Protein: P28702 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P28702 (Uniprot)	RXRB_HUMAN	RXRB	Retinoic acid receptor RXR-beta	human	No

Protein Function

Uniprot: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE).

MoonDB Dissimilar Functions

Showing 1 to 2 of 2 entries

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	169	GO:0006725	cellular aromatic compound metabolic process	345	5.44e-126	5.27e-27
GO:0007165	signal transduction	169	GO:0034641	cellular nitrogen compound metabolic process	789	4.22e-144	6.90e-18

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
118	GO:0019538	protein metabolic process
118	GO:0060255	regulation of macromolecule metabolic process
118	GO:0007165	signal transduction
169	GO:0030522	intracellular receptor signaling pathway
169	GO:0045892	negative regulation of transcription, DNA-templated
169	GO:0045944	positive regulation of transcription from RNA polymerase II promoter
169	GO:0043401	steroid hormone mediated signaling pathway
196	GO:0034645	cellular macromolecule biosynthetic process
196	GO:0006464	cellular protein modification process
196	GO:0090304	nucleic acid metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
169	GO:0005654	nucleoplasm
196	GO:0005634	nucleus
345	GO:0070013	intracellular organelle lumen
345	GO:0005634	nucleus
672	GO:0031981	nuclear lumen
789	GO:0005654	nucleoplasm

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Protein GO Annotations

Biological Processes

Showing 1 to 4 of 4 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006367	transcription initiation from RNA polymerase II promoter	TAS
GO:0043401	steroid hormone mediated signaling pathway	IEA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA
GO:0048384	retinoic acid receptor signaling pathway	IEA

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Cellular Components

Showing 1 to 2 of 2 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	TAS

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 49 entries

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Interactor	Also a MoonDB EMF protein
APCD1_HUMAN	No
ATP5I_HUMAN	No
CAC1B_HUMAN	No
CLCA_HUMAN	No
CPLX1_HUMAN	No
CPSF5_HUMAN	No
DJB14_HUMAN	No
DP13A_HUMAN	Yes: Q9UKG1 (MoonDB)
EIF3A_HUMAN	No
ENPL_HUMAN	No

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Publications Associated

Showing 1 to 9 of 9 entries

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PMID	Article Title
1310259	Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently.
1315958	Isolation of a full-length cDNA clone encoding a N-terminally variant form of the human retinoid X receptor beta.
8381386	Cloning and chromosome mapping of human retinoid X receptor beta: selective amino acid sequence conservation of a nuclear hormone receptor in mammals.
11782480	The structural basis for the specificity of retinoid-X receptor-selective agonists: new insights into the role of helix H12.
12970175	Crystal structure of the heterodimeric complex of LXRalpha and RXRbeta ligand-binding domains in a fully agonistic conformation.
14574404	The DNA sequence and analysis of human chromosome 6.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
24129315	Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
24275569	An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 18 entries

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Domain Name	Domain ID	Source
HOLI	SM00430	SMART
Hormone_recep	PF00104	Pfam
NHR_like_dom_sf	IPR035500	InterPro
NR_LBD	PS51843	PROSITE
Nucl_hrmn_rcpt_lig-bd	IPR000536	InterPro
Nuclear_hrmn_rcpt	IPR001723	InterPro
NUCLEAR_REC_DBD_1	PS00031	PROSITE
NUCLEAR_REC_DBD_2	PS51030	PROSITE
Retinoid-X_rcpt/HNF4	IPR000003	InterPro
RETINOIDXR	PR00545	PRINTS

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