Protein: P55055

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P55055 (Uniprot) NR1H2_HUMAN NR1H2 Oxysterols receptor LXR-beta human No
Uniprot: Nuclear receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 169 GO:0006139 nucleobase-containing compound metabolic process 27 1.10e-111 5.07e-25
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
27 GO:0090304 nucleic acid metabolic process
27 GO:0060255 regulation of macromolecule metabolic process
42 GO:0031325 positive regulation of cellular metabolic process
42 GO:0010604 positive regulation of macromolecule metabolic process
42 GO:0051173 positive regulation of nitrogen compound metabolic process
42 GO:0006355 regulation of transcription, DNA-templated
42 GO:0007165 signal transduction
99 GO:0031325 positive regulation of cellular metabolic process
99 GO:0010628 positive regulation of gene expression
99 GO:0051173 positive regulation of nitrogen compound metabolic process
99 GO:0019538 protein metabolic process
99 GO:0006357 regulation of transcription from RNA polymerase II promoter
99 GO:0007165 signal transduction
169 GO:0030522 intracellular receptor signaling pathway
169 GO:0045892 negative regulation of transcription, DNA-templated
169 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
169 GO:0043401 steroid hormone mediated signaling pathway
672 GO:0034645 cellular macromolecule biosynthetic process
672 GO:0006139 nucleobase-containing compound metabolic process
672 GO:1901362 organic cyclic compound biosynthetic process
672 GO:0009889 regulation of biosynthetic process
672 GO:0010468 regulation of gene expression
823 GO:0044267 cellular protein metabolic process
823 GO:0071310 cellular response to organic substance
823 GO:0010629 negative regulation of gene expression
823 GO:0031325 positive regulation of cellular metabolic process
823 GO:0010628 positive regulation of gene expression
823 GO:0051173 positive regulation of nitrogen compound metabolic process
823 GO:0006357 regulation of transcription from RNA polymerase II promoter
823 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
27 GO:0031981 nuclear lumen
42 GO:0005829 cytosol
42 GO:0005654 nucleoplasm
99 GO:0005654 nucleoplasm
169 GO:0005654 nucleoplasm
672 GO:0031981 nuclear lumen
823 GO:0005829 cytosol
823 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA
GO:0006367 transcription initiation from RNA polymerase II promoter TAS
GO:0010745 negative regulation of macrophage derived foam cell differentiation IC
GO:0010867 positive regulation of triglyceride biosynthetic process IMP
GO:0010875 positive regulation of cholesterol efflux IMP
GO:0010884 positive regulation of lipid storage IEA
GO:0010887 negative regulation of cholesterol storage IMP
GO:0032270 positive regulation of cellular protein metabolic process IMP
GO:0032369 negative regulation of lipid transport IMP
GO:0032376 positive regulation of cholesterol transport IDA
GO:0042632 cholesterol homeostasis IEA
GO:0043401 steroid hormone mediated signaling pathway IEA
GO:0044255 cellular lipid metabolic process IEA
GO:0045723 positive regulation of fatty acid biosynthetic process IMP
GO:0045861 negative regulation of proteolysis IEA
GO:0045892 negative regulation of transcription, DNA-templated IDA
GO:0045893 positive regulation of transcription, DNA-templated IDA
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA
GO:0048384 retinoic acid receptor signaling pathway IEA
GO:0048550 negative regulation of pinocytosis IMP
GO:0051006 positive regulation of lipoprotein lipase activity IMP
GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway NAS
GO:0090108 positive regulation of high-density lipoprotein particle assembly IEA
GO:0090187 positive regulation of pancreatic juice secretion IEA
GO:0090340 positive regulation of secretion of lysosomal enzymes IEA
GO:2000188 regulation of cholesterol homeostasis ISS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005737 cytoplasm IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
7926814 NER, a new member of the gene family encoding the human steroid hormone nuclear receptor.
12819202 The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15057824 The DNA sequence and biology of human chromosome 19.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
25661920 CCAR2 negatively regulates nuclear receptor LXRalpha by competing with SIRT1 deacetylase.
No results found.
Domain Name Domain ID Source
Nucl_hrmn_rcpt_lig-bd IPR000536 InterPro
Znf_hrmn_rcpt IPR001628 InterPro
Nuclear_hrmn_rcpt IPR001723 InterPro
Znf_NHR/GATA IPR013088 InterPro
Liver_X_rcpt IPR023257 InterPro
NHR_like_dom_sf IPR035500 InterPro
JC4014 JC4014 PIR
Hormone_recep PF00104 Pfam
zf-C4 PF00105 Pfam
STROIDFINGER PR00047 PRINTS
STRDHORMONER PR00398 PRINTS
LIVERXRECPTR PR02034 PRINTS
NUCLEAR_REC_DBD_1 PS00031 PROSITE
NUCLEAR_REC_DBD_2 PS51030 PROSITE
NR_LBD PS51843 PROSITE
ZnF_C4 SM00399 SMART
HOLI SM00430 SMART
SSF48508 SSF48508 SUPFAM