Protein: P37231

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P37231 (Uniprot) PPARG_HUMAN PPARG Peroxisome proliferator-activated receptor gamma human No
Uniprot: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).(Microbial infection) Upon treatment with M.tuberculosis or its lipoprotein LpqH, phosphorylation of MAPK p38 and IL-6 production are modulated, probably via this protein. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 169 GO:0034641 cellular nitrogen compound metabolic process 245, 789 4.22e-144 6.90e-18
GO:0007165 signal transduction 169 GO:0006725 cellular aromatic compound metabolic process 345 5.44e-126 5.27e-27
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
42 GO:0031325 positive regulation of cellular metabolic process
42 GO:0010604 positive regulation of macromolecule metabolic process
42 GO:0051173 positive regulation of nitrogen compound metabolic process
42 GO:0006355 regulation of transcription, DNA-templated
42 GO:0007165 signal transduction
165 GO:0006464 cellular protein modification process
165 GO:0070887 cellular response to chemical stimulus
165 GO:0031325 positive regulation of cellular metabolic process
165 GO:0010604 positive regulation of macromolecule metabolic process
165 GO:0051173 positive regulation of nitrogen compound metabolic process
165 GO:0051246 regulation of protein metabolic process
165 GO:0006355 regulation of transcription, DNA-templated
165 GO:0007165 signal transduction
169 GO:0030522 intracellular receptor signaling pathway
169 GO:0045892 negative regulation of transcription, DNA-templated
169 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
169 GO:0043401 steroid hormone mediated signaling pathway
245 GO:0044271 cellular nitrogen compound biosynthetic process
245 GO:0090304 nucleic acid metabolic process
245 GO:1901362 organic cyclic compound biosynthetic process
245 GO:2000112 regulation of cellular macromolecule biosynthetic process
245 GO:0019219 regulation of nucleobase-containing compound metabolic process
301 GO:0006464 cellular protein modification process
301 GO:0060255 regulation of macromolecule metabolic process
341 GO:0070887 cellular response to chemical stimulus
341 GO:0045893 positive regulation of transcription, DNA-templated
341 GO:0006357 regulation of transcription from RNA polymerase II promoter
345 GO:0006139 nucleobase-containing compound metabolic process
345 GO:0060255 regulation of macromolecule metabolic process
357 GO:0071310 cellular response to organic substance
357 GO:0031324 negative regulation of cellular metabolic process
357 GO:0010605 negative regulation of macromolecule metabolic process
357 GO:0051172 negative regulation of nitrogen compound metabolic process
357 GO:0031325 positive regulation of cellular metabolic process
357 GO:0010604 positive regulation of macromolecule metabolic process
357 GO:0051173 positive regulation of nitrogen compound metabolic process
357 GO:0009966 regulation of signal transduction
357 GO:0006357 regulation of transcription from RNA polymerase II promoter
367 GO:0010467 gene expression
367 GO:0007399 nervous system development
367 GO:0006139 nucleobase-containing compound metabolic process
367 GO:0019538 protein metabolic process
367 GO:0051128 regulation of cellular component organization
367 GO:0060255 regulation of macromolecule metabolic process
367 GO:0007165 signal transduction
465 GO:0031325 positive regulation of cellular metabolic process
465 GO:0010604 positive regulation of macromolecule metabolic process
465 GO:0051173 positive regulation of nitrogen compound metabolic process
465 GO:0006357 regulation of transcription from RNA polymerase II promoter
465 GO:0007165 signal transduction
602 GO:0006464 cellular protein modification process
626 GO:0006915 apoptotic process
626 GO:0044267 cellular protein metabolic process
626 GO:0071310 cellular response to organic substance
626 GO:0051253 negative regulation of RNA metabolic process
626 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
626 GO:0010629 negative regulation of gene expression
626 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
