Protein: Q09472

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q09472 (Uniprot) EP300_HUMAN EP300 Histone acetyltransferase p300 human No
Uniprot: Functions as histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac) (PubMed:23911289). Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA) or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation or propionylation, respectively (PubMed:25818647, PubMed:17267393). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (E)-but-2-enoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393).(Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. more..
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 169 GO:0006725 cellular aromatic compound metabolic process 57 5.44e-126 5.27e-27
GO:0007165 signal transduction 169 GO:0034641 cellular nitrogen compound metabolic process 180 4.22e-144 6.90e-18
GO:0007165 signal transduction 169 GO:0006139 nucleobase-containing compound metabolic process 592 1.10e-111 5.07e-25
Module ID (MoonGO) GO ID (BP) GO Name
51 GO:0060255 regulation of macromolecule metabolic process
57 GO:0006139 nucleobase-containing compound metabolic process
77 GO:0007165 signal transduction
99 GO:0031325 positive regulation of cellular metabolic process
99 GO:0010628 positive regulation of gene expression
99 GO:0051173 positive regulation of nitrogen compound metabolic process
99 GO:0019538 protein metabolic process
99 GO:0006357 regulation of transcription from RNA polymerase II promoter
99 GO:0007165 signal transduction
164 GO:0044267 cellular protein metabolic process
164 GO:0060255 regulation of macromolecule metabolic process
164 GO:0007165 signal transduction
169 GO:0030522 intracellular receptor signaling pathway
169 GO:0045892 negative regulation of transcription, DNA-templated
169 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
169 GO:0043401 steroid hormone mediated signaling pathway
180 GO:0044271 cellular nitrogen compound biosynthetic process
180 GO:0070887 cellular response to chemical stimulus
180 GO:0006139 nucleobase-containing compound metabolic process
180 GO:0031325 positive regulation of cellular metabolic process
180 GO:0010604 positive regulation of macromolecule metabolic process
180 GO:2000112 regulation of cellular macromolecule biosynthetic process
180 GO:0010468 regulation of gene expression
207 GO:0007165 signal transduction
220 GO:0060255 regulation of macromolecule metabolic process
306 GO:0044267 cellular protein metabolic process
306 GO:0060255 regulation of macromolecule metabolic process
306 GO:0007165 signal transduction
330 GO:0006464 cellular protein modification process
330 GO:0006796 phosphate-containing compound metabolic process
330 GO:0031325 positive regulation of cellular metabolic process
330 GO:0010604 positive regulation of macromolecule metabolic process
330 GO:0051173 positive regulation of nitrogen compound metabolic process
330 GO:2000112 regulation of cellular macromolecule biosynthetic process
330 GO:0010468 regulation of gene expression
330 GO:0019219 regulation of nucleobase-containing compound metabolic process
330 GO:0051246 regulation of protein metabolic process
330 GO:0007165 signal transduction
330 GO:0006351 transcription, DNA-templated
341 GO:0070887 cellular response to chemical stimulus
341 GO:0045893 positive regulation of transcription, DNA-templated
341 GO:0006357 regulation of transcription from RNA polymerase II promoter
403 GO:0060255 regulation of macromolecule metabolic process
429 GO:0016070 RNA metabolic process
429 GO:0034645 cellular macromolecule biosynthetic process
429 GO:0044271 cellular nitrogen compound biosynthetic process
429 GO:0019538 protein metabolic process
429 GO:0010468 regulation of gene expression
429 GO:0010556 regulation of macromolecule biosynthetic process
429 GO:0019219 regulation of nucleobase-containing compound metabolic process
