Protein: P19793 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P19793 (Uniprot)	RXRA_HUMAN	RXRA	Retinoic acid receptor RXR-alpha	human	No

Protein Function

Uniprot: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) compo more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	169	GO:0034641	cellular nitrogen compound metabolic process	245, 789	4.22e-144	6.90e-18
GO:0007165	signal transduction	169	GO:0006725	cellular aromatic compound metabolic process	345	5.44e-126	5.27e-27

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
42	GO:0031325	positive regulation of cellular metabolic process
42	GO:0010604	positive regulation of macromolecule metabolic process
42	GO:0051173	positive regulation of nitrogen compound metabolic process
42	GO:0006355	regulation of transcription, DNA-templated
42	GO:0007165	signal transduction
45	GO:0071495	cellular response to endogenous stimulus
45	GO:0071310	cellular response to organic substance
45	GO:0032270	positive regulation of cellular protein metabolic process
45	GO:0006468	protein phosphorylation
45	GO:0042325	regulation of phosphorylation

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
42	GO:0005829	cytosol
42	GO:0005654	nucleoplasm
45	GO:0005829	cytosol
45	GO:0031981	nuclear lumen
45	GO:0005886	plasma membrane
122	GO:0005829	cytosol
122	GO:0043232	intracellular non-membrane-bounded organelle
122	GO:0005654	nucleoplasm
162	GO:0005634	nucleus
169	GO:0005654	nucleoplasm

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA
GO:0001701	in utero embryonic development	IEA
GO:0001893	maternal placenta development	IEA
GO:0006367	transcription initiation from RNA polymerase II promoter	TAS
GO:0006766	vitamin metabolic process	TAS
GO:0007566	embryo implantation	IEA
GO:0008203	cholesterol metabolic process	TAS
GO:0015721	bile acid and bile salt transport	TAS
GO:0019048	modulation by virus of host morphology or physiology	IDA
GO:0019216	regulation of lipid metabolic process	TAS

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000790	nuclear chromatin	IDA
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	TAS
GO:0043234	protein complex	IDA
GO:0043235	receptor complex	IDA
GO:0090575	RNA polymerase II transcription factor complex	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ACV1B_HUMAN	No
ARI5A_HUMAN	No
BCL3_HUMAN	No
BRD8_HUMAN	No
CASP2_HUMAN	No
CENPR_HUMAN	No
CLOCK_HUMAN	No
CNOT1_HUMAN	No
CSK2B_HUMAN	Yes: P67870 (MoonDB)
CTNB1_HUMAN	No

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Publications Associated

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PMID	Article Title
1310260	9-cis retinoic acid is a high affinity ligand for the retinoid X receptor.
2159111	Nuclear receptor that identifies a novel retinoic acid response pathway.
7746322	Structural determinants of nuclear receptor assembly on DNA direct repeats.
7760929	Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha.
7925381	NMR assignments and secondary structure of the retinoid X receptor alpha DNA-binding domain. Evidence for the novel C-terminal helix.
9267036	Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.
9698548	High-resolution solution structure of the retinoid X receptor DNA-binding domain.
10195690	Conserved amino acids in the ligand-binding and tau(i) domains of the peroxisome proliferator-activated receptor alpha are necessary for heterodimerization with RXR.
10567404	A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo.
10669605	Structural basis of RXR-DNA interactions.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
HOLI	SM00430	SMART
Hormone_recep	PF00104	Pfam
NHR_like_dom_sf	IPR035500	InterPro
NR_LBD	PS51843	PROSITE
Nuc_recep-AF1	IPR021780	InterPro
Nuc_recep-AF1	PF11825	Pfam
Nucl_hrmn_rcpt_lig-bd	IPR000536	InterPro
Nuclear_hrmn_rcpt	IPR001723	InterPro
NUCLEAR_REC_DBD_1	PS00031	PROSITE
NUCLEAR_REC_DBD_2	PS51030	PROSITE

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