Protein: Q12873 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q12873 (Uniprot)	CHD3_HUMAN	CHD3	Chromodomain-helicase-DNA-binding protein 3	human	No

Protein Function

Uniprot: Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity.

MoonDB Dissimilar Functions

Showing 1 to 2 of 2 entries

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006139	nucleobase-containing compound metabolic process	27	GO:0007165	signal transduction	609	1.10e-111	5.07e-25
GO:0006725	cellular aromatic compound metabolic process	484	GO:0007165	signal transduction	609	5.44e-126	5.27e-27

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MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 56 entries

Search:

Module ID (MoonGO)	GO ID (BP)	GO Name
27	GO:0090304	nucleic acid metabolic process
27	GO:0060255	regulation of macromolecule metabolic process
51	GO:0060255	regulation of macromolecule metabolic process
81	GO:0006139	nucleobase-containing compound metabolic process
99	GO:0031325	positive regulation of cellular metabolic process
99	GO:0010628	positive regulation of gene expression
99	GO:0051173	positive regulation of nitrogen compound metabolic process
99	GO:0019538	protein metabolic process
99	GO:0006357	regulation of transcription from RNA polymerase II promoter
99	GO:0007165	signal transduction

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Cellular Components

Showing 1 to 10 of 28 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
27	GO:0031981	nuclear lumen
51	GO:0005634	nucleus
81	GO:0005829	cytosol
81	GO:0031981	nuclear lumen
99	GO:0005654	nucleoplasm
191	GO:0031981	nuclear lumen
207	GO:0005829	cytosol
207	GO:0005654	nucleoplasm
376	GO:0005829	cytosol
376	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

Showing 1 to 9 of 9 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006333	chromatin assembly or disassembly	IEA
GO:0006351	transcription, DNA-templated	IEA
GO:0006355	regulation of transcription, DNA-templated	NAS
GO:0006357	regulation of transcription from RNA polymerase II promoter	TAS
GO:0007051	spindle organization	IDA
GO:0007098	centrosome cycle	IDA
GO:0016575	histone deacetylation	IEA
GO:0032508	DNA duplex unwinding	IEA
GO:1901796	regulation of signal transduction by p53 class mediator	TAS

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Cellular Components

Showing 1 to 7 of 7 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	NAS
GO:0005654	nucleoplasm	TAS
GO:0005730	nucleolus	IDA
GO:0005737	cytoplasm	IDA
GO:0005813	centrosome	IDA
GO:0005815	microtubule organizing center	IDA
GO:0016581	NuRD complex	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 92 entries

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Interactor	Also a MoonDB EMF protein
ACTY_HUMAN	No
ADHX_HUMAN	No
ADT3_HUMAN	No
AIMP2_HUMAN	No
ATIF1_HUMAN	No
BARD1_HUMAN	No
BHE40_HUMAN	Yes: O14503 (MoonDB)
CASP6_HUMAN	No
CASP8_HUMAN	No
CBPE_HUMAN	No

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Publications Associated

Showing 1 to 10 of 20 entries

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PMID	Article Title
7560064	Molecular analysis of a major antigenic region of the 240 kD protein of Mi-2 autoantigen.
9326634	Characterization of the CHD family of proteins.
9688266	Identification of a human 17p-located cDNA encoding a protein of the Snf2-like helicase family.
9804427	Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex.
11230151	Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD.
12505151	Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3.
16625196	DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
17081983	Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
17626165	Chromatin remodeling proteins interact with pericentrin to regulate centrosome integrity.
18669648	A quantitative atlas of mitotic phosphorylation.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 48 entries

Search:

Domain Name	Domain ID	Source
CHD3	IPR028722	InterPro
CHD_C2	IPR012957	InterPro
CHD_N	IPR012958	InterPro
CHDCT2	PF08074	Pfam
CHDNT	PF08073	Pfam
Chromo	PF00385	Pfam
CHROMO	SM00298	SMART
CHROMO	cd00024	CDD
Chromo-like_dom_sf	IPR016197	InterPro
Chromo/chromo_shadow_dom	IPR000953	InterPro

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