Protein: Q9UKG1

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9UKG1 (Uniprot) DP13A_HUMAN APPL1 DCC-interacting protein 13-alpha human Yes
Uniprot: Adapter protein that interacts with proteins involved in different cellular signaling pathways. Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. Involved in the regulation of the insulin receptor signaling pathway. more..
Dissimilar Functions Manual Curation

Function 1: Endocytic function. Links Rab5 to nuclear signal transduction. Condition: cytoplasm localisation.

Function 2: Nucleosome remodelling, transcription regulation. Condition: nuclear localisation.

Publications (PMID): 15016378, 15261672, 19686092, 19433865

MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0010646 regulation of cell communication 284 GO:0006725 cellular aromatic compound metabolic process 53 4.64e-30 1.07e-07
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
53 GO:0006139 nucleobase-containing compound metabolic process
53 GO:0016567 protein ubiquitination
53 GO:0060255 regulation of macromolecule metabolic process
284 GO:0009966 regulation of signal transduction
655 GO:0006464 cellular protein modification process
655 GO:0071310 cellular response to organic substance
655 GO:0035556 intracellular signal transduction
655 GO:0031325 positive regulation of cellular metabolic process
655 GO:0010604 positive regulation of macromolecule metabolic process
655 GO:0051173 positive regulation of nitrogen compound metabolic process
655 GO:0032268 regulation of cellular protein metabolic process
655 GO:0009966 regulation of signal transduction
655 GO:0006355 regulation of transcription, DNA-templated
655 GO:0009719 response to endogenous stimulus
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
43 GO:0005634 nucleus
53 GO:0005829 cytosol
53 GO:0005654 nucleoplasm
227 GO:0005634 nucleus
284 GO:0005829 cytosol
284 GO:0005886 plasma membrane
651 GO:0005829 cytosol
655 GO:0005829 cytosol
655 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0007049 cell cycle IEA
GO:0007165 signal transduction TAS
GO:0008283 cell proliferation IDA
GO:0008286 insulin receptor signaling pathway IMP
GO:0046324 regulation of glucose import IMP
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand TAS
GO:1903076 regulation of protein localization to plasma membrane IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005737 cytoplasm IC
GO:0005769 early endosome ISS
GO:0005829 cytosol IDA
GO:0010008 endosome membrane TAS
GO:0012506 vesicle membrane IDA
GO:0016581 NuRD complex IDA
GO:0031901 early endosome membrane IEA
GO:0070062 extracellular exosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0010008 endosome membrane 1.38e-08 8.40e-30
GO:0005634 nucleus GO:0012506 vesicle membrane 9.35e-29 3.51e-48
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
PMID Article Title
10490823 Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2.
10718198 Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.
12011067 Mediation of the DCC apoptotic signal by DIP13 alpha.
12168954 Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
15016378 APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16959974 The consensus coding sequences of human breast and colorectal cancers.
17525332 ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
17765681 A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway.
18669648 A quantitative atlas of mitotic phosphorylation.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20133602 Two closely related endocytic proteins that share a common OCRL-binding motif with APPL1.
21233288 The PH domain proteins IPIP27A and B link OCRL1 to receptor recycling in the endocytic pathway.
21269460 Initial characterization of the human central proteome.
21666675 Recognition of the F&H motif by the Lowe syndrome protein OCRL.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
26073777 Loss-of-function mutations in APPL1 in familial diabetes mellitus.
OMIM ID Disease Name
616511 Maturity-onset diabetes of the young 14
Domain Name Domain ID Source
PH_domain IPR001849 InterPro
PTB/PI_dom IPR006020 InterPro
PH-like_dom_sf IPR011993 InterPro
AH/BAR_dom_sf IPR027267 InterPro
APPL1_BAR IPR037929 InterPro
PH PF00169 Pfam
PID PF00640 Pfam
PID PS01179 PROSITE
PH_DOMAIN PS50003 PROSITE
PH SM00233 SMART
PTB SM00462 SMART
SSF103657 SSF103657 SUPFAM
BAR_APPL1 cd07631 CDD