No
A0A0C4DGV4_HUMAN	No
AES_HUMAN	Yes: Q08117 (MoonDB)
AMOL2_HUMAN	No
ANDR_HUMAN	Yes: P10275 (MoonDB)
ANXA7_HUMAN	No
APC5_HUMAN	No
APR_HUMAN	No
ATP7B_HUMAN	No
ATS4_HUMAN	No

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Publications Associated

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PMID	Article Title
8384553	Fusion between a novel Kruppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia.
8387545	Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia.
9770450	Crystal structure of the BTB domain from PLZF.
10500192	Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene.
10537309	Structure-function studies of the BTB/POZ transcriptional repression domain from the promyelocytic leukemia zinc finger oncoprotein.
10572087	A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF.
11161217	Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis.
14528312	Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16676348	A new hepatocytic isoform of PLZF lacking the BTB domain interacts with ATP7B, the Wilson disease protein, and positively regulates ERK signal transduction.

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OMIM Diseases Associated

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OMIM ID	Disease Name
612447	Skeletal defects, genital hypoplasia, and mental retardation

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Protein Domains Associated

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Domain Name	Domain ID	Source
BTB	PF00651	Pfam
BTB	PS50097	PROSITE
BTB	SM00225	SMART
BTB/POZ_dom	IPR000210	InterPro
S36336	S36336	PIR
SKP1/BTB/POZ_sf	IPR011333	InterPro
SSF54695	SSF54695	SUPFAM
SSF57667	SSF57667	SUPFAM
ZINC_FINGER_C2H2_1	PS00028	PROSITE
ZINC_FINGER_C2H2_2	PS50157	PROSITE

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