626 GO:0010941 regulation of cell death
626 GO:0009966 regulation of signal transduction
626 GO:0009719 response to endogenous stimulus
701 GO:0031327 negative regulation of cellular biosynthetic process
701 GO:0010558 negative regulation of macromolecule biosynthetic process
701 GO:0051172 negative regulation of nitrogen compound metabolic process
701 GO:0006357 regulation of transcription from RNA polymerase II promoter
701 GO:0007165 signal transduction
789 GO:0044271 cellular nitrogen compound biosynthetic process
789 GO:0044267 cellular protein metabolic process
789 GO:0071310 cellular response to organic substance
789 GO:0031325 positive regulation of cellular metabolic process
789 GO:0010604 positive regulation of macromolecule metabolic process
789 GO:0051173 positive regulation of nitrogen compound metabolic process
789 GO:2000112 regulation of cellular macromolecule biosynthetic process
789 GO:0010468 regulation of gene expression
789 GO:0007165 signal transduction
867 GO:0044267 cellular protein metabolic process
867 GO:0071495 cellular response to endogenous stimulus
867 GO:0071310 cellular response to organic substance
867 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
867 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
42 GO:0005829 cytosol
42 GO:0005654 nucleoplasm
165 GO:0005829 cytosol
165 GO:0043232 intracellular non-membrane-bounded organelle
165 GO:0005654 nucleoplasm
169 GO:0005654 nucleoplasm
245 GO:0005634 nucleus
301 GO:0005829 cytosol
301 GO:0005634 nucleus
341 GO:0005654 nucleoplasm
345 GO:0070013 intracellular organelle lumen
345 GO:0005634 nucleus
357 GO:0005654 nucleoplasm
367 GO:0005829 cytosol
367 GO:0070013 intracellular organelle lumen
367 GO:0005634 nucleus
465 GO:0005654 nucleoplasm
602 GO:0005634 nucleus
626 GO:0005829 cytosol
626 GO:0005654 nucleoplasm
701 GO:0005654 nucleoplasm
789 GO:0005654 nucleoplasm
867 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA
GO:0001890 placenta development ISS
GO:0002674 negative regulation of acute inflammatory response IEA
GO:0006367 transcription initiation from RNA polymerase II promoter TAS
GO:0006629 lipid metabolic process TAS
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
GO:0007165 signal transduction IDA
GO:0007186 G-protein coupled receptor signaling pathway IEA
GO:0007507 heart development IEA
GO:0007584 response to nutrient TAS
GO:0008217 regulation of blood pressure IMP
GO:0009409 response to cold IEA
GO:0009612 response to mechanical stimulus IEA
GO:0010742 macrophage derived foam cell differentiation IDA
GO:0010745 negative regulation of macrophage derived foam cell differentiation IDA
GO:0010871 negative regulation of receptor biosynthetic process IDA
GO:0010887 negative regulation of cholesterol storage IDA
GO:0010891 negative regulation of sequestering of triglyceride IDA
GO:0015909 long-chain fatty acid transport ISS
GO:0016525 negative regulation of angiogenesis IDA
GO:0019395 fatty acid oxidation IEA
GO:0030224 monocyte differentiation IDA
GO:0030308 negative regulation of cell growth IEA
GO:0030855 epithelial cell differentiation ISS
GO:0031000 response to caffeine IEA
GO:0031100 animal organ regeneration IEA
GO:0032526 response to retinoic acid IDA
GO:0032869 cellular response to insulin stimulus IMP
GO:0032966 negative regulation of collagen biosynthetic process IEA
GO:0033189 response to vitamin A IEA
GO:0033993 response to lipid ISS
GO:0035357 peroxisome proliferator activated receptor signaling pathway IMP
GO:0035902 response to immobilization stress IEA
GO:0042493 response to drug IEA
GO:0042593 glucose homeostasis IMP
GO:0042594 response to starvation IEA
GO:0042752 regulation of circadian rhythm ISS
GO:0042953 lipoprotein transport IDA
GO:0043388 positive regulation of DNA binding IMP
GO:0043401 steroid hormone mediated signaling pathway IEA
GO:0043537 negative regulation of blood vessel endothelial cell migration IDA
GO:0043627 response to estrogen IEA
GO:0045087 innate immune response TAS
GO:0045165 cell fate commitment ISS
GO:0045600 positive regulation of fat cell differentiation ISS
