Protein: Q09472 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q09472 (Uniprot)	EP300_HUMAN	EP300	Histone acetyltransferase p300	human	No

Protein Function

Uniprot: Functions as histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac) (PubMed:23911289). Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA) or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation or propionylation, respectively (PubMed:25818647, PubMed:17267393). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (E)-but-2-enoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393).(Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. more..

MoonDB Dissimilar Functions

Showing 1 to 3 of 3 entries

Search:

GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	169	GO:0006725	cellular aromatic compound metabolic process	57	5.44e-126	5.27e-27
GO:0007165	signal transduction	169	GO:0034641	cellular nitrogen compound metabolic process	180	4.22e-144	6.90e-18
GO:0007165	signal transduction	169	GO:0006139	nucleobase-containing compound metabolic process	592	1.10e-111	5.07e-25

Previous1Next

MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 83 entries

Search:

Module ID (MoonGO)	GO ID (BP)	GO Name
51	GO:0060255	regulation of macromolecule metabolic process
57	GO:0006139	nucleobase-containing compound metabolic process
77	GO:0007165	signal transduction
99	GO:0031325	positive regulation of cellular metabolic process
99	GO:0010628	positive regulation of gene expression
99	GO:0051173	positive regulation of nitrogen compound metabolic process
99	GO:0019538	protein metabolic process
99	GO:0006357	regulation of transcription from RNA polymerase II promoter
99	GO:0007165	signal transduction
164	GO:0044267	cellular protein metabolic process

Previous1 2 3 4 5…9Next

Cellular Components

Showing 1 to 10 of 32 entries

Search:

Module ID (MoonGO)	GO ID (CC)	GO Name
51	GO:0005634	nucleus
57	GO:0005634	nucleus
77	GO:0070013	intracellular organelle lumen
77	GO:0005634	nucleus
99	GO:0005654	nucleoplasm
169	GO:0005654	nucleoplasm
180	GO:0005829	cytosol
180	GO:0070013	intracellular organelle lumen
180	GO:0044428	nuclear part
207	GO:0005829	cytosol

Previous1 2 3 4Next

Protein GO Annotations

Biological Processes

Showing 1 to 10 of 54 entries

Search:

GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA
GO:0001666	response to hypoxia	IDA
GO:0001756	somitogenesis	IEA
GO:0002223	stimulatory C-type lectin receptor signaling pathway	TAS
GO:0006283	transcription-coupled nucleotide-excision repair	TAS
GO:0006355	regulation of transcription, DNA-templated	IDA
GO:0006366	transcription from RNA polymerase II promoter	IEA
GO:0006473	protein acetylation	IDA
GO:0006475	internal protein amino acid acetylation	IDA
GO:0006915	apoptotic process	IMP

Previous1 2 3 4 5 6Next

Cellular Components

Showing 1 to 6 of 6 entries

Search:

GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000123	histone acetyltransferase complex	IEA
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	TAS
GO:0005667	transcription factor complex	IEA
GO:0005694	chromosome	IEA
GO:0005829	cytosol	IDA

Previous1Next

Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 122 entries

Search:

Interactor	Also a MoonDB EMF protein
ACSM5_HUMAN	No
ACTB_HUMAN	No
AHR_HUMAN	No
ALKB4_HUMAN	No
AP2A_HUMAN	No
ARSF_HUMAN	No
ATF5_HUMAN	No
BCL3_HUMAN	No
C1R_HUMAN	No
CACO1_HUMAN	No

Previous1 2 3 4 5…13Next

Publications Associated

Showing 1 to 10 of 105 entries

Search:

PMID	Article Title
7523245	Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.
7870179	Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP.
8684459	A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A.
8917528	An essential role for p300/CBP in the cellular response to hypoxia.
8945521	The transcriptional coactivators p300 and CBP are histone acetyltransferases.
9528808	Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300.
9590696	Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex.
9862959	Exogenous expression of a dominant negative RORalpha1 vector in muscle cells impairs differentiation: RORalpha1 directly interacts with p300 and myoD.
9887100	Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1.
10545121	HIV-1 tat transcriptional activity is regulated by acetylation.

Previous1 2 3 4 5…11Next

OMIM Diseases Associated

Showing 1 to 1 of 1 entries

Search:

OMIM ID	Disease Name
613684	Rubinstein-Taybi syndrome 2

Previous1Next

Protein Domains Associated

Showing 1 to 10 of 39 entries

Search:

Domain Name	Domain ID	Source
A54277	A54277	PIR
BROMO	SM00297	SMART
Bromodomain	IPR001487	InterPro
Bromodomain	PF00439	Pfam
BROMODOMAIN	PR00503	PRINTS
Bromodomain-like_sf	IPR036427	InterPro
BROMODOMAIN_1	PS00633	PROSITE
BROMODOMAIN_2	PS50014	PROSITE
Bromodomain_CS	IPR018359	InterPro
CBP_P300_HAT	IPR031162	InterPro

Previous1 2 3 4Next