Protein: Q9Y6Q9 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q9Y6Q9 (Uniprot)	NCOA3_HUMAN	NCOA3	Nuclear receptor coactivator 3	human	No

Protein Function

Uniprot: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear r more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	169	GO:0034641	cellular nitrogen compound metabolic process	35	4.22e-144	6.90e-18
GO:0007165	signal transduction	169	GO:0006139	nucleobase-containing compound metabolic process	592	1.10e-111	5.07e-25

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
35	GO:0044271	cellular nitrogen compound biosynthetic process
35	GO:0044267	cellular protein metabolic process
35	GO:0090304	nucleic acid metabolic process
35	GO:0010468	regulation of gene expression
35	GO:0009966	regulation of signal transduction
165	GO:0006464	cellular protein modification process
165	GO:0070887	cellular response to chemical stimulus
165	GO:0031325	positive regulation of cellular metabolic process
165	GO:0010604	positive regulation of macromolecule metabolic process
165	GO:0051173	positive regulation of nitrogen compound metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
35	GO:0005829	cytosol
35	GO:0005634	nucleus
35	GO:0005886	plasma membrane
165	GO:0005829	cytosol
165	GO:0043232	intracellular non-membrane-bounded organelle
165	GO:0005654	nucleoplasm
169	GO:0005654	nucleoplasm
221	GO:0005829	cytosol
221	GO:0043232	intracellular non-membrane-bounded organelle
221	GO:0005654	nucleoplasm

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006351	transcription, DNA-templated	IEA
GO:0010628	positive regulation of gene expression	IMP
GO:0016573	histone acetylation	IEA
GO:0030521	androgen receptor signaling pathway	NAS
GO:0030522	intracellular receptor signaling pathway	IBA
GO:0032870	cellular response to hormone stimulus	IBA
GO:0035624	receptor transactivation	TAS
GO:0043697	cell dedifferentiation	ISS
GO:0045618	positive regulation of keratinocyte differentiation	IMP
GO:0045893	positive regulation of transcription, DNA-templated	NAS

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000790	nuclear chromatin	IDA
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	TAS
GO:0005737	cytoplasm	IDA
GO:0005829	cytosol	IDA
GO:0043234	protein complex	IMP
GO:0070062	extracellular exosome	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0000790	nuclear chromatin	GO:0005737	cytoplasm	4.55e-08	5.17e-23
GO:0005634	nucleus	GO:0070062	extracellular exosome	6.30e-13	4.54e-26
GO:0005654	nucleoplasm	GO:0070062	extracellular exosome	3.37e-20	1.23e-35

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ANDR_HUMAN	Yes: P10275 (MoonDB)
ANR11_HUMAN	No
ARNT2_HUMAN	No
BABA2_HUMAN	No
CBP_HUMAN	No
CDKN3_HUMAN	No
COT1_HUMAN	No
DCTN6_HUMAN	No
EP300_HUMAN	Yes: Q09472 (MoonDB)
ERR1_HUMAN	No

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Publications Associated

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PMID	Article Title
9238002	RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2.
9252329	AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer.
9267036	Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.
9346901	TRAM-1, a novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1.
9727751	Polymorphic exonic CAG microsatellites in the gene amplified in breast cancer (AIB1 gene).
10490106	Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase.
11094166	RAC-3 is a NF-kappa B coactivator.
11250900	A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA.
11780052	The DNA sequence and comparative analysis of human chromosome 20.
11971985	Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) coactivator activity by I kappa B kinase.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
BHLH	PS50888	PROSITE
bHLH_dom	IPR011598	InterPro
DUF1518	IPR010011	InterPro
DUF1518	PF07469	Pfam
DUF1518	SM01151	SMART
DUF4927	IPR032565	InterPro
DUF4927	PF16279	Pfam
HLH	SM00353	SMART
HLH	cd00083	CDD
HLH_DNA-bd_sf	IPR036638	InterPro

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