GO:0045713 low-density lipoprotein particle receptor biosynthetic process IDA
GO:0045892 negative regulation of transcription, DNA-templated ISS
GO:0045893 positive regulation of transcription, DNA-templated IMP
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA
GO:0046321 positive regulation of fatty acid oxidation IEA
GO:0048469 cell maturation IDA
GO:0048511 rhythmic process IEA
GO:0048662 negative regulation of smooth muscle cell proliferation IDA
GO:0048714 positive regulation of oligodendrocyte differentiation IEA
GO:0050872 white fat cell differentiation TAS
GO:0051091 positive regulation of DNA binding transcription factor activity IDA
GO:0051974 negative regulation of telomerase activity IEA
GO:0055088 lipid homeostasis TAS
GO:0055098 response to low-density lipoprotein particle stimulus IDA
GO:0060100 positive regulation of phagocytosis, engulfment IEA
GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway IMP
GO:0060694 regulation of cholesterol transporter activity IC
GO:0060850 regulation of transcription involved in cell fate commitment ISS
GO:0061614 pri-miRNA transcription from RNA polymerase II promoter IDA
GO:0071300 cellular response to retinoic acid IEA
GO:0071306 cellular response to vitamin E IEA
GO:0071380 cellular response to prostaglandin E stimulus IEA
GO:0071455 cellular response to hyperoxia IEA
GO:1901558 response to metformin IEA
GO:2000230 negative regulation of pancreatic stellate cell proliferation IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005829 cytosol ISS
GO:0043231 intracellular membrane-bounded organelle IDA
GO:0043234 protein complex IDA
GO:0048471 perinuclear region of cytoplasm IEA
GO:0090575 RNA polymerase II transcription factor complex IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
7787419 Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping.
8702406 Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors gamma 1 and gamma 2.
8706692 A human peroxisome-proliferator-activated receptor-gamma is activated by inducers of adipogenesis, including thiazolidinedione drugs.
9065481 Identification, characterization, and tissue distribution of human peroxisome proliferator-activated receptor (PPAR) isoforms PPARgamma2 versus PPARgamma1 and activation with retinoid X receptor agonists and antagonists.
9144532 Differential expression of PPAR gamma1 and gamma2 isoforms in human adipose tissue.
9356045 No coding mutations are detected in the peroxisome proliferator-activated receptor-gamma gene in Japanese patients with lipoatrophic diabetes.
9425261 Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPAR-gamma) gene in diabetic Caucasians: identification of a pro12ala PPAR-gamma-2 missense mutation.
9744270 Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma.
9753710 Obesity associated with a mutation in a genetic regulator of adipocyte differentiation.
9806549 A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity.
9813012 Crystal structure of the ligand binding domain of the human nuclear receptor PPARgamma.
10394368 Loss-of-function mutations in PPAR-gamma associated with human colon cancer.
10407229 Missense variants in the human peroxisome proliferator-activated receptor-gamma2 gene in lean and obese subjects.
10523018 Two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene are associated with severe overweight among obese women.
10622252 Dominant negative mutations in human PPAR-gamma associated with severe insulin resistance, diabetes mellitus and hypertension.
10681503 Cloning and characterization of RAP250, a nuclear receptor coactivator.
10851250 Over-representation of PPARgamma sequence variants in sporadic cases of glioblastoma multiforme: preliminary evidence for common low penetrance modifiers for brain tumour risk in the general population.
10882139 Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors.
11587644 Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family.
11698662 Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors.
11788685 A novel heterozygous mutation in peroxisome proliferator-activated receptor-gamma gene in a patient with familial partial lipodystrophy.