479 GO:0016070 RNA metabolic process
479 GO:0034645 cellular macromolecule biosynthetic process
479 GO:0044271 cellular nitrogen compound biosynthetic process
479 GO:0044267 cellular protein metabolic process
479 GO:0010468 regulation of gene expression
479 GO:0007165 signal transduction
569 GO:0007165 signal transduction
592 GO:0090304 nucleic acid metabolic process
592 GO:0034654 nucleobase-containing compound biosynthetic process
608 GO:0060255 regulation of macromolecule metabolic process
626 GO:0006915 apoptotic process
626 GO:0044267 cellular protein metabolic process
626 GO:0071310 cellular response to organic substance
626 GO:0051253 negative regulation of RNA metabolic process
626 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
626 GO:0010629 negative regulation of gene expression
626 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
626 GO:0010941 regulation of cell death
626 GO:0009966 regulation of signal transduction
626 GO:0009719 response to endogenous stimulus
720 GO:0006464 cellular protein modification process
720 GO:0071310 cellular response to organic substance
720 GO:0006355 regulation of transcription, DNA-templated
720 GO:0006366 transcription from RNA polymerase II promoter
792 GO:0060255 regulation of macromolecule metabolic process
823 GO:0044267 cellular protein metabolic process
823 GO:0071310 cellular response to organic substance
823 GO:0010629 negative regulation of gene expression
823 GO:0031325 positive regulation of cellular metabolic process
823 GO:0010628 positive regulation of gene expression
823 GO:0051173 positive regulation of nitrogen compound metabolic process
823 GO:0006357 regulation of transcription from RNA polymerase II promoter
823 GO:0007165 signal transduction
Module ID (MoonGO) GO ID (CC) GO Name
51 GO:0005634 nucleus
57 GO:0005634 nucleus
77 GO:0070013 intracellular organelle lumen
77 GO:0005634 nucleus
99 GO:0005654 nucleoplasm
169 GO:0005654 nucleoplasm
180 GO:0005829 cytosol
180 GO:0070013 intracellular organelle lumen
180 GO:0044428 nuclear part
207 GO:0005829 cytosol
207 GO:0005654 nucleoplasm
216 GO:0005829 cytosol
220 GO:0005634 nucleus
306 GO:0070062 extracellular exosome
330 GO:0005829 cytosol
330 GO:0005654 nucleoplasm
341 GO:0005654 nucleoplasm
403 GO:0005634 nucleus
429 GO:0070013 intracellular organelle lumen
429 GO:0005634 nucleus
479 GO:0070013 intracellular organelle lumen
479 GO:0044428 nuclear part
592 GO:0005634 nucleus
608 GO:0043232 intracellular non-membrane-bounded organelle
608 GO:0005634 nucleus
626 GO:0005829 cytosol
626 GO:0005654 nucleoplasm
720 GO:0005829 cytosol
720 GO:0005654 nucleoplasm
792 GO:0005829 cytosol
823 GO:0005829 cytosol
823 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA
GO:0001666 response to hypoxia IDA
GO:0001756 somitogenesis IEA
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0006283 transcription-coupled nucleotide-excision repair TAS
GO:0006355 regulation of transcription, DNA-templated IDA
GO:0006366 transcription from RNA polymerase II promoter IEA
GO:0006473 protein acetylation IDA
GO:0006475 internal protein amino acid acetylation IDA
GO:0006915 apoptotic process IMP
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response ISS
GO:0007219 Notch signaling pathway TAS
GO:0007399 nervous system development TAS
GO:0007507 heart development IEA
GO:0007519 skeletal muscle tissue development IEA
GO:0007623 circadian rhythm ISS
GO:0009887 animal organ morphogenesis IEA
GO:0010506 regulation of autophagy TAS
GO:0010742 macrophage derived foam cell differentiation IDA
GO:0016032 viral process IEA
GO:0016573 histone acetylation IDA
GO:0016579 protein deubiquitination TAS
GO:0018076 N-terminal peptidyl-lysine acetylation IDA
GO:0018393 internal peptidyl-lysine acetylation IDA
GO:0030183 B cell differentiation IEA
