Protein: P22736

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P22736 (Uniprot) NR4A1_HUMAN NR4A1 Nuclear receptor subfamily 4 group A member 1 human No
Uniprot: Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0006725 cellular aromatic compound metabolic process 152 GO:0007165 signal transduction 169 5.44e-126 5.27e-27
GO:0007165 signal transduction 169 GO:0034641 cellular nitrogen compound metabolic process 180 4.22e-144 6.90e-18
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
42 GO:0031325 positive regulation of cellular metabolic process
42 GO:0010604 positive regulation of macromolecule metabolic process
42 GO:0051173 positive regulation of nitrogen compound metabolic process
42 GO:0006355 regulation of transcription, DNA-templated
42 GO:0007165 signal transduction
45 GO:0071495 cellular response to endogenous stimulus
45 GO:0071310 cellular response to organic substance
45 GO:0032270 positive regulation of cellular protein metabolic process
45 GO:0006468 protein phosphorylation
45 GO:0042325 regulation of phosphorylation
45 GO:0009966 regulation of signal transduction
49 GO:0006464 cellular protein modification process
49 GO:0031324 negative regulation of cellular metabolic process
49 GO:0010629 negative regulation of gene expression
49 GO:0051172 negative regulation of nitrogen compound metabolic process
49 GO:0006357 regulation of transcription from RNA polymerase II promoter
49 GO:0007165 signal transduction
152 GO:0006139 nucleobase-containing compound metabolic process
164 GO:0044267 cellular protein metabolic process
164 GO:0060255 regulation of macromolecule metabolic process
164 GO:0007165 signal transduction
169 GO:0030522 intracellular receptor signaling pathway
169 GO:0045892 negative regulation of transcription, DNA-templated
169 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
169 GO:0043401 steroid hormone mediated signaling pathway
178 GO:0060255 regulation of macromolecule metabolic process
178 GO:0007165 signal transduction
180 GO:0044271 cellular nitrogen compound biosynthetic process
180 GO:0070887 cellular response to chemical stimulus
180 GO:0006139 nucleobase-containing compound metabolic process
180 GO:0031325 positive regulation of cellular metabolic process
180 GO:0010604 positive regulation of macromolecule metabolic process
180 GO:2000112 regulation of cellular macromolecule biosynthetic process
180 GO:0010468 regulation of gene expression
248 GO:0044267 cellular protein metabolic process
248 GO:0045893 positive regulation of transcription, DNA-templated
248 GO:0051246 regulation of protein metabolic process
248 GO:0007165 signal transduction
330 GO:0006464 cellular protein modification process
330 GO:0006796 phosphate-containing compound metabolic process
330 GO:0031325 positive regulation of cellular metabolic process
330 GO:0010604 positive regulation of macromolecule metabolic process
330 GO:0051173 positive regulation of nitrogen compound metabolic process
330 GO:2000112 regulation of cellular macromolecule biosynthetic process
330 GO:0010468 regulation of gene expression
330 GO:0019219 regulation of nucleobase-containing compound metabolic process
330 GO:0051246 regulation of protein metabolic process
330 GO:0007165 signal transduction
330 GO:0006351 transcription, DNA-templated
376 GO:0044267 cellular protein metabolic process
376 GO:0007165 signal transduction
387 GO:0019538 protein metabolic process
387 GO:0060255 regulation of macromolecule metabolic process
387 GO:0007165 signal transduction
521 GO:0060255 regulation of macromolecule metabolic process
536 GO:0010604 positive regulation of macromolecule metabolic process
536 GO:0051173 positive regulation of nitrogen compound metabolic process
536 GO:0019538 protein metabolic process
536 GO:0007165 signal transduction
594 GO:0044267 cellular protein metabolic process
594 GO:0010467 gene expression
594 GO:0060255 regulation of macromolecule metabolic process
701 GO:0031327 negative regulation of cellular biosynthetic process
701 GO:0010558 negative regulation of macromolecule biosynthetic process
