Protein: O00499 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
O00499 (Uniprot)	BIN1_HUMAN	BIN1	Myc box-dependent-interacting protein 1	human	No

Protein Function

Uniprot: May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0010646	regulation of cell communication	284	GO:0006139	nucleobase-containing compound metabolic process	497	6.71e-28	7.52e-07

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MoonDB Network Modules

Biological Processes

Showing 1 to 6 of 6 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
284	GO:0009966	regulation of signal transduction
497	GO:0090304	nucleic acid metabolic process
497	GO:0060255	regulation of macromolecule metabolic process
750	GO:0048468	cell development
750	GO:0060255	regulation of macromolecule metabolic process
750	GO:0007165	signal transduction

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
284	GO:0005829	cytosol
284	GO:0005886	plasma membrane
497	GO:0005634	nucleus
750	GO:0005829	cytosol
750	GO:0043232	intracellular non-membrane-bounded organelle
750	GO:0005634	nucleus
750	GO:0005886	plasma membrane

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006897	endocytosis	IEA
GO:0006997	nucleus organization	IMP
GO:0008283	cell proliferation	TAS
GO:0016032	viral process	IEA
GO:0030100	regulation of endocytosis	IEA
GO:0042692	muscle cell differentiation	IEA
GO:0043065	positive regulation of apoptotic process	IDA
GO:0045664	regulation of neuron differentiation	IMP
GO:0048711	positive regulation of astrocyte differentiation	IMP
GO:0051647	nucleus localization	IEA

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Cellular Components

Showing 1 to 10 of 12 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005635	nuclear envelope	IEA
GO:0005737	cytoplasm	IDA
GO:0005829	cytosol	TAS
GO:0015629	actin cytoskeleton	TAS
GO:0016020	membrane	IDA
GO:0030018	Z disc	ISS
GO:0030315	T-tubule	ISS
GO:0030424	axon	IDA
GO:0031674	I band	ISS
GO:0033268	node of Ranvier	ISS

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
CASP_HUMAN	No
CLIP1_HUMAN	No
CUX1_HUMAN	No
DLGP4_HUMAN	No
DP13A_HUMAN	Yes: Q9UKG1 (MoonDB)
DYN1_HUMAN	No
F16P1_HUMAN	No
FHL2_HUMAN	No
GRB2_HUMAN	Yes: P62993 (MoonDB)
ITA1_HUMAN	No

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Publications Associated

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PMID	Article Title
8782822	BIN1 is a novel Myc-interacting protein with features of a tumour suppressor.
9182667	Amphiphysin II (SH3P9; BIN1), a member of the amphiphysin/Rvs family, is concentrated in the cortical cytomatrix of axon initial segments and nodes of Ranvier in brain and around T tubules in skeletal muscle.
9195986	Identification and characterization of a nerve terminal-enriched amphiphysin isoform.
9223448	cDNA cloning of a novel amphiphysin isoform and tissue-specific expression of its multiple splice variants.
9395479	Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing.
9418903	A role for the putative tumor suppressor Bin1 in muscle cell differentiation.
9603201	Multiple amphiphysin II splice variants display differential clathrin binding: identification of two distinct clathrin-binding sites.
10903846	Bin2, a functionally nonredundant member of the BAR adaptor gene family.
15815621	Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
16530520	The SH3 binding motif of HCV NS5A protein interacts with Bin1 and is important for apoptosis and infectivity.

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OMIM Diseases Associated

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OMIM ID	Disease Name
255200	Myopathy, centronuclear, 2

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Protein Domains Associated

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Domain Name	Domain ID	Source
AH/BAR_dom_sf	IPR027267	InterPro
Amphiphysin	IPR003005	InterPro
AMPHIPHYSIN	PR01251	PRINTS
Amphiphysin-2_SH3	IPR035471	InterPro
AMPHIPHYSIN2	PR01253	PRINTS
Amphiphysin_2	IPR003023	InterPro
BAR	PF03114	Pfam
BAR	PS51021	PROSITE
BAR	SM00721	SMART
BAR_dom	IPR004148	InterPro

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