11971969 ERAP140, a conserved tissue-specific nuclear receptor coactivator.
12039952 Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha.
12453919 PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy.
12672231 Synthesis and biological and structural characterization of the dual-acting peroxisome proliferator-activated receptor alpha/gamma agonist ragaglitazar.
14569127 Effect of the peroxisome proliferator activated receptor-gamma gene Pro12Ala variant on body mass index: a meta-analysis.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15047147 ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor.
15056000 Structure-based design of potent retinoid X receptor alpha agonists.
15258145 A new class of peroxisome proliferator-activated receptor agonists with a novel binding epitope shows antidiabetic effects.
15356014 Ala12Ala genotype of the peroxisome proliferator-activated receptor gamma2 protects against atherosclerosis.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15562396 Effects of peroxisome proliferator-activated receptor-gamma 2 Pro12Ala polymorphism on body fat distribution in female Korean subjects.
15687259 Hic-5 regulates an epithelial program mediated by PPARgamma.
15974597 Design and synthesis of alpha-aryloxyphenylacetic acid derivatives: a novel class of PPARalpha/gamma dual agonists with potent antihyperglycemic and lipid modulating activity.
15976031 Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner.
16150867 3-phosphoinositide-dependent protein kinase-1 activates the peroxisome proliferator-activated receptor-gamma and promotes adipocyte differentiation.
16239304 Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the DNA-binding domain of peroxisome proliferator-activated receptor gamma.
16451087 Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: design, synthesis, structural biology, and molecular docking studies.
16640330 Structure-based drug design of a novel family of PPARgamma partial agonists: virtual screening, X-ray crystallography, and in vitro/in vivo biological activities.
16641997 The DNA sequence, annotation and analysis of human chromosome 3.
16842753 Identification of a truncated alternative splicing variant of human PPARgamma1 that exhibits dominant negative activity.
16919947 Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis.
17101779 Interaction with MEK causes nuclear export and downregulation of peroxisome proliferator-activated receptor gamma.
20829347 Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma.
21047783 Additional sex comb-like (ASXL) proteins 1 and 2 play opposite roles in adipogenesis via reciprocal regulation of peroxisome proliferator-activated receptor {gamma}.
22351778 Familial focal segmental glomerulosclerosis (FSGS)-linked alpha-actinin 4 (ACTN4) protein mutants lose ability to activate transcription by nuclear hormone receptors.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23525231 THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation.
25504154 Mycobacterium tuberculosis 19-kDa lipoprotein induces Toll-like receptor 2-dependent peroxisome proliferator-activated receptor gamma expression and promotes inflammatory responses in human macrophages.
OMIM ID Disease Name
137800 Glioma 1
601665 Obesity
604367 Lipodystrophy, familial partial, 3
Domain Name Domain ID Source
Nucl_hrmn_rcpt_lig-bd IPR000536 InterPro
Znf_hrmn_rcpt IPR001628 InterPro
Nuclear_hrmn_rcpt IPR001723 InterPro
1Cnucl_rcpt IPR003074 InterPro
PPAR-gamma IPR003077 InterPro
Znf_NHR/GATA IPR013088 InterPro
PPARgamma_N IPR022590 InterPro
NHR_like_dom_sf IPR035500 InterPro
JC4859 JC4859 PIR
PC4290 PC4290 PIR
PC4429 PC4429 PIR
Hormone_recep PF00104 Pfam
zf-C4 PF00105 Pfam
PPARgamma_N PF12577 Pfam
STROIDFINGER PR00047 PRINTS
STRDHORMONER PR00398 PRINTS
PROXISOMEPAR PR01288 PRINTS
PROXISOMPAGR PR01291 PRINTS
NUCLEAR_REC_DBD_1 PS00031 PROSITE
NUCLEAR_REC_DBD_2 PS51030 PROSITE
NR_LBD PS51843 PROSITE
ZnF_C4 SM00399 SMART
HOLI SM00430 SMART
SSF48508 SSF48508 SUPFAM