GO:0030220 platelet formation IEA
GO:0030324 lung development IEA
GO:0031648 protein destabilization IMP
GO:0032092 positive regulation of protein binding IEA
GO:0032481 positive regulation of type I interferon production TAS
GO:0034644 cellular response to UV IDA
GO:0035855 megakaryocyte development IEA
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
GO:0043627 response to estrogen IDA
GO:0043923 positive regulation by host of viral transcription IDA
GO:0043967 histone H4 acetylation IMP
GO:0043969 histone H2B acetylation IDA
GO:0045444 fat cell differentiation ISS
GO:0045652 regulation of megakaryocyte differentiation TAS
GO:0045815 positive regulation of gene expression, epigenetic TAS
GO:0045944 positive regulation of transcription from RNA polymerase II promoter TAS
GO:0050821 protein stabilization ISS
GO:0051091 positive regulation of DNA binding transcription factor activity IDA
GO:0051726 regulation of cell cycle TAS
GO:0060765 regulation of androgen receptor signaling pathway IDA
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
GO:0061921 peptidyl-lysine propionylation IDA
GO:0090043 regulation of tubulin deacetylation IDA
GO:0140066 peptidyl-lysine crotonylation IDA
GO:0140067 peptidyl-lysine butyrylation IDA
GO:1900034 regulation of cellular response to heat TAS
GO:1901796 regulation of signal transduction by p53 class mediator TAS
GO:1904837 beta-catenin-TCF complex assembly TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000123 histone acetyltransferase complex IEA
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005667 transcription factor complex IEA
GO:0005694 chromosome IEA
GO:0005829 cytosol IDA
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
CRX_HUMAN No
TRAF2_HUMAN No
UBQL1_HUMAN No
GOGA2_HUMAN Yes: Q08379 (MoonDB)
XRCC6_HUMAN Yes: P12956 (MoonDB)
GRB2_HUMAN Yes: P62993 (MoonDB)
PLK1_HUMAN Yes: P53350 (MoonDB)
AP2A_HUMAN No
PLS1_HUMAN No
DDIT3_HUMAN No
HNRL1_HUMAN No
SNAI1_HUMAN No
JMY_HUMAN No
SMRD1_HUMAN No
WASL_HUMAN No
STA5A_HUMAN No
P53_HUMAN Yes: P04637 (MoonDB)
TYY1_HUMAN No
NOXA1_HUMAN No
ESR2_HUMAN Yes: Q92731 (MoonDB)
PPARG_HUMAN Yes: P37231 (MoonDB)
CREB1_HUMAN No
SRBP2_HUMAN No
FBX25_HUMAN No
HIF1A_HUMAN No
EWS_HUMAN No
SMAD3_HUMAN Yes: P84022 (MoonDB)
SRTD1_HUMAN No
TF65_HUMAN No
SMAD2_HUMAN No
CSN6_HUMAN No
SMAD5_HUMAN No
TNIP2_HUMAN No
CLH1_HUMAN Yes: Q00610 (MoonDB)
PRDX4_HUMAN No
ACSM5_HUMAN No
ACTB_HUMAN No
AHR_HUMAN No
ALKB4_HUMAN No
ARSF_HUMAN No
ATF5_HUMAN No
BCL3_HUMAN No
C1R_HUMAN No
CACO1_HUMAN No
CARM1_HUMAN No
CD2_HUMAN No
CEBPB_HUMAN No
CFAH_HUMAN No
CITE2_HUMAN No
CITE4_HUMAN No
CNOT4_HUMAN No
CSKP_HUMAN No
CSN2_HUMAN No
DECR2_HUMAN No
DPOD2_HUMAN No
DTX1_HUMAN No
EGR1_HUMAN No
ENOA_HUMAN Yes: P06733 (MoonDB)
EPO_HUMAN No
ESR1_HUMAN Yes: P03372 (MoonDB)
FBXL5_HUMAN No
FINC_HUMAN No
GANP_HUMAN No
GOPC_HUMAN No
GRIP1_HUMAN No
HEMGN_HUMAN No
HIPK2_HUMAN No
HPS6_HUMAN No
IGBP1_HUMAN No
IPSP_HUMAN No
ITIH3_HUMAN No
JUN_HUMAN No
K1C18_HUMAN No
KCTD5_HUMAN No
KHDR1_HUMAN No
LCP2_HUMAN No
LYAG_HUMAN No
M3K5_HUMAN No
MAF_HUMAN No
MAGD1_HUMAN No
MARE1_HUMAN No
MDM2_HUMAN Yes: Q00987 (MoonDB)
MIC60_HUMAN No
MSTO1_HUMAN No
NBN_HUMAN No
NCOA2_HUMAN No
NCOA3_HUMAN Yes: Q9Y6Q9 (MoonDB)
NOTC1_HUMAN No
NP1L1_HUMAN No
NP1L4_HUMAN No
NPY5R_HUMAN No
NR1I3_HUMAN No
NR4A1_HUMAN Yes: P22736 (MoonDB)
OXDA_HUMAN No
P73_HUMAN No
PAK2_HUMAN No
PAX8_HUMAN No
PCKGM_HUMAN No
PHS_HUMAN Yes: P61457 (MoonDB)
PLMN_HUMAN No
PLS2_HUMAN No
PO3F2_HUMAN No
PPARA_HUMAN No
PPARD_HUMAN No
PROX1_HUMAN No
RIPK1_HUMAN No
RL27_HUMAN No
RORA_HUMAN No
SAV1_HUMAN No
SEPP1_HUMAN No
SP1_HUMAN No
SPF27_HUMAN No
TAF1B_HUMAN No
TINAL_HUMAN No
TPO_HUMAN No
TRIP4_HUMAN No
TSNAX_HUMAN No
USF2_HUMAN No
VDR_HUMAN Yes: P11473 (MoonDB)
VPS18_HUMAN No
WDR59_HUMAN No
ZC12A_HUMAN No
PMID Article Title
7523245 Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.
