Protein: P63165

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P63165 (Uniprot) SUMO1_HUMAN SUMO1 Small ubiquitin-related modifier 1 human No
Uniprot: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 169 GO:0034641 cellular nitrogen compound metabolic process 504, 810 4.22e-144 6.90e-18
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
17 GO:0006355 regulation of transcription, DNA-templated
99 GO:0031325 positive regulation of cellular metabolic process
99 GO:0010628 positive regulation of gene expression
99 GO:0051173 positive regulation of nitrogen compound metabolic process
99 GO:0019538 protein metabolic process
99 GO:0006357 regulation of transcription from RNA polymerase II promoter
99 GO:0007165 signal transduction
155 GO:0006464 cellular protein modification process
155 GO:0060255 regulation of macromolecule metabolic process
169 GO:0030522 intracellular receptor signaling pathway
169 GO:0045892 negative regulation of transcription, DNA-templated
169 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
169 GO:0043401 steroid hormone mediated signaling pathway
191 GO:0006355 regulation of transcription, DNA-templated
192 GO:0034645 cellular macromolecule biosynthetic process
192 GO:0006464 cellular protein modification process
192 GO:0010467 gene expression
192 GO:0090304 nucleic acid metabolic process
192 GO:0009893 positive regulation of metabolic process
192 GO:0060255 regulation of macromolecule metabolic process
192 GO:0007165 signal transduction
201 GO:0006464 cellular protein modification process
201 GO:0031325 positive regulation of cellular metabolic process
201 GO:0010604 positive regulation of macromolecule metabolic process
201 GO:0051173 positive regulation of nitrogen compound metabolic process
201 GO:0010646 regulation of cell communication
201 GO:0023051 regulation of signaling
201 GO:0006355 regulation of transcription, DNA-templated
201 GO:0007165 signal transduction
207 GO:0007165 signal transduction
234 GO:0044267 cellular protein metabolic process
234 GO:0071310 cellular response to organic substance
234 GO:0033554 cellular response to stress
234 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
234 GO:0010629 negative regulation of gene expression
234 GO:0051172 negative regulation of nitrogen compound metabolic process
234 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
234 GO:0007165 signal transduction
286 GO:0034645 cellular macromolecule biosynthetic process
286 GO:0090304 nucleic acid metabolic process
286 GO:0034654 nucleobase-containing compound biosynthetic process
286 GO:0010468 regulation of gene expression
287 GO:0006464 cellular protein modification process
287 GO:0006355 regulation of transcription, DNA-templated
300 GO:0016070 RNA metabolic process
300 GO:0044271 cellular nitrogen compound biosynthetic process
300 GO:0031325 positive regulation of cellular metabolic process
300 GO:0010604 positive regulation of macromolecule metabolic process
300 GO:0051173 positive regulation of nitrogen compound metabolic process
300 GO:2000112 regulation of cellular macromolecule biosynthetic process
300 GO:0010468 regulation of gene expression
300 GO:0019219 regulation of nucleobase-containing compound metabolic process
325 GO:0006355 regulation of transcription, DNA-templated
343 GO:0060255 regulation of macromolecule metabolic process
362 GO:0006464 cellular protein modification process
362 GO:0060255 regulation of macromolecule metabolic process
394 GO:0006464 cellular protein modification process
394 GO:0031325 positive regulation of cellular metabolic process
394 GO:0010604 positive regulation of macromolecule metabolic process
394 GO:0051173 positive regulation of nitrogen compound metabolic process
394 GO:0032268 regulation of cellular protein metabolic process
394 GO:0006355 regulation of transcription, DNA-templated
394 GO:0007165 signal transduction
454 GO:0031326 regulation of cellular biosynthetic process
454 GO:0060255 regulation of macromolecule metabolic process
465 GO:0031325 positive regulation of cellular metabolic process
465 GO:0010604 positive regulation of macromolecule metabolic process
465 GO:0051173 positive regulation of nitrogen compound metabolic process
465 GO:0006357 regulation of transcription from RNA polymerase II promoter
465 GO:0007165 signal transduction
504 GO:0044271 cellular nitrogen compound biosynthetic process
504 GO:0044267 cellular protein metabolic process
504 GO:0031324 negative regulation of cellular metabolic process
504 GO:0010629 negative regulation of gene expression
