Protein: P28702

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P28702 (Uniprot) RXRB_HUMAN RXRB Retinoic acid receptor RXR-beta human No
Uniprot: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE).
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 169 GO:0006725 cellular aromatic compound metabolic process 345 5.44e-126 5.27e-27
GO:0007165 signal transduction 169 GO:0034641 cellular nitrogen compound metabolic process 789 4.22e-144 6.90e-18
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
118 GO:0019538 protein metabolic process
118 GO:0060255 regulation of macromolecule metabolic process
118 GO:0007165 signal transduction
169 GO:0030522 intracellular receptor signaling pathway
169 GO:0045892 negative regulation of transcription, DNA-templated
169 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
169 GO:0043401 steroid hormone mediated signaling pathway
196 GO:0034645 cellular macromolecule biosynthetic process
196 GO:0006464 cellular protein modification process
196 GO:0090304 nucleic acid metabolic process
196 GO:0031326 regulation of cellular biosynthetic process
196 GO:0010468 regulation of gene expression
196 GO:0010556 regulation of macromolecule biosynthetic process
196 GO:0007165 signal transduction
345 GO:0006139 nucleobase-containing compound metabolic process
345 GO:0060255 regulation of macromolecule metabolic process
605 GO:0007165 signal transduction
672 GO:0034645 cellular macromolecule biosynthetic process
672 GO:0006139 nucleobase-containing compound metabolic process
672 GO:1901362 organic cyclic compound biosynthetic process
672 GO:0009889 regulation of biosynthetic process
672 GO:0010468 regulation of gene expression
769 GO:0007165 signal transduction
789 GO:0044271 cellular nitrogen compound biosynthetic process
789 GO:0044267 cellular protein metabolic process
789 GO:0071310 cellular response to organic substance
789 GO:0031325 positive regulation of cellular metabolic process
789 GO:0010604 positive regulation of macromolecule metabolic process
789 GO:0051173 positive regulation of nitrogen compound metabolic process
789 GO:2000112 regulation of cellular macromolecule biosynthetic process
789 GO:0010468 regulation of gene expression
789 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
169 GO:0005654 nucleoplasm
196 GO:0005634 nucleus
345 GO:0070013 intracellular organelle lumen
345 GO:0005634 nucleus
672 GO:0031981 nuclear lumen
789 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006367 transcription initiation from RNA polymerase II promoter TAS
GO:0043401 steroid hormone mediated signaling pathway IEA
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA
GO:0048384 retinoic acid receptor signaling pathway IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
1310259 Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently.
1315958 Isolation of a full-length cDNA clone encoding a N-terminally variant form of the human retinoid X receptor beta.
8381386 Cloning and chromosome mapping of human retinoid X receptor beta: selective amino acid sequence conservation of a nuclear hormone receptor in mammals.
11782480 The structural basis for the specificity of retinoid-X receptor-selective agonists: new insights into the role of helix H12.
12970175 Crystal structure of the heterodimeric complex of LXRalpha and RXRbeta ligand-binding domains in a fully agonistic conformation.
14574404 The DNA sequence and analysis of human chromosome 6.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
24129315 Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
No results found.
Domain Name Domain ID Source
Retinoid-X_rcpt/HNF4 IPR000003 InterPro
Nucl_hrmn_rcpt_lig-bd IPR000536 InterPro
Znf_hrmn_rcpt IPR001628 InterPro
Nuclear_hrmn_rcpt IPR001723 InterPro
Znf_NHR/GATA IPR013088 InterPro
NHR_like_dom_sf IPR035500 InterPro
Hormone_recep PF00104 Pfam
zf-C4 PF00105 Pfam
STROIDFINGER PR00047 PRINTS
STRDHORMONER PR00398 PRINTS
RETINOIDXR PR00545 PRINTS
NUCLEAR_REC_DBD_1 PS00031 PROSITE
NUCLEAR_REC_DBD_2 PS51030 PROSITE
NR_LBD PS51843 PROSITE
S37781 S37781 PIR
ZnF_C4 SM00399 SMART
HOLI SM00430 SMART
SSF48508 SSF48508 SUPFAM