7870179 Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP.
8684459 A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A.
8917528 An essential role for p300/CBP in the cellular response to hypoxia.
8945521 The transcriptional coactivators p300 and CBP are histone acetyltransferases.
9528808 Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300.
9590696 Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex.
9862959 Exogenous expression of a dominant negative RORalpha1 vector in muscle cells impairs differentiation: RORalpha1 directly interacts with p300 and myoD.
9887100 Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1.
10545121 HIV-1 tat transcriptional activity is regulated by acetylation.
10591208 The DNA sequence of human chromosome 22.
10700188 Mutations truncating the EP300 acetylase in human cancers.
10722728 The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors.
10733570 A novel transcriptional repression domain mediates p21(WAF1/CIP1) induction of p300 transactivation.
10823961 Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator.
10824998 MOZ is fused to p300 in an acute monocytic leukemia with t(8;22).
11073989 Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle.
11073990 A novel Rb- and p300-binding protein inhibits transactivation by MyoD.
11080476 Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones.
11349124 A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression.
11430825 Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300.
11433299 Acetylation control of the retinoblastoma tumour-suppressor protein.
11463834 The oncoprotein Tax binds the SRC-1-interacting domain of CBP/p300 to mediate transcriptional activation.
11481323 Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha.
11518699 Regulation of transcription by AMP-activated protein kinase: phosphorylation of p300 blocks its interaction with nuclear receptors.
11559821 Human T-lymphotropic virus type 1 p30(II) regulates gene transcription by binding CREB binding protein/p300.
11564735 Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor.
11581164 Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein.
11581372 Adenovirus DNA binding protein interacts with the SNF2-related CBP activator protein (SrCap) and inhibits SrCap-mediated transcription.
11701890 A transcriptional switch mediated by cofactor methylation.
11744733 Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2.
11864910 Interaction between the hematopoietic Ets transcription factor Spi-B and the coactivator CREB-binding protein associated with negative cross-talk with c-Myb.
11909954 Scaffold/matrix attachment region elements interact with a p300-scaffold attachment factor A complex and are bound by acetylated nucleosomes.
11959990 Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha.
11997499 Synergy among nuclear receptor coactivators: selective requirement for protein methyltransferase and acetyltransferase activities.
12402037 Acetylation inactivates the transcriptional repressor BCL6.
12446687 Identification of a promoter-specific transcriptional activation domain at the C-terminus of the Wnt effector protein T-cell factor 4.
12527917 Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300.
12586840 Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2.
12718889 P300 transcriptional repression is mediated by SUMO modification.
12750254 p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity.
12778114 Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2.
12837748 Acetylated SP3 is a transcriptional activator.
12929931 P300/CBP acts as a coactivator to cartilage homeoprotein-1 (Cart1), paired-like homeoprotein, through acetylation of the conserved lysine residue adjacent to the homeodomain.
14605447 SATB1 makes a complex with p300 and represses gp91(phox) promoter activity.
14645221 Histone acetyltransferase-dependent chromatin remodeling and the vascular clock.
14716005 Dendrite development regulated by CREST, a calcium-regulated transcriptional activator.
14752053 Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD.
15004546 Regulation of the p300 HAT domain via a novel activation loop.
15075319 Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86.
15186775 Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53.
15297880 Regulation of human SRY subcellular distribution by its acetylation/deacetylation.
15509808 Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53.
15632193 SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1.
15706485 Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease.
15731352 Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination.
15890677 The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcription.
16478997 Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription.
16574662 Nuclear Rho kinase, ROCK2, targets p300 acetyltransferase.
16617102 MTA1, a transcriptional activator of breast cancer amplified sequence 3.
16762839 HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription.
16809611 BCL11B participates in the activation of IL2 gene expression in CD4+ T lymphocytes.
16864582 The transcriptional activity of CITED1 is regulated by phosphorylation in a cell cycle-dependent manner.
17065153 Kinetic and mass spectrometric analysis of p300 histone acetyltransferase domain autoacetylation.
17226766 Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF.
