Protein: P30041

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P30041 (Uniprot) PRDX6_HUMAN PRDX6 Peroxiredoxin-6 human Yes
Uniprot: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis. more..
Dissimilar Functions Manual Curation

Function 1: Peroxidase. Condition: cytosol localisation.

Function 2: Phospholipase activity. Condition: lysosomal localisation.

Publications (PMID): 10893423, 20919932

Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
536 GO:0010604 positive regulation of macromolecule metabolic process
536 GO:0051173 positive regulation of nitrogen compound metabolic process
536 GO:0019538 protein metabolic process
536 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
119 GO:0005829 cytosol
536 GO:0005829 cytosol
536 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006979 response to oxidative stress IMP
GO:0034599 cellular response to oxidative stress TAS
GO:0042744 hydrogen peroxide catabolic process IEA
GO:0043312 neutrophil degranulation TAS
GO:0045454 cell redox homeostasis IEA
GO:0046475 glycerophospholipid catabolic process IMP
GO:0048026 positive regulation of mRNA splicing, via spliceosome IGI
GO:0055114 oxidation-reduction process IEA
GO:0098869 cellular oxidant detoxification IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005576 extracellular region TAS
GO:0005615 extracellular space IDA
GO:0005634 nucleus IDA
GO:0005737 cytoplasm IDA
GO:0005829 cytosol TAS
GO:0016020 membrane IDA
GO:0035578 azurophil granule lumen TAS
GO:0048471 perinuclear region of cytoplasm IDA
GO:0070062 extracellular exosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005576 extracellular region GO:0005634 nucleus 4.48e-91 1.28e-107
GO:0005615 extracellular space GO:0005634 nucleus 6.26e-54 1.10e-77
GO:0005634 nucleus GO:0016020 membrane 0.00e+00 4.39e-236
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
PMID Article Title
1286669 Human liver protein map: a reference database established by microsequencing and gel comparison.
7788527 Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.
8313871 Plasma and red blood cell protein maps: update 1993.
8999971 Identification of a human cDNA clone for lysosomal type Ca2+-independent phospholipase A2 and properties of the expressed protein.
9050990 The human homologue of a bovine non-selenium glutathione peroxidase is a novel keratinocyte growth factor-regulated gene.
9497358 Characterization of a mammalian peroxiredoxin that contains one conserved cysteine.
9587003 Crystal structure of a novel human peroxidase enzyme at 2.0-A resolution.
10893423 1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities.
12059788 A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress.
12665801 Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15592455 Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
16186110 Saitohin, which is nested in the tau locus and confers allele-specific susceptibility to several neurodegenerative diseases, interacts with peroxiredoxin 6.
16710414 The DNA sequence and biological annotation of human chromosome 1.
18669648 A quantitative atlas of mitotic phosphorylation.
19188445 APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20716133 The novel protein MANI modulates neurogenesis and neurite-cone growth.
21269460 Initial characterization of the human central proteome.
22223895 Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
22905912 Resveratrol-induced changes of the human adipocyte secretion profile.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25944712 N-terminome analysis of the human mitochondrial proteome.
27353378 Crystal structures of human peroxiredoxin 6 in different oxidation states.
No results found.
Domain Name Domain ID Source
Hs1CysPrx01 4426 PeroxiBase
AhpC/TSA IPR000866 InterPro
Thioredoxin_domain IPR013766 InterPro
Peroxiredoxin_C IPR019479 InterPro
Peroxiredoxin_AhpC-typ IPR024706 InterPro
Thioredoxin-like_sf IPR036249 InterPro
AhpC-TSA PF00578 Pfam
1-cysPrx_C PF10417 Pfam
AHPC PIRSF000239 PIRSF
THIOREDOXIN_2 PS51352 PROSITE
SSF52833 SSF52833 SUPFAM