504 GO:0051172 negative regulation of nitrogen compound metabolic process
504 GO:0051252 regulation of RNA metabolic process
504 GO:2000112 regulation of cellular macromolecule biosynthetic process
569 GO:0007165 signal transduction
593 GO:0034645 cellular macromolecule biosynthetic process
593 GO:0006464 cellular protein modification process
593 GO:0060255 regulation of macromolecule metabolic process
602 GO:0006464 cellular protein modification process
705 GO:0060255 regulation of macromolecule metabolic process
716 GO:0010646 regulation of cell communication
716 GO:0023051 regulation of signaling
716 GO:0007165 signal transduction
753 GO:0044267 cellular protein metabolic process
753 GO:0034654 nucleobase-containing compound biosynthetic process
753 GO:0031325 positive regulation of cellular metabolic process
753 GO:0010604 positive regulation of macromolecule metabolic process
753 GO:0051173 positive regulation of nitrogen compound metabolic process
753 GO:0031326 regulation of cellular biosynthetic process
753 GO:0019219 regulation of nucleobase-containing compound metabolic process
753 GO:0009966 regulation of signal transduction
780 GO:0006355 regulation of transcription, DNA-templated
810 GO:0044271 cellular nitrogen compound biosynthetic process
810 GO:0006139 nucleobase-containing compound metabolic process
810 GO:2000112 regulation of cellular macromolecule biosynthetic process
810 GO:0010468 regulation of gene expression
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
17 GO:0005829 cytosol
17 GO:0005654 nucleoplasm
65 GO:0012505 endomembrane system
65 GO:0016021 integral component of membrane
99 GO:0005654 nucleoplasm
155 GO:0005634 nucleus
169 GO:0005654 nucleoplasm
191 GO:0031981 nuclear lumen
192 GO:0005829 cytosol
192 GO:0005654 nucleoplasm
201 GO:0005829 cytosol
201 GO:0005654 nucleoplasm
207 GO:0005829 cytosol
207 GO:0005654 nucleoplasm
234 GO:0012505 endomembrane system
234 GO:0005654 nucleoplasm
286 GO:0044428 nuclear part
287 GO:0005829 cytosol
287 GO:0043232 intracellular non-membrane-bounded organelle
287 GO:0031981 nuclear lumen
300 GO:0070013 intracellular organelle lumen
300 GO:0044428 nuclear part
325 GO:0005829 cytosol
325 GO:0043232 intracellular non-membrane-bounded organelle
325 GO:0005654 nucleoplasm
343 GO:0005634 nucleus
362 GO:0070013 intracellular organelle lumen
362 GO:0005634 nucleus
394 GO:0005654 nucleoplasm
454 GO:0005634 nucleus
465 GO:0005654 nucleoplasm
504 GO:0005654 nucleoplasm
593 GO:0005634 nucleus
602 GO:0005634 nucleus
705 GO:0070013 intracellular organelle lumen
716 GO:0016021 integral component of membrane
716 GO:0005886 plasma membrane
753 GO:0005634 nucleus
780 GO:0005654 nucleoplasm
810 GO:0044428 nuclear part
858 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS
GO:0006281 DNA repair TAS
GO:0006303 double-strand break repair via nonhomologous end joining TAS
GO:0016032 viral process IEA
GO:0016925 protein sumoylation TAS
GO:0030578 PML body organization IEA
GO:0031334 positive regulation of protein complex assembly IDA
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
GO:0032880 regulation of protein localization TAS
GO:0034605 cellular response to heat IDA
GO:0043392 negative regulation of DNA binding IDA
GO:0043433 negative regulation of DNA binding transcription factor activity IMP
GO:0045759 negative regulation of action potential IDA
GO:0045892 negative regulation of transcription, DNA-templated IDA
GO:0050821 protein stabilization IDA
GO:0060021 palate development ISS
GO:0060334 regulation of interferon-gamma-mediated signaling pathway TAS
GO:0070911 global genome nucleotide-excision repair TAS
GO:0071276 cellular response to cadmium ion IDA
GO:0086004 regulation of cardiac muscle cell contraction IEA
GO:0090204 protein localization to nuclear pore IEA
GO:1901896 positive regulation of calcium-transporting ATPase activity IEA
GO:1902260 negative regulation of delayed rectifier potassium channel activity IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000792 heterochromatin IEA
GO:0001650 fibrillar center IEA
GO:0001741 XY body IEA
GO:0005634 nucleus IDA
GO:0005643 nuclear pore TAS
GO:0005654 nucleoplasm TAS
GO:0005730 nucleolus IDA
GO:0005737 cytoplasm IEA
GO:0005886 plasma membrane IDA
GO:0008076 voltage-gated potassium channel complex IDA
GO:0016604 nuclear body IDA
GO:0016605 PML body IDA
GO:0016607 nuclear speck IEA
GO:0030425 dendrite IEA
GO:0031510 SUMO activating enzyme complex IDA
GO:0031965 nuclear membrane IDA
GO:0045202 synapse IEA
GO:0097165 nuclear stress granule IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0000792 heterochromatin GO:0005886 plasma membrane 5.86e-03 1.10e-44