17267393 Lysine propionylation and butyrylation are novel post-translational modifications in histones.
17872950 Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion.
18273021 The structural basis of protein acetylation by the p300/CBP transcriptional coactivator.
18669648 A quantitative atlas of mitotic phosphorylation.
18695000 PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis.
18722353 Acetylation of Sirt2 by p300 attenuates its deacetylase activity.
18809579 PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation.
18995842 The SIRT2 deacetylase regulates autoacetylation of p300.
19217391 Structural basis for p300 Taz2-p53 TAD1 binding and modulation by phosphorylation.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19680224 SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20081228 Cyclin-dependent kinase-9 is a component of the p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes.
20955178 Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation.
21030595 HDAC3 is negatively regulated by the nuclear protein DBC1.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
22223895 Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
22464331 Histone recognition and large-scale structural analysis of the human bromodomain family.
23145062 Human ALKBH4 interacts with proteins associated with transcription.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23415232 Regulation of transcription through acetylation of H3K122 on the lateral surface of the histone octamer.
23911289 A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters.
23934153 Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation.
23999430 Kruppel-like factor 15 is critical for vascular inflammation.
24177535 Constitutive nuclear localization of an alternatively spliced sirtuin-2 isoform.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24324267 Zinc finger protein 451 is a novel Smad corepressor in transforming growth factor-beta signaling.
24382891 Human Kruppel-related 3 (HKR3) is a novel transcription activator of alternate reading frame (ARF) gene.
24413532 Differential regulation of estrogen receptor alpha expression in breast cancer cells by metastasis-associated protein 1.
24476420 Clinical and molecular characterization of Rubinstein-Taybi syndrome patients carrying distinct novel mutations of the EP300 gene.
24819397 Structure of the p300 histone acetyltransferase bound to acetyl-coenzyme A and its analogues.
24939902 CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis.
25219498 Modification of ASC1 by UFM1 is crucial for ERalpha transactivation and breast cancer development.
25245946 Two ZNF509 (ZBTB49) isoforms induce cell-cycle arrest by activating transcription of p21/CDKN1A and RB upon exposure to genotoxic stress.
25818647 Intracellular crotonyl-CoA stimulates transcription through p300-catalyzed histone crotonylation.
26479788 PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection.
27189267 Heat shock factor 1 mediates latent HIV reactivation.
27959755 Multisystem anomalies in severe combined immunodeficiency with mutant BCL11B.
OMIM ID Disease Name
613684 Rubinstein-Taybi syndrome 2
Domain Name Domain ID Source
A54277 A54277 PIR
Znf_TAZ IPR000197 InterPro
Znf_ZZ IPR000433 InterPro
Bromodomain IPR001487 InterPro
KIX_dom IPR003101 InterPro
Nuc_rcpt_coact IPR009110 InterPro
RING_CBP-p300 IPR010303 InterPro
Histone_AcTrfase_Rtt109/CBP IPR013178 InterPro
Nuc_rcpt_coact_CREBbp IPR014744 InterPro
Bromodomain_CS IPR018359 InterPro
CBP_P300_HAT IPR031162 InterPro
TAZ_dom_sf IPR035898 InterPro
Bromodomain-like_sf IPR036427 InterPro
KIX_dom_sf IPR036529 InterPro
Nuc_rcpt_coact_CREBbp_sf IPR037073 InterPro
Bromodomain PF00439 Pfam
ZZ PF00569 Pfam
zf-TAZ PF02135 Pfam
KIX PF02172 Pfam
DUF902 PF06001 Pfam
HAT_KAT11 PF08214 Pfam
Creb_binding PF09030 Pfam
BROMODOMAIN PR00503 PRINTS
BROMODOMAIN_1 PS00633 PROSITE
ZF_ZZ_1 PS01357 PROSITE
BROMODOMAIN_2 PS50014 PROSITE
ZF_TAZ PS50134 PROSITE
ZF_ZZ_2 PS50135 PROSITE
KIX PS50952 PROSITE
CBP_P300_HAT PS51727 PROSITE
ZnF_ZZ SM00291 SMART
BROMO SM00297 SMART
ZnF_TAZ SM00551 SMART
KAT11 SM01250 SMART
SSF47040 SSF47040 SUPFAM
SSF47370 SSF47370 SUPFAM
SSF57933 SSF57933 SUPFAM
SSF69125 SSF69125 SUPFAM
RING_CBP-p300 cd15802 CDD