Protein: P50552 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P50552 (Uniprot)	VASP_HUMAN	VASP	Vasodilator-stimulated phosphoprotein	human	No

Protein Function

Uniprot: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growi more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0019538	protein metabolic process	164, 248	GO:0016070	RNA metabolic process	715	5.15e-08	2.82e-13

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
164	GO:0044267	cellular protein metabolic process
164	GO:0060255	regulation of macromolecule metabolic process
164	GO:0007165	signal transduction
248	GO:0044267	cellular protein metabolic process
248	GO:0045893	positive regulation of transcription, DNA-templated
248	GO:0051246	regulation of protein metabolic process
248	GO:0007165	signal transduction
419	GO:0022607	cellular component assembly
715	GO:0006396	RNA processing
715	GO:0060255	regulation of macromolecule metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
248	GO:0031981	nuclear lumen
419	GO:0044430	cytoskeletal part
419	GO:0005829	cytosol
715	GO:0031981	nuclear lumen

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0001843	neural tube closure	IEA
GO:0007411	axon guidance	TAS
GO:0008154	actin polymerization or depolymerization	IEA
GO:0030838	positive regulation of actin filament polymerization	IDA
GO:0034329	cell junction assembly	TAS
GO:0051289	protein homotetramerization	IEA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	IDA
GO:0005923	bicellular tight junction	IEA
GO:0005925	focal adhesion	IDA
GO:0015629	actin cytoskeleton	TAS
GO:0031258	lamellipodium membrane	IEA
GO:0031527	filopodium membrane	IEA
GO:0070062	extracellular exosome	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ABI1_HUMAN	No
ABI2_HUMAN	Yes: Q9NYB9 (MoonDB)
ABI3_HUMAN	No
ACTG_HUMAN	No
DMRTB_HUMAN	No
FR1OP_HUMAN	No
FRS3_HUMAN	No
NOL3_HUMAN	No
NR4A1_HUMAN	Yes: P22736 (MoonDB)
PLS1_HUMAN	No

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Publications Associated

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PMID	Article Title
7737110	The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins.
7828592	Molecular cloning, structural analysis and functional expression of the proline-rich focal adhesion and microfilament-associated protein VASP.
7925440	Phosphorylation of focal adhesion vasodilator-stimulated phosphoprotein at Ser157 in intact human platelets correlates with fibrinogen receptor inhibition.
8182057	cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets.
8812448	Cloning of the VASP (vasodilator-stimulated phosphoprotein) genes in human and mouse: structure, sequence, and chromosomal localization.
10087267	Role of proteins of the Ena/VASP family in actin-based motility of Listeria monocytogenes.
10438535	The EVH2 domain of the vasodilator-stimulated phosphoprotein mediates tetramerization, F-actin binding, and actin bundle formation.
10637295	LPP, an actin cytoskeleton protein related to zyxin, harbors a nuclear export signal and transcriptional activation capacity.
10801818	Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins.
10990454	Dual epitope recognition by the VASP EVH1 domain modulates polyproline ligand specificity and binding affinity.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 13 entries

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Domain Name	Domain ID	Source
PH-like_dom_sf	IPR011993	InterPro
PTHR11202:SF12	PTHR11202:SF12	PANTHER
S51797	S51797	PIR
SSF50729	SSF50729	SUPFAM
Vasodilator_Phospo	PIRSF038010	PIRSF
VASP	IPR034367	InterPro
VASP/EVL	IPR017354	InterPro
VASP_tetra	IPR014885	InterPro
VASP_tetra	PF08776	Pfam
WH1	PF00568	Pfam

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