Protein: Q9Y6Q9

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9Y6Q9 (Uniprot) NCOA3_HUMAN NCOA3 Nuclear receptor coactivator 3 human No
Uniprot: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 169 GO:0034641 cellular nitrogen compound metabolic process 35 4.22e-144 6.90e-18
GO:0007165 signal transduction 169 GO:0006139 nucleobase-containing compound metabolic process 592 1.10e-111 5.07e-25
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
35 GO:0044271 cellular nitrogen compound biosynthetic process
35 GO:0044267 cellular protein metabolic process
35 GO:0090304 nucleic acid metabolic process
35 GO:0010468 regulation of gene expression
35 GO:0009966 regulation of signal transduction
165 GO:0006464 cellular protein modification process
165 GO:0070887 cellular response to chemical stimulus
165 GO:0031325 positive regulation of cellular metabolic process
165 GO:0010604 positive regulation of macromolecule metabolic process
165 GO:0051173 positive regulation of nitrogen compound metabolic process
165 GO:0051246 regulation of protein metabolic process
165 GO:0006355 regulation of transcription, DNA-templated
165 GO:0007165 signal transduction
169 GO:0030522 intracellular receptor signaling pathway
169 GO:0045892 negative regulation of transcription, DNA-templated
169 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
169 GO:0043401 steroid hormone mediated signaling pathway
221 GO:0006464 cellular protein modification process
221 GO:0071310 cellular response to organic substance
221 GO:0031325 positive regulation of cellular metabolic process
221 GO:0010604 positive regulation of macromolecule metabolic process
221 GO:0051173 positive regulation of nitrogen compound metabolic process
221 GO:0006357 regulation of transcription from RNA polymerase II promoter
221 GO:0007165 signal transduction
330 GO:0006464 cellular protein modification process
330 GO:0006796 phosphate-containing compound metabolic process
330 GO:0031325 positive regulation of cellular metabolic process
330 GO:0010604 positive regulation of macromolecule metabolic process
330 GO:0051173 positive regulation of nitrogen compound metabolic process
330 GO:2000112 regulation of cellular macromolecule biosynthetic process
330 GO:0010468 regulation of gene expression
330 GO:0019219 regulation of nucleobase-containing compound metabolic process
330 GO:0051246 regulation of protein metabolic process
330 GO:0007165 signal transduction
330 GO:0006351 transcription, DNA-templated
535 GO:0008219 cell death
535 GO:0044267 cellular protein metabolic process
535 GO:0071495 cellular response to endogenous stimulus
535 GO:0071310 cellular response to organic substance
535 GO:0010605 negative regulation of macromolecule metabolic process
535 GO:0045893 positive regulation of transcription, DNA-templated
535 GO:0006357 regulation of transcription from RNA polymerase II promoter
535 GO:0007165 signal transduction
592 GO:0090304 nucleic acid metabolic process
592 GO:0034654 nucleobase-containing compound biosynthetic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
35 GO:0005829 cytosol
35 GO:0005634 nucleus
35 GO:0005886 plasma membrane
165 GO:0005829 cytosol
165 GO:0043232 intracellular non-membrane-bounded organelle
165 GO:0005654 nucleoplasm
169 GO:0005654 nucleoplasm
221 GO:0005829 cytosol
221 GO:0043232 intracellular non-membrane-bounded organelle
221 GO:0005654 nucleoplasm
330 GO:0005829 cytosol
330 GO:0005654 nucleoplasm
535 GO:0005829 cytosol
535 GO:0043232 intracellular non-membrane-bounded organelle
535 GO:0005654 nucleoplasm
592 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006351 transcription, DNA-templated IEA
GO:0010628 positive regulation of gene expression IMP
GO:0016573 histone acetylation IEA
GO:0030521 androgen receptor signaling pathway NAS
GO:0030522 intracellular receptor signaling pathway IBA
GO:0032870 cellular response to hormone stimulus IBA
GO:0035624 receptor transactivation TAS
GO:0043697 cell dedifferentiation ISS
GO:0045618 positive regulation of keratinocyte differentiation IMP
GO:0045893 positive regulation of transcription, DNA-templated NAS
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA
GO:0071392 cellular response to estradiol stimulus IDA
GO:1902459 positive regulation of stem cell population maintenance ISS
GO:2000035 regulation of stem cell division ISS
GO:2001141 regulation of RNA biosynthetic process IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000790 nuclear chromatin IDA
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005737 cytoplasm IDA
GO:0005829 cytosol IDA
GO:0043234 protein complex IMP
GO:0070062 extracellular exosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0000790 nuclear chromatin GO:0005737 cytoplasm 4.55e-08 5.17e-23
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
GO:0005654 nucleoplasm GO:0070062 extracellular exosome 3.37e-20 1.23e-35
PMID Article Title
9238002 RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2.
9252329 AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer.
9267036 Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.
9346901 TRAM-1, a novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1.
9727751 Polymorphic exonic CAG microsatellites in the gene amplified in breast cancer (AIB1 gene).
10490106 Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase.
11094166 RAC-3 is a NF-kappa B coactivator.
11250900 A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA.
11780052 The DNA sequence and comparative analysis of human chromosome 20.
11971985 Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) coactivator activity by I kappa B kinase.
12917342 BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation.
14645221 Histone acetyltransferase-dependent chromatin remodeling and the vascular clock.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15698540 FLASH interacts with p160 coactivator subtypes and differentially suppresses transcriptional activity of steroid hormone receptors.
16951154 Male germ cell-associated kinase, a male-specific kinase regulated by androgen, is a coactivator of androgen receptor in prostate cancer cells.
16957778 The catalytic subunit of the proteasome is engaged in the entire process of estrogen receptor-regulated transcription.
16964243 A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
17998543 ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification.
18669648 A quantitative atlas of mitotic phosphorylation.
19339517 CK1delta modulates the transcriptional activity of ERalpha via AIB1 in an estrogen-dependent manner and regulates ERalpha-AIB1 interactions.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21269460 Initial characterization of the human central proteome.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24129315 Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
No results found.
Domain Name Domain ID Source
PAS IPR000014 InterPro
Nuc_rcpt_coact IPR009110 InterPro
DUF1518 IPR010011 InterPro
bHLH_dom IPR011598 InterPro
PAS_fold IPR013767 InterPro
Nuc_rcpt_coact_Ncoa-typ IPR014920 InterPro
SRC/p160_LXXLL IPR014935 InterPro
WD40/YVTN_repeat-like_dom_sf IPR015943 InterPro
Nuclear_rcpt_coactivator IPR017426 InterPro
NCOA3 IPR028818 InterPro
DUF4927 IPR032565 InterPro
PAS-like_dom_sf IPR035965 InterPro
HLH_DNA-bd_sf IPR036638 InterPro
Nuc_rcpt_coact_Ncoa_int_sf IPR037077 InterPro
PAS PF00989 Pfam
DUF1518 PF07469 Pfam
Nuc_rec_co-act PF08815 Pfam
SRC-1 PF08832 Pfam
DUF4927 PF16279 Pfam
Nuclear_receptor_coactivator PIRSF038181 PIRSF
PAS PS50112 PROSITE
BHLH PS50888 PROSITE
PTHR10684 PTHR10684 PANTHER
PTHR10684:SF3 PTHR10684:SF3 PANTHER
PAS SM00091 SMART
HLH SM00353 SMART
DUF1518 SM01151 SMART
SSF47459 SSF47459 SUPFAM
SSF55785 SSF55785 SUPFAM
SSF69125 SSF69125 SUPFAM
T03851 T03851 PIR
HLH cd00083 CDD
PAS cd00130 CDD