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
GO:0005634 nucleus GO:0008076 voltage-gated potassium channel complex 5.52e-06 7.82e-07
GO:0005634 nucleus GO:0045202 synapse 1.10e-08 8.94e-15
GO:0005643 nuclear pore GO:0005886 plasma membrane 1.14e-02 8.77e-07
GO:0005654 nucleoplasm GO:0005886 plasma membrane 9.14e-199 6.17e-196
GO:0005654 nucleoplasm GO:0008076 voltage-gated potassium channel complex 8.67e-04 1.18e-05
GO:0005654 nucleoplasm GO:0045202 synapse 3.30e-10 4.22e-25
GO:0005730 nucleolus GO:0005886 plasma membrane 7.70e-47 3.09e-07
GO:0005886 plasma membrane GO:0016604 nuclear body 1.42e-38 3.32e-172
GO:0005886 plasma membrane GO:0016607 nuclear speck 2.37e-16 9.27e-101
PMID Article Title
8806687 PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia.
8812453 UBL1, a human ubiquitin-like protein associating with human RAD51/RAD52 proteins.
8906799 Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin.
8978815 A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex.
9019411 A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2.
9119407 SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family.
9162015 Preferential modification of nuclear proteins by a novel ubiquitin-like molecule.
9654451 Structure determination of the small ubiquitin-related modifier SUMO-1.
10574707 Cell cycle regulation of PML modification and ND10 composition.
10961991 Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif.
12383504 Molecular features of human ubiquitin-like SUMO genes and their encoded proteins.
12565818 The homeodomain-interacting kinase PKM (HIPK-2) modifies ND10 through both its kinase domain and a SUMO-1 interaction motif and alters the posttranslational modification of PML.
12924945 Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15296745 A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex.
15487983 Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15608651 Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection.
15660128 Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1.
15723079 SUMO modification of the ubiquitin-conjugating enzyme E2-25K.
15815621 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
15931224 Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex.
15959518 Crystal structure of thymine DNA glycosylase conjugated to SUMO-1.
16204249 Small ubiquitin-like modifier (SUMO) recognition of a SUMO binding motif: a reversal of the bound orientation.
16712526 Crystal structure of the SENP1 mutant C603S-SUMO complex reveals the hydrolytic mechanism of SUMO-specific protease.
16955485 Functional modulation of parkin through physical interaction with SUMO-1.
16990542 SUMO1 haploinsufficiency leads to cleft lip and palate.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
17099698 SUMO protease SENP1 induces isomerization of the scissile peptide bond.
17956732 RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia.
18408734 RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation.
18538659 Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
18707152 Phosphorylation of SUMO-1 occurs in vivo and is conserved through evolution.
19223394 SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitability.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20388717 In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21829689 SUMOylation of DEC1 protein regulates its transcriptional activity and enhances its stability.
21965678 SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function.
22398289 SUMO binding by the Epstein-Barr virus protein kinase BGLF4 is crucial for BGLF4 function.
22406621 The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA.
23086935 PolySUMO-binding proteins identified through a string search.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24651376 Characterization of nuclear localization and SUMOylation of the ATBF1 transcription factor in epithelial cells.
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner.
25755297 System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
25772364 SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
28112733 Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
OMIM ID Disease Name
613705 Non-syndromic orofacial cleft 10
Domain Name Domain ID Source
Ubiquitin_dom IPR000626 InterPro
Rad60/SUMO-like_dom IPR022617 InterPro
Ubiquitin-like_domsf IPR029071 InterPro
Sumo IPR033950 InterPro
Rad60-SLD PF11976 Pfam
UBIQUITIN_2 PS50053 PROSITE
UBQ SM00213 SMART
SSF54236 SSF54236 SUPFAM
Sumo cd01763 CDD