Protein: P55055 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P55055 (Uniprot)	NR1H2_HUMAN	NR1H2	Oxysterols receptor LXR-beta	human	No

Protein Function

Uniprot: Nuclear receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	169	GO:0006139	nucleobase-containing compound metabolic process	27	1.10e-111	5.07e-25

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
27	GO:0090304	nucleic acid metabolic process
27	GO:0060255	regulation of macromolecule metabolic process
42	GO:0031325	positive regulation of cellular metabolic process
42	GO:0010604	positive regulation of macromolecule metabolic process
42	GO:0051173	positive regulation of nitrogen compound metabolic process
42	GO:0006355	regulation of transcription, DNA-templated
42	GO:0007165	signal transduction
99	GO:0031325	positive regulation of cellular metabolic process
99	GO:0010628	positive regulation of gene expression
99	GO:0051173	positive regulation of nitrogen compound metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
27	GO:0031981	nuclear lumen
42	GO:0005829	cytosol
42	GO:0005654	nucleoplasm
99	GO:0005654	nucleoplasm
169	GO:0005654	nucleoplasm
672	GO:0031981	nuclear lumen
823	GO:0005829	cytosol
823	GO:0005654	nucleoplasm

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA
GO:0006367	transcription initiation from RNA polymerase II promoter	TAS
GO:0010745	negative regulation of macrophage derived foam cell differentiation	IC
GO:0010867	positive regulation of triglyceride biosynthetic process	IMP
GO:0010875	positive regulation of cholesterol efflux	IMP
GO:0010884	positive regulation of lipid storage	IEA
GO:0010887	negative regulation of cholesterol storage	IMP
GO:0032270	positive regulation of cellular protein metabolic process	IMP
GO:0032369	negative regulation of lipid transport	IMP
GO:0032376	positive regulation of cholesterol transport	IDA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	TAS
GO:0005737	cytoplasm	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
7B2_HUMAN	No
ACVL1_HUMAN	No
ASM_HUMAN	No
BAG6_HUMAN	No
CDN1A_HUMAN	Yes: P38936 (MoonDB)
CHD3_HUMAN	Yes: Q12873 (MoonDB)
CO4A5_HUMAN	No
CREL2_HUMAN	No
CSAD_HUMAN	No
DUS12_HUMAN	No

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Publications Associated

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PMID	Article Title
7926814	NER, a new member of the gene family encoding the human steroid hormone nuclear receptor.
12819202	The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15057824	The DNA sequence and biology of human chromosome 19.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
25661920	CCAR2 negatively regulates nuclear receptor LXRalpha by competing with SIRT1 deacetylase.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 18 entries

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Domain Name	Domain ID	Source
HOLI	SM00430	SMART
Hormone_recep	PF00104	Pfam
JC4014	JC4014	PIR
Liver_X_rcpt	IPR023257	InterPro
LIVERXRECPTR	PR02034	PRINTS
NHR_like_dom_sf	IPR035500	InterPro
NR_LBD	PS51843	PROSITE
Nucl_hrmn_rcpt_lig-bd	IPR000536	InterPro
Nuclear_hrmn_rcpt	IPR001723	InterPro
NUCLEAR_REC_DBD_1	PS00031	PROSITE

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