Protein: O00499

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
O00499 (Uniprot) BIN1_HUMAN BIN1 Myc box-dependent-interacting protein 1 human No
Uniprot: May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0010646 regulation of cell communication 284 GO:0006139 nucleobase-containing compound metabolic process 497 6.71e-28 7.52e-07
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
284 GO:0009966 regulation of signal transduction
497 GO:0090304 nucleic acid metabolic process
497 GO:0060255 regulation of macromolecule metabolic process
750 GO:0048468 cell development
750 GO:0060255 regulation of macromolecule metabolic process
750 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
284 GO:0005829 cytosol
284 GO:0005886 plasma membrane
497 GO:0005634 nucleus
750 GO:0005829 cytosol
750 GO:0043232 intracellular non-membrane-bounded organelle
750 GO:0005634 nucleus
750 GO:0005886 plasma membrane
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006897 endocytosis IEA
GO:0006997 nucleus organization IMP
GO:0008283 cell proliferation TAS
GO:0016032 viral process IEA
GO:0030100 regulation of endocytosis IEA
GO:0042692 muscle cell differentiation IEA
GO:0043065 positive regulation of apoptotic process IDA
GO:0045664 regulation of neuron differentiation IMP
GO:0048711 positive regulation of astrocyte differentiation IMP
GO:0051647 nucleus localization IEA
GO:0060988 lipid tube assembly IMP
GO:0061024 membrane organization TAS
GO:0071156 regulation of cell cycle arrest IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005635 nuclear envelope IEA
GO:0005737 cytoplasm IDA
GO:0005829 cytosol TAS
GO:0015629 actin cytoskeleton TAS
GO:0016020 membrane IDA
GO:0030018 Z disc ISS
GO:0030315 T-tubule ISS
GO:0030424 axon IDA
GO:0031674 I band ISS
GO:0033268 node of Ranvier ISS
GO:0043194 axon initial segment ISS
GO:0060987 lipid tube IMP
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
8782822 BIN1 is a novel Myc-interacting protein with features of a tumour suppressor.
9182667 Amphiphysin II (SH3P9; BIN1), a member of the amphiphysin/Rvs family, is concentrated in the cortical cytomatrix of axon initial segments and nodes of Ranvier in brain and around T tubules in skeletal muscle.
9195986 Identification and characterization of a nerve terminal-enriched amphiphysin isoform.
9223448 cDNA cloning of a novel amphiphysin isoform and tissue-specific expression of its multiple splice variants.
9395479 Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing.
9418903 A role for the putative tumor suppressor Bin1 in muscle cell differentiation.
9603201 Multiple amphiphysin II splice variants display differential clathrin binding: identification of two distinct clathrin-binding sites.
10903846 Bin2, a functionally nonredundant member of the BAR adaptor gene family.
15815621 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
16530520 The SH3 binding motif of HCV NS5A protein interacts with Bin1 and is important for apoptosis and infectivity.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
17676042 Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy.
17974005 The full-ORF clone resource of the German cDNA consortium.
18669648 A quantitative atlas of mitotic phosphorylation.
19367720 Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
OMIM ID Disease Name
255200 Myopathy, centronuclear, 2
Domain Name Domain ID Source
SH3_domain IPR001452 InterPro
Amphiphysin IPR003005 InterPro
Amphiphysin_2 IPR003023 InterPro
BAR_dom IPR004148 InterPro
AH/BAR_dom_sf IPR027267 InterPro
Amphiphysin-2_SH3 IPR035471 InterPro
SH3-like_dom_sf IPR036028 InterPro
JC5593 JC5593 PIR
BAR PF03114 Pfam
SH3_9 PF14604 Pfam
SH3DOMAIN PR00452 PRINTS
AMPHIPHYSIN PR01251 PRINTS
AMPHIPHYSIN2 PR01253 PRINTS
SH3 PS50002 PROSITE
BAR PS51021 PROSITE
PTHR45479 PTHR45479 PANTHER
SH3 SM00326 SMART
BAR SM00721 SMART
SSF103657 SSF103657 SUPFAM
SSF50044 SSF50044 SUPFAM
SH3_Bin1 cd12139 CDD