Protein: P30041 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P30041 (Uniprot)	PRDX6_HUMAN	PRDX6	Peroxiredoxin-6	human	Yes

Protein Function

Uniprot: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 f more..

Dissimilar Functions Manual Curation

Function 1: Peroxidase. Condition: cytosol localisation.

Function 2: Phospholipase activity. Condition: lysosomal localisation.

Publications (PMID): 10893423, 20919932

MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
536	GO:0010604	positive regulation of macromolecule metabolic process
536	GO:0051173	positive regulation of nitrogen compound metabolic process
536	GO:0019538	protein metabolic process
536	GO:0007165	signal transduction

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
119	GO:0005829	cytosol
536	GO:0005829	cytosol
536	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006979	response to oxidative stress	IMP
GO:0034599	cellular response to oxidative stress	TAS
GO:0042744	hydrogen peroxide catabolic process	IEA
GO:0043312	neutrophil degranulation	TAS
GO:0045454	cell redox homeostasis	IEA
GO:0046475	glycerophospholipid catabolic process	IMP
GO:0048026	positive regulation of mRNA splicing, via spliceosome	IGI
GO:0055114	oxidation-reduction process	IEA
GO:0098869	cellular oxidant detoxification	IMP

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Cellular Components

Showing 1 to 9 of 9 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005576	extracellular region	TAS
GO:0005615	extracellular space	IDA
GO:0005634	nucleus	IDA
GO:0005737	cytoplasm	IDA
GO:0005829	cytosol	TAS
GO:0016020	membrane	IDA
GO:0035578	azurophil granule lumen	TAS
GO:0048471	perinuclear region of cytoplasm	IDA
GO:0070062	extracellular exosome	IDA

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Dissimilar Cellular Components (PrOnto)

Showing 1 to 4 of 4 entries

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005576	extracellular region	GO:0005634	nucleus	4.48e-91	1.28e-107
GO:0005615	extracellular space	GO:0005634	nucleus	6.26e-54	1.10e-77
GO:0005634	nucleus	GO:0016020	membrane	0.00e+00	4.39e-236
GO:0005634	nucleus	GO:0070062	extracellular exosome	6.30e-13	4.54e-26

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
1433E_HUMAN	Yes: P62258 (MoonDB)
A1AG2_HUMAN	No
CASP8_HUMAN	No
CASPA_HUMAN	No
GPX4_HUMAN	No
GSTP1_HUMAN	No
HNF4G_HUMAN	No
NCF2_HUMAN	No
NR4A1_HUMAN	Yes: P22736 (MoonDB)
PAXI1_HUMAN	No

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Publications Associated

Showing 1 to 10 of 28 entries

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PMID	Article Title
1286669	Human liver protein map: a reference database established by microsequencing and gel comparison.
7788527	Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.
8313871	Plasma and red blood cell protein maps: update 1993.
8999971	Identification of a human cDNA clone for lysosomal type Ca2+-independent phospholipase A2 and properties of the expressed protein.
9050990	The human homologue of a bovine non-selenium glutathione peroxidase is a novel keratinocyte growth factor-regulated gene.
9497358	Characterization of a mammalian peroxiredoxin that contains one conserved cysteine.
9587003	Crystal structure of a novel human peroxidase enzyme at 2.0-A resolution.
10893423	1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities.
12059788	A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress.
12665801	Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 11 entries

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Domain Name	Domain ID	Source
1-cysPrx_C	PF10417	Pfam
AHPC	PIRSF000239	PIRSF
AhpC-TSA	PF00578	Pfam
AhpC/TSA	IPR000866	InterPro
Hs1CysPrx01	4426	PeroxiBase
Peroxiredoxin_AhpC-typ	IPR024706	InterPro
Peroxiredoxin_C	IPR019479	InterPro
SSF52833	SSF52833	SUPFAM
Thioredoxin-like_sf	IPR036249	InterPro
THIOREDOXIN_2	PS51352	PROSITE

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