701 GO:0051172 negative regulation of nitrogen compound metabolic process
701 GO:0006357 regulation of transcription from RNA polymerase II promoter
701 GO:0007165 signal transduction
736 GO:0006139 nucleobase-containing compound metabolic process
736 GO:0060255 regulation of macromolecule metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
42 GO:0005829 cytosol
42 GO:0005654 nucleoplasm
45 GO:0005829 cytosol
45 GO:0031981 nuclear lumen
45 GO:0005886 plasma membrane
49 GO:0043232 intracellular non-membrane-bounded organelle
49 GO:0005654 nucleoplasm
152 GO:0005829 cytosol
152 GO:0005634 nucleus
169 GO:0005654 nucleoplasm
178 GO:0005634 nucleus
180 GO:0005829 cytosol
180 GO:0070013 intracellular organelle lumen
180 GO:0044428 nuclear part
248 GO:0031981 nuclear lumen
330 GO:0005829 cytosol
330 GO:0005654 nucleoplasm
376 GO:0005829 cytosol
376 GO:0005634 nucleus
387 GO:0005829 cytosol
387 GO:0005654 nucleoplasm
411 GO:0005634 nucleus
521 GO:0070013 intracellular organelle lumen
521 GO:0005634 nucleus
536 GO:0005829 cytosol
536 GO:0005634 nucleus
594 GO:0070013 intracellular organelle lumen
594 GO:0005634 nucleus
671 GO:0005829 cytosol
671 GO:0070013 intracellular organelle lumen
671 GO:0005634 nucleus
701 GO:0005654 nucleoplasm
736 GO:0005829 cytosol
736 GO:0070013 intracellular organelle lumen
736 GO:0044428 nuclear part
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0001938 positive regulation of endothelial cell proliferation IMP
GO:0002042 cell migration involved in sprouting angiogenesis IDA
GO:0006367 transcription initiation from RNA polymerase II promoter TAS
GO:0007165 signal transduction TAS
GO:0030522 intracellular receptor signaling pathway IEA
GO:0035767 endothelial cell chemotaxis IMP
GO:0035924 cellular response to vascular endothelial growth factor stimulus IMP
GO:0043401 steroid hormone mediated signaling pathway IEA
GO:0043491 protein kinase B signaling TAS
GO:0044344 cellular response to fibroblast growth factor stimulus IMP
GO:0045444 fat cell differentiation ISS
GO:0045786 negative regulation of cell cycle ISS
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA
GO:0061469 regulation of type B pancreatic cell proliferation ISS
GO:0071376 cellular response to corticotropin-releasing hormone stimulus ISS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005829 cytosol IDA
GO:0031965 nuclear membrane IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
1651101 Phorbol ester, forskolin, and serum induction of a human colon nuclear hormone receptor gene related to the NUR 77/NGFI-B genes.
2283997 A human early response gene homologous to murine nur77 and rat NGFI-B, and related to the nuclear receptor superfamily.
2626032 Isolation and characterization of human TR3 receptor: a member of steroid receptor superfamily.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15459248 CR6-interacting factor 1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivation.
15466594 Negative cross-talk between the human orphan nuclear receptor Nur77/NAK-1/TR3 and nuclear factor-kappaB.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16541075 The finished DNA sequence of human chromosome 12.
17360704 RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation.
18669648 A quantitative atlas of mitotic phosphorylation.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
20438716 Regulation of Nur77 protein turnover through acetylation and deacetylation induced by p300 and HDAC1.
22983157 The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK.
No results found.
Domain Name Domain ID Source
A37251 A37251 PIR
Nucl_hrmn_rcpt_lig-bd IPR000536 InterPro
Znf_hrmn_rcpt IPR001628 InterPro
Nuclear_hrmn_rcpt IPR001723 InterPro
Nuc_orph_rcpt IPR003070 InterPro
Nuc_orp_HMR_rcpt IPR003071 InterPro
Znf_NHR/GATA IPR013088 InterPro
NHR_like_dom_sf IPR035500 InterPro
Hormone_recep PF00104 Pfam
zf-C4 PF00105 Pfam
STROIDFINGER PR00047 PRINTS
STRDHORMONER PR00398 PRINTS
NUCLEARECPTR PR01284 PRINTS
HMRNUCRECPTR PR01285 PRINTS
NUCLEAR_REC_DBD_1 PS00031 PROSITE
NUCLEAR_REC_DBD_2 PS51030 PROSITE
NR_LBD PS51843 PROSITE
ZnF_C4 SM00399 SMART
HOLI SM00430 SMART
SSF48508 SSF48